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1. 发明申请

US20090208581A1 FORMULATIONS LIMITING SPREAD OF PULMONARY INFECTIONS 有权
标题翻译：限制肺部感染蔓延的制剂
公开(公告)号：US20090208581A1
公开(公告)日：2009-08-20
申请号：US12351328
申请日：2009-01-09
申请人： David A. Edwards , Howard A. Stone
发明人： David A. Edwards , Howard A. Stone
IPC分类号： A61K9/14 , C08B37/00 , C07K14/00 , A61K31/74 , A61K38/16 , A61K31/715 , C08B37/02 , C08G65/34 , C07K14/76 , A61K31/721 , A61K31/765 , A61K38/38 , A61P31/12 , A01K29/00 , A61D7/00
CPC分类号： A61K9/0075 , A61K9/0078 , A61K31/355 , A61K31/685 , A61K31/715
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as vital infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles. These may include proteins such as albumin or polysaccharides such as dextran, which also has surface active properties, or polymers such as polyethylene oxide (PEO) or biodegradable synthetic polymers which can be used to encapsulate or deliver the materials to be delivered. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
摘要翻译：已经开发了用于肺部输送以治疗或减少诸如人体中的重要感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫的疾病的感染性的制剂。用于肺部给药的制剂包括显着改变诸如表面活性剂和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。制剂可以粉末施用，其中颗粒基本上由改变表面张力的材料组成。载体可以是溶液，例如醇，尽管可以使用水溶液，或与材料混合的材料改变表面张力以形成颗粒。这些可以包括诸如白蛋白或多糖的蛋白质，例如还具有表面活性的葡聚糖，或聚合物如聚环氧乙烷（PEO）或可生物降解的合成聚合物，其可用于封装或递送待递送材料。药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。这些可以与制剂一起施用或掺入制剂中。

2. 发明授权

US08858917B2 Methods for limiting spread of pulmonary infections 有权
标题翻译：限制肺部感染传播的方法
公开(公告)号：US08858917B2
公开(公告)日：2014-10-14
申请号：US12351328
申请日：2009-01-09
申请人： David A. Edwards , Howard A. Stone
发明人： David A. Edwards , Howard A. Stone
IPC分类号： A61K9/00 , A61K31/685 , A61K9/14 , A61K31/74 , A61K31/355 , A61K31/715
CPC分类号： A61K9/0075 , A61K9/0078 , A61K31/355 , A61K31/685 , A61K31/715
摘要： Formulations have been developed for pulmonary delivery to treat or reduce the infectivity of diseases such as vital infections, especially tuberculosis, SARS, influenza and respiratory synticial virus in humans and hoof and mouth disease in animals. Formulations for pulmonary administration include a material that significantly alters physical properties such as surface tension and surface elasticity of lung mucus lining fluid, which may be a surfactant and, optionally, a carrier. The formulation may be administered as a powder where the particles consist basically of the material altering surface tension. The carrier may be a solution, such as an alcohol, although an aqueous solution may be utilized, or a material mixed with the material altering surface tension to form particles. These may include proteins such as albumin or polysaccharides such as dextran, which also has surface active properties, or polymers such as polyethylene oxide (PEO) or biodegradable synthetic polymers which can be used to encapsulate or deliver the materials to be delivered. Drugs, especially antivirals or antibiotics, may optionally be included with the formulation. These may be administered with or incorporated into the formulation.
摘要翻译：已经开发了用于肺部输送以治疗或减少诸如人体中的重要感染，特别是结核病，SARS，流感和呼吸道合成病毒以及动物蹄和口蹄疫的疾病的感染性的制剂。用于肺部给药的制剂包括显着改变诸如表面活性剂和任选的载体的肺粘液衬里液体的表面张力和表面弹性的物理性质的材料。制剂可以粉末施用，其中颗粒基本上由改变表面张力的材料组成。载体可以是溶液，例如醇，尽管可以使用水溶液，或与材料混合的材料改变表面张力以形成颗粒。这些可以包括诸如白蛋白或多糖的蛋白质，例如还具有表面活性的葡聚糖，或聚合物如聚环氧乙烷（PEO）或可生物降解的合成聚合物，其可用于封装或递送待递送材料。药物，特别是抗病毒剂或抗生素，可以任选地包括在制剂中。这些可以与制剂一起施用或掺入制剂中。

