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31. 发明授权

US06652886B2 Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents 有权
公开(公告)号：US06652886B2
公开(公告)日：2003-11-25
申请号：US09785525
申请日：2001-02-16
申请人： Cheol Hee Ahn , Sung Wan Kim
发明人： Cheol Hee Ahn , Sung Wan Kim
IPC分类号： A61K950
CPC分类号： A61K9/5146 , A61K47/59 , A61K47/593 , A61K47/595 , A61K47/60 , Y10S977/773 , Y10S977/906
摘要： A biodegradable, novel cationic coopolymer comprising a a poly(alkylenimine)(PAI), a hydrophilic polymer, and a biodegradable linker, wherein the biodegradable linker covalently links the PAI and the hydrophilic polymer. The biodegradable cationic copolymers in the present invention can be used in drug delivery and are especially useful for delivery of a nucleic acid or any anionic bioactive agent to various organs and tissues after local or systemic administration.

32. 发明授权

US06217912B1 Polyester analogue of poly-L-lysine as a soluble, biodegradable gene delivery carrier 失效
标题翻译：聚-L-赖氨酸的聚酯类似物作为可溶性，可生物降解的基因递送载体
公开(公告)号：US06217912B1
公开(公告)日：2001-04-17
申请号：US09352473
申请日：1999-07-13
申请人： Jong Sang Park , Young Hun Choi , Sung Wan Kim
发明人： Jong Sang Park , Young Hun Choi , Sung Wan Kim
IPC分类号： A61K4714
CPC分类号： C12N15/87 , A61K9/1647 , A61K47/62 , A61K48/00 , C08G63/664 , C08G63/6852
摘要： Poly[&agr;-(4-aminobutyl)-L-glycolic acid] (PAGA) is disclosed as a biodegradable composition suitable for delivering a gene into a cell. Methods of making and using PAGA are also disclosed.
摘要翻译：公开了聚[α-（4-氨基丁基）-L-乙醇酸]（PAGA）作为适于将基因输送到细胞中的可生物降解的组合物。还公开了制造和使用PAGA的方法。

33. 发明授权

US4718903A Artificial heart 失效
标题翻译：人造心脏
公开(公告)号：US4718903A
公开(公告)日：1988-01-12
申请号：US906849
申请日：1986-09-15
申请人： Byoung G. Min , Chang-Soon Koh , Jun-Lyang No , Gil-Jung Chun , Hi-Chan Kim , Dong-Chul Han , Sung-Wan Kim
发明人： Byoung G. Min , Chang-Soon Koh , Jun-Lyang No , Gil-Jung Chun , Hi-Chan Kim , Dong-Chul Han , Sung-Wan Kim
IPC分类号： A61B16/00 , A61M1/10 , A61M1/12 , A61F2/22
CPC分类号： A61M1/1046 , A61M1/1048 , A61M1/12
摘要： An artificial heart blood pump including a driving motor which can be contained within the human body and which performs pumping action when supplied from an electric power source from outside of the human body. The pump includes left and right ventricles defined by elastomeric films fixed inside a pump body near each side. Each ventricle has an inlet and an outlet provided with respective check valves. Within the pump body generally between the elastomeric films is a movable body having a cylindrical case with a bidirectional driving motor built in. The movable body rolls from side to side during operation to alternately press against the elastomeric films and discharge blood alternately from the ventricles. To cause the movable body to roll from side to side, the movable body has an end portion rotatably connected to each end of the cylindrical case, and the end portions each have a groove slidably engaging a side guide rail on inner surfaces of the pump body so as to prevent rotation of the end portions within and relative to the pump body. Power transmitting means, preferably in the form of a pair of planetary gear trains, connects a motor shaft to one of the end portions so as to provide bidirectional relative rotation between the cylindrical case and the one end portion such that the cylindrical case rotates within the pump body. To convert this rotation to side-to-side rolling, a semi-circumferential row of gear teeth on said cylindrical case engages a toothed rack on an inner surface of the pump body.
摘要翻译：一种人造心脏血泵，其包括能够容纳在人体内的驱动电动机，并且在从人体外部从电力供给时进行抽动动作。泵包括由固定在靠近每一侧的泵体内部的弹性膜限定的左心室和右心室。每个心室都有一个入口和一个带有相应止回阀的出口。通常在弹性膜之间的泵体内是具有内置双向驱动电动机的圆筒形壳体的可移动体。可动体在操作过程中从一侧向另一侧滚动以交替地压靠弹性体膜并从血液交替排出血液。为了使可动体从一侧向另一侧滚动，可移动体具有可旋转地连接到圆筒形壳体的每一端的端部，并且端部各自具有与泵体的内表面可滑动地接合侧导轨的凹槽以防止端部在泵体内部和相对于泵体旋转。优选地以一对行星齿轮系的形式的动力传递装置将马达轴连接到一个端部部分，以便在圆筒形壳体和一个端部之间提供双向相对旋转，使得圆柱形壳体在泵体。为了将该转动转换为侧向滚动，所述圆筒形壳体上的半圆周齿轮齿啮合在泵体的内表面上的齿形齿条。

