专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20220127122A1 BEVERAGE PRODUCT AMENDMENT APPARATUS AND METHOD OF USE THEREOF 有权
公开(公告)号：US20220127122A1
公开(公告)日：2022-04-28
申请号：US17120135
申请日：2020-12-12
申请人： Gavin Hazen , Kevin H. Hazen , Alton J. Reich , Michael Roth
发明人： Gavin Hazen , Kevin H. Hazen , Alton J. Reich , Michael Roth
IPC分类号： B67C3/02 , A23L33/105 , A23L2/52 , A23D7/005 , A23D7/04 , B67C7/00
摘要： The invention comprises a method and apparatus for amending a food product, comprising the steps of: (1) receiving into a second geographic zone the food product from a first geographic zone, where packaging greater than five milligrams per serving of tetrahydrocannabinol (THC) in the food product is illegal in the first geographic zone and legal in the second geographic zone; (2) forming a composition of the tetrahydrocannabinol comprising a viscosity of less than 2,000 mPa sec; and (3) injecting the food product with the composition of the tetrahydrocannabinol to form an amended food product, where the composition preferably comprises an emulsion of tetrahydrocannabinol, an emulsifier, and water with a mean particle size of less than 1000 nm and a viscosity of less than 100 mPa sec.

2. 发明申请

US20150041656A1 MULTIPLEXED NONINVASIVE ANALYZER APPARATUS AND METHOD OF USE THEREOF 审中-公开
标题翻译：多重非易失性分析仪装置及其使用方法
公开(公告)号：US20150041656A1
公开(公告)日：2015-02-12
申请号：US13963933
申请日：2013-08-09
申请人： Vlad Novotny , Sandeep Gulati , Thomas George , Timothy Ruchti , Alan Abul-Haj , Kevin H. Hazen
发明人： Vlad Novotny , Sandeep Gulati , Thomas George , Timothy Ruchti , Alan Abul-Haj , Kevin H. Hazen
IPC分类号： G01J3/42 , A61B5/145 , A61B5/1455
CPC分类号： G01J3/42 , A61B5/0022 , A61B5/1079 , A61B5/14532 , A61B5/1455 , A61B5/14552 , A61B5/6801 , G01N21/474 , G01N2021/4742 , G01N2021/4747 , G01N2201/0826
摘要： A noninvasive analyzer apparatus and method of use thereof is described using a plurality of time resolved sample illumination zones coupled to at least one two-dimensional detector array monitoring a plurality of detection zones. Control of illumination times and/or patterns along with selected detection zones yields pathlength resolved groups of spectra. Sectioned pixels and/or zones of the detector are optionally filtered for different light throughput as a function of wavelength. The pathlength resolved groups of spectra are subsequently analyzed to determine an analyte property. Optionally, in the mapping and/or collection phase, incident light is controllably varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, intensity, and/or detection angle. Optionally, one or more physiological property and/or model property related to a physiological property is used in the analyte property determination.
摘要翻译：使用耦合到监视多个检测区域的至少一个二维检测器阵列的多个时分解样本照明区域来描述非侵入性分析仪装置及其使用方法。照射时间和/或图案与所选检测区域的控制产生光程长度解析组。选择性地检测检测器的截面像素和/或区域作为波长的函数的不同光通量。随后分析路径长度解析的光谱组以确定分析物质。可选地，在映射和/或收集阶段，入射光可以根据以下任何方式在时间上可控地变化：样本探针位置，入射光立体角，入射光角，焦深，能量，强度和/或检测角。任选地，在分析物质性测定中使用与生理特性相关的一种或多种生理特性和/或模型性质。

3. 发明授权

US07606608B2 Optical sampling interface system for in-vivo measurement of tissue 有权
标题翻译：用于体内测量组织的光学取样界面系统
公开(公告)号：US07606608B2
公开(公告)日：2009-10-20
申请号：US11008001
申请日：2004-12-08
申请人： Thomas B. Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen L. Monfre , Alexander D. Lorenz , Timothy L. Ruchti , Kevin H. Hazen , Donovan D. Berry , Roxanne E. Abul-Haj
发明人： Thomas B. Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen L. Monfre , Alexander D. Lorenz , Timothy L. Ruchti , Kevin H. Hazen , Donovan D. Berry , Roxanne E. Abul-Haj
IPC分类号： A61B5/1455
CPC分类号： G01N21/359 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/6833
摘要： An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.
摘要翻译：公开了一种光学采样接口系统，其最小化并补偿由采样变化和测量位置状态波动引起的误差。本发明的实施例使用至少一个引导组织弯液面的形成的引导件，使由于表面不规则性引起的干扰最小化，控制组织体积的变化，使用两部分引导系统，使用指导控制样品探针的旋转并允许探针的z轴移动，使用独立的基本模块和样品模块与导轨结合使用，并使用控制旋转的指南。可选组件包括闭塞元件和耦合流体。

