专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07606608B2 Optical sampling interface system for in-vivo measurement of tissue 有权
标题翻译：用于体内测量组织的光学取样界面系统
公开(公告)号：US07606608B2
公开(公告)日：2009-10-20
申请号：US11008001
申请日：2004-12-08
申请人： Thomas B. Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen L. Monfre , Alexander D. Lorenz , Timothy L. Ruchti , Kevin H. Hazen , Donovan D. Berry , Roxanne E. Abul-Haj
发明人： Thomas B. Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen L. Monfre , Alexander D. Lorenz , Timothy L. Ruchti , Kevin H. Hazen , Donovan D. Berry , Roxanne E. Abul-Haj
IPC分类号： A61B5/1455
CPC分类号： G01N21/359 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/6833
摘要： An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.
摘要翻译：公开了一种光学采样接口系统，其最小化并补偿由采样变化和测量位置状态波动引起的误差。本发明的实施例使用至少一个引导组织弯液面的形成的引导件，使由于表面不规则性引起的干扰最小化，控制组织体积的变化，使用两部分引导系统，使用指导控制样品探针的旋转并允许探针的z轴移动，使用独立的基本模块和样品模块与导轨结合使用，并使用控制旋转的指南。可选组件包括闭塞元件和耦合流体。

2. 发明授权

US07519406B2 Noninvasive analyzer sample probe interface method and apparatus 有权
标题翻译：无创分析仪样品探针接口方法和装置
公开(公告)号：US07519406B2
公开(公告)日：2009-04-14
申请号：US11117104
申请日：2005-04-27
申请人： Thomas B. Blank , George M. Acosta , Timothy L. Ruchti , Mutua Mattu , Alexander D. Lorenz , Kevin H. Hazen , James R. Henderson
发明人： Thomas B. Blank , George M. Acosta , Timothy L. Ruchti , Mutua Mattu , Alexander D. Lorenz , Kevin H. Hazen , James R. Henderson
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/1495 , A61B5/4869 , A61B2560/0223 , A61B2560/0233 , A61B2562/0242 , G01N21/359
摘要： A method and apparatus are provided for noninvasive sampling. More particularly, the method and apparatus relate to control of motion of an optical sample probe interface relative to a tissue sample site. A dynamic probe interface, is used to collect spectra of a targeted sample, control positioning of the sample probe relative to the tissue sample in terms of at least one of x-, y-, and z-axes, and/or control of sample tissue displacement to minimize spectral variations resulting from the sampling process and increase analyte property estimation precision and accuracy.
摘要翻译：提供了一种用于无创采样的方法和装置。更具体地，该方法和装置涉及光学样本探针界面相对于组织样本位点的运动的控制。使用动态探针接口来收集目标样品的光谱，根据x-，y-和z-轴中的至少一个来控制样品探针相对于组织样品的定位和/或样品的控制组织位移以最小化由采样过程导致的频谱变化，并增加分析物质的估计精度和精度。

3. 发明申请

US20080319382A1 METHOD AND APPARATUS FOR COUPLING A CHANNELED SAMPLE PROBE TO TISSUE 有权
标题翻译：用于将通道样品探针耦合到组织的方法和装置
公开(公告)号：US20080319382A1
公开(公告)日：2008-12-25
申请号：US12109224
申请日：2008-04-24
申请人： Thomas B. Blank , Stephen L. Monfre , Kevin H. Hazen , Timothy L. Ruchti , Christopher Slawinski , Sedar R. Brown
发明人： Thomas B. Blank , Stephen L. Monfre , Kevin H. Hazen , Timothy L. Ruchti , Christopher Slawinski , Sedar R. Brown
IPC分类号： A61M37/00 , A61B5/1455
CPC分类号： G01N21/359 , A61B5/14532 , A61B5/1455 , A61B2562/146
摘要： Sampling is controlled in order to enhance analyte concentration estimation derived from noninvasive sampling. More particularly, sampling is controlled using controlled fluid delivery to a region between a tip of a sample probe and a tissue measurement site. The controlled fluid delivery enhances coverage of a skin sample site with the thin layer of fluid. Delivery of contact fluid is controlled in terms of spatial delivery, volume, thickness, distribution, temperature, and/or pressure.
摘要翻译：控制采样以增强从无创采样得到的分析物浓度估计。更具体地，使用受控流体输送到样品探针的尖端和组织测量部位之间的区域来控制取样。受控的流体输送增强了皮肤样品位点与薄层流体的覆盖。在空间传送，体积，厚度，分布，温度和/或压力方面控制接触流体的传送。

