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1. 发明授权

US6025378A Bicyclic heterocyclic compounds 失效
标题翻译：双环杂环化合物
公开(公告)号：US6025378A
公开(公告)日：2000-02-15
申请号：US99557
申请日：1998-06-18
申请人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
发明人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
IPC分类号： C07D237/06 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/517 , A61K31/535 , A61K31/5355 , A61K31/54 , A61K31/541 , A61K31/5415 , A61P3/06 , A61P9/10 , C07D209/48 , C07D235/08 , C07D235/10 , C07D235/28 , C07D237/32 , C07D239/91 , C07D263/58 , C07D265/36 , C07D275/06 , C07D277/20 , C07D277/56 , C07D279/16 , C07D401/04 , C07D409/04 , C07D417/04 , C07D471/04 , C07D498/04 , A61K31/42 , A61K31/47 , C07D215/00 , C07D263/04 , C07D263/30 , C07D403/02 , C07D413/00
CPC分类号： C07D209/48 , C07D235/08 , C07D235/10 , C07D235/28 , C07D237/32 , C07D239/91 , C07D263/58 , C07D275/06 , C07D279/16 , C07D401/04 , C07D409/04 , C07D417/04
摘要： The bicyclic heterocyclic compounds are prepared by reaction of correspondingly substituted carboxylic acids with amines, in particular with phenylglycinolamine. The bicyclic heterocyclic compounds according to the invention are suitable as active compounds in medicaments, in particular in medicaments having an antiatherosclerotic action.
摘要翻译：双环杂环化合物通过相应地取代的羧酸与胺，特别是苯基甘氨酚的反应来制备。根据本发明的双环杂环化合物适合作为药物中的活性化合物，特别是具有抗动脉粥样硬化作用的药物。

2. 发明授权

US5849751A Amides and sulphonamides of benzylamines having heterocyclic substituents 失效
标题翻译：具有杂环取代基的苄胺的酰胺和磺酰胺
公开(公告)号：US5849751A
公开(公告)日：1998-12-15
申请号：US675668
申请日：1996-07-03
申请人： Ulrich Muller , Richard Connell , Hilmar Bischoff , Dirk Denzer , Stefan Lohmer , Stefan Wohlfeil , Rudi Grutzmann
发明人： Ulrich Muller , Richard Connell , Hilmar Bischoff , Dirk Denzer , Stefan Lohmer , Stefan Wohlfeil , Rudi Grutzmann
IPC分类号： A61K31/435 , A61P3/06 , A61P9/00 , A61P9/10 , C07D471/04 , A61K31/44
CPC分类号： C07D471/04
摘要： Amides and sulphonamides of benzylamines having heterocyclic substituents are prepared by first converting the corresponding carboxylic acids into the corresponding amines and then substituting these on the amine nitrogen in a corresponding manner. The new amides and sulphonamides of benzylamines having heterocyclic substituents can be used as active compounds in medicaments, in particular in antiatherosclerotic medicaments.
摘要翻译：通过首先将相应的羧酸转化为相应的胺，然后以相应的方式将其替换在胺氮上来制备具有杂环取代基的苄胺的酰胺和磺酰胺。具有杂环取代基的苄胺的新酰胺和磺酰胺可用作药物中的活性化合物，特别是抗动脉粥样硬化药物。

