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31. 发明申请

WO2006052936A2 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：作为蛋白激酶抑制剂的化合物和组合物
公开(公告)号：WO2006052936A2
公开(公告)日：2006-05-18
申请号：PCT/US2005040372
申请日：2005-11-07
申请人： IRM LLC , WAN YONGQIN , MI YUAN , FAN YI , CHENG DAI , LIU YI , GRAY NATHANAEL SCHIANDER , ALBAUGH PAMELA A
发明人： WAN YONGQIN , MI YUAN , FAN YI , CHENG DAI , LIU YI , GRAY NATHANAEL SCHIANDER , ALBAUGH PAMELA A
IPC分类号： A61K31/4178
CPC分类号： C07D403/14 , C07D403/06
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC , Raf, ROCK-II, Rsk1, SGK, TrkA, TrkB and TrkC kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，Bcr-Abl异常活化的疾病或病症，cSrc，TPR-Met，Tie2，MET，FGFR3，Aurora，Ax1，Bmx，BTK，c-kit，CHK2，Flt3，MST2，p70S6K，PDGFR，PKB，PKC，Raf，ROCK-II，Rsk1，SGK，TrkA ，TrkB和TrkC激酶。

32. 发明申请

WO2005039486A3 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：作为蛋白激酶抑制剂的化合物和组合物
公开(公告)号：WO2005039486A3
公开(公告)日：2006-03-16
申请号：PCT/US2004027997
申请日：2004-08-27
申请人： IRM LLC , DING QIANG , GRAY NATHANAEL SCHIANDER , LI BING , LIU YI , UNO TETSUO
发明人： DING QIANG , GRAY NATHANAEL SCHIANDER , LI BING , LIU YI , UNO TETSUO
IPC分类号： A61K20060101 , A61K31/4745 , A61K31/519 , A61K31/675 , C07D471/02 , C07D487/02 , C07D487/04 , C07D471/04 , A61K31/4355
CPC分类号： C07D487/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, CSK, TrkB, FGFR3, Fes, Lck, B-RAF, C-RAF, MKK6, SAPK2a and SAPK2ß kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症，Bmx，CSK，TrkB，FGFR3，Fes，Lck，B-RAF，C-RAF，MKK6，SAPK2a和SAPK2β激酶。

33. 发明申请

WO2005034869A3 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：作为蛋白激酶抑制剂的化合物和组合物
公开(公告)号：WO2005034869A3
公开(公告)日：2005-07-07
申请号：PCT/US2004033009
申请日：2004-10-08
申请人： IRM LLC , DING QIANG , XIE YONGPING , GRAY NATHANAEL SCHIANDER , YOU SHULI , CHOPIUK GREG , JIANG JIQING , LIU YI , STEENSMA RUO , WANG XING , SIM TAEBO
发明人： DING QIANG , XIE YONGPING , GRAY NATHANAEL SCHIANDER , YOU SHULI , CHOPIUK GREG , JIANG JIQING , LIU YI , STEENSMA RUO , WANG XING , SIM TAEBO
IPC分类号： A61K20060101 , A61K31/44 , A61K31/47 , A61K31/4706 , A61K31/4745 , A61K31/519 , C07D215/16 , C07D471/00 , C07D471/02 , A61K31/514
CPC分类号： C07D471/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, CSK, JNK1, JNK2, PDGF-R, p38, p70S6K, TGF beta , SRC, EGFR, c-Kit, trkB, FGFR3, Fes, Lck, Syk, RAF, MKK4, MKK6 and SAPK2 beta kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症，CSK，JNK1，JNK2，PDGF-R，p38，p70S6K，TGFβ，SRC，EGFR，c-Kit，trkB，FGFR3，Fes，Lck，Syk，RAF，MKK4，MKK6和SAPK2β激酶。

