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31. 发明申请

US20090247840A1 METHOD AND APPARATUS FOR COUPLING A SAMPLE PROBE WITH A SAMPLE SITE 有权
标题翻译：用于将样品探针与样品位点相结合的方法和装置
公开(公告)号：US20090247840A1
公开(公告)日：2009-10-01
申请号：US12393867
申请日：2009-02-26
申请人： Thomas B. BLANK , Roxanne E. ABUL-HAJ
发明人： Thomas B. BLANK , Roxanne E. ABUL-HAJ
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B2562/146 , G01N21/01 , G01N21/359 , G01N21/474
摘要： The invention comprises method and apparatus for fluid delivery between a sample probe and a sample. The fluid delivery system includes: a fluid reservoir, a delivery channel, a manifold or plenum, a channel or moat, a groove, and/or a dendritic pathway to deliver a thin and distributed layer of a fluid to a sample probe head and/or to a sample site. The fluid delivery system reduces sampling errors due to mechanical tissue distortion, specular reflectance, probe placement, and/or mechanically induced sample site stress/strain associated with optical sampling of the sample.
摘要翻译：本发明包括用于在样品探针和样品之间流体递送的方法和装置。流体输送系统包括：流体储存器，输送通道，歧管或增压室，通道或沟槽，沟槽和/或树枝状路径，以将薄的和分布的流体层递送到样品探针头和/ 或到一个样本站点。流体输送系统减少由于样品的光学取样所引起的机械组织变形，镜面反射率，探针放置和/或机械诱导的样本位点应力/应变引起的采样误差。

32. 发明申请

US20090098587A1 METHOD OF SCREENING FOR DISORDERS OF GLUCOSE METABOLISM 审中-公开
标题翻译：葡萄糖代谢障碍筛查方法
公开(公告)号：US20090098587A1
公开(公告)日：2009-04-16
申请号：US12099740
申请日：2008-04-08
申请人： Donald Hetzel , Stephen L. Monfre , Kevin H. Hazen , Timothy L. Ruchti , Thomas B. Blank , Linda Hockersmith , Andrew Cone
发明人： Donald Hetzel , Stephen L. Monfre , Kevin H. Hazen , Timothy L. Ruchti , Thomas B. Blank , Linda Hockersmith , Andrew Cone
IPC分类号： C12Q1/54
CPC分类号： C12Q1/54 , A61B5/14532 , A61B5/7264 , G01N33/66 , G01N2800/042 , G16H50/20 , G16H50/70
摘要： A method of screening for disorders of glucose metabolism such as impaired glucose tolerance and diabetes allows prevention, or early detection and treatment of diabetic complications such as cardiovascular disease, retinopathy, and other disorders of the major organs and systems. A mathematical algorithm evaluates the shape of a subject's glucose profile and classifies the profile into one of several predefined clusters, each cluster corresponding either to a normal condition or one of several abnormal conditions. The series of blood glucose values making up the glucose tolerance curve may be measured using any glucose analyzer including: invasive, minimally invasive and noninvasive types. The method is executed on a processing device programmed to perform the steps of the method. Depending on the outcome of the screening, a subject may be provided with additional information concerning their condition and/or counseled to consult further with their health care provider.
摘要翻译：筛选葡萄糖代谢紊乱如葡萄糖耐量异常和糖尿病的方法允许预防或早期检测和治疗糖尿病并发症如心血管疾病，视网膜病变和主要器官和系统的其他病症。数学算法评估受试者的葡萄糖谱的形状并将轮廓分类为几个预定义的簇之一，每个簇对应于正常条件或几个异常条件之一。构成葡萄糖耐量曲线的一系列血糖值可以使用任何葡萄糖分析仪来测量，包括：侵入性，微创和非侵入性类型。该方法在被编程为执行该方法的步骤的处理装置上执行。根据筛查结果，可以向受试者提供有关其病情的信息和/或咨询，以进一步咨询其医护人员。