4. 发明授权

US07519406B2 Noninvasive analyzer sample probe interface method and apparatus 有权
标题翻译：无创分析仪样品探针接口方法和装置
公开(公告)号：US07519406B2
公开(公告)日：2009-04-14
申请号：US11117104
申请日：2005-04-27
申请人： Thomas B. Blank , George M. Acosta , Timothy L. Ruchti , Mutua Mattu , Alexander D. Lorenz , Kevin H. Hazen , James R. Henderson
发明人： Thomas B. Blank , George M. Acosta , Timothy L. Ruchti , Mutua Mattu , Alexander D. Lorenz , Kevin H. Hazen , James R. Henderson
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/1495 , A61B5/4869 , A61B2560/0223 , A61B2560/0233 , A61B2562/0242 , G01N21/359
摘要： A method and apparatus are provided for noninvasive sampling. More particularly, the method and apparatus relate to control of motion of an optical sample probe interface relative to a tissue sample site. A dynamic probe interface, is used to collect spectra of a targeted sample, control positioning of the sample probe relative to the tissue sample in terms of at least one of x-, y-, and z-axes, and/or control of sample tissue displacement to minimize spectral variations resulting from the sampling process and increase analyte property estimation precision and accuracy.
摘要翻译：提供了一种用于无创采样的方法和装置。更具体地，该方法和装置涉及光学样本探针界面相对于组织样本位点的运动的控制。使用动态探针接口来收集目标样品的光谱，根据x-，y-和z-轴中的至少一个来控制样品探针相对于组织样品的定位和/或样品的控制组织位移以最小化由采样过程导致的频谱变化，并增加分析物质的估计精度和精度。

5. 发明申请

US20080319382A1 METHOD AND APPARATUS FOR COUPLING A CHANNELED SAMPLE PROBE TO TISSUE 有权
标题翻译：用于将通道样品探针耦合到组织的方法和装置
公开(公告)号：US20080319382A1
公开(公告)日：2008-12-25
申请号：US12109224
申请日：2008-04-24
申请人： Thomas B. Blank , Stephen L. Monfre , Kevin H. Hazen , Timothy L. Ruchti , Christopher Slawinski , Sedar R. Brown
发明人： Thomas B. Blank , Stephen L. Monfre , Kevin H. Hazen , Timothy L. Ruchti , Christopher Slawinski , Sedar R. Brown
IPC分类号： A61M37/00 , A61B5/1455
CPC分类号： G01N21/359 , A61B5/14532 , A61B5/1455 , A61B2562/146
摘要： Sampling is controlled in order to enhance analyte concentration estimation derived from noninvasive sampling. More particularly, sampling is controlled using controlled fluid delivery to a region between a tip of a sample probe and a tissue measurement site. The controlled fluid delivery enhances coverage of a skin sample site with the thin layer of fluid. Delivery of contact fluid is controlled in terms of spatial delivery, volume, thickness, distribution, temperature, and/or pressure.
摘要翻译：控制采样以增强从无创采样得到的分析物浓度估计。更具体地，使用受控流体输送到样品探针的尖端和组织测量部位之间的区域来控制取样。受控的流体输送增强了皮肤样品位点与薄层流体的覆盖。在空间传送，体积，厚度，分布，温度和/或压力方面控制接触流体的传送。

6. 发明授权

US07133710B2 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 有权
标题翻译：用于通过近红外光谱法无损测量葡萄糖的紧凑装置
公开(公告)号：US07133710B2
公开(公告)日：2006-11-07
申请号：US10472856
申请日：2003-03-07
申请人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
发明人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B5/1495 , A61B5/6833 , A61B5/7203 , A61B5/7225 , A61B5/726 , A61B2560/0223 , A61B2560/0233 , A61B2560/0252 , A61B2560/0412 , A61B2560/0443 , A61B2560/0456 , A61B2562/0242 , A61B2562/146 , A61B2562/227 , A61B2562/228 , G01N21/359 , G01N21/49
摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyze is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
摘要翻译：本发明涉及通过紧凑型分析仪监测生物参数。优选的装置是基于光谱仪的系统，其连续地或半连续地连接到人类受试者并收集用于确定采样组织中的生物学参数的光谱测量。优选的目标分析是葡萄糖。优选的分析仪是用于测定体内葡萄糖浓度的基于近红外的葡萄糖分析仪。

