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31. 发明申请

US20150194045A1 Devices and methods for generating gunshot alerts 审中-公开
标题翻译：用于生成枪声警报的设备和方法
公开(公告)号：US20150194045A1
公开(公告)日：2015-07-09
申请号：US13589887
申请日：2012-08-20
申请人： David A. Edwards , Narciso Macia
发明人： David A. Edwards , Narciso Macia
IPC分类号： G08B25/10
CPC分类号： G08B13/1672 , G01H3/00
摘要： Devices and methods for generating gunshot alerts are provided. In some embodiments, devices for generating a gunshot alert are provided, the devices comprising: a microphone having an output; an amplifier having an input coupled to the output of the microphone and an output; a band-pass filter having an input coupled to the output of the amplifier and an output; an analog to digital converter having an input coupled to the output of the band-pass filter and an output; a microcontroller having an input coupled to the output of the analog to digital converter and an output; and a notification device having an input coupled to the output of the microcontroller.
摘要翻译：提供了产生枪声警报的设备和方法。在一些实施例中，提供了用于产生枪声警报的装置，所述装置包括：具有输出的麦克风; 具有耦合到所述麦克风的输出的输入和输出的放大器; 带通滤波器，具有耦合到放大器的输出端的输入端和输出端; 具有耦合到带通滤波器的输出的输入和输出的模数转换器; 微控制器，具有耦合到模数转换器的输出的输入端和输出端; 以及具有耦合到微控制器的输出的输入的通知装置。

32. 外观设计

USD664446S1 Aerosol dispenser 有权
标题翻译：气雾剂
公开(公告)号：USD664446S1
公开(公告)日：2012-07-31
申请号：US29400658
申请日：2011-08-31
申请人： David A. Edwards
设计人： David A. Edwards

33. 发明申请

US20120031830A1 Transporting and Treating Water 审中-公开
标题翻译：运输和处理水
公开(公告)号：US20120031830A1
公开(公告)日：2012-02-09
申请号：US13127921
申请日：2009-11-09
申请人： David A. Edwards , Joseph Shivers , Kevin Burrows , Steve Teng , Michael Silvestri , Werner Hugo van Vuuren , Mathieu Lehanneur , Jose Sanchez
发明人： David A. Edwards , Joseph Shivers , Kevin Burrows , Steve Teng , Michael Silvestri , Werner Hugo van Vuuren , Mathieu Lehanneur , Jose Sanchez
IPC分类号： B01D35/00 , B65D33/02 , B01D29/00
CPC分类号： C02F1/002 , A45F3/02 , A45F3/04 , A45F3/20 , B65D37/00
摘要： Water can be transported and/or treated using a system or container in which a collapsible framework is attached to a membrane. A collapsible water container defining a volume for receiving, transporting, and delivering water can include: a membrane of material substantially impermeable to water, the membrane having a substantially cylindrical expanded configuration with a central axis and substantially contracted configuration; wherein the membrane configured to rotatably expand about the axis when water is placed within the volume defined by the collapsible water container and rotatably contract about the axis when water is removed from the volume defined by the collapsible water container.
摘要翻译：水可以使用其中可折叠框架附接到膜的系统或容器来运输和/或处理水。限定用于接收，运输和输送水的体积的可折叠的水容器可以包括：基本上不透水的材料膜，所述膜具有基本上圆柱形的膨胀构型，具有中心轴线和基本上收缩的构型; 其中所述膜构造成当水被放置在由所述可折叠的水容器限定的体积内时围绕所述轴线可旋转地膨胀，并且当水从所述可折叠的水容器限定的体积中移除时，所述膜可绕所述轴线旋转收缩。

34. 发明申请

US20120017011A1 OUT-OF-BAND ACCESS TO STORAGE DEVICES THROUGH PORT-SHARING HARDWARE 有权
标题翻译：通过端口共享硬件访问存储设备的带外
公开(公告)号：US20120017011A1
公开(公告)日：2012-01-19
申请号：US12836341
申请日：2010-07-14
申请人： David A. Edwards , Eng Hun Ooi , Venkat R. Gokulrangan , Hormuzd M. Khosravi , Chai Huat Gan
发明人： David A. Edwards , Eng Hun Ooi , Venkat R. Gokulrangan , Hormuzd M. Khosravi , Chai Huat Gan
IPC分类号： G06F3/00
CPC分类号： G06F3/0604 , G06F3/0617 , G06F3/0659 , G06F3/067
摘要： A method, apparatus, system, and computer program product for enabling out-of-band access to storage devices through port-sharing hardware. Providing out-of-band access to storage devices enables system management functions to be performed when an operating system is non-functional as well as when the operating system is active. Storage commands originating with a management service can be interleaved with storage commands issued by the host operating system. The host operating system maintains ownership and control over its storage devices, but management activities can be performed while the host operating system is operational.
摘要翻译：一种用于通过端口共享硬件对存储设备进行带外访问的方法，装置，系统和计算机程序产品。提供对存储设备的带外访问可使系统管理功能在操作系统不起作用以及操作系统处于活动状态时执行。源自管理服务的存储命令可以与主机操作系统发出的存储命令交错。主机操作系统维护对其存储设备的所有权和控制权，但是可以在主机操作系统运行时执行管理活动。

