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31. 发明授权

US07767683B2 Hydrogen succinate salts of trans-4-((1R, 3S)-6-chloro-3-phenylindan-1-YL)-1,2,2-trimethylpiperazine and the use as a medicament 有权
标题翻译：反-4 - （（1R，3S）-6-氯-3-苯基茚-1-基）-1,2,2-三甲基哌嗪的琥珀酸琥珀酸盐和用作药物的用途
公开(公告)号：US07767683B2
公开(公告)日：2010-08-03
申请号：US10568572
申请日：2004-08-18
申请人： Heidi Lopez de Diego , Ole Nielsen , Lone Munch Ringgard , Henrik Svane , Allan Carsten Dahl , Mark Howells , Benny Bang-Andersen , Lars Ole Lyngso , Sherry Lynn Collier
发明人： Heidi Lopez de Diego , Ole Nielsen , Lone Munch Ringgard , Henrik Svane , Allan Carsten Dahl , Mark Howells , Benny Bang-Andersen , Lars Ole Lyngso , Sherry Lynn Collier
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D295/073 , C07B2200/07 , C07C17/16 , C07C25/22 , C07C29/143 , C07C35/32 , C07C2602/08 , C07D241/04 , C12P7/22 , C12P41/004 , C07C35/52
摘要： 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen succinate, pharmaceutical compositions containing the salt and the medical use thereof, including for the treatment of schizophrenia and other psychotic disorders. Also described are methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and medical uses thereof.
摘要翻译： 4 - （（1R，3S）-6-氯-3-苯基茚基-1-基）-1,2,2-三甲基哌嗪氢琥珀酸盐，含有该盐及其医疗用途的药物组合物，包括用于治疗精神分裂症和其他精神障碍。还描述了制备4 - （（1R，3S）-6-氯-3-苯基茚-1-基）-1,2,2-三甲基哌嗪的方法及其医疗用途。

32. 发明授权

US07723533B2 Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base 有权
标题翻译：依他普仑和包含依他普仑碱的分散片的结晶基
公开(公告)号：US07723533B2
公开(公告)日：2010-05-25
申请号：US12046999
申请日：2008-03-12
申请人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
发明人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
IPC分类号： C07D307/87
CPC分类号： C07D307/81
摘要： The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-furancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.
摘要翻译：本发明涉及众所周知的抗抑郁药物依他普仑S-1- [3-（二甲基氨基）丙基] -1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃腈的结晶碱，其制剂的所述碱的方法，使用碱，通过所述方法获得的盐以及含有这些盐的制剂来制备依他普仑的纯化盐如草酸盐的方法，以及制备纯化的依他普仑游离碱或其盐的方法使用氢溴酸盐，通过所述方法获得的盐和含有这些盐的制剂，例如草酸盐。最后，本发明涉及硬度至少为22N，口服崩解时间小于120秒的可分散片剂，其包含吸附在水溶性填料上的活性药物成分，其中活性药物成分的熔点为 40-100℃的范围，以及制造这种可分散片剂的方法。

33. 发明申请

US20080161388A1 CRYSTALLINE BASE OF ESCITALOPRAM AND ORODISPERSIBLE TABLETS COMPRISING ESCITALOPRAM BASE 有权
标题翻译：包括ESCITALOPRAM基板的晶圆和可折叠片
公开(公告)号：US20080161388A1
公开(公告)日：2008-07-03
申请号：US12046984
申请日：2008-03-12
申请人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
发明人： Robert Dancer , Hans Petersen , Ole Nielsen , Michael Harold Rock , Helle Eliasen , Ken Liljegren
IPC分类号： A61K31/343 , C07D307/87
CPC分类号： C07D307/81
摘要： The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-furancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.
摘要翻译：本发明涉及众所周知的抗抑郁药物依他普仑S-1- [3-（二甲基氨基）丙基] -1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃腈的结晶碱，其制剂的所述碱的方法，使用碱，通过所述方法获得的盐以及含有这些盐的制剂来制备依他普仑的纯化盐如草酸盐的方法，以及制备纯化的依他普仑游离碱或其盐的方法使用氢溴酸盐，通过所述方法获得的盐和含有这些盐的制剂，例如草酸盐。最后，本发明涉及硬度至少为22N，口服崩解时间小于120秒的可分散片剂，其包含吸附在水溶性填料上的活性药物成分，其中活性药物成分的熔点为 40-100℃的范围，以及制造这种可分散片剂的方法。