33. 发明授权

US07509153B2 Method and apparatus for control of skin perfusion for indirect glucose measurement 失效
标题翻译：用于控制间接葡萄糖测量的皮肤灌注的方法和装置
公开(公告)号：US07509153B2
公开(公告)日：2009-03-24
申请号：US10384049
申请日：2003-03-07
申请人： Thomas B. Blank , Timothy L. Ruchti , Mutua Mattu , Marcy Makarewicz , Stephen L. Monfre , Alexander D. Lorenz
发明人： Thomas B. Blank , Timothy L. Ruchti , Mutua Mattu , Marcy Makarewicz , Stephen L. Monfre , Alexander D. Lorenz
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/1491 , A61B5/1495 , A61B2560/0223 , G01N21/31 , G01N21/33 , G01N21/359 , G01N21/65 , G01N2021/3595
摘要： A method and apparatus for noninvasive glucose measurement measures glucose indirectly from the natural response of tissue to variations in analyte concentration. The indirect measurement method utilizes factors affected by or correlated with the concentration of glucose, such as refractive index, electrolyte distribution or tissue scattering. Measurement reliability is greatly improved by stabilizing optical properties of the tissue at the measurement site, thus blood perfusion rates at the sample site are regulated. Perfusion is monitored and stabilized by spectroscopically measuring a control parameter, such as skin temperature, that directly affects perfusion. The control parameter is maintained in a range about a set point, thus stabilizing perfusion. Skin temperature is controlled using a variety of means, including the use of active heating and cooling elements, passive devices, such as thermal wraps, and through the use of a heated coupling medium having favorable heat transfer properties.
摘要翻译：用于非侵入性葡萄糖测量的方法和装置从组织的自然反应间接测量葡萄糖对分析物浓度的变化。间接测量方法利用受葡萄糖浓度影响或与葡萄糖浓度相关的因素，如折射率，电解质分布或组织散射。通过稳定测量部位的组织的光学特性，可以大大提高测量可靠性，从而调节样品位置的血液灌注速率。通过光谱测量直接影响灌注的控制参数（如皮肤温度）来监测和稳定灌注。控制参数保持在设定点的范围内，从而稳定灌注。使用各种手段控制皮肤温度，包括使用主动加热和冷却元件，无源器件，例如热封，以及通过使用具有良好传热特性的加热耦合介质。

34. 发明授权

US07299080B2 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 有权
标题翻译：用于通过近红外光谱法无损测量葡萄糖的紧凑装置
公开(公告)号：US07299080B2
公开(公告)日：2007-11-20
申请号：US10820322
申请日：2004-04-07
申请人： George Acosta , James R. Henderson , N. Alan Abul-Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
发明人： George Acosta , James R. Henderson , N. Alan Abul-Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/1075 , A61B5/14532 , A61B5/1495 , A61B5/441 , A61B5/4869 , A61B5/4872 , A61B5/6824 , A61B5/7203 , A61B5/726 , A61B2560/0233 , A61B2562/0233 , A61B2562/0242 , G01N21/359 , G01N21/474 , G01N21/49
摘要： A near IR spectrometer-based analyzer attaches continuously or semi-continuously to a human subject and collects spectral measurements for determining a biological parameter in the sampled tissue, such as glucose concentration. The analyzer includes an optical system optimized to target the cutaneous layer of the sampled tissue so that interference from the adipose layer is minimized. The optical system includes at least one optical probe. Spacing between optical paths and detection fibers of each probe and between probes is optimized to minimize sampling of the adipose subcutaneous layer and to maximize collection of light backscattered from the cutaneous layer. Penetration depth is optimized by limiting range of distances between paths and detection fibers. Minimizing sampling of the adipose layer greatly reduces interference contributed by the fat band in the sample spectrum, increasing signal-to-noise ratio. Providing multiple probes also minimizes interference in the sample spectrum due to placement errors.
摘要翻译：基于近红外光谱仪的分析仪连续或半连续地连接到人类受试者并且收集用于确定采样组织中的生物学参数（诸如葡萄糖浓度）的光谱测量。该分析仪包括优化的靶向采样组织的皮肤层的光学系统，使得来自脂肪层的干扰最小化。光学系统包括至少一个光学探针。针对每个探针和探针之间的光路和检测纤维之间的间距进行优化，以最小化脂肪皮下层的取样，并最大限度地收集从皮肤层反射的光。穿透深度通过限制路径和检测光纤之间的距离范围进行优化。最小化脂肪层的取样大大减少了样品谱中脂肪带所造成的干扰，提高了信噪比。提供多个探针也可以最小化由于放置误差而导致的样品光谱干扰。

35. 发明授权

US07206623B2 Optical sampling interface system for in vivo measurement of tissue 失效
公开(公告)号：US07206623B2
公开(公告)日：2007-04-17
申请号：US10170921
申请日：2002-06-12
申请人： Thomas B. Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen L. Monfre , Alexander D. Lorenz , Timothy L. Ruchti
发明人： Thomas B. Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen L. Monfre , Alexander D. Lorenz , Timothy L. Ruchti
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/01 , A61B5/061 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/6824 , A61B5/6833 , A61B5/6843 , A61B2560/0233 , A61B2562/12 , A61B2562/146
摘要： An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement. Separate components of system can be individually deployed.