4. 发明授权

US07133710B2 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 有权
标题翻译：用于通过近红外光谱法无损测量葡萄糖的紧凑装置
公开(公告)号：US07133710B2
公开(公告)日：2006-11-07
申请号：US10472856
申请日：2003-03-07
申请人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
发明人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B5/1495 , A61B5/6833 , A61B5/7203 , A61B5/7225 , A61B5/726 , A61B2560/0223 , A61B2560/0233 , A61B2560/0252 , A61B2560/0412 , A61B2560/0443 , A61B2560/0456 , A61B2562/0242 , A61B2562/146 , A61B2562/227 , A61B2562/228 , G01N21/359 , G01N21/49
摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyze is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
摘要翻译：本发明涉及通过紧凑型分析仪监测生物参数。优选的装置是基于光谱仪的系统，其连续地或半连续地连接到人类受试者并收集用于确定采样组织中的生物学参数的光谱测量。优选的目标分析是葡萄糖。优选的分析仪是用于测定体内葡萄糖浓度的基于近红外的葡萄糖分析仪。

5. 发明授权

US07039446B2 Indirect measurement of tissue analytes through tissue properties 失效
标题翻译：通过组织特性间接测量组织分析物
公开(公告)号：US07039446B2
公开(公告)日：2006-05-02
申请号：US10349573
申请日：2003-01-22
申请人： Timothy L. Ruchti , Thomas B. Blank , Alexander D. Lorenz , Stephen L. Monfre , Kevin H. Hazen , Suresh N. Thennadil
发明人： Timothy L. Ruchti , Thomas B. Blank , Alexander D. Lorenz , Stephen L. Monfre , Kevin H. Hazen , Suresh N. Thennadil
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0071 , A61B5/0075 , A61B5/14532 , A61B5/1495 , A61B2560/0223 , G01N21/274 , G01N21/31 , G01N21/33 , G01N21/359 , G01N21/65 , G01N2021/3595
摘要： Methods and system for noninvasive determination of tissue analytes utilize tissue properties as reflected in key features of an analytical signal to improve measurement accuracy and precision. Physiological conditions such as changes in water distribution among tissue compartments lead to complex alterations in the measured analytical signal of skin, leading to a biased noninvasive analyte measurement. Changes in the tissue properties are detected by identifying key features in the analytical signal responsive to physiological variations. Conditions not conducive to the noninvasive measurement are detected. Noninvasive measurements that are biased by physiological changes in tissue are compensated. In an alternate embodiment, the analyte is measured indirectly based on natural physiological response of tissue to changes in analyte concentration. A system capable of such measurements is provided.
摘要翻译：非侵入性测定组织分析物的方法和系统利用分析信号的关键特征反映的组织性质来提高测量精度和精度。生理条件如组织间隔水分配变化导致测量的皮肤分析信号的复杂变化，导致偏向的非侵入性分析物测量。通过识别响应于生理变化的分析信号中的关键特征来检测组织性质的变化。检测到不利于非侵入性测量的条件。由组织中生理变化偏向的无创测量得到补偿。在替代实施方案中，基于组织对分析物浓度变化的天然生理反应间接测量分析物。提供能够进行这种测量的系统。