34. 发明申请

US20070138173A1 STORAGE CONTAINER AND METHOD OF FORMING SAME 审中-公开
标题翻译：储存容器及其形成方法
公开(公告)号：US20070138173A1
公开(公告)日：2007-06-21
申请号：US11480340
申请日：2006-06-30
申请人： Ole Nielsen
发明人： Ole Nielsen
IPC分类号： B65D6/28
CPC分类号： B65D88/022 , B65D88/121 , B65D90/0006
摘要： A storage container is provided, having a first container portion and a second container portion. The first container portion is approximately 24 feet in length, having a first front portion. The second container portion is approximately 16 feet in length, having a second front portion. The first and second front portions are coupled to form a storage container approximately 40 feet in length and having a opening extending approximately 40 feet through the storage container. A first panel of the first front portion is mounted to an inside surface of the storage container and a second panel of the second front portion is mounted to an inside surface of the storage container.
摘要翻译：提供了具有第一容器部分和第二容器部分的储存容器。第一容器部分的长度约为24英尺，具有第一前部。第二容器部分的长度约为16英尺，具有第二前部。第一和第二前部连接以形成大约40英尺长的存储容器，并具有通过存储容器延伸大约40英尺的开口。第一前部的第一面板被安装到存储容器的内表面，并且第二前部的第二面板安装到存储容器的内表面。

35. 发明申请

US20070021733A1 Internal fluid connector 审中-公开
标题翻译：内部流体连接器
公开(公告)号：US20070021733A1
公开(公告)日：2007-01-25
申请号：US11407647
申请日：2006-04-20
申请人： Steffen Hansen , Bjorn Larsen , Claus Moller , Ole Nielsen , Jim Radmer , Jan Preuthun , Philip Sparholt , Erik Ethelfeld
发明人： Steffen Hansen , Bjorn Larsen , Claus Moller , Ole Nielsen , Jim Radmer , Jan Preuthun , Philip Sparholt , Erik Ethelfeld
IPC分类号： A61K9/22
CPC分类号： A61M5/14248 , A61M5/14216 , A61M5/14224 , A61M5/14526 , A61M5/1486 , A61M2005/14252 , A61M2005/14268 , A61M2005/14506 , A61M2005/14513 , A61M2005/1585
摘要： A medical device is provided comprising a reservoir adapted to contain a fluid drug in an interior thereof, and a pump assembly. The pump assembly comprises a pump inlet, a pump outlet and an internal flow path arranged there between, and a fluid connector having an inlet and an outlet. The fluid connector is arranged to be operated from an initial state in which the fluid connector is arranged within the interior of the pump and an actuated state in which fluid communication is established between the interior of the reservoir and the interior of the pump assembly via the fluid connector and with the outlet of the fluid connector being arranged in the flow path of the pump assembly.
摘要翻译：提供了一种医疗装置，其包括适于在其内部容纳流体药物的储存器和泵组件。泵组件包括泵入口，泵出口和布置在其间的内部流动路径，以及具有入口和出口的流体连接器。流体连接器布置成从初始状态操作，其中流体连接器布置在泵的内部内，以及致动状态，其中在储存器的内部和泵组件的内部之间建立流体连通流体连接器并且流体连接器的出口布置在泵组件的流动路径中。