3. 发明申请

US20140377130A1 SYSTEMS, METHODS AND ARTICLES TO PROVIDE OLFACTORY SENSATIONS 审中-公开
标题翻译：系统，方法和提供OLFACTORY SENSATIONS的文章
公开(公告)号：US20140377130A1
公开(公告)日：2014-12-25
申请号：US14213683
申请日：2014-03-14
申请人： David A. Edwards , Rachel Diane Field , Amy Michelle Yin , Eyal Shahar
发明人： David A. Edwards , Rachel Diane Field , Amy Michelle Yin , Eyal Shahar
IPC分类号： G05B15/02 , A61L9/02 , A61L9/03
CPC分类号： G05B15/02 , A61L9/02 , A61L9/03 , A61L9/035 , A61L2209/133 , A61L2209/134 , H04M1/21
摘要： A scent release system includes scent cartridges containing temperature activated scent media. The scent cartridges may bear machine-readable identification that specifies which scent media are carried by the cartridge. The scent release system can be controlled by a timer to initiate a phase change of the scent media to selectively release one or more scents, followed by a reverse phase change to selectively stop release of the respective scents. A scent release system in conjunction with a mobile electronic device, such as a smart phone, allows sending and receiving scent messages. The scent release system can be built into a case for the mobile electronic device, eliminating the need for a separate unit. A private scent delivery device in the form of a headset can be worn by users of a scent release system or by scent message recipients.
摘要翻译：气味释放系统包括含有温度活化香味介质的香味盒。气味墨盒可以承载机器可读的识别，其指定墨盒所携带的香味介质。香味释放系统可以由定时器控制以启动香味介质的相变，以选择性地释放一种或多种香料，随后进行反向相变以选择性地停止释放相应的香味。与诸如智能电话的移动电子设备结合的气味释放系统允许发送和接收香味消息。气味释放系统可以内置在移动电子设备的外壳中，无需单独的单元。耳机形式的私人气味递送装置可以由气味释放系统的用户或香味消息接收者穿戴。

4. 发明授权

US08856534B2 Method and apparatus for secure scan of data storage device from remote server 有权
标题翻译：从远程服务器安全扫描数据存储设备的方法和装置
公开(公告)号：US08856534B2
公开(公告)日：2014-10-07
申请号：US12785146
申请日：2010-05-21
申请人： Hormuzd M. Khosravi , David A. Edwards , Venkat R. Gokulrangan , Yasser Rasheed
发明人： Hormuzd M. Khosravi , David A. Edwards , Venkat R. Gokulrangan , Yasser Rasheed
IPC分类号： G06F15/177 , H04L9/32
CPC分类号： G06F21/64 , G06F21/567 , G06F21/606 , G06F21/85 , G06F2213/0038
摘要： A method and device for providing a secure scan of a data storage device from a remote server are disclosed. In some embodiments, a computing device may include an in-band processor configured to execute an operating system and at least one host driver, communication circuitry configured to communicate with a remote server, and an out-of-band (OOB) processor capable of communicating with the remote server using the communication circuitry irrespective of the state of the operating system. The OOB processor may be configured to receive a block read request from the remote server, instruct the at least one host driver to send a storage command to a data storage device, receive data retrieved from the data storage device and authentication metadata generated by the data storage device, and transmit the data and the authentication metadata to the remote server.
摘要翻译：公开了一种从远程服务器提供数据存储设备的安全扫描的方法和设备。在一些实施例中，计算设备可以包括带内处理器，其被配置为执行操作系统和至少一个主机驱动器，被配置为与远程服务器通信的通信电路和能够与远程服务器通信的带外（OOB）使用通信电路与远程服务器通信，而与操作系统的状态无关。 OOB处理器可以被配置为从远程服务器接收块读取请求，指示至少一个主机驱动程序向数据存储设备发送存储命令，接收从数据存储设备检索的数据和由数据生成的认证元数据存储设备，并将数据和认证元数据传输到远程服务器。

