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1. 发明申请

US20080213373A1 Particles for Treatment of Pulmonary Infection 有权
标题翻译：用于治疗肺部感染的颗粒
公开(公告)号：US20080213373A1
公开(公告)日：2008-09-04
申请号：US11720595
申请日：2005-10-19
申请人： David A. Edwards , Jennifer Fiegel , Jean Sung
发明人： David A. Edwards , Jennifer Fiegel , Jean Sung
IPC分类号： A61K9/14
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1694 , Y10S514/924
摘要： Formulations have been developed to treat or reduce the spread of respiratory infections, especially chronic or drug resistant infections, particularly tuberculosis (TB), severe acute respiratory syndrome (SARS), meningococcal meningitis, Respiratory syncytial virus (RSV), influenza, and small pox. Formulations include a drug or vaccine in the form of a microparticle, nanoparticle, or aggregate of nanoparticles, and, optionally, a carrier, which can be delivered by inhalation. Giving the drugs via an inhaler sidesteps the problems associated with oral or injectable drugs by bypassing the stomach and liver, and delivering the medication directly into the lungs. In one embodiment, the particle containing the agent is a large porous aerosol particle (LPPs). In another embodiment, the particles are nanoparticles, which can be administered as porous nanoparticle aggregates with micron diameters that disperse into nanoparticles following administration. Optionally, the nanoparticles are coated, such as with a surfactant or protein coating. The formulation may be administered as a powder or administered as a solution or via an enteral or non-pulmonary parenteral route of administration. The formulation is preferably administered as a pulmonary formulation. In the preferred embodiment for treatment of TB, the vaccine is a BCG vaccine that is stable at room temperature, or is an antibiotic effective against TB, such as capreomycin or PA-824, loaded at a very high percentage into the microparticles or nanoparticles. In one embodiment, a patient is treated with formulations delivering both antibiotic and vaccine.
摘要翻译：已经开发了治疗或减少呼吸道感染传播的制剂，特别是慢性或耐药性感染，特别是结核病（TB），严重急性呼吸综合征（SARS），脑膜炎球菌性脑膜炎，呼吸道合胞病毒（RSV），流感和小痘。制剂包括纳米颗粒的微粒，纳米颗粒或骨料形式的药物或疫苗，以及任选的可以通过吸入递送的载体。通过吸入器给药可以通过绕过胃和肝来避开与口服或可注射药物相关的问题，并将药物直接送入肺部。在一个实施方案中，含有该试剂的颗粒是大的多孔气溶胶颗粒（LPPs）。在另一个实施方案中，颗粒是纳米颗粒，其可以作为具有微米直径的多孔纳米颗粒聚集体施用，其在施用后分散到纳米颗粒中。任选地，包覆纳米颗粒，例如用表面活性剂或蛋白质涂层。制剂可以粉末形式施用或作为溶液给药或通过肠内或非肺部非肠道途径给药。制剂优选作为肺制剂施用。在用于治疗结核病的优选实施方案中，疫苗是在室温下稳定的BCG疫苗，或者是针对TB有效的抗生素，例如卷曲霉素或PA-824，其以非常高的百分比加载到微粒或纳米颗粒中。在一个实施方案中，用递送抗生素和疫苗的制剂治疗患者。