36. 发明授权

US07038774B2 Method of characterizing spectrometer instruments and providing calibration models to compensate for instrument variation 失效
标题翻译：表征光谱仪器并提供校准模型以补偿仪器变化的方法
公开(公告)号：US07038774B2
公开(公告)日：2006-05-02
申请号：US10870727
申请日：2004-06-16
申请人： Kevin H. Hazen , Thomas B. Blank , Stephen Monfre , Timothy L. Ruchti
发明人： Kevin H. Hazen , Thomas B. Blank , Stephen Monfre , Timothy L. Ruchti
IPC分类号： G01J3/28
CPC分类号： G01N21/359 , A61B5/0075 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/7264 , A61B2560/0223 , A61B2560/0233 , G01J3/28 , G01J2003/2866 , G01N21/274 , G01N21/3563 , G01N21/4785 , G01N21/49
摘要： Spectrometer instruments are characterized by classifying their spectra into previously defined clusters. The spectra are mapped to the clusters and a classification is made based on similarity of extracted spectral features to one of the previously defined clusters. Calibration models for each cluster are provided to compensate for instrumental variation. Calibration models are provided either by transferring a master calibration to slave calibrations or by calculating a separate calibration for each cluster. In one embodiment, a simplified method of calibration transfer maps clusters to each other, so that a calibration transferred between clusters models only the difference between the two clusters, substantially reducing the complexity of the model.
摘要翻译：光谱仪器的特点是将其光谱分类为先前定义的簇。光谱被映射到簇，并且基于提取的光谱特征与先前定义的簇之一的相似性进行分类。提供每个集群的校准模型以补偿工具变化。通过将主校准传送到从站校准或通过为每个集群计算单独的校准来提供校准模型。在一个实施例中，校准传递的简化方法将群集彼此映射，使得在群集之间传递的校准仅模拟两个群集之间的差异，从而显着降低了模型的复杂性。

37. 发明授权

US06864978B1 Method of characterizing spectrometer instruments and providing calibration models to compensate for instrument variation 有权
标题翻译：表征光谱仪器并提供校准模型以补偿仪器变化的方法
公开(公告)号：US06864978B1
公开(公告)日：2005-03-08
申请号：US09664973
申请日：2000-09-18
申请人： Kevin H. Hazen , Thomas B. Blank , Stephen Monfre , Timothy L. Ruchti
发明人： Kevin H. Hazen , Thomas B. Blank , Stephen Monfre , Timothy L. Ruchti
IPC分类号： G01N21/35 , A61B5/00 , A61B5/107 , A61B5/145 , A61B5/1455 , A61B5/1495 , G01J3/02 , G01J3/28 , G01N21/27 , G01N21/47 , G01N21/49 , G06F19/00
CPC分类号： G01N21/359 , A61B5/0075 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/7264 , A61B2560/0223 , A61B2560/0233 , G01J3/28 , G01J2003/2866 , G01N21/274 , G01N21/3563 , G01N21/4785 , G01N21/49
摘要： Spectrometer instruments are characterized by classifying their spectra into previously defined clusters. The spectra are mapped to the clusters and a classification is made based on similarity of extracted spectral features to one of the previously defined clusters. Calibration models for each cluster are provided to compensate for instrumental variation. Calibration models are provided either by transferring a master calibration to slave calibrations or by calculating a separate calibration for each cluster.A simplified method of calibration transfer maps clusters to each other, so that a calibration transferred between clusters models only the difference between the two clusters, substantially reducing the complexity of the model.
摘要翻译：光谱仪器的特点是将其光谱分类为先前定义的簇。光谱被映射到簇，并且基于提取的光谱特征与先前定义的簇之一的相似性进行分类。提供每个集群的校准模型以补偿工具变化。校准模型通过将主校准传送到从站校准或通过为每个群集计算单独的校准来提供校准模型。简化的校准传输方法将群集彼此映射，使得群集之间传递的校准仅模拟两个群集之间的差异，大大降低了模型的复杂性。

