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31. 发明授权

US5376671A Propenoyl-imidazole derivatives 失效
标题翻译：丙烯酰 - 咪唑衍生物
公开(公告)号：US5376671A
公开(公告)日：1994-12-27
申请号：US43779
申请日：1993-04-06
申请人： Matthias Muller-Gliemann , Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Martin Beuck , Stanislav Kazda , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil
发明人： Matthias Muller-Gliemann , Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Martin Beuck , Stanislav Kazda , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil
IPC分类号： A61K31/415 , C07D233/64 , C07D233/68
CPC分类号： C07D233/68
摘要： Propenoyl-imidazole derivatives are prepared by reaction of appropriate imidazoylaldehydes with CH-acidic compounds and subsequent dehydration of the intermediates. The propenoyl-imidazole derivatives can be employed as active compounds in medicaments for the treatment of arterial hypertension and atherosclerosis.
摘要翻译：丙烯酰 - 咪唑衍生物通过合适的咪唑基醛与CH-酸性化合物的反应制备，随后中间体脱水。丙烯酰 - 咪唑衍生物可用作用于治疗动脉高血压和动脉粥样硬化的药物中的活性化合物。

32. 发明授权

US5354749A Sulfonylbenzyl-substituted benzo- and pyridopyridones 失效
标题翻译：磺酰基苄基取代的苯并 - 和吡啶并吡啶酮
公开(公告)号：US5354749A
公开(公告)日：1994-10-11
申请号：US58548
申请日：1993-05-05
申请人： Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch
发明人： Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch
IPC分类号： A61K31/435 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/472 , A61P9/10 , A61P9/12 , A61P43/00 , C07D211/60 , C07D213/64 , C07D213/84 , C07D213/89 , C07D215/227 , C07D217/24 , C07D295/22 , C07D295/26 , C07D401/12 , C07D491/052 , C07D471/04
CPC分类号： C07D401/12 , C07D217/24
摘要： Sulfonylbenzyl-substituted benzo- and pyridopyridones are prepared by reacting corresponding benzo- and pyridopyridones with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted benzo- and pyridopyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hyper tension and atherosclerosis.
摘要翻译：磺酰基苄基取代的苯并 - 和吡啶并吡啶酮是通过使相应的苯并 - 和吡啶并吡啶酮与磺酰基苄基化合物反应来制备的。磺酰基苄基取代的苯并 - 和吡啶并吡啶酮可用作药物中的活性化合物，特别是用于治疗动脉超压和动脉粥样硬化。

33. 发明授权

US6025378A Bicyclic heterocyclic compounds 失效
标题翻译：双环杂环化合物
公开(公告)号：US6025378A
公开(公告)日：2000-02-15
申请号：US99557
申请日：1998-06-18
申请人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
发明人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
IPC分类号： C07D237/06 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/517 , A61K31/535 , A61K31/5355 , A61K31/54 , A61K31/541 , A61K31/5415 , A61P3/06 , A61P9/10 , C07D209/48 , C07D235/08 , C07D235/10 , C07D235/28 , C07D237/32 , C07D239/91 , C07D263/58 , C07D265/36 , C07D275/06 , C07D277/20 , C07D277/56 , C07D279/16 , C07D401/04 , C07D409/04 , C07D417/04 , C07D471/04 , C07D498/04 , A61K31/42 , A61K31/47 , C07D215/00 , C07D263/04 , C07D263/30 , C07D403/02 , C07D413/00
CPC分类号： C07D209/48 , C07D235/08 , C07D235/10 , C07D235/28 , C07D237/32 , C07D239/91 , C07D263/58 , C07D275/06 , C07D279/16 , C07D401/04 , C07D409/04 , C07D417/04
摘要： The bicyclic heterocyclic compounds are prepared by reaction of correspondingly substituted carboxylic acids with amines, in particular with phenylglycinolamine. The bicyclic heterocyclic compounds according to the invention are suitable as active compounds in medicaments, in particular in medicaments having an antiatherosclerotic action.
摘要翻译：双环杂环化合物通过相应地取代的羧酸与胺，特别是苯基甘氨酚的反应来制备。根据本发明的双环杂环化合物适合作为药物中的活性化合物，特别是具有抗动脉粥样硬化作用的药物。