34. 发明申请

WO2013012915A8 HETEROCYCLIC COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：杂环化合物及其用途
公开(公告)号：WO2013012915A8
公开(公告)日：2014-02-27
申请号：PCT/US2012047186
申请日：2012-07-18
申请人： INFINITY PHARMACEUTICALS INC , CASTRO ALFREDO C , EVANS CATHERINE A , JANARDANANNAIR SOMARAJANNAIR , LESCARBEAU ANDRE , LIU TAO , SNYDER DANIEL A , TREMBLAY MARTIN R , REN PINGDA , LIU YI , LI LIANSHENG , CHAN KATRINA
发明人： CASTRO ALFREDO C , EVANS CATHERINE A , JANARDANANNAIR SOMARAJANNAIR , LESCARBEAU ANDRE , LIU TAO , SNYDER DANIEL A , TREMBLAY MARTIN R , REN PINGDA , LIU YI , LI LIANSHENG , CHAN KATRINA
IPC分类号： C07D471/04 , A61K31/4725 , A61P37/00 , C07D487/04
CPC分类号： C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
摘要翻译：本文描述了调节激酶活性（包括PI3激酶活性）的化合物和药物组合物，以及化合物，药物组合物和治疗与激酶活性（包括PI3激酶活性）相关的疾病和病症的方法。

35. 发明申请

WO2012148540A8 COMBINATION OF KINASE INHIBITORS AND USES THEREOF 审中-公开
标题翻译：激酶抑制剂的组合及其用途
公开(公告)号：WO2012148540A8
公开(公告)日：2013-09-26
申请号：PCT/US2012026399
申请日：2012-02-23
申请人： INTELLIKINE LLC , REN PINGDA , LIU YI , JESSEN KATAYOUN , GUO XIN , ROMMEL CHRISTIAN , WILSON TROY EDWARD
发明人： REN PINGDA , LIU YI , JESSEN KATAYOUN , GUO XIN , ROMMEL CHRISTIAN , WILSON TROY EDWARD
IPC分类号： A61K31/535
CPC分类号： A61K31/5377 , A61K9/0053 , A61K31/4439 , A61K31/4745 , A61K31/498 , A61K31/501 , A61K31/517 , A61K31/519 , A61K31/527 , A61K31/53 , A61K31/541 , A61K31/551 , A61K45/06 , A61K31/4709 , A61K2300/00
摘要： The present invention provides for a method for treating a disease condition associated with PI3 -kinase alpha and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3 -kinase alpha and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth.
摘要翻译：本发明提供用于治疗受试者中与PI3激酶α和/或mTOR相关的疾病状况的方法。另一方面，本发明提供了治疗与受试者中PI3激酶α和/或mTOR相关的疾病状况的方法。另一方面，阐述了抑制细胞中Akt（S473）和Akt（T308）的磷酸化的方法。

36. 发明申请

WO2012126424A2 METHOD AND DEVICE FOR FORWARDING DATA PACKET 审中-公开
标题翻译：用于前向数据包的方法和设备
公开(公告)号：WO2012126424A2
公开(公告)日：2012-09-27
申请号：PCT/CN2012075715
申请日：2012-05-18
申请人： HUAWEI TECH CO LTD , LIU YI
发明人： LIU YI
IPC分类号： H04L12/56
CPC分类号： H04L47/34
摘要： Provided are a method and device for forwarding a data packet. The implementation of the method comprises: a data packet forwarding device receives a data packet, with the data packet being a data packet encapsulated by a communication protocol which requires undamaged and ordered arrival of data packets at the receiving end; the data packet forwarding device judges whether or not the data packet arrives at the data packet forwarding device in accordance with the correct order; if it does not, then the data packet will be stored in a cache queue corresponding to the link to which the data packet belongs; and the data packet forwarding device sends the data packets in the cache queue to the receiving end according to the serial number of the data packet from small to big successively. By way of adjusting the sequence of the data packets before the data packets are sent to the receiving end in the above method, the sending sequence of the data packets is closer to the original sequence thereof, which can lower the disordered sequence rate of the data packets and reduce the problem of bandwidth occupation by the repeated sending of the ACK request and the retransmission of the data packets by the receiving end, thus improving the throughput rate of the network.
摘要翻译：提供了用于转发数据分组的方法和设备。该方法的实现包括：数据分组转发设备接收数据分组，数据分组是由通信协议封装的数据分组，其需要数据分组在接收端的无损和有序的到达; 数据包转发装置根据正确的顺序判断数据包是否到达数据包转发装置; 如果没有，那么数据包将被存储在对应于数据包所属链路的缓存队列中; 并且数据分组转发设备根据数据分组的序列号从小到大依次将高速缓存队列中的数据分组发送到接收端。通过在上述方法中将数据分组发送到接收端之前调整数据分组的顺序，数据分组的发送序列更接近其原始序列，这可以降低数据的无序序列速率并通过接收端重复发送ACK请求和重传数据包来减少带宽占用的问题，从而提高网络的吞吐率。