38. 发明授权

US06512936B1 Multi-tier method of classifying sample spectra for non-invasive blood analyte prediction 失效
标题翻译：对非侵入性血液分析物预测的样本光谱进行分类的多层方法
公开(公告)号：US06512936B1
公开(公告)日：2003-01-28
申请号：US09665201
申请日：2000-09-18
申请人： Stephen L. Monfre , Thomas B. Blank , Timothy L. Ruchti , Suresh Thennadil
发明人： Stephen L. Monfre , Thomas B. Blank , Timothy L. Ruchti , Suresh Thennadil
IPC分类号： A61B500
CPC分类号： G06K9/6217 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/7264 , A61B2560/0223 , A61B2560/0233 , G01N21/274 , G01N21/359 , G01N21/4785 , G01N21/49 , Y10S128/92
摘要： A method of multi-tier classification and calibration in noninvasive blood analyte prediction minimizes prediction error by limiting co-varying spectral interferents. Tissue samples are categorized based on subject demographic and instrumental skin measurements, including in vivo near-IR spectral measurements. A multi-tier intelligent pattern classification sequence organizes spectral data into clusters having a high degree of internal consistency in tissue properties. In each tier, categories are successively refined using subject demographics, spectral measurement information and other device measurements suitable for developing tissue classifications. The multi-tier classification approach to calibration utilizes multivariate statistical arguments and multi-tiered classification using spectral features. Variables used in the multi-tiered classification can be skin surface hydration, skin surface temperature, tissue volume hydration, and an assessment of relative optical thickness of the dermis by the near-IR fat band. All tissue parameters are evaluated using the NIR spectrum signal along key wavelength segments.
摘要翻译：非侵入性血液分析物预测中的多层分类和校准方法通过限制共同变化的光谱干扰来最小化预测误差。组织样品根据受试者的人口统计学和仪器皮肤测量进行分类，包括体内近红外光谱测量。多层智能图案分类序列将光谱数据组织成具有组织性质内部高度一致性的簇。在每个层次中，使用主题人口统计学，光谱测量信息和适合于开发组织分类的其它装置测量法来连续地改进类别。校准的多层分类方法利用多变量统计学参数和使用光谱特征的多层次分类。用于多层分类的变量可以是皮肤表面水合，皮肤表面温度，组织体积水合，以及近红外脂肪带对真皮的相对光学厚度的评估。使用沿关键波长段的NIR光谱信号评估所有组织参数。

39. 发明授权

US08718738B2 Method and apparatus for coupling a sample probe with a sample site 有权
标题翻译：用于将样品探针与样品位点偶联的方法和装置
公开(公告)号：US08718738B2
公开(公告)日：2014-05-06
申请号：US12393867
申请日：2009-02-26
申请人： Thomas B. Blank , Roxanne E. Abul-Haj
发明人： Thomas B. Blank , Roxanne E. Abul-Haj
IPC分类号： A61B5/00 , G02B6/24
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B2562/146 , G01N21/01 , G01N21/359 , G01N21/474
摘要： The invention comprises method and apparatus for fluid delivery between a sample probe and a sample. The fluid delivery system includes: a fluid reservoir, a delivery channel, a manifold or plenum, a channel or moat, a groove, and/or a dendritic pathway to deliver a thin and distributed layer of a fluid to a sample probe head and/or to a sample site. The fluid delivery system reduces sampling errors due to mechanical tissue distortion, specular reflectance, probe placement, and/or mechanically induced sample site stress/strain associated with optical sampling of the sample.
摘要翻译：本发明包括用于在样品探针和样品之间流体递送的方法和装置。流体输送系统包括：流体储存器，输送通道，歧管或增压室，通道或沟槽，沟槽和/或树枝状路径，以将薄的和分布的流体层递送到样品探针头和/ 或到一个样本站点。流体输送系统减少由于样品的光学取样所引起的机械组织变形，镜面反射率，探针放置和/或机械诱导的样本位点应力/应变引起的采样误差。

40. 发明授权

US07640140B2 Method of processing noninvasive spectra 有权
标题翻译：无创光谱处理方法
公开(公告)号：US07640140B2
公开(公告)日：2009-12-29
申请号：US11095331
申请日：2005-03-30
申请人： Timothy L. Ruchti , Thomas B. Blank , Alexander D. Lorenz
发明人： Timothy L. Ruchti , Thomas B. Blank , Alexander D. Lorenz
IPC分类号： G06F19/00 , A61B5/00
CPC分类号： A61B5/14532
摘要： This invention provides a method and apparatus that corrects for tissue related interference calibration and/or measurement of biological parameters noninvasively. The invention concerns such terms as outlier identification, filtering, spectral correction, and baseline subtraction steps that, when used together, provides for noninvasive measurement of biological parameters, such as glucose concentration.
摘要翻译：本发明提供一种非侵入性校正组织相关干扰校准和/或生物参数测量的方法和装置。本发明涉及诸如异常值识别，过滤，光谱校正和基线减法步骤之类的术语，当它们一起使用时，提供诸如葡萄糖浓度的生物学参数的非侵入性测量。

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