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31. 发明申请

US20100280348A1 METHOD AND IMPLANTABLE SYSTEM FOR BLOOD-GLUCOSE CONCENTRATION MONITORING USING PARALLEL METHODOLOGIES 有权
标题翻译：使用并行方法对血液葡萄糖浓度监测的方法和可植入系统
公开(公告)号：US20100280348A1
公开(公告)日：2010-11-04
申请号：US12433414
申请日：2009-04-30
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
IPC分类号： A61B5/145
CPC分类号： A61B5/0006 , A61B5/0205 , A61B5/04012 , A61B5/0428 , A61B5/0452 , A61B5/14532 , A61B5/14542 , A61B5/14551 , A61B5/1459 , A61B5/4836 , A61B5/4866 , A61B5/6846 , A61B5/686 , A61B5/7285 , A61B5/746
摘要： In an implantable medical device for monitoring glucose concentration in the blood, a blood-glucose concentration analysis is performed using correlations of blood-glucose concentration with measures of metabolic oxygen consumption including oxymetric, and/or temperature. Analysis of electrocardiographic data is used in a parallel method to detect and/or confirm the onset and/or existence and/or extent of hypoglycemia and/or hyperglycemia. Blood-glucose concentration calculation is enhanced by using the combination of the oxygen metabolism analysis and electrocardiographic analysis.
摘要翻译：在用于监测血液中葡萄糖浓度的可植入医疗装置中，使用血糖浓度与包括氧测量和/或温度在内的代谢氧消耗量的相关性进行血糖浓度分析。使用并行方法来分析心电图数据以检测和/或确认低血糖和/或高血糖症的发作和/或存在和/或程度。通过使用氧代谢分析和心电图分析的组合，提高血糖浓度计算。

32. 发明授权

US08571642B2 Pre-ejection interval (PEI) monitoring devices, systems and methods 有权
标题翻译：预喷射间隔（PEI）监测装置，系统和方法
公开(公告)号：US08571642B2
公开(公告)日：2013-10-29
申请号：US12882084
申请日：2010-09-14
申请人： Jong Gill , Brian Jeffrey Wenzel , Allen Keel , Wenbo Hou , Edward Karst , Taraneh G. Farazi
发明人： Jong Gill , Brian Jeffrey Wenzel , Allen Keel , Wenbo Hou , Edward Karst , Taraneh G. Farazi
IPC分类号： A61B5/02
CPC分类号： A61B5/0456 , A61B5/02028 , A61B5/0295 , A61B5/0422 , A61B5/686 , A61B5/7239 , A61N1/3684
摘要： Provided herein are implantable systems, and methods for use therewith, for monitoring a patient's pre-ejection interval (PEI). A signal indicative of cardiac electrical activity and a signal indicative of changes in arterial blood volume are obtained. One or more predetermined features of the signal indicative of cardiac electrical activity and the signal indicative of changes in arterial blood volume are detected. The patient's PEI is determined by determining an interval between the predetermined feature of the signal indicative of cardiac electrical activity and the predetermined feature of the signal indicative of changes in arterial blood volume.
摘要翻译：本文提供了可植入系统及其使用的方法，用于监测患者的预喷射间隔（PEI）。获得指示心脏电活动的信号和指示动脉血容量变化的信号。检测到指示心脏电活动的信号的一个或多个预定特征以及指示动脉血容量变化的信号。通过确定指示心脏电活动的信号的预定特征与指示动脉血容量变化的信号的预定特征之间的间隔来确定患者的PEI。

33. 发明申请

US20120221069A1 Systems and Methods for Activating and Controlling Impedance-Based Detection Systems of Implantable Medical Devices 有权
公开(公告)号：US20120221069A1
公开(公告)日：2012-08-30
申请号：US13035793
申请日：2011-02-25
申请人： Stuart Rosenberg , Cecilia Qin Xi , Yelena Nabutovsky , Brian Jeffrey Wenzel , Jong Gill , William Hsu
发明人： Stuart Rosenberg , Cecilia Qin Xi , Yelena Nabutovsky , Brian Jeffrey Wenzel , Jong Gill , William Hsu
IPC分类号： A61N1/365
CPC分类号： A61B5/0538 , A61B5/686 , A61N1/36507 , A61N1/36521 , A61N1/36592 , A61N1/3684
摘要： Techniques are provided for use with implantable medical devices for addressing encapsulation effects, particularly in the detection of cardiac decompensation events such as heart failure (HF) or cardiogenic pulmonary edema (PE.) In one example, during an acute interval following device implant, cardiac decompensation is detected using heart rate variability (HRV), ventricular evoked response (ER) or various other non-impedance-based parameters that are insensitive to component encapsulation effects. During the subsequent chronic interval, decompensation is detected using intracardiac or transthoracic impedance signals. In another example, the degree of maturation of encapsulation of implanted components is assessed using impedance frequency-response measurements or based on the frequency bandwidth of heart sounds or other physiological signals. In this manner, impedance-based HF/PE detection systems can be activated as soon as component encapsulation has matured, without necessarily waiting until completion of a preset post-implant maturation interval, often set to forty-five days or more.