7. 发明授权

US07039446B2 Indirect measurement of tissue analytes through tissue properties 失效
标题翻译：通过组织特性间接测量组织分析物
公开(公告)号：US07039446B2
公开(公告)日：2006-05-02
申请号：US10349573
申请日：2003-01-22
申请人： Timothy L. Ruchti , Thomas B. Blank , Alexander D. Lorenz , Stephen L. Monfre , Kevin H. Hazen , Suresh N. Thennadil
发明人： Timothy L. Ruchti , Thomas B. Blank , Alexander D. Lorenz , Stephen L. Monfre , Kevin H. Hazen , Suresh N. Thennadil
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0071 , A61B5/0075 , A61B5/14532 , A61B5/1495 , A61B2560/0223 , G01N21/274 , G01N21/31 , G01N21/33 , G01N21/359 , G01N21/65 , G01N2021/3595
摘要： Methods and system for noninvasive determination of tissue analytes utilize tissue properties as reflected in key features of an analytical signal to improve measurement accuracy and precision. Physiological conditions such as changes in water distribution among tissue compartments lead to complex alterations in the measured analytical signal of skin, leading to a biased noninvasive analyte measurement. Changes in the tissue properties are detected by identifying key features in the analytical signal responsive to physiological variations. Conditions not conducive to the noninvasive measurement are detected. Noninvasive measurements that are biased by physiological changes in tissue are compensated. In an alternate embodiment, the analyte is measured indirectly based on natural physiological response of tissue to changes in analyte concentration. A system capable of such measurements is provided.
摘要翻译：非侵入性测定组织分析物的方法和系统利用分析信号的关键特征反映的组织性质来提高测量精度和精度。生理条件如组织间隔水分配变化导致测量的皮肤分析信号的复杂变化，导致偏向的非侵入性分析物测量。通过识别响应于生理变化的分析信号中的关键特征来检测组织性质的变化。检测到不利于非侵入性测量的条件。由组织中生理变化偏向的无创测量得到补偿。在替代实施方案中，基于组织对分析物浓度变化的天然生理反应间接测量分析物。提供能够进行这种测量的系统。

8. 发明授权

US06777240B2 Intra-serum and intra-gel for modeling human skin tissue 失效
标题翻译：血清内和凝胶内用于建模人体皮肤组织
公开(公告)号：US06777240B2
公开(公告)日：2004-08-17
申请号：US10241344
申请日：2002-09-11
申请人： Kevin H. Hazen , James Matthew Welch , Stephen F. Malin , Timothy L. Ruchti , Alexander D. Lorenz , Tamara L. Troy , Suresh Thennadil , Thomas B. Blank
发明人： Kevin H. Hazen , James Matthew Welch , Stephen F. Malin , Timothy L. Ruchti , Alexander D. Lorenz , Tamara L. Troy , Suresh Thennadil , Thomas B. Blank
IPC分类号： G01N3100
CPC分类号： G01N21/274 , A61B5/0075 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/7264 , A61B2560/0223 , A61B2560/0233 , G01N21/359 , G01N21/4785 , G01N21/49 , Y10T436/10
摘要： The invention provides a class of samples that model the human body. This family of samples is based upon emulsions of oil in water with lecithin acting as the emulsifier. These solutions that have varying particle sizes may be spiked with basis set components (albumin, urea and glucose) to simulate skin tissues further. The family of samples is such that other organic compounds such as collagen, elastin, globulin and bilirubin may be added, as can salts such as Na+, K+and Cl−. Layers of varying thickness with known index of refraction and particle size distributions may be generated using simple crosslinking reagents, such as collagen (gelatin). The resulting samples are flexible in each analyte's concentration and match the skin layers of the body in terms of the samples reduced scattering and absorption coefficients, &mgr;'s and &mgr;a. This family of samples is provided for use in the medical field where lasers and spectroscopy based analyzers are used in treatment of the body. In particular, knowledge may be gained on net analyte signal, photon depth of penetration, photon radial diffusion, photon interaction between tissue layers, photon density (all as a function of frequency) and on instrument parameter specifications such as resolution and required dynamic range (A/D bits required). In particular, applications to delineate such parameters have been developed for the application of noninvasive glucose determination in the near-IR region from 700 to 2500 nm with an emphasis on the region 1000 to 2500 nm (10,000 to 4,000 cm−1).
摘要翻译：本发明提供了一类对人体进行建模的样品。该样品系基于水中的油与卵磷脂作为乳化剂的乳液。具有不同粒径的这些溶液可以加入基础组分（白蛋白，尿素和葡萄糖）以进一步模拟皮肤组织。样品家族可以加入其它有机化合物如胶原蛋白，弹性蛋白，球蛋白和胆红素，也可以加入诸如Na +，K +和Cl - 的盐。可以使用简单的交联试剂如胶原（明胶）产生具有已知折射率和粒度分布的不同厚度的层。所得样品在每种分析物的浓度上是柔性的，并且根据样品减少的散射和吸收系数mu和μa来匹配身体的皮肤层。该样品系列用于医疗领域，其中使用激光和基于光谱的分析仪来治疗身体。特别地，可以获得关于净分析物信号，光子穿透深度，光子径向扩散，组织层之间的光子相互作用，光子密度（全部作为频率的函数）以及仪器参数规格（例如分辨率和所需动态范围）需要A / D位）。特别地，已经开发出描绘这些参数的应用，用于在700至2500nm的近红外区域中应用非侵入性葡萄糖测定，重点在1000至2500nm（10,000至4000cm -1）的区域。