36. 发明申请

US20050171135A1 1'-[4-[1-(4-fluorophenyl)-1H-indole-3-Y1]-spiro[isobenzofuran-1(3H), 4'-piperidine]hydrohalogenides 审中-公开
标题翻译： 1' - [4- [1-（4-氟苯基）-1H-吲哚-3-Y1] - 螺[异苯并呋喃-1（3H），4'-哌啶]氢卤酸
公开(公告)号：US20050171135A1
公开(公告)日：2005-08-04
申请号：US11012084
申请日：2004-12-13
申请人： Niels Mork , Heidi Lopez de Diego , Ole Nielsen
发明人： Niels Mork , Heidi Lopez de Diego , Ole Nielsen
IPC分类号： A61K31/438 , A61P9/10 , A61P21/00 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , C07D491/10 , C07D491/107 , A61K31/4747
CPC分类号： C07D491/10
摘要： The present invention relates to a hydrohalogenide of 1′-[4-[1-(4-fluorophenyl)-1H-indole-3-yl]-1-butyl]-spiro[isobenzofuran-1(3H),4′-piperidine], pharmaceutical compositions containing the acid addition salts and the use thereof for the treatment of psychic and neurological disorders.
摘要翻译：本发明涉及1' - [4- [1-（4-氟苯基）-1H-吲哚-3-基] -1-丁基] - 螺[异苯并呋喃-1（3H）），4'-哌啶 ]，含有酸加成盐的药物组合物及其用于治疗心理和神经障碍的用途。

37. 发明授权

US4160714A Measuring chamber unit 失效
标题翻译：测量室单元
公开(公告)号：US4160714A
公开(公告)日：1979-07-10
申请号：US898933
申请日：1978-04-21
申请人： Jorgen Andersen , Ole Nielsen
发明人： Jorgen Andersen , Ole Nielsen
IPC分类号： G01N27/403 , G01N27/28
CPC分类号： G01N27/403
摘要： A block-shaped measuring chamber unit, especially for use in electrochemical measuring apparatuses for defining measuring chambers therein. The block-shaped unit has oppositely directed or otherwise differently orientated surface parts each defining a depression to be used as a measuring chamber. These depressions are interconnected by means of straight bores or passages extending through the block-shaped unit. The block-shaped unit is preferably made from machinable glass-ceramic.
摘要翻译：一种块状测量室单元，特别用于在其中限定测量室的电化学测量装置中。块状单元具有相反的方向或以其他方式取向的表面部分，每个表面部分限定用作测量室的凹陷。这些凹陷通过延伸穿过块形单元的直孔或通道相互连接。块状单元优选地由可机加工的玻璃陶瓷制成。

38. 发明授权

US3673839A Method of manufacturing a foil material embossed on both sides,a roll nip and a machine for carrying out the method 失效
标题翻译：用于制造双面铆钉的材料的方法，用于实施方法的滚丝机和机器
公开(公告)号：US3673839A
公开(公告)日：1972-07-04
申请号：US3673839D
申请日：1970-08-11
申请人： OLE NIELSEN , MAX BEIDIL
发明人： NIELSEN OLE , BEIDIL MAX
IPC分类号： B29C51/08 , B29C51/22 , B31F1/07 , B44B5/00
CPC分类号： B29C51/22 , B29C51/082 , B31F1/07 , B31F2201/0723 , B31F2201/0735 , B31F2201/0738 , B31F2201/0743 , B31F2201/0753 , B31F2201/0782
摘要： A method for embossing foil material by inserting the foil material in the roll nip between two rolls being provided with projections, each projection of a roll being surrounded on all sides by projections of the other roll, each projection of a roll is axially offset relative to the peripherally adjacent projections on the same roll, the projections of one roll form lines oblique to an axial line and so that the foil material from each projection peak on each roll is stretched to the surrounding projection peaks of the other roll.