34. 发明授权

US08208999B2 System and method for estimating electrical conduction delays from immittance values measured using an implantable medical device 有权
标题翻译：用于使用可植入医疗装置测量的导纳值估计导电延迟的系统和方法
公开(公告)号：US08208999B2
公开(公告)日：2012-06-26
申请号：US12127963
申请日：2008-05-28
申请人： Brian Jeffrey Wenzel , Dorin Panescu , Mihir Naware , Jeffery Siou
发明人： Brian Jeffrey Wenzel , Dorin Panescu , Mihir Naware , Jeffery Siou
IPC分类号： A61B5/04
CPC分类号： A61B5/0215 , A61B5/0002 , A61B5/002 , A61B5/053 , A61B5/4839 , A61B5/686 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/742 , A61B5/746 , A61B2560/0223 , A61N1/36521
摘要： Techniques are provided for estimating electrical conduction delays with the heart of a patient based on measured immittance values. In one example, impedance or admittance values are measured within the heart of a patient by a pacemaker or other implantable medical device, then used by the device to estimate cardiac electrical conduction delays. A first set of predetermined conversion factors may be used to convert the measured immittance values into conduction delay values. In some examples, the device then uses the estimated conduction delay values to estimate LAP or other cardiac pressure values. A second set of predetermined conversion factors may be used to convert the estimated conduction delays into pressure values. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP.
摘要翻译：提供了用于基于测量的导纳值估计与患者心脏的导电延迟的技术。在一个示例中，阻抗或导纳值由起搏器或其他可植入医疗装置在患者的心脏内测量，然后由装置用于估计心脏导电延迟。可以使用第一组预定转换因子将测量的导纳值转换为导通延迟值。在一些示例中，器件然后使用估计的传导延迟值来估计LAP或其他心脏压力值。可以使用第二组预定转换因子将估计的传导延迟转换为压力值。还描述了基于估计的LAP自适应地调整起搏参数的技术。

35. 发明授权

US08504152B2 System and method for estimating cardiac pressure based on cardiac electrical conduction delays using an implantable medical device 有权
公开(公告)号：US08504152B2
公开(公告)日：2013-08-06
申请号：US11779350
申请日：2007-07-18
申请人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
发明人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
IPC分类号： A61N1/365
CPC分类号： A61B5/02156 , A61B5/0215 , A61B5/72 , A61N1/365 , A61N1/36564 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/37258
摘要： Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.

36. 发明申请

US20120065528A1 PRE-EJECTION INTERVAL (PEI) MONITORING DEVICES, SYSTEMS AND METHODS 有权
标题翻译：预引导间隔（PEI）监控设备，系统和方法
公开(公告)号：US20120065528A1
公开(公告)日：2012-03-15
申请号：US12882084
申请日：2010-09-14
申请人： Jong Gill , Brian Jeffrey Wenzel , Allen Keel , Wenbo Hou , Edward Karst , Taraneh G. Farazi
发明人： Jong Gill , Brian Jeffrey Wenzel , Allen Keel , Wenbo Hou , Edward Karst , Taraneh G. Farazi
IPC分类号： A61B5/042
CPC分类号： A61B5/0456 , A61B5/02028 , A61B5/0295 , A61B5/0422 , A61B5/686 , A61B5/7239 , A61N1/3684
摘要： Provided herein are implantable systems, and methods for use therewith, for monitoring a patient's pre-ejection interval (PEI). A signal indicative of cardiac electrical activity and a signal indicative of changes in arterial blood volume are obtained. One or more predetermined features of the signal indicative of cardiac electrical activity and the signal indicative of changes in arterial blood volume are detected. The patient's PEI is determined by determining an interval between the predetermined feature of the signal indicative of cardiac electrical activity and the predetermined feature of the signal indicative of changes in arterial blood volume.
摘要翻译：本文提供了可植入系统及其使用的方法，用于监测患者的预喷射间隔（PEI）。获得指示心脏电活动的信号和指示动脉血容量变化的信号。检测到指示心脏电活动的信号的一个或多个预定特征以及指示动脉血容量变化的信号。通过确定指示心脏电活动的信号的预定特征与指示动脉血容量变化的信号的预定特征之间的间隔来确定患者的PEI。