34. 发明授权

US12079843B2 On-line advertisement method using advertisement website 有权
公开(公告)号：US12079843B2
公开(公告)日：2024-09-03
申请号：US17684649
申请日：2022-03-02
申请人： Sung Wan Kim
发明人： Sung Wan Kim
IPC分类号： G06Q30/02 , G06Q30/0241 , G06Q30/0251 , G06Q30/0272 , G06Q30/0273
CPC分类号： G06Q30/0277 , G06Q30/0255 , G06Q30/0272 , G06Q30/0273 , G06Q30/0275
摘要： Disclosed is an on-line advertisement method using an advertisement website. An on-line advertisement method according to an embodiment of the present invention provides an advertisement available to a user terminal at a current position of a user terminal which accesses an advertisement website.

35. 发明授权

US08241198B2 Ventricular assist device capable of implantation of stem cells 有权
标题翻译：能够植入干细胞的心室辅助装置
公开(公告)号：US08241198B2
公开(公告)日：2012-08-14
申请号：US12513310
申请日：2007-11-05
申请人： David A. Bull , Rafe C. Connors , Harold M. Erickson , James Yockman , Sung Wan Kim
发明人： David A. Bull , Rafe C. Connors , Harold M. Erickson , James Yockman , Sung Wan Kim
IPC分类号： A61M1/12
CPC分类号： A61K35/34 , A61B8/12 , A61M1/1001 , A61M1/1006 , A61M1/1008 , A61M1/12 , A61M1/122 , A61M1/127 , A61M1/3472 , A61M1/3618 , A61M1/3621 , A61M1/3667 , A61M1/3689 , C12N5/0662
摘要： A biologic ventricular assist device that also has the capability to capture, grow, and administer stem cells to regenerate and restore damaged myocardium in the heart. The device works in conjunction with a traditional ventricular assist device and possesses an additional external path or tube that is in-line with the path of the ventricular assist device. The external path allows for the administration of stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, as well as leading to a stem cell collecting accessory (14) that captures circulating stem cells. The stem cell collecting accessory is also associated with a chamber (39) for culturing the captured stem cells. The cultured stem cells can be delivered back to the heart by an electro-mechanical or ultrasound/echocardiographic delivery system that runs through the external path back into the ventricular assist device and allows for the delivery of the stem cells, or other therapeutic biologic or pharmacologic agents, directly into the internal chambers of the heart. Administering the stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, either alone or in combination, to the heart allows the myocardium to regenerate and repair itself even while the heart is attached to the ventricular assist device, ultimately allowing the heart to regenerate, recover and allow the VAD to be removed.
摘要翻译：一种生物心室辅助装置，其还具有捕获，生长和施用干细胞以再生和恢复心脏中损伤的心肌的能力。该装置与传统的心室辅助装置一起工作，并且具有与心室辅助装置的路径一致的额外的外部路径或管。外部途径允许施用干细胞，基因，遗传修饰的细胞或其他治疗生物或药理学试剂，以及导致捕获循环干细胞的干细胞收集附件（14）。干细胞收集附件还与用于培养所捕获的干细胞的室（39）相关联。培养的干细胞可以通过机电或超声/超声心动图输送系统递送回心脏，该系统通过外部路径返回到心室辅助装置，并允许输送干细胞或其他治疗性生物学或药理学代理人，直接进入内心的内心。将心脏单独或组合的干细胞，基因，遗传修饰的细胞或其他治疗性生物或药理学剂施用于心脏，即使在心脏附着于心室辅助装置时也能使心肌再生和修复自身，最终允许心脏再生，恢复并允许VAD被去除。