35. 外观设计

USD631538S1 Food inhaler 有权
标题翻译：食物吸入器
公开(公告)号：USD631538S1
公开(公告)日：2011-01-25
申请号：US29334903
申请日：2009-04-03
申请人： David A. Edwards , Jonathan Jacques Kamler , Jonathan Man , Jose Sanchez
设计人： David A. Edwards , Jonathan Jacques Kamler , Jonathan Man , Jose Sanchez

36. 发明授权

US07698884B2 Power transmission arrangement 有权
标题翻译：动力传动装置
公开(公告)号：US07698884B2
公开(公告)日：2010-04-20
申请号：US12222551
申请日：2008-08-12
申请人： Alan R. Maguire , David C. Butt , Martyn Richards , Geoffrey E. Kirk , David A. Edwards , Glenn A. Knight
发明人： Alan R. Maguire , David C. Butt , Martyn Richards , Geoffrey E. Kirk , David A. Edwards , Glenn A. Knight
IPC分类号： F02C3/107 , F02C7/36 , F02C7/32
CPC分类号： F02C7/268 , F02C3/107 , F02C7/27 , F02C7/275 , F02C7/36 , Y10S74/05
摘要： A power transmission arrangement comprises a first power transmission member connectable to a first main shaft of an engine. The arrangement also includes a second power transmission member connectable to a second main shaft of the engine and to a third power transmission member. A coupling assembly is provided which has a selectable coupling condition to couple the first power transmission member to the second power transmission member to allow power to be transmitted from the third power transmission member to the first main shaft of the engine via the first power transmission member. The coupling assembly has a decoupling condition to decouple the first power transmission member from the second power transmission member to allow power to be transmitted from the main shaft of the engine to the third power transmission member via the second power transmission member.
摘要翻译：动力传递装置包括可连接到发动机的第一主轴的第一动力传递构件。该装置还包括可连接到发动机的第二主轴和第三动力传递构件的第二动力传递构件。提供了一种联接组件，其具有可选择的联接状态，以将第一动力传递构件联接到第二动力传递构件，以允许动力经由第一动力传递构件从第三动力传递构件传递到发动机的第一主轴。联接组件具有去耦条件，以将第一动力传递构件与第二动力传递构件分离，以允许动力经由第二动力传递构件从发动机的主轴传递到第三动力传递构件。

37. 发明申请

US20090208581A1 FORMULATIONS LIMITING SPREAD OF PULMONARY INFECTIONS 有权
标题翻译：限制肺部感染蔓延的制剂
公开(公告)号：US20090208581A1
公开(公告)日：2009-08-20
申请号：US12351328
申请日：2009-01-09
申请人： David A. Edwards , Howard A. Stone
发明人： David A. Edwards , Howard A. Stone
IPC分类号： A61K9/14 , C08B37/00 , C07K14/00 , A61K31/74 , A61K38/16 , A61K31/715 , C08B37/02 , C08G65/34 , C07K14/76 , A61K31/721 , A61K31/765 , A61K38/38 , A61P31/12 , A01K29/00 , A61D7/00
CPC分类号： A61K9/0075 , A61K9/0078 , A61K31/355 , A61K31/685 , A61K31/715
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as vital infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles. These may include proteins such as albumin or polysaccharides such as dextran, which also has surface active properties, or polymers such as polyethylene oxide (PEO) or biodegradable synthetic polymers which can be used to encapsulate or deliver the materials to be delivered. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
摘要翻译：已经开发了用于肺部输送以治疗或减少诸如人体中的重要感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫的疾病的感染性的制剂。用于肺部给药的制剂包括显着改变诸如表面活性剂和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。制剂可以粉末施用，其中颗粒基本上由改变表面张力的材料组成。载体可以是溶液，例如醇，尽管可以使用水溶液，或与材料混合的材料改变表面张力以形成颗粒。这些可以包括诸如白蛋白或多糖的蛋白质，例如还具有表面活性的葡聚糖，或聚合物如聚环氧乙烷（PEO）或可生物降解的合成聚合物，其可用于封装或递送待递送材料。药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。这些可以与制剂一起施用或掺入制剂中。