6. 发明授权

US06777240B2 Intra-serum and intra-gel for modeling human skin tissue 失效
标题翻译：血清内和凝胶内用于建模人体皮肤组织
公开(公告)号：US06777240B2
公开(公告)日：2004-08-17
申请号：US10241344
申请日：2002-09-11
申请人： Kevin H. Hazen , James Matthew Welch , Stephen F. Malin , Timothy L. Ruchti , Alexander D. Lorenz , Tamara L. Troy , Suresh Thennadil , Thomas B. Blank
发明人： Kevin H. Hazen , James Matthew Welch , Stephen F. Malin , Timothy L. Ruchti , Alexander D. Lorenz , Tamara L. Troy , Suresh Thennadil , Thomas B. Blank
IPC分类号： G01N3100
CPC分类号： G01N21/274 , A61B5/0075 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/7264 , A61B2560/0223 , A61B2560/0233 , G01N21/359 , G01N21/4785 , G01N21/49 , Y10T436/10
摘要： The invention provides a class of samples that model the human body. This family of samples is based upon emulsions of oil in water with lecithin acting as the emulsifier. These solutions that have varying particle sizes may be spiked with basis set components (albumin, urea and glucose) to simulate skin tissues further. The family of samples is such that other organic compounds such as collagen, elastin, globulin and bilirubin may be added, as can salts such as Na+, K+and Cl−. Layers of varying thickness with known index of refraction and particle size distributions may be generated using simple crosslinking reagents, such as collagen (gelatin). The resulting samples are flexible in each analyte's concentration and match the skin layers of the body in terms of the samples reduced scattering and absorption coefficients, &mgr;'s and &mgr;a. This family of samples is provided for use in the medical field where lasers and spectroscopy based analyzers are used in treatment of the body. In particular, knowledge may be gained on net analyte signal, photon depth of penetration, photon radial diffusion, photon interaction between tissue layers, photon density (all as a function of frequency) and on instrument parameter specifications such as resolution and required dynamic range (A/D bits required). In particular, applications to delineate such parameters have been developed for the application of noninvasive glucose determination in the near-IR region from 700 to 2500 nm with an emphasis on the region 1000 to 2500 nm (10,000 to 4,000 cm−1).
摘要翻译：本发明提供了一类对人体进行建模的样品。该样品系基于水中的油与卵磷脂作为乳化剂的乳液。具有不同粒径的这些溶液可以加入基础组分（白蛋白，尿素和葡萄糖）以进一步模拟皮肤组织。样品家族可以加入其它有机化合物如胶原蛋白，弹性蛋白，球蛋白和胆红素，也可以加入诸如Na +，K +和Cl - 的盐。可以使用简单的交联试剂如胶原（明胶）产生具有已知折射率和粒度分布的不同厚度的层。所得样品在每种分析物的浓度上是柔性的，并且根据样品减少的散射和吸收系数mu和μa来匹配身体的皮肤层。该样品系列用于医疗领域，其中使用激光和基于光谱的分析仪来治疗身体。特别地，可以获得关于净分析物信号，光子穿透深度，光子径向扩散，组织层之间的光子相互作用，光子密度（全部作为频率的函数）以及仪器参数规格（例如分辨率和所需动态范围）需要A / D位）。特别地，已经开发出描绘这些参数的应用，用于在700至2500nm的近红外区域中应用非侵入性葡萄糖测定，重点在1000至2500nm（10,000至4000cm -1）的区域。

7. 发明授权

US06738652B2 Classification and screening of test subjects according to optical thickness of skin 失效
标题翻译：根据皮肤的光学厚度对检查对象进行分类和筛选
公开(公告)号：US06738652B2
公开(公告)日：2004-05-18
申请号：US10297787
申请日：2002-12-09
申请人： Mutua Mattu , Thomas B. Blank , Marcy R. Makarewicz , Branden Rosenhan
发明人： Mutua Mattu , Thomas B. Blank , Marcy R. Makarewicz , Branden Rosenhan
IPC分类号： A61B500
CPC分类号： A61B5/441 , A61B5/0059 , A61B5/1075 , A61B5/442 , A61B5/4869 , A61B5/4872 , A61B5/7264 , A61B2560/0223 , A61B2562/0242
摘要： A method for classifying live subjects according to optical thickness of the skin is based on noninvasive, near-infrared reflectance measurements on skin tissue. An indicator of skin optical thickness is derived through analysis of the water, fat, and protein marker bands in the near infrared spectrum. The skin thickness indicator may then be used to evaluate the suitability of the subject for calibration on a standardized set of optical probes. The optical probes in the standardized set are designed to cover a range of penetration depths by varying the distance distribution between illuminator and detector fibers on each probe tip.
摘要翻译：根据皮肤的光学厚度对活体进行分类的方法是基于皮肤组织上的无创的近红外反射测量。通过分析近红外光谱中的水，脂肪和蛋白质标记带，得出皮肤光学厚度的指标。然后可以使用皮肤厚度指示器来评估受试者在标准化的一组光学探针上的校准的适合性。标准化组中的光学探针被设计成通过改变每个探针尖端上的照射器和检测器光纤之间的距离分布来覆盖一定范围的穿透深度。

8. 发明授权

US06640117B2 Method and apparatus for minimizing spectral effects attributable to tissue state variations during NIR-based non-invasive blood analyte determination 有权
标题翻译：用于最小化归因于基于NIR的非侵入性血液分析物测定期间的组织状态变化的光谱效应的方法和装置
公开(公告)号：US06640117B2
公开(公告)日：2003-10-28
申请号：US09955531
申请日：2001-09-17
申请人： Marcy R. Makarewicz , Mutua Mattu , Thomas B. Blank , Stephen L. Monfre , Timothy L. Ruchti
发明人： Marcy R. Makarewicz , Mutua Mattu , Thomas B. Blank , Stephen L. Monfre , Timothy L. Ruchti
IPC分类号： A61B500
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1455 , A61B5/1491
摘要： A method and apparatus for minimizing confounding effects in a noninvasive in-vivo spectral measurement caused by fluctuations in tissue state monitors a selected tissue state parameter spectroscopically and maintains the selected parameter within a target range, at which spectral effects attributable to the changes in the selected parameter are minimized. The invention includes both active and passive control. A preferred embodiment of the invention provides a method and apparatus for minimizing the confounding effects in near IR spectral measurements attributable to shifts in skin temperature at a tissue measurement site. Spectroscopic monitoring of skin temperature at the measurement site provides near-instantaneous temperature readings by eliminating thermal time constants. A thermistor positioned at the measurement site provides active control. The spectrometer and the temperature control device are incorporated into a single instrument for noninvasive measurement of blood glucose concentration.
摘要翻译：用于最小化由组织状态的波动引起的非侵入性体内光谱测量中的混杂效应的方法和装置通过光谱方式监测所选择的组织状态参数，并将所选择的参数保持在目标范围内，在该范围内，归因于所选择的变化的光谱效应参数最小化。本发明包括主动和被动控制。本发明的一个优选实施例提供了一种方法和装置，用于最小化归因于组织测量部位的皮肤温度变化的近红外光谱测量中的混杂效应。光谱监测测量点的皮肤温度通过消除热时间常数提供近乎瞬时的温度读数。位于测量位置的热敏电阻提供主动控制。光谱仪和温度控制装置被并入单个仪器中用于非侵入性测量血糖浓度。