36. 发明授权

US08153155B2 Arginine-conjugated bioreducible poly(disulfide amine) polymers for gene delivery system 有权
标题翻译：用于基因递送系统的精氨酸缀合的生物还原性聚（二硫化胺）聚合物
公开(公告)号：US08153155B2
公开(公告)日：2012-04-10
申请号：US12496568
申请日：2009-07-01
申请人： Sun Hwa Kim , Ji Hoon Jeong , Tae-il Kim , Sung Wan Kim , David A. Bull
发明人： Sun Hwa Kim , Ji Hoon Jeong , Tae-il Kim , Sung Wan Kim , David A. Bull
IPC分类号： A61K9/14 , C07H21/04
CPC分类号： A61K9/5146 , A61K47/34 , A61K47/59 , A61K47/595 , A61K47/6455 , A61K48/0041 , C12N15/111 , C12N2320/32
摘要： An arginine-grafted bioreducible poly(disulfide amine) (“ABP”) as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with siRNA. ABP is biodegraded under reducing conditions, such as in the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian cells and exhibits no cytotoxicity. ABP is an effective delivery vehicle for gene silencing with siRNA and may be used for treating cancer.
摘要翻译：描述了精氨酸接枝的可生物还原的聚（二硫化胺）（“ABP”）作为有效和无毒的基因递送的试剂。 ABP用siRNA形成小于200nm的带正电荷的纳米颗粒。 ABP在还原条件下如细胞质中生物降解。与哺乳动物细胞中的聚乙烯亚胺相比，ABP的转染效率高得多，不显示细胞毒性。 ABP是用于siRNA基因沉默的有效递送载体，可用于治疗癌症。

37. 发明授权

US08058256B2 Polymeric carrier for delivery of small interfering RNA 有权
标题翻译：用于递送小干扰RNA的聚合载体
公开(公告)号：US08058256B2
公开(公告)日：2011-11-15
申请号：US12691566
申请日：2010-01-21
申请人： Won Jong Kim , Sung Wan Kim
发明人： Won Jong Kim , Sung Wan Kim
IPC分类号： A61K48/00 , A61K38/04 , A61K51/00 , C07K5/00
CPC分类号： C12N15/87
摘要： A carrier for delivering small interfering RNA (siRNA) into cells includes a cholesterol residue covalently bonded to oligoarginine. Mixing the siRNA with the carrier produces a complex-containing composition. Contacting a cell with the complex-containing composition results in delivery of the siRNA into the cell. Delivery of an siRNA targeted to vascular endothelial growth factor is a treatment for cancer. Methods of making the carrier and complex are also disclosed.
摘要翻译：将小干扰RNA（siRNA）递送到细胞中的载体包括共价键合到寡精氨酸的胆固醇残基。将siRNA与载体混合产生含有复合物的组合物。将细胞与含有复合物的组合物接触导致siRNA递送到细胞中。靶向血管内皮生长因子的siRNA的递送是癌症的治疗。还公开了制备载体和复合物的方法。