37. 发明申请

US20120065527A1 Methods and Systems for Monitoring Aterial Stiffness 审中-公开
标题翻译：监测动静刚度的方法和系统
公开(公告)号：US20120065527A1
公开(公告)日：2012-03-15
申请号：US12882099
申请日：2010-09-14
申请人： Jong Gill , Brian Jeffrey Wenzel , Allen Keel , Wenbo Hou , Edward Karst , Taraneh G. Farazi
发明人： Jong Gill , Brian Jeffrey Wenzel , Allen Keel , Wenbo Hou , Edward Karst , Taraneh G. Farazi
IPC分类号： A61B5/0295
CPC分类号： A61B5/02007 , A61B5/0295 , A61B5/686
摘要： Implanted systems and methods for monitoring a patient's arterial stiffness are provided. An implanted sensor is used to produce a signal indicative of changes in arterial blood volume for a plurality of beats of the patient's heart. A pulse duration metric is determined for each of a plurality of pulses of the signal, wherein each pulse of the signal corresponds to a beat of the patient's heart. Arterial stiffness is monitored based on the determined pulse duration metric for the plurality of pulses of the signal. This can include monitoring arterial stiffness based on a dispersion of the pulse duration metric and/or an average of the pulse duration metric.
摘要翻译：提供了用于监测患者动脉硬度的植入系统和方法。植入的传感器用于产生指示患者心脏的多个节拍的动脉血容量变化的信号。为信号的多个脉冲中的每一个确定脉冲持续时间度量，其中信号的每个脉冲对应于患者心脏的搏动。基于确定的信号的多个脉冲的脉冲持续时间度量监测动脉硬度。这可以包括基于脉冲持续时间度量的偏差和/或脉冲持续时间度量的平均值监视动脉硬度。

38. 发明授权

US09113789B2 System and method for estimating electrical conduction delays from immittance values measured using an implantable medical device 有权
标题翻译：用于使用可植入医疗装置测量的导纳值估计导电延迟的系统和方法
公开(公告)号：US09113789B2
公开(公告)日：2015-08-25
申请号：US13485512
申请日：2012-05-31
申请人： Brian Jeffrey Wenzel , Dorin Panescu , Mihir Naware , Jeffery Siou
发明人： Brian Jeffrey Wenzel , Dorin Panescu , Mihir Naware , Jeffery Siou
IPC分类号： A61B5/02 , A61B5/0215 , A61B5/053 , A61N1/365 , A61B5/00
CPC分类号： A61B5/0215 , A61B5/0002 , A61B5/002 , A61B5/053 , A61B5/4839 , A61B5/686 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/742 , A61B5/746 , A61B2560/0223 , A61N1/36521
摘要： Techniques are provided for estimating electrical conduction delays with the heart of a patient based on measured immittance values. In one example, impedance or admittance values are measured within the heart of a patient by a pacemaker or other implantable medical device, then used by the device to estimate cardiac electrical conduction delays. A first set of predetermined conversion factors may be used to convert the measured immittance values into conduction delay values. In some examples, the device then uses the estimated conduction delay values to estimate LAP or other cardiac pressure values. A second set of predetermined conversion factors may be used to convert the estimated conduction delays into pressure values. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP.
摘要翻译：提供了用于基于测量的导纳值估计与患者心脏的导电延迟的技术。在一个示例中，阻抗或导纳值由起搏器或其他可植入医疗装置在患者的心脏内测量，然后由装置用于估计心脏导电延迟。可以使用第一组预定转换因子将测量的导纳值转换为导通延迟值。在一些示例中，器件然后使用估计的传导延迟值来估计LAP或其他心脏压力值。可以使用第二组预定转换因子将估计的传导延迟转换为压力值。还描述了基于估计的LAP自适应地调整起搏参数的技术。