9. 发明授权

US06512937B2 Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction 有权
标题翻译：开发用于非侵入性血液分析物预测的局部校准模型的多层方法
公开(公告)号：US06512937B2
公开(公告)日：2003-01-28
申请号：US09825687
申请日：2001-04-03
申请人： Thomas B. Blank , Stephen L. Monfre , Timothy L. Ruchti , Suresh Thennadil
发明人： Thomas B. Blank , Stephen L. Monfre , Timothy L. Ruchti , Suresh Thennadil
IPC分类号： A61B500
CPC分类号： G01N21/274 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/7264 , A61B5/7267 , A61B2560/0223 , A61B2560/0233 , G01N21/359 , G01N21/4785 , G01N21/49 , Y10S128/92
摘要： A method of multi-tier classification and calibration in noninvasive blood analyte prediction minimizes prediction error by limiting co-varying spectral interferents. Tissue samples are categorized based on subject demographic and instrumental skin measurements, including in vivo near-IR spectral measurements. A multi-tier intelligent pattern classification sequence organizes spectral data into clusters having a high degree of internal consistency in tissue properties. In each tier, categories are successively refined using subject demographics, spectral measurement information and other device measurements suitable for developing tissue classifications. The multi-tier classification approach to calibration utilizes multivariate statistical arguments and multi-tiered classification using spectral features. Variables used in the multi-tiered classification can be skin surface hydration, skin surface temperature, tissue volume hydration, and an assessment of relative optical thickness of the dermis by the near-IR fat band. All tissue parameters are evaluated using the NIR spectrum signal along key wavelength segments.
摘要翻译：非侵入性血液分析物预测中的多层分类和校准方法通过限制共同变化的光谱干扰来最小化预测误差。组织样品根据受试者的人口统计学和仪器皮肤测量进行分类，包括体内近红外光谱测量。多层智能图案分类序列将光谱数据组织成具有组织性质内部高度一致性的簇。在每个层次中，使用主体人口统计学，光谱测量信息和适合于开发组织分类的其他设备测量来连续地改进类别。多层分类校准方法利用多变量统计学参数和使用光谱特征的多层次分类。用于多层分类的变量可以是皮肤表面水合，皮肤表面温度，组织体积水合，以及近红外脂肪带对真皮的相对光学厚度的评估。使用沿关键波长段的NIR光谱信号评估所有组织参数。

10. 发明授权

US06487429B2 Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor 失效
公开(公告)号：US06487429B2
公开(公告)日：2002-11-26
申请号：US09766872
申请日：2001-01-18
申请人： Linda Hockersmith , Thomas B. Blank , Stephen L. Monfre , Timothy L. Ruchti
发明人： Linda Hockersmith , Thomas B. Blank , Stephen L. Monfre , Timothy L. Ruchti
IPC分类号： A61B500
CPC分类号： A61B5/14532
摘要： A method of calibrating a non-invasive blood glucose measurement instrument to a diabetic test subject employs targeted glycemic profiles in anti-correlated pairs. During calibration, reference blood glucose determinations are made using conventional invasive sampling methods. Concurrently, noninvasive spectral measurements are made using the noninvasive glucose monitor. Through controlled oral ingestion by the subject of calculated amounts of carbohydrate, the subject's blood glucose level is manipulated to mimic the patterns of the targeted profiles. During a first visit, a first profile of a pair is induced; during a second visit the inverse of the first profile is induced. The targeted profiles produce reference blood glucose values in which correlation to sampling factors is reduced or eliminated, thus the resulting calibration is correlated to glucose, and not to other analytes, sampling factors or environmental factors. A formula is provided for calculating the required amount of carbohydrate to ingest to induce a targeted glycemic profile in a test subject.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式