9. 发明申请

US20220127026A1 FOOD PRODUCT AMENDMENT APPARATUS AND METHOD OF USE THEREOF 有权
公开(公告)号：US20220127026A1
公开(公告)日：2022-04-28
申请号：US17111366
申请日：2020-12-03
申请人： Kevin H. Hazen , Mason Cave , Alton J. Reich , Sara Geneva Noreau Kerr , Michael Roth , Gavin Hazen
发明人： Kevin H. Hazen , Mason Cave , Alton J. Reich , Sara Geneva Noreau Kerr , Michael Roth , Gavin Hazen
IPC分类号： B65B3/10 , A23L33/105 , A23D7/005 , B65B31/00 , G06Q50/26 , G06Q10/08
摘要： The invention comprises an apparatus and a method for amending an incomplete product and/or a product to form an amended product, such as by receiving the original product in a first pressurized container, breaking a pressure seal of the first pressurized container, adding tetrahydrocannabinol (THC) to the first pressurized container, and resealing the first pressurized container, such as where optionally a portion of the amendment process is at a second physical location separated from a first location by a state line and/or a legislative boundary.

10. 发明申请

US20150018646A1 DYNAMIC SAMPLE MAPPING NONINVASIVE ANALYZER APPARATUS AND METHOD OF USE THEREOF 审中-公开
标题翻译：动态样品映射非易失性分析仪器及其使用方法
公开(公告)号：US20150018646A1
公开(公告)日：2015-01-15
申请号：US13941411
申请日：2013-07-12
申请人： Sandeep Gulati , Thomas George , Timothy Ruchti , Alan Abul-Haj , Kevin H. Hazen
发明人： Sandeep Gulati , Thomas George , Timothy Ruchti , Alan Abul-Haj , Kevin H. Hazen
IPC分类号： A61B5/1455 , A61B5/145 , A61B5/107
CPC分类号： G01J3/42 , A61B5/0022 , A61B5/1079 , A61B5/14532 , A61B5/1455 , A61B5/14552 , A61B5/6801 , G01N21/474 , G01N2021/4742 , G01N2021/4747 , G01N2201/0826
摘要： A noninvasive analyzer apparatus and method of use thereof is described using a sample mapping phase to establish one or more analyzer/software parameters used in a subsequent individual and/or group specific data collection phase. For example, in the sample mapping phase distance between incident and collected light is varied as a function of time for collected noninvasive spectra. Spectra collected in the sample mapping phase are analyzed to determine a physiological property of the subject, such as dermal thickness, hydration, collagen density, epidermal thickness, and/or subcutaneous fat depth. Using the physiological property or measure thereof, the analyzer is optically reconfigured for the individual to yield subsequent spectra having enhanced features for noninvasive analyte property determination. Similarly, in the mapping and/or collection phase, the incident light is varied in time in terms of any of: sample probe position, incident light solid angle, incident light angle, depth of focus, energy, and/or intensity.
摘要翻译：使用样本映射阶段来描述非侵入性分析仪装置及其使用方法，以建立在随后的个体和/或组特定数据收集阶段中使用的一个或多个分析器/软件参数。例如，在样本映射中，入射光和收集光之间的距离随收集的无创光谱的时间而变化。分析在样品测绘阶段收集的光谱，以确定受试者的生理性质，例如真皮厚度，水合，胶原密度，表皮厚度和/或皮下脂肪深度。使用生理特性或其测量方式，分析仪对于个体进行光学重新配置，以产生具有用于非侵入性分析物质确定的增强特征的后续光谱。类似地，在映射和/或收集阶段，入射光在时间上根据以下任一种而变化：样本探针位置，入射光立体角，入射光角，焦深，能量和/或强度。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式