39. 发明授权

US08843197B2 Method and system to correct contractility based on non-heart failure factors 有权
标题翻译：基于非心力衰竭因子校正收缩性的方法和系统
公开(公告)号：US08843197B2
公开(公告)日：2014-09-23
申请号：US13049774
申请日：2011-03-16
申请人： Stuart Rosenberg , Cecilia Qin Xi , Jong Gill , Brian Jeffrey Wenzel , Yelena Nabutovsky , William Hsu
发明人： Stuart Rosenberg , Cecilia Qin Xi , Jong Gill , Brian Jeffrey Wenzel , Yelena Nabutovsky , William Hsu
IPC分类号： A61N1/365 , A61B5/02 , A61B5/042 , A61N1/362
CPC分类号： A61N1/36585 , A61B5/02028 , A61B5/042 , A61N1/3627 , A61N1/36507 , A61N1/36521 , A61N1/36564 , A61N1/36578
摘要： A method for trending heart failure measures cardiogenic impedance (CI) and obtains signals representing estimates for or direct measurements of at least one of cardiac volume and pressure of the heart when the CI measurements were obtained. The method identifies correction factors based on the signals and applies the correction factors to the contractility estimates. A system for trending heart failure includes a contractility module to determine contractility estimates from CI measurements taken along at least a first vector through a heart, and a collection module to receive signals representing estimates for or direct measurements of at least one of cardiac volume and pressure of the heart when the CI measurements were obtained. The system further includes a factor module to identify correction factors based on the signals and a correction module to apply the correction factors to the contractility estimates.
摘要翻译：用于趋势性心力衰竭的方法测量心源性阻抗（CI）并且获得当获得CI测量时表示心脏体积和心脏压力中的至少一个的估计或直接测量的信号。该方法基于信号识别校正因子，并将修正因子应用于收缩率估计。用于趋向心力衰竭的系统包括收缩模块，用于根据通过心脏的至少第一载体进行的CI测量来确定收缩性估计，以及收集模块，用于接收代表心脏体积和压力中的至少一个的估计或直接测量的信号的CI测量值。该系统还包括一个因素模块，用于基于信号识别校正因子，以及一个校正模块，以将校正因子应用于收缩性估计。

40. 发明申请

US20120239104A1 METHOD AND SYSTEM TO CORRECT CONTRACTILITY BASED ON NON-HEART FAILURE FACTORS 有权
标题翻译：基于非心脏衰竭因子校正合并的方法和系统
公开(公告)号：US20120239104A1
公开(公告)日：2012-09-20
申请号：US13049774
申请日：2011-03-16
申请人： Stuart Rosenberg , Cecilia Qin Xi , Jong Gill , Brian Jeffrey Wenzel , Yelena Nabutovsky , William Hsu
发明人： Stuart Rosenberg , Cecilia Qin Xi , Jong Gill , Brian Jeffrey Wenzel , Yelena Nabutovsky , William Hsu
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61B5/02028 , A61B5/042 , A61N1/3627 , A61N1/36507 , A61N1/36521 , A61N1/36564 , A61N1/36578
摘要： A method is provided for trending heart failure based on heart contractility information comprises measuring cardiogenic impedance (CI) measurements along at least a first vector through a heart over a period of time. The method determines contractility estimates from the CI measurements, the contractility estimates relating to contractility of the heart. The method further obtains physiologic and/or surrogate signals representing estimates for or direct measurements of at least one of cardiac volume and pressure of the heart when the CI measurements were obtained. The method identifies correction factors based on the physiologic and/or surrogate signals and applies the correction factors to the contractility estimates to produce contractility trend values over the period of time. A system is provided for trending heart failure based on heart contractility information which comprises inputs to receive cardiogenic impedance (CI) measurements taken along at least a first vector through a heart over a period of time. The system includes a contractility module to determine contractility estimates from the CI measurements, the contractility estimates relating to contractility of the heart and a collection module to receive physiologic and/or surrogate signals representing estimates for or direct measurements of at least one of cardiac volume and pressure of the heart when the CI measurements were obtained. A factor module is also provided to identify correction factors based on the physiologic and/or surrogate signals and a correction module to apply the correction factors to the contractility estimates to produce contractility trend values over the period of time.
摘要翻译：提供了一种基于心脏收缩性信息来趋向于心力衰竭的方法，包括在一段时间内通过心脏沿着至少第一载体测量心源阻抗（CI）测量。该方法确定CI测量的收缩性估计值，与心脏收缩性相关的收缩性估计值。当获得CI测量时，该方法进一步获得表示心脏体积和心脏压力中的至少一个的估计值或直接测量值的生理和/或替代信号。该方法基于生理和/或替代信号识别校正因子，并将修正因子应用于收缩性估计以产生一段时间内的收缩趋势值。提供了一种用于基于心脏收缩性信息来趋向心力衰竭的系统，其包括用于在一段时间内通过心脏沿着至少第一载体进行的心源阻抗（CI）测量的输入。该系统包括收缩性模块，用于根据CI测量值确定收缩性估计值，与心脏的收缩性相关的收缩性估计值以及收集模块以接收表示心脏体积和/或心脏容积中的至少一个的估计值或/或直接测量值的生理和/或替代信号，获得CI测量时心脏的压力。还提供了一个因素模块，用于根据生理和/或替代信号识别校正因子，以及校正模块，以将修正因子应用于收缩性估计，以产生一段时间内的收缩趋势值。

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