37. 发明申请

WO2010129279A3 ELECTROADDRESSING AND IN-FILM BIOPROCESSING USING STIMULI-RESPONSIVE HYDROGEL-FORMING POLYMERS 审中-公开
标题翻译：使用刺激性水凝胶形成聚合物进行电加工和膜内生物处理
公开(公告)号：WO2010129279A3
公开(公告)日：2011-05-05
申请号：PCT/US2010032575
申请日：2010-04-27
申请人： UNIV MARYLAND BIOTECH INST , SHI XIAO-WEN , LIU YI , PAYNE GREGORY F , YANG XIAOHUA
发明人： SHI XIAO-WEN , LIU YI , PAYNE GREGORY F , YANG XIAOHUA
IPC分类号： C12N11/04 , C08B37/04 , C08B37/12
CPC分类号： C12N11/04 , B01J2219/00576 , B01J2219/00641 , B01J2219/00644 , B01J2219/00653 , B01J2219/00725 , B01J2219/00743 , C09D105/04 , G01N33/5438
摘要： Methods for the generation of hydrogels formed by electrodeposition of an electroaddressable polymer are described. The hydrogels may contain one or more cell populations electroaddressed or electroaddressable to a location within the hydrogel and where the cells of the cell populations are entrapped by the hydrogel and are capable of expansion within the hydrogel and may be releasable from the hydrogel. Further provided are electroaddressable polysaccharide blends for the in-film expansion of a cell population, allowing probing of the cells and formation of immunocomplexes. Further provided are methods of using hydrogels containing electroaddressed or electroaddressable cell populations in in-film bioprocessing methods such as cell-based biosensing, protein-based biosensing, and in studies of cell signaling.
摘要翻译：描述了通过电解可聚合物的电沉积形成的水凝胶的产生方法。水凝胶可以含有一个或多个电解地址或电可寻址到水凝胶内的位置的细胞群，并且其中细胞群的细胞被水凝胶包埋并且能够在水凝胶内膨胀并且可以从水凝胶中释放。还提供了用于细胞群的膜内扩增的电可寻址多糖共混物，允许细胞的探查和免疫复合物的形成。还提供了在膜内生物处理方法如基于细胞的生物传感，基于蛋白质的生物传感和细胞信号传导研究中使用含有电解或电可寻址细胞群的水凝胶的方法。

38. 发明申请

WO2010129816A2 HETEROCYCLIC COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：杂环化合物及其用途
公开(公告)号：WO2010129816A2
公开(公告)日：2010-11-11
申请号：PCT/US2010033939
申请日：2010-05-06
申请人： INTELLIKINE INC , REN PINGDA , LIU YI , WILSON TROY EDWARD , LI LIANSHENG
发明人： REN PINGDA , LIU YI , WILSON TROY EDWARD , LI LIANSHENG
IPC分类号： A61K31/519 , A61K31/52
CPC分类号： C07D473/34 , C07D401/14 , C07D487/04
摘要： Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the isoquinolone entities, and methods of using these chemical entities for treating diseases and conditions associated with P13 kinase activity are described herein.
摘要翻译：本文描述了调节PI3激酶活性的杂环实体，含有异喹诺酮实体的药物组合物，以及使用这些化学实体治疗与P13激酶活性相关的疾病和病症的方法。