34. 发明授权

US5925646A Heterocyclic aryl-, alkyl- and cycloalkylacetamides 失效
标题翻译：杂环芳基，烷基和环烷基乙酰胺
公开(公告)号：US5925646A
公开(公告)日：1999-07-20
申请号：US8709
申请日：1998-01-16
申请人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Martin Beuck , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
发明人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Martin Beuck , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/47 , A61P3/06 , A61P9/08 , A61P9/10 , C07C69/732 , C07C69/734 , C07D213/65 , C07D215/14 , C07D401/12 , C07D409/12 , A61K31/445 , C07C233/11 , C07D213/51
CPC分类号： C07D401/12 , C07C69/732 , C07C69/734 , C07D213/65 , C07D215/14 , C07D409/12
摘要： The heterocyclic aryl-, alkyl- and cycloalkylacetamides are prepared by reacting the appropriately substituted acetic acids with amines, if appropriate in complexed form. The heterocyclic aryl-, alkyl- and cycloalkylacetamides can be used as active compounds in medicaments, in particular in antiatherosclerotic medicaments.
摘要翻译：杂环芳基 - ，烷基 - 和环烷基乙酰胺通过使适当取代的乙酸与胺反应制备，如果合适的话可以配合形式。杂环芳基 - ，烷基 - 和环烷基乙酰胺可用作药物中的活性化合物，特别是抗动脉粥样硬化药物。

35. 发明授权

US5849751A Amides and sulphonamides of benzylamines having heterocyclic substituents 失效
标题翻译：具有杂环取代基的苄胺的酰胺和磺酰胺
公开(公告)号：US5849751A
公开(公告)日：1998-12-15
申请号：US675668
申请日：1996-07-03
申请人： Ulrich Muller , Richard Connell , Hilmar Bischoff , Dirk Denzer , Stefan Lohmer , Stefan Wohlfeil , Rudi Grutzmann
发明人： Ulrich Muller , Richard Connell , Hilmar Bischoff , Dirk Denzer , Stefan Lohmer , Stefan Wohlfeil , Rudi Grutzmann
IPC分类号： A61K31/435 , A61P3/06 , A61P9/00 , A61P9/10 , C07D471/04 , A61K31/44
CPC分类号： C07D471/04
摘要： Amides and sulphonamides of benzylamines having heterocyclic substituents are prepared by first converting the corresponding carboxylic acids into the corresponding amines and then substituting these on the amine nitrogen in a corresponding manner. The new amides and sulphonamides of benzylamines having heterocyclic substituents can be used as active compounds in medicaments, in particular in antiatherosclerotic medicaments.
摘要翻译：通过首先将相应的羧酸转化为相应的胺，然后以相应的方式将其替换在胺氮上来制备具有杂环取代基的苄胺的酰胺和磺酰胺。具有杂环取代基的苄胺的新酰胺和磺酰胺可用作药物中的活性化合物，特别是抗动脉粥样硬化药物。

36. 发明授权

US5834481A Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives 失效
标题翻译：异环取代的苯基 - 环己烷羧酸衍生物
公开(公告)号：US5834481A
公开(公告)日：1998-11-10
申请号：US889683
申请日：1997-07-08
申请人： Ulrich E. Muller , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
发明人： Ulrich E. Muller , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
IPC分类号： C07D403/10 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/435 , A61K31/44 , A61P9/10 , A61P9/12 , A61P43/00 , C07D209/86 , C07D209/90 , C07D209/94 , C07D213/86 , C07D257/04 , C07D401/10 , C07D471/04 , C07D209/82
CPC分类号： C07D471/04 , C07D209/86
摘要： Heterotricyclically substituted phenyl-cyclohexanecarboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicaments.
摘要翻译：异环取代的苯基 - 环己烷羧酸衍生物通过使杂环化合物与被苄基卤基取代的环己烷羧酸衍生物反应来制备。这些化合物可以用作药物中的活性化合物。