3. 发明授权

US5714494A Xanthines in the 7th position with a benzyl acetic acid moiety 失效
标题翻译：第七位的黄嘌呤与苄基乙酸部分
公开(公告)号：US5714494A
公开(公告)日：1998-02-03
申请号：US710503
申请日：1996-09-18
申请人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
发明人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
IPC分类号： A61K31/52 , A61K31/522 , A61P9/00 , A61P9/10 , C07D473/06 , C07D473/08 , C07D473/22
CPC分类号： C07D473/06 , C07D473/08
摘要： Substituted xanthines of formula ##STR1## in which A represents a radical of the formula ##STR2## in which R.sup.3, R.sup.4, R.sup.6 and R.sup.7 denote hydrogen, cycloalkyl, aryl having 6 to 10 carbon atoms, or denote straight-chain of branched alkyl or alkenyl, each of which is optionally substituted; T, V, X and Y are identical or different and denote an oxygen or sulphur atom; R.sup.5 and R.sup.8 are identical or different and denote hydrogen, halogen, cycloalkyl having 3 to 8 carbon atoms or straight-chain or branched alkyl or alkenyl in each case having up to 8 carbon atoms, optionally substituted or R.sup.5 and R.sup.8 denote aryl having 6 to 10 carbon atoms or a 5- to 7-membered aromatic, optionally benzo-fused heterocycle having up to 3 heteroatoms S, N and/or O, each of which is optionally substituted; L represents an oxygen or sulphur atom; R.sup.2 represents mercapto, hydroxyl, straight-chain or branched alkoxy having up to 8 carbon atoms or the group of the formula ##STR3## in which R.sup.13 denotes hydrogen or straight-chain or branched alkyl having up to 4 carbon atoms; R.sup.14 denotes hydrogen, phenyl or a 5- to 6-membered aromatic heterocycle having up to 3 heteroatoms S, N and/or O; and R.sup.15 denotes hydrogen or straight-chain or branched alkyl having up to 8 carbon atom, optionally substituted by hydroxyl, and their salts are prepared by reaction of the suitable unsubstituted xanthines with halogenomethylphenylacetic acids and subsequent reaction of the carboxylic esters or acids with phenylglycinolamine. The substituted xanthines are suitable as active compounds in medicaments, in particular in antiatherosclerotic medicaments.
摘要翻译：式（I）的取代黄嘌呤其中A表示式为“IMAGE”的基团，其中R 3，R 4，R 6和R 7表示氢，环烷基，具有6至10个碳原子的芳基，或表示直链支链烷基或烯基，其各自任选被取代; T，V，X和Y相同或不同，表示氧或硫原子; R5和R8相同或不同，表示氢，卤素，具有3-8个碳原子的环烷基或具有至多8个碳原子的直链或支链烷基或链烯基，任选取代或R 5和R 8表示具有6至 10个碳原子或5至7元芳族，任选苯并稠合的杂环，其具有至多3个杂原子S，N和/或O，每个杂原子任选被取代; L表示氧或硫原子; R 2表示具有至多8个碳原子的巯基，羟基，直链或支链烷氧基或式“IMAGE”的基团，其中R13表示氢或具有至多4个碳原子的直链或支链烷基; R14表示氢，苯基或具有至多3个S，N和/或O的杂原子的5至6元芳族杂环; 并且R 15表示氢或具有至多8个碳原子的直链或支链烷基，任选被羟基取代，并且它们的盐通过合适的未取代黄嘌呤与卤代甲基苯基乙酸的反应制备，随后羧酸酯或酸与苯基甘氨酚的反应来制备。取代黄嘌呤在药物，特别是抗动脉粥样硬化药物中适合作为活性化合物。

4. 发明授权

US5811429A Bicyclic heterocyclic compounds 失效
公开(公告)号：US5811429A
公开(公告)日：1998-09-22
申请号：US761921
申请日：1996-12-09
申请人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
发明人： Richard Connell , Siegfried Goldmann , Ulrich Muller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Grutzmann , Stefan Wohlfeil
IPC分类号： C07D237/06 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/517 , A61K31/535 , A61K31/5355 , A61K31/54 , A61K31/541 , A61K31/5415 , A61P3/06 , A61P9/10 , C07D209/48 , C07D235/08 , C07D235/10 , C07D235/28 , C07D237/32 , C07D239/91 , C07D263/58 , C07D265/36 , C07D275/06 , C07D277/20 , C07D277/56 , C07D279/16 , C07D401/04 , C07D409/04 , C07D417/04 , C07D471/04 , C07D498/04 , C07D239/72 , C07D413/00
CPC分类号： C07D209/48 , C07D235/08 , C07D235/10 , C07D235/28 , C07D237/32 , C07D239/91 , C07D263/58 , C07D275/06 , C07D279/16 , C07D401/04 , C07D409/04 , C07D417/04
摘要： The bicyclic heterocyclic compounds are prepared by reaction of correspondingly substituted carboxylic acids with amines, in particular with phenylglycinolamine. The bicyclic heterocyclic compounds according to the invention are suitable as active compounds in medicaments, in particular in medicaments having an antiatherosclerotic action.