39. 发明申请

US20130194565A1 APPARATUS AND METHOD FOR MEASURING RETROREFLECTIVITY OF A SURFACE 有权
标题翻译：测量表面反向选择性的装置和方法
公开(公告)号：US20130194565A1
公开(公告)日：2013-08-01
申请号：US13576044
申请日：2011-02-04
申请人： Kaj Sørensen , Asbjørn Mejnertsen , Jan Harries Hansen , Hans Ole Nielsen
发明人： Kaj Sørensen , Asbjørn Mejnertsen , Jan Harries Hansen , Hans Ole Nielsen
IPC分类号： G01N21/55
CPC分类号： G01N21/55 , G01N2021/551
摘要： An apparatus for measuring the retroreflectivity of a surface. The apparatus comprises a light source for illuminating an area of said surface at an incident angle relative to the surface; a detector for detecting light reflected back from the surface at an observation angle relative to the surface; a signal processing unit adapted to receive a detector signal from the detector and to determine, from at least the received detector signal, a measure of retro reflectivity of the surface; a range finder for measuring a distance between the apparatus and the illuminated area. The signal processing unit is further adapted to adjust the measure of retroreflectivity responsive to the measured distance.
摘要翻译：用于测量表面的后向反射率的装置。该装置包括用于以相对于该表面入射的角度照射所述表面的区域的光源; 用于检测从表面以相对于表面观察角度反射回的光的检测器; 信号处理单元，适于从所述检测器接收检测器信号，并且从至少所接收的检测器信号确定所述表面的复现反射率的量度; 用于测量设备和照明区域之间的距离的测距仪。信号处理单元还适于响应于测量的距离来调节后向反射率的测量。

40. 发明授权

US07399987B1 Planar electron emitter (PEE) 失效
标题翻译：平面电子发射体（PEE）
公开(公告)号：US07399987B1
公开(公告)日：2008-07-15
申请号：US09700463
申请日：1999-06-11
申请人： Petr Viscor , Niels Ole Nielsen , Armin Delong , Vladimir Kolarik
发明人： Petr Viscor , Niels Ole Nielsen , Armin Delong , Vladimir Kolarik
IPC分类号： H01J19/24
CPC分类号： B82Y10/00 , H01J1/312 , H01J35/065 , H01J2235/062
摘要： A planar electron emitter, based on the existence of quasi-ballistic transport of electrons is disclosed. In its preferred embodiment the planar electron emitter structure consists of a body of finite gap pure semiconductor or insulator, the said body of macroscopic thickness (˜1 mm) being terminated by two parallel surfaces and of a set of two electrodes deposited/grown on the said two free surfaces such that when a low external electrical field (˜100 V/cm) is applied to this structure, consisting of two electrodes and the said semiconductor or insulating body sandwiched between them, a large fraction of electrons injected into the said semiconductor or insulator body from the negatively charged electrode (cathode) is quasi-ballistic in nature, that is this fraction of injected electrons is accelerated within the said semiconductor or insulator body without suffering any appreciable inelastic energy losses, thereby achieving sufficient energy and appropriate momentum at the positively charged electrode (anode) to be able to traverse through the said anode and to escape from the said structure into empty space (vacuum), said semiconductor or insulator body comprises a material or material system having a predetermined crystal orientation.
摘要翻译：公开了一种基于电子的准弹道输运的存在的平面电子发射体。在其优选实施例中，平面电子发射器结构由有限间隙纯半导体或绝缘体的主体组成，所述宏观厚度（〜1mm）的主体由两个平行表面和一组两个沉积/生长在所述两个自由表面使得当由两个电极和夹在其间的所述半导体或绝缘体组成的该结构施加低的外部电场（〜100V / cm）时，注入到所述半导体中的大部分电子或来自带负电荷的电极（阴极）的绝缘体本质上是准弹道的，也就是说，注入的电子的这一部分在所述半导体或绝缘体内部被加速，而不会受到任何明显的非弹性能量损失，从而实现足够的能量和适当的动量带正电的电极（阳极）能够穿过所述阳极并从所述结构件逸出所述半导体或绝缘体包括具有预定晶体取向的材料或材料体系。

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