37. 发明授权

US5714494A Xanthines in the 7th position with a benzyl acetic acid moiety 失效
标题翻译：第七位的黄嘌呤与苄基乙酸部分
公开(公告)号：US5714494A
公开(公告)日：1998-02-03
申请号：US710503
申请日：1996-09-18
申请人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
发明人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
IPC分类号： A61K31/52 , A61K31/522 , A61P9/00 , A61P9/10 , C07D473/06 , C07D473/08 , C07D473/22
CPC分类号： C07D473/06 , C07D473/08
摘要： Substituted xanthines of formula ##STR1## in which A represents a radical of the formula ##STR2## in which R.sup.3, R.sup.4, R.sup.6 and R.sup.7 denote hydrogen, cycloalkyl, aryl having 6 to 10 carbon atoms, or denote straight-chain of branched alkyl or alkenyl, each of which is optionally substituted; T, V, X and Y are identical or different and denote an oxygen or sulphur atom; R.sup.5 and R.sup.8 are identical or different and denote hydrogen, halogen, cycloalkyl having 3 to 8 carbon atoms or straight-chain or branched alkyl or alkenyl in each case having up to 8 carbon atoms, optionally substituted or R.sup.5 and R.sup.8 denote aryl having 6 to 10 carbon atoms or a 5- to 7-membered aromatic, optionally benzo-fused heterocycle having up to 3 heteroatoms S, N and/or O, each of which is optionally substituted; L represents an oxygen or sulphur atom; R.sup.2 represents mercapto, hydroxyl, straight-chain or branched alkoxy having up to 8 carbon atoms or the group of the formula ##STR3## in which R.sup.13 denotes hydrogen or straight-chain or branched alkyl having up to 4 carbon atoms; R.sup.14 denotes hydrogen, phenyl or a 5- to 6-membered aromatic heterocycle having up to 3 heteroatoms S, N and/or O; and R.sup.15 denotes hydrogen or straight-chain or branched alkyl having up to 8 carbon atom, optionally substituted by hydroxyl, and their salts are prepared by reaction of the suitable unsubstituted xanthines with halogenomethylphenylacetic acids and subsequent reaction of the carboxylic esters or acids with phenylglycinolamine. The substituted xanthines are suitable as active compounds in medicaments, in particular in antiatherosclerotic medicaments.
摘要翻译：式（I）的取代黄嘌呤其中A表示式为“IMAGE”的基团，其中R 3，R 4，R 6和R 7表示氢，环烷基，具有6至10个碳原子的芳基，或表示直链支链烷基或烯基，其各自任选被取代; T，V，X和Y相同或不同，表示氧或硫原子; R5和R8相同或不同，表示氢，卤素，具有3-8个碳原子的环烷基或具有至多8个碳原子的直链或支链烷基或链烯基，任选取代或R 5和R 8表示具有6至 10个碳原子或5至7元芳族，任选苯并稠合的杂环，其具有至多3个杂原子S，N和/或O，每个杂原子任选被取代; L表示氧或硫原子; R 2表示具有至多8个碳原子的巯基，羟基，直链或支链烷氧基或式“IMAGE”的基团，其中R13表示氢或具有至多4个碳原子的直链或支链烷基; R14表示氢，苯基或具有至多3个S，N和/或O的杂原子的5至6元芳族杂环; 并且R 15表示氢或具有至多8个碳原子的直链或支链烷基，任选被羟基取代，并且它们的盐通过合适的未取代黄嘌呤与卤代甲基苯基乙酸的反应制备，随后羧酸酯或酸与苯基甘氨酚的反应来制备。取代黄嘌呤在药物，特别是抗动脉粥样硬化药物中适合作为活性化合物。