5. 发明申请

US20090286695A1 LUMINESCENT STEM CELLS AND USES THEREOF 审中-公开
标题翻译：发光干细胞及其用途
公开(公告)号：US20090286695A1
公开(公告)日：2009-11-19
申请号：US12160426
申请日：2007-01-10
申请人： Silvia Cainarca , Cinzia Nucci , Sabrina Corazza , Stefan Lohmer
发明人： Silvia Cainarca , Cinzia Nucci , Sabrina Corazza , Stefan Lohmer
IPC分类号： C40B30/06 , C12N5/10
CPC分类号： C07K14/43595 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , C12N15/8509
摘要： It is described a stable recombinant stem cell able to express an apophotoprotein and produce a bioluminescent signal in the presence of a suitable chromophore as substrate in response to intracellular calcium concentration variation: methods for identifying agents modulating the differentiation of stem cells towards a specific cell lineage; methods for identifying a ligand able to stimulate a specific cell lineage target; methods for identifying an antagonist to ligand known to stimulate a specific cell lineage target uses of stable recombinant stem cells for in vitro testing of toxicity and/teratology of a substance.
摘要翻译：描述了一种稳定的重组干细胞，其能够在适当的生色团存在下产生一个脱辅基蛋白质并产生生物发光信号，以响应细胞内钙浓度的变化：用于鉴定调节干细胞向特定细胞谱系分化的试剂的方法 ; 用于鉴定能够刺激特定细胞谱系靶标的配体的方法; 用于鉴定已知刺激特异性细胞谱系靶标的配体的拮抗剂的方法用于稳定的重组干细胞用于体外测试物质的毒性和/致畸性。

6. 发明授权

US06235770B1 Indolyl-substituted phenylacetic acid derivatives 失效
标题翻译：吲哚基取代的苯乙酸衍生物
公开(公告)号：US06235770B1
公开(公告)日：2001-05-22
申请号：US09435544
申请日：1999-11-08
申请人： Richard Connell , Siegfried Goldmann , Ulrich Müller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Grützmann , Stefan Wohlfeil
发明人： Richard Connell , Siegfried Goldmann , Ulrich Müller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Grützmann , Stefan Wohlfeil
IPC分类号： A61K31405
CPC分类号： C07D471/04 , C07D209/08 , C07D209/42 , C07D235/16
摘要： The indolyl-substituted phenylacetic acid derivatives are prepared by reacting the corresponding phenylacetic acids with the required amines. The indolyl-substituted phenylacetic acid derivatives are suitable as active compounds in medicaments, in particular in antiarteriosclerotic medicaments.
摘要翻译：吲哚基取代的苯乙酸衍生物通过使相应的苯乙酸与所需的胺反应来制备。吲哚基取代的苯乙酸衍生物在药物，特别是抗动脉硬化药物中适合作为活性化合物。

7. 发明授权

US06200971B1 Bicyclic heterocyclic compounds 失效
标题翻译：双环杂环化合物
公开(公告)号：US06200971B1
公开(公告)日：2001-03-13
申请号：US09420304
申请日：1999-10-18
申请人： Richard Connell , Siegfried Goldmann , Ulrich Müller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Gr{umlaut over (u )}tzmann , Stefan Wohlfeil
发明人： Richard Connell , Siegfried Goldmann , Ulrich Müller , Stefan Lohmer , Hilmar Bischoff , Dirk Denzer , Rudi Gr{umlaut over (u )}tzmann , Stefan Wohlfeil
IPC分类号： A61K3154
CPC分类号： C07D209/48 , C07D235/08 , C07D235/10 , C07D235/28 , C07D237/32 , C07D239/91 , C07D263/58 , C07D275/06 , C07D279/16 , C07D401/04 , C07D409/04 , C07D417/04
摘要： The bicyclic heterocyclic compounds are prepared by reaction of correspondingly substituted carboxylic acids with amines, in particular with phenylglycinolamine. The bicyclic heterocyclic compounds according to the invention are suitable as active compounds in medicaments, in particular in medicaments having an antiatherosclerotic action.
摘要翻译：双环杂环化合物通过相应地取代的羧酸与胺，特别是苯基甘氨酚的反应来制备。根据本发明的双环杂环化合物适合作为药物中的活性化合物，特别是具有抗动脉粥样硬化作用的药物。