38. 发明申请

US20080213373A1 Particles for Treatment of Pulmonary Infection 有权
标题翻译：用于治疗肺部感染的颗粒
公开(公告)号：US20080213373A1
公开(公告)日：2008-09-04
申请号：US11720595
申请日：2005-10-19
申请人： David A. Edwards , Jennifer Fiegel , Jean Sung
发明人： David A. Edwards , Jennifer Fiegel , Jean Sung
IPC分类号： A61K9/14
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1694 , Y10S514/924
摘要： Formulations have been developed to treat or reduce the spread of respiratory infections, especially chronic or drug resistant infections, particularly tuberculosis (TB), severe acute respiratory syndrome (SARS), meningococcal meningitis, Respiratory syncytial virus (RSV), influenza, and small pox. Formulations include a drug or vaccine in the form of a microparticle, nanoparticle, or aggregate of nanoparticles, and, optionally, a carrier, which can be delivered by inhalation. Giving the drugs via an inhaler sidesteps the problems associated with oral or injectable drugs by bypassing the stomach and liver, and delivering the medication directly into the lungs. In one embodiment, the particle containing the agent is a large porous aerosol particle (LPPs). In another embodiment, the particles are nanoparticles, which can be administered as porous nanoparticle aggregates with micron diameters that disperse into nanoparticles following administration. Optionally, the nanoparticles are coated, such as with a surfactant or protein coating. The formulation may be administered as a powder or administered as a solution or via an enteral or non-pulmonary parenteral route of administration. The formulation is preferably administered as a pulmonary formulation. In the preferred embodiment for treatment of TB, the vaccine is a BCG vaccine that is stable at room temperature, or is an antibiotic effective against TB, such as capreomycin or PA-824, loaded at a very high percentage into the microparticles or nanoparticles. In one embodiment, a patient is treated with formulations delivering both antibiotic and vaccine.
摘要翻译：已经开发了治疗或减少呼吸道感染传播的制剂，特别是慢性或耐药性感染，特别是结核病（TB），严重急性呼吸综合征（SARS），脑膜炎球菌性脑膜炎，呼吸道合胞病毒（RSV），流感和小痘。制剂包括纳米颗粒的微粒，纳米颗粒或骨料形式的药物或疫苗，以及任选的可以通过吸入递送的载体。通过吸入器给药可以通过绕过胃和肝来避开与口服或可注射药物相关的问题，并将药物直接送入肺部。在一个实施方案中，含有该试剂的颗粒是大的多孔气溶胶颗粒（LPPs）。在另一个实施方案中，颗粒是纳米颗粒，其可以作为具有微米直径的多孔纳米颗粒聚集体施用，其在施用后分散到纳米颗粒中。任选地，包覆纳米颗粒，例如用表面活性剂或蛋白质涂层。制剂可以粉末形式施用或作为溶液给药或通过肠内或非肺部非肠道途径给药。制剂优选作为肺制剂施用。在用于治疗结核病的优选实施方案中，疫苗是在室温下稳定的BCG疫苗，或者是针对TB有效的抗生素，例如卷曲霉素或PA-824，其以非常高的百分比加载到微粒或纳米颗粒中。在一个实施方案中，用递送抗生素和疫苗的制剂治疗患者。

39. 发明授权

US07048908B2 Particles for inhalation having sustained release properties 有权
公开(公告)号：US07048908B2
公开(公告)日：2006-05-23
申请号：US10202616
申请日：2002-07-23
申请人： Sujit K. Basu , Jeffrey Hrkach , Michael Lipp , Katharina Elbert , David A. Edwards
发明人： Sujit K. Basu , Jeffrey Hrkach , Michael Lipp , Katharina Elbert , David A. Edwards
IPC分类号： A61K9/12 , A61K9/127
CPC分类号： A61K9/0075 , A61K9/1617 , A61K38/28 , A61K47/544 , Y10S514/958
摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.

40. 发明授权

US06956021B1 Stable spray-dried protein formulations 有权
标题翻译：稳定的喷雾干燥蛋白制剂
公开(公告)号：US06956021B1
公开(公告)日：2005-10-18
申请号：US09383054
申请日：1999-08-25
申请人： David A. Edwards , Jeffrey S. Hrkach
发明人： David A. Edwards , Jeffrey S. Hrkach
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K38/00 , A61K38/27 , A61K47/00
CPC分类号： A61K9/0075 , A61K9/1617 , Y10S514/951 , Y10S514/97 , Y10S514/975
摘要： Spray-dried particles having improved protein stability are produced by spray-drying a mixture including a protein, a phospholipid and an organic-aqueous co-solvent. Spray-dried particles which include at least 1 weight % phospholipid, having a tap density of less than 0.4 g/cm3 can be prepared. The particles can be delivered to the pulmonary system of a patient.
摘要翻译：具有改善的蛋白质稳定性的喷雾干燥颗粒通过喷雾干燥包括蛋白质，磷脂和有机 - 水性共溶剂的混合物而产生。包含至少1重量％磷脂的喷雾干燥颗粒，其振实密度小于0.4g / cm 3，可以制备。颗粒可以输送到患者的肺部系统。

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