38. 发明授权

US5576342A Phenylglycinamides of heterocyclically substitued phenylacetic acid derivatives 失效
标题翻译：杂环取代苯乙酸衍生物的苯基甘氨酰胺
公开(公告)号：US5576342A
公开(公告)日：1996-11-19
申请号：US210810
申请日：1994-03-18
申请人： Ulrich M uller , J urgen Dressel , Peter Fey , Rudolf Hanko , Walter H ubsch , Thomas Kr amer , Matthias M uller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
发明人： Ulrich M uller , J urgen Dressel , Peter Fey , Rudolf Hanko , Walter H ubsch , Thomas Kr amer , Matthias M uller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
IPC分类号： C07D233/68 , C07D401/12 , C07D405/12 , C12N9/04 , C12N15/81 , A61K31/535 , A61K31/415 , C07D403/10 , C07D413/10
CPC分类号： C07D401/12 , C07D233/68 , C07D405/12 , C12N15/815 , C12N9/0006 , C07K2319/00
摘要： Phenylglycinamides of heterocyclically substituted phenylacetic acid derivatives are prepared by reacting phenylacetic acids with glycinamides. The compounds can be used as active compounds in medicaments.
摘要翻译：通过使苯乙酸与甘氨酰胺反应制备杂环取代的苯乙酸衍生物的苯基甘氨酰胺。该化合物可用作药物中的活性化合物。

39. 发明授权

US5527809A Substituted imidazo[4,5-b]pyridines and benzimidazoles 失效
标题翻译：取代的咪唑并[4,5-b]吡啶和苯并咪唑
公开(公告)号：US5527809A
公开(公告)日：1996-06-18
申请号：US187925
申请日：1994-01-27
申请人： Matthias Muller-Gliemann , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
发明人： Matthias Muller-Gliemann , Jurgen Dressel , Peter Fey , Rudolf H. Hanko , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/435 , A61P9/10 , A61P9/12 , A61P43/00 , C07D235/06 , C07D235/08 , C07D235/16 , C07D235/18 , C07D471/04
CPC分类号： C07D471/04 , C07D235/08 , C07D235/18
摘要： Substituted imidazo[4,5-b]pyridines and benzimidazoles are prepared by reacting imidazo[4,5-b]pyridines or benzimidazoles with appropriately substituted benzyl halides. The substituted imidazo[4,5-b]pyridines or benzimidazoles can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
摘要翻译：通过咪唑并[4,5-b]吡啶或苯并咪唑与适当取代的苄基卤反应制备取代的咪唑并[4,5-b]吡啶和苯并咪唑。取代的咪唑并[4,5-b]吡啶或苯并咪唑可用作药物中的活性化合物，特别是用于治疗动脉高血压和动脉粥样硬化。

40. 发明授权

US5492923A Substituted pyridines and 2-oxo-1,2-dihydropyridines 失效
标题翻译：取代的吡啶和2-氧代-1,2-二氢吡啶
公开(公告)号：US5492923A
公开(公告)日：1996-02-20
申请号：US235831
申请日：1994-04-29
申请人： Peter Fey , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
发明人： Peter Fey , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
IPC分类号： C07D213/60 , A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61K31/455 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , A61P27/02 , A61P43/00 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/84 , C07D401/10
CPC分类号： C07D401/10
摘要： Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
摘要翻译：通过相应地取代的卤代苯与四唑基硼酸的反应来制备取代的吡啶和2-氧代-1,2-二氢吡啶。根据本发明的取代的吡啶和2-氧代-1,2-二氢吡啶可以用作药物中的活性化合物，特别是用于治疗动脉高血压和动脉粥样硬化。

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