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31. 发明申请

WO2011149878A1 AN AMINOPYRAZOLE TRIAZOLOTHIADIAZOLE INHIBITOR OF C-MET PROTEIN KINASE 审中-公开
标题翻译： C-MET蛋白激酶的氨基吡唑三唑并噻唑类抑制剂
公开(公告)号：WO2011149878A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/037659
申请日：2011-05-24
申请人： VERTEX PHARMACEUTICALS INCORPORATED , LAUFFER, David, J. , LI, Pan , ROEPER, Stefanie , IBRAHIM, Shereen , KULDIPKUMAR, Anuj, K. , SHI, Yi , MILLER, David, B., Jr.
发明人： LAUFFER, David, J. , LI, Pan , ROEPER, Stefanie , IBRAHIM, Shereen , KULDIPKUMAR, Anuj, K. , SHI, Yi , MILLER, David, B., Jr.
IPC分类号： C07D513/04 , A61K31/4709 , A61P35/00
CPC分类号： C07D513/04
摘要： The present invention relates to anhydrous and hydrated forms of Compound 1, which are useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising compounds of formula I and methods of using the compositions in the treatment of proliferative disorders.
摘要翻译：本发明涉及化合物1的无水和水合形式，其可用于抑制c-Met蛋白激酶。本发明还提供包含式I化合物的药学上可接受的组合物和使用该组合物治疗增殖性疾病的方法。

32. 发明申请

WO2009089241A2 SYSTEMS AND METHODS FOR AN ADAPTIVE POWER CONTROLLED MAC PROTOCOL FOR WIRELESS AD HOC NETWORKS 审中-公开
标题翻译：用于无线自组织网络的自适应功率控制MAC协议的系统和方法
公开(公告)号：WO2009089241A2
公开(公告)日：2009-07-16
申请号：PCT/US2009/030261
申请日：2009-01-07
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , LI, Pan , FANG, Yuguang
发明人： LI, Pan , FANG, Yuguang
IPC分类号： H04W52/24 , H04W52/30 , H04W80/02 , H04W84/18
CPC分类号： H04W52/10 , H04W24/00 , H04W52/243 , H04W52/367 , H04W84/18
摘要： An embodiment generally relates to a method of transmitting. The method includes detecting an incoming packet at a wireless network interface and determining a minimum power level based on a transmission power level contained in the incoming packet. The method also includes determining whether any neighboring nodes are transmitting and determining an allowable power level to a sender of the incoming packet. The method further includes transmitting the reply packet at the allowable power level in response to the allowable power level being greater than the minimum power level.
摘要翻译：一个实施例通常涉及一种传输方法。该方法包括在无线网络接口处检测输入分组并且基于输入分组中包含的发送功率电平来确定最小功率电平。该方法还包括确定是否有任何相邻节点正在传送并且确定到传入分组的发送方的可允许功率电平。该方法进一步包括响应于可允许功率电平大于最小功率电平而以可允许功率电平发送应答包。

33. 发明申请

WO2009045992A2 C-MET PROTEIN KINASE INHIBITORS 审中-公开
标题翻译： C-MET蛋白激酶抑制剂
公开(公告)号：WO2009045992A2
公开(公告)日：2009-04-09
申请号：PCT/US2008078239
申请日：2008-09-30
申请人： VERTEX PHARMA , LAUFFER DAVID , LI PAN , WAAL NATHAN , MCGINTY KIRA , TANG QING , RONKIN STEVEN , FARMER LUC , SHANNON DEAN , JACOBS DYLAN
发明人： LAUFFER DAVID , LI PAN , WAAL NATHAN , MCGINTY KIRA , TANG QING , RONKIN STEVEN , FARMER LUC , SHANNON DEAN , JACOBS DYLAN
IPC分类号： A61K31/4439
CPC分类号： C07D401/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to compounds of formula I useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative disorders. Formula (I).
摘要翻译：本发明涉及用于抑制c-Met蛋白激酶的式I化合物。本发明还提供了包含本发明化合物的药学上可接受的组合物以及使用该组合物治疗增殖性疾病的方法。公式（I）。

34. 发明申请

WO2008036272A1 HETEROCYCLIC INHIBITORS OF c-MET AND USES THEREOF 审中-公开
标题翻译： c-MET的杂环抑制剂及其用途
公开(公告)号：WO2008036272A1
公开(公告)日：2008-03-27
申请号：PCT/US2007/020222
申请日：2007-09-18
申请人： VERTEX PHARMACEUTICALS INCORPORATED , ARONOV, Alexander , COME, Jon , COURT, John , DEININGER, David , LAUFFER, David , LI, Pan , MCGINTY, Kira , NANTHAKUMAR, Suganthini , STAMOS, Dean , TANNER, Kirk
发明人： ARONOV, Alexander , COME, Jon , COURT, John , DEININGER, David , LAUFFER, David , LI, Pan , MCGINTY, Kira , NANTHAKUMAR, Suganthini , STAMOS, Dean , TANNER, Kirk
IPC分类号： C07D497/04 , C07D513/04 , A61K31/433 , A61P35/00
CPC分类号： C07D497/04 , C07D513/04
摘要： The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
摘要翻译：本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。