38. 发明申请

US20110015257A1 Hypoxia Inducible VEGF Plasmid for Ischemic Disease 有权
标题翻译：缺氧可诱导VEGF质粒缺血性疾病
公开(公告)号：US20110015257A1
公开(公告)日：2011-01-20
申请号：US12649141
申请日：2009-12-29
申请人： Minhyung Lee , Sung Wan Kim
发明人： Minhyung Lee , Sung Wan Kim
IPC分类号： A61K31/711 , A61P9/10
CPC分类号： C07K14/52 , A61K48/0058 , C12N15/85 , C12N2830/002
摘要： Plasmids useful for treating ischemic disease, such as ischemic heart disease, are described. The plasmids express vascular endothelial growth factor (VEGF) under the control of a promoter (RTP801) that is up-regulated under hypoxic conditions. Pharmaceutical compositions for treating ischemic disease include mixtures of the hypoxia-regulated VEGF plasmids and pharmaceutically acceptable carriers. Methods for treating ischemic disease include administering such pharmaceutical compositions to a person in need of such treatment.
摘要翻译：描述了可用于治疗缺血性疾病如缺血性心脏病的质粒。质粒在缺氧条件下上调的启动子（RTP801）的控制下表达血管内皮生长因子（VEGF）。用于治疗缺血性疾病的药物组合物包括缺氧调节的VEGF质粒和药学上可接受的载体的混合物。用于治疗缺血性疾病的方法包括将这种药物组合物给予需要这种治疗的人。

39. 发明申请

US20100130722A1 POLYMERIC CARRIER FOR DELIVERY OF SMALL INTERFERING RNA 有权
标题翻译：用于递送小干扰RNA的聚合载体
公开(公告)号：US20100130722A1
公开(公告)日：2010-05-27
申请号：US12691566
申请日：2010-01-21
申请人： Won Jong Kim , Sung Wan Kim
发明人： Won Jong Kim , Sung Wan Kim
IPC分类号： C07K7/06 , C07K7/08 , C07K5/11
CPC分类号： C12N15/87
摘要： A carrier for delivering small interfering RNA (siRNA) into cells includes a cholesterol residue covalently bonded to oligoarginine. Mixing the siRNA with the carrier produces a complex-containing composition. Contacting a cell with the complex-containing composition results in delivery of the siRNA into the cell. Delivery of an siRNA targeted to vascular endothelial growth factor is a treatment for cancer. Methods of making the carrier and complex are also disclosed.
摘要翻译：将小干扰RNA（siRNA）递送到细胞中的载体包括共价键合到寡精氨酸的胆固醇残基。将siRNA与载体混合产生含有复合物的组合物。将细胞与含有复合物的组合物接触导致siRNA递送到细胞中。靶向血管内皮生长因子的siRNA的递送是癌症的治疗。还公开了制备载体和复合物的方法。

40. 发明申请

US20090233365A1 ARGININE-CONJUGATED BIOREDUCIBLE POLY(DISULFIDE AMINE) POLYMERS FOR GENE DELIVERY SYSTEMS 有权
标题翻译：用于基因递送系统的ARGININE-CONJUGATED BIOREDUCIBLE POLY（DISULFIDE AMINE）POLYMERS
公开(公告)号：US20090233365A1
公开(公告)日：2009-09-17
申请号：US12370515
申请日：2009-02-12
申请人： Sung Wan Kim , Tae-il Kim
发明人： Sung Wan Kim , Tae-il Kim
IPC分类号： C12N15/87 , C07C321/14 , C07H21/00 , C07H21/02 , C12N5/06
CPC分类号： A61K48/0041 , A61K9/5146 , A61K47/34 , A61K47/6455 , C12N15/111 , C12N2320/32
摘要： An arginine-grafted bioreducible poly(disulfide amine) (“ABP”) as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with plasmid DNA. ABP is biodegraded under reducing conditions, such as the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian cells and exhibits no cytotoxicity.
摘要翻译：描述了精氨酸接枝的可生物还原的聚（二硫化胺）（“ABP”）作为有效和无毒的基因递送的试剂。 ABP与质粒DNA形成小于200nm的带正电荷的纳米颗粒。 ABP在还原条件下生物降解，如细胞质。与哺乳动物细胞中的聚乙烯亚胺相比，ABP的转染效率高得多，不显示细胞毒性。

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