8. 发明授权

US6114341A Pyrimido[1,2-a]indoles 失效
标题翻译：嘧啶并[1,2-a]吲哚
公开(公告)号：US6114341A
公开(公告)日：2000-09-05
申请号：US829015
申请日：1997-03-31
申请人： Ulrich Muller , Peter Eckenberg , Rudi Grutzmann , Hilmar Bischoff , Dirk Denzer , Stefan Wohlfeil , Stefan Lohmer , Ulrich Nielsch , Peter Kolkhof
发明人： Ulrich Muller , Peter Eckenberg , Rudi Grutzmann , Hilmar Bischoff , Dirk Denzer , Stefan Wohlfeil , Stefan Lohmer , Ulrich Nielsch , Peter Kolkhof
IPC分类号： A61K31/505 , A61P9/00 , A61P9/10 , C07D20060101 , C07D487/04 , A01N43/54 , C07D239/00
CPC分类号： C07D487/04
摘要： The pyrimido[1,2-a]indoles according to the invention are prepared by reacting appropriately substituted phenylacetic acid derivatives with phenylglycinols. The pyrimido[1,2-a]indoles can be used as active compounds in medicaments, in particular in medicaments with antiatherosclerotic activity.
摘要翻译：通过使适当取代的苯乙酸衍生物与苯基甘氨醇反应制备本发明的嘧啶并[1,2-a]吲哚。嘧啶并[1,2-a]吲哚可用作药物中的活性化合物，特别是具有抗动脉粥样硬化活性的药物。

9. 发明授权

US5935983A Use of phenylcyclohexylcarboxamides 失效
标题翻译：苯基环己基甲酰胺的应用
公开(公告)号：US5935983A
公开(公告)日：1999-08-10
申请号：US960075
申请日：1997-10-24
申请人： Matthias Muller-Gliemann , Ulrich Muller , Martin Beuck , Siegfried Zaiss , Christoph Gerdes , Anke Domdey-Bette , Rudi Grutzmann , Stefan Lohmer , Stefan Wohlfeil , Ozkan Yalkinoglu , James Elting , Dirk Denzer
发明人： Matthias Muller-Gliemann , Ulrich Muller , Martin Beuck , Siegfried Zaiss , Christoph Gerdes , Anke Domdey-Bette , Rudi Grutzmann , Stefan Lohmer , Stefan Wohlfeil , Ozkan Yalkinoglu , James Elting , Dirk Denzer
IPC分类号： C07D235/16 , A61K31/415 , A61K31/4184 , A61K31/4188 , A61K31/435 , A61K31/437 , A61K31/44 , A61P9/00 , A61P9/10 , C07D235/08 , C07D235/18 , C07D471/04
CPC分类号： C07D471/04 , A61K31/4184 , A61K31/437 , C07D235/08 , C07D235/18
摘要： The phenylcyclohexylcarboxamides, some of which are known, are suitable as active compounds in medicaments, in particular in medicaments for the treatment of restenosis.
摘要翻译：其中一些已知的苯基环己基甲酰胺适合作为药物中的活性化合物，特别是用于治疗再狭窄的药物。

10. 发明授权

US07601805B2 Photoprotein with improved bioluminescence 有权
标题翻译：具有改善的生物发光的光蛋白
公开(公告)号：US07601805B2
公开(公告)日：2009-10-13
申请号：US10530658
申请日：2003-10-21
申请人： Maria Foti , Stefan Lohmer
发明人： Maria Foti , Stefan Lohmer
IPC分类号： C07K14/00 , C07H21/02 , C07H21/04 , C12P21/06 , C12N1/20 , C12N1/00 , C12N5/00 , C12N5/02 , C12N5/04 , C12N5/10 , C12Q1/00
CPC分类号： G01N33/542 , C07K14/43595 , C07K2319/00 , G01N2500/10
摘要： Disclosed is a photoprotein with improved luminescent activity, the use thereof as calcium indicator and in cell-based assays for the detection and measurement of intracellular calcium.
摘要翻译：公开了具有改善的发光活性的光蛋白，其作为钙指示剂的用途以及用于检测和测量细胞内钙的基于细胞的测定。

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