2. 发明授权

US08846607B2 Particles for treatment of pulmonary infection 有权
标题翻译：用于治疗肺部感染的颗粒
公开(公告)号：US08846607B2
公开(公告)日：2014-09-30
申请号：US11720595
申请日：2005-10-19
申请人： David A. Edwards , Jennifer Fiegel , Jean Sung
发明人： David A. Edwards , Jennifer Fiegel , Jean Sung
IPC分类号： A61K9/14 , A61P31/06 , A61P11/00 , A61K38/12 , A61K9/00 , A61K9/16
CPC分类号： A61K9/0075 , A61K9/1617 , A61K9/1694 , Y10S514/924
摘要： Formulations have been developed to treat or reduce the spread of respiratory infections, especially chronic or drug resistant infections, particularly tuberculosis (TB), severe acute respiratory syndrome (SARS), meningococcal meningitis, Respiratory syncytial virus (RSV), influenza, and small pox. Formulations include a drug or vaccine in the form of a microparticle, nanoparticle, or aggregate of nanoparticles, and, optionally, a carrier, which can be delivered by inhalation. Giving the drugs via an inhaler sidesteps the problems associated with oral or injectable drugs by bypassing the stomach and liver, and delivering the medication directly into the lungs. In one embodiment, the particle containing the agent is a large porous aerosol particle (LPPs). In another embodiment, the particles are nanoparticles, which can be administered as porous nanoparticle aggregates with micron diameters that disperse into nanoparticles following administration. Optionally, the nanoparticles are coated, such as with a surfactant or protein coating. The formulation may be administered as a powder or administered as a solution or via an enteral or non-pulmonary parenteral route of administration. The formulation is preferably administered as a pulmonary formulation. In the preferred embodiment for treatment of TB, the vaccine is a BCG vaccine that is stable at room temperature, or is an antibiotic effective against TB, such as capreomycin or PA-824, loaded at a very high percentage into the microparticles or nanoparticles. In one embodiment, a patient is treated with formulations delivering both antibiotic and vaccine.
摘要翻译：已经开发了治疗或减少呼吸道感染传播的制剂，特别是慢性或耐药性感染，特别是结核病（TB），严重急性呼吸综合征（SARS），脑膜炎球菌性脑膜炎，呼吸道合胞病毒（RSV），流感和小痘。制剂包括纳米颗粒的微粒，纳米颗粒或骨料形式的药物或疫苗，以及任选的可以通过吸入递送的载体。通过吸入器给药可以通过绕过胃和肝来避开与口服或可注射药物相关的问题，并将药物直接送入肺部。在一个实施方案中，含有该试剂的颗粒是大的多孔气溶胶颗粒（LPPs）。在另一个实施方案中，颗粒是纳米颗粒，其可以作为具有微米直径的多孔纳米颗粒聚集体施用，其在施用后分散到纳米颗粒中。任选地，包覆纳米颗粒，例如用表面活性剂或蛋白质涂层。制剂可以粉末形式施用或作为溶液给药或通过肠内或非肺部非肠道途径给药。制剂优选作为肺制剂施用。在用于治疗结核病的优选实施方案中，疫苗是在室温下稳定的BCG疫苗，或者是针对TB有效的抗生素，例如卷曲霉素或PA-824，其以非常高的百分比加载到微粒或纳米颗粒中。在一个实施方案中，用递送抗生素和疫苗的制剂治疗患者。

3. 发明授权

US07163697B2 Biodegradable polymer compositions, compositions and uses related thereto 有权
标题翻译：可生物降解的聚合物组合物，组合物和与之相关的用途
公开(公告)号：US07163697B2
公开(公告)日：2007-01-16
申请号：US10177748
申请日：2002-06-21
申请人： Justin Hanes , Jie Fu , Jennifer Fiegel
发明人： Justin Hanes , Jie Fu , Jennifer Fiegel
IPC分类号： A61K9/32 , A61K9/50 , C08G63/02 , C08G65/34
CPC分类号： A61K9/5146 , A61K9/0073 , A61K9/1641
摘要： The present application is directed to biodegradable polymers, compositions, including microspheres and nanospheres, formed of such polymers, and methods of using such polymers and compositions. In certain embodiments, the subject polymer compositions include therapeutic agents, optionally providing sustained release of the encapsulated agent after administration to a patient.
摘要翻译：本申请涉及由这样的聚合物形成的可生物降解的聚合物，包括微球和纳米球的组合物，以及使用这种聚合物和组合物的方法。在某些实施方案中，本发明聚合物组合物包括治疗剂，任选地在给予患者后提供包封的药剂的持续释放。

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