5. 发明申请

US20110289146A1 METHOD AND APPARATUS ALLOWING SCAN OF DATA STORAGE DEVICE FROM REMOTE SERVER 有权
标题翻译：从远程服务器允许数据存储设备扫描的方法和设备
公开(公告)号：US20110289146A1
公开(公告)日：2011-11-24
申请号：US12785131
申请日：2010-05-21
申请人： Hormuzd Khosravi , David Durham , David A. Edwards , Venkat R. Gokulrangan , Men Long , Yasser Rasheed
发明人： Hormuzd Khosravi , David Durham , David A. Edwards , Venkat R. Gokulrangan , Men Long , Yasser Rasheed
IPC分类号： G06F15/167 , G06F12/00
CPC分类号： G06F21/57 , G06F21/56
摘要： A method and device allowing a scan of a data storage device from a remote server are disclosed. In some embodiments, a computing device may include an out-of-band (OOB) configured to compute a first hash value for data stored in one or more sectors of a data storage device at a first time; receive, using communication circuitry, a request to transmit a portion of the data stored in the one or more sectors of the data storage device at a second time, the second time being subsequent to the first time; compute a second hash value for the data stored in the one or more sectors of the data storage device at the second time; and transmit, using the communication circuitry, the requested portion of the data, only if the second hash value does not match the first hash value.
摘要翻译：公开了允许从远程服务器扫描数据存储设备的方法和设备。在一些实施例中，计算设备可以包括带外（OOB），其被配置为在第一时间对存储在数据存储设备的一个或多个扇区中的数据计算第一散列值; 接收使用通信电路的请求，以在第二时间之后的第二时间第二时间发送存储在数据存储装置的一个或多个扇区中的数据的一部分的请求; 在第二次计算存储在数据存储设备的一个或多个扇区中的数据的第二哈希值; 并且仅当所述第二散列值与所述第一散列值不匹配时，才使用所述通信电路来发送所请求的数据部分。

6. 再颁专利

USRE41996E1 Composition and methods for enhancing receptor-mediated cellular internalization 有权
标题翻译：用于增强受体介导的细胞内化的组合物和方法
公开(公告)号：USRE41996E1
公开(公告)日：2010-12-14
申请号：US11821513
申请日：2007-06-21
申请人： Daniel R. Deaver , David A. Edwards , Robert S. Langer
发明人： Daniel R. Deaver , David A. Edwards , Robert S. Langer
IPC分类号： A61F2/02 , A61F13/02 , A61K9/48 , A61K9/20 , A61K9/14
CPC分类号： A61K9/0046 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/006 , A61K9/0073 , A61K9/06 , A61K31/56 , A61K31/573 , A61K31/715 , A61K47/38 , A61K48/00 , A61K48/0008 , A61K48/0083 , Y10S977/906
摘要： Compositions and methods for improving cellular internalization of one or more compounds are disclosed. The compositions include a compound to be delivered and a biocompatible viscous material, such as a hydrogel, lipogel, or highly viscous sol. The composition also include, or are administered in conjunction with, an enhancer in an amount effective to maximize expression of or binding to receptors and enhance RME of the compound into the cells. This leads to high transport rates of compounds to be delivered across cell membranes, facilitating more efficient delivery of drugs and diagnostic agents. Compositions are applied topically orally, nasally, vaginally, rectally, and ocularly. The enhancer is administered with the composition or separately, either systemically or preferably locally. The compound to be delivered can also be the enhancer.
摘要翻译：公开了用于改善一种或多种化合物的细胞内化的组合物和方法。组合物包括待递送的化合物和生物相容的粘性材料，例如水凝胶，脂凝胶或高粘度溶胶。该组合物还包括或者与增效剂一起施用，其量可以有效地最大程度地使受体的表达或结合，并增强化合物进入细胞的RME。这导致要跨细胞膜递送的化合物的高传输速率，有助于更有效地递送药物和诊断剂。组合物经口，鼻，阴道，直肠和眼部局部应用。增强剂与组合物一起施用或分开施用，全部或优选局部施用。待递送的化合物也可以是增强剂。

7. 发明授权

US06977087B2 Aerodynamically light particles for pulmonary drug delivery 失效
标题翻译：用于肺部药物递送的空气动力学轻微颗粒
公开(公告)号：US06977087B2
公开(公告)日：2005-12-20
申请号：US10090418
申请日：2002-03-01
申请人： David A. Edwards , Giovannia Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdell Aziz Ben-Jebria , Robert S. Langer
发明人： David A. Edwards , Giovannia Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdell Aziz Ben-Jebria , Robert S. Langer
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K31/56 , A61K31/568 , A61K38/28
CPC分类号： A61K9/0075 , A61K9/1647 , A61K31/56 , A61K31/568 , A61K38/28
摘要： Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear α-hydroxy-acid polyester backbone having at least one amino acid group incorporated herein and at least on poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic or diagnostic agent to the alveolar region of the lung. The aerodynamically light particles optionally can incorporate a therapeutic or diagnostic agent, and may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of a wide variety of incorporated agents.
摘要翻译：提供用于递送至肺系统的改善的空气动力学轻微颗粒，以及其制备和给药方法。在优选的实施方案中，空气动力学轻微颗粒由可生物降解的材料制成，并且振实密度小于0.4g / cm 3，质量平均直径在5μm和30μm之间。颗粒可以由可生物降解的材料如可生物降解的聚合物形成。例如，颗粒可以由官能化的聚酯接枝共聚物形成，所述官能化聚酯接枝共聚物由具有至少一个引入本文的氨基酸基团和至少在从氨基酸延伸的聚（氨基酸）侧链上的直链α-羟基酸聚酯主链组成集团在聚酯骨干。在一个实施方案中，具有大平均直径（例如大于5μm）的空气动力学轻的颗粒可用于增强治疗或诊断剂递送至肺的肺泡区域。空气动力学轻微颗粒任选地可以掺入治疗剂或诊断剂，并且可以有效地雾化用于给予呼吸道以允许各种并入药剂的全身或局部递送。