35. 发明申请

WO2005040345A3 4-AZOLE SUBSTITUTED IMIDAZOLE COMPOSITIONS USEFUL AS INHIBITORS OR C-MET RECEPTOR TYROSINE KINASE 审中-公开
标题翻译：作为抑制剂或C-MET受体酪氨酸激酶的4-AZO取代的咪唑组合物
公开(公告)号：WO2005040345A3
公开(公告)日：2005-08-18
申请号：PCT/US2004031401
申请日：2004-09-24
申请人： VERTEX PHARMA , ARONOV ALEX , LAUFFER DAVID J , LI PAN , TOMLINSON RONALD C
发明人： ARONOV ALEX , LAUFFER DAVID J , LI PAN , TOMLINSON RONALD C
IPC分类号： A61K31/4178 , A61K31/4196 , A61K31/42 , C07D233/90 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/04 , C07D413/14 , A61K31/41 , A61K31/4155 , A61K31/4184 , A61K31/422 , A61P3/08 , A61P9/00 , A61P29/00 , A61P31/12
CPC分类号： C07D405/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders. Formula (I) where Q is C1-6 alkylidene chain wherein one methylene unit of Q is replaced by -C(O)N(R)-, -C(O)-, -C(O)O-, -N(R)-, -O-, -S-, -SO2-, or -SO2N(R)-; each R is independently hydrogen or an optionally substituted C1-6 aliphatic group, wherein: two R groups on the same nitrogen atom are optionally taken together with said nitrogen atom to form an optionally substituted 3-7 membered saturated, partially unsaturated, of fully unsaturated ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R is H, -N(R)2, or an optionally substituted ring selected from a 3-7 membered saturated or partially unsaturated ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur; a 5-6 membered aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or an 8-10 membered bicyclic partially unsaturated or aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R is an optionally substituted 6-membered aryl ring having 0-3 nitrogens; R is R, CN, NO2, halogen, N(R)2, OR, or SR; and Ring A is an optionally substituted ring selected from formulas (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m), (n), (o) or (p).
摘要翻译：本发明涉及可用于蛋白激酶抑制剂的化合物。本发明还提供了制备本发明化合物的方法，包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。式（I）其中Q是C 1-6亚烷基链，其中Q的一个亚甲基单元被-C（O）N（R） - ， - C（O） - ， - C（O）（R） - ， - O - ， - S - ， - SO 2 - 或-SO 2 N（R） - ; 每个R独立地为氢或任选取代的C 1-6脂族基团，其中：相同氮原子上的两个R基团任选与所述氮原子一起形成任选取代的3-7元饱和，部分不饱和的完全不饱和的具有1-3个独立地选自氮，氧或硫的杂原子的环; R 1是H，-N（R）2或任选取代的环，其选自具有0-3个独立地选自氮，氧或硫的杂原子的3-7元饱和或部分不饱和的环; 具有0-4个独立地选自氮，氧或硫的杂原子的5-6元芳环; 或具有0-4个独立地选自氮，氧或硫的杂原子的8-10元双环部分不饱和或芳环; R 2是具有0-3个氮的任选取代的6元芳环; R 3是R，CN，NO 2，卤素，N（R）2，OR或SR; 环A是选自式（a），（b），（c），（d），（e），（f），（g），（h），（i），（j），（k），（l），（m），（n），（o）或（p）。

36. 发明授权

US08597231B2 Peritoneal dialysis system having heater pan and weight sensor 有权
标题翻译：腹膜透析系统具有加热锅和重量传感器
公开(公告)号：US08597231B2
公开(公告)日：2013-12-03
申请号：US13550243
申请日：2012-07-16
申请人： Robert Childers , Scott Keeling , Li Pan
发明人： Robert Childers , Scott Keeling , Li Pan
IPC分类号： A61M1/00
CPC分类号： A61M1/281 , A61M1/0023 , A61M1/1643 , A61M1/28 , A61M1/282 , A61M1/288 , A61M2205/12
摘要： A peritoneal dialysis machine includes: (i) a housing; (ii) an actuator carried by the housing so as to be able to interact with a peritoneal dialysis fluid carrying disposable; (iii) at least one heating element carried by the