39. 发明申请

WO2010040047A3 CHITOSAN-COATED WIRES FOR BIOSENSING 审中-公开
标题翻译：用于生物传感器的壳聚糖涂层电线
公开(公告)号：WO2010040047A3
公开(公告)日：2010-07-22
申请号：PCT/US2009059372
申请日：2009-10-02
申请人： UNIV MARYLAND BIOTECH INST , LIU YI , SHI XIAO-WEN , PAYNE GREGORY F , MEYER W LEE
发明人： LIU YI , SHI XIAO-WEN , PAYNE GREGORY F , MEYER W LEE
IPC分类号： G01N33/50
CPC分类号： G01N33/54393
摘要： A method of forming a bioelectronic device including a protein on an electrically conductive substrate, by electrodepositing aminopolysaccharide chitosan on the substrate while applying a cathodic voltage to the substrate, to form an aminopolysaccharide chitosan film thereon, applying an anodic voltage to the substrate in the presence of NaCl to activate the aminopolysaccharide chitosan film so that it is reactive with protein. The method also optionally includes reacting the aminopolysaccharide film, after activation thereof, with the protein, so that the protein assembles on and is coupled to the substrate, thereby forming a bioelectronic device. The protein can include single or multiple protein species, and including biosensing proteins. Additional methods include biosensing of electrochemically active compounds either present in a sample or generated during a biological recognition event and devices useful in such methods. The resulting devices are useful as sensors in hand-held devices, textiles, garments and the like.
摘要翻译：一种在导电基底上形成包括蛋白质的生物电子装置的方法，通过在基底上电沉积氨基多糖脱乙酰壳多糖，同时对基底施加阴极电压，在其上形成氨基多糖脱乙酰壳多糖膜，在存在的情况下向基底施加阳极电压的NaCl活化氨基多糖壳聚糖膜，使其与蛋白质反应。该方法还任选地包括使氨基多糖膜在其活化后与蛋白质反应，以使得蛋白质聚集并耦合至基底，由此形成生物电子装置。蛋白质可以包括单个或多个蛋白质种类，并且包括生物传感蛋白质。另外的方法包括对存在于样品中或在生物学识别事件期间产生的电化学活性化合物的生物传感以及在这些方法中有用的装置。所得到的装置可用作手持装置，纺织品，服装等中的传感器。

40. 发明申请

WO2006074270A2 SYNTHESIS OF CCR5 RECEPTOR ANTAGONISTS 审中-公开
标题翻译： CCR5受体拮抗剂的合成
公开(公告)号：WO2006074270A2
公开(公告)日：2006-07-13
申请号：PCT/US2006000262
申请日：2006-01-05
申请人： SCHERING CORP , WU WENXUE , D SA BOSCO , LIANG FENG , TRAN LOC THANH , LEONG WILLIAM , DAHANUKAR VILAS , ZAVIALOV ILIA A , ORR CECILIA , ZHAO SHANNON , LEE HONG-CHANG , LIU YI , NGUYEN HOA N , SHIH XIONGWEI , ZHU MAN
发明人： WU WENXUE , D SA BOSCO , LIANG FENG , TRAN LOC THANH , LEONG WILLIAM , DAHANUKAR VILAS , ZAVIALOV ILIA A , ORR CECILIA , ZHAO SHANNON , LEE HONG-CHANG , LIU YI , NGUYEN HOA N , SHIH XIONGWEI , ZHU MAN
IPC分类号： C07D401/14 , C07D211/26
CPC分类号： C07D211/96 , C07D211/26 , C07D401/14
摘要： The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.
摘要翻译：本发明涉及4- [4 - [（R） - [1- [环丙基磺酰基] -4-哌啶基]（3-氟苯基）甲基] -3（S） - 甲基-1-哌嗪基] 1 - [（4,6-二甲基-5-嘧啶基）羰基] -4-甲基哌啶]，以及通过新途径从容易获得的起始原料中间产物。

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