8. 发明授权

US06399102B1 Aerodynamically light particles for pulmonary drug delivery 有权
公开(公告)号：US06399102B1
公开(公告)日：2002-06-04
申请号：US09562988
申请日：2000-05-01
申请人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdellaziz Ben-Jebria , Robert S. Langer
发明人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdellaziz Ben-Jebria , Robert S. Langer
IPC分类号： A61K914
CPC分类号： A61K9/0075 , A61K9/1647 , A61K31/137
摘要： Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of biodegradable material and have a tap density of less than 0.4 g/cm3 and a mass mean diameter between 5 &mgr;m and 30 &mgr;m. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear &agr;-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 &mgr;m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.

9. 发明授权

US5985320A Materials and methods for enhancing cellular internalization 失效
标题翻译：用于增强细胞内化的材料和方法
公开(公告)号：US5985320A
公开(公告)日：1999-11-16
申请号：US810275
申请日：1997-03-03
申请人： David A. Edwards , Daniel R. Deaver , Robert S. Langer
发明人： David A. Edwards , Daniel R. Deaver , Robert S. Langer
IPC分类号： A61K9/06 , A61K9/00 , A61K9/127 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K38/22 , A61K38/43 , A61K38/55 , A61K39/395 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K48/00 , A61K49/00
CPC分类号： A61K9/0043 , A61K47/38 , A61K9/0034 , A61K47/10 , A61K47/26 , A61K47/36 , Y10S436/829
摘要： Compositions and methods for delivering agents across cell membranes are disclosed. The compositions include an agent to be delivered, a viscous material, such as a hydrogel, lipogel or viscous sol, and, optionally, a carrier that includes a ligand that binds to or interacts with cell surface receptors. The agent to be delivered binds to or otherwise interacts with cell surface receptors, is attached, either covalently or ionically to a molecule that binds to or interacts with a cell surface receptor, or is associated with the carrier. Agents to be delivered include bioactive compounds and diagnostic agents. The compositions have an apparent viscosity roughly equal to the viscosity of the cytosol in the cell to which the agent is to be delivered. The rate of cellular internalization is higher when the viscosity of the viscous material and that of the cytosol in the cell are approximately the same, relative to when they are not the same. The compositions enhance cellular entry of bioactive agents and diagnostic materials when administered vaginally, nasally, rectally ocularly, orally, or to the respiratory or pulmonary system.
摘要翻译：公开了用于递送细胞膜的药剂的组合物和方法。组合物包括待递送的试剂，粘性物质，例如水凝胶，脂凝胶或粘稠溶胶，以及任选的包含与细胞表面受体结合或与细胞表面受体相互作用的配体的载体。待递送的药剂与细胞表面受体结合或以其他方式相互作用，与结合细胞表面受体或与细胞表面受体相关的分子共价或离子地连接。待递送的试剂包括生物活性化合物和诊断剂。组合物的表观粘度大致等于试剂要递送的细胞中细胞溶胶的粘度。当粘性物质和细胞质中的细胞溶胶的粘度相差不大时，细胞内化速率较高。当阴道，鼻，直肠眼，口服或呼吸或肺部系统施用时，组合物增强生物活性剂和诊断材料的细胞进入。

10. 发明授权

US5874064A Aerodynamically light particles for pulmonary drug delivery 失效
公开(公告)号：US5874064A
公开(公告)日：1999-02-23
申请号：US739308
申请日：1996-10-29
申请人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdell Aziz Ben-Jebria , Robert S. Langer
发明人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdell Aziz Ben-Jebria , Robert S. Langer
IPC分类号： A61K9/12 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/72 , A61K31/137 , A61K47/32
CPC分类号： A61K9/0075 , A61K31/137 , A61K9/1647
摘要： Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm.sup.3 and a mass mean diameter between 5 .mu.m and 30 .mu.m. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear .alpha.-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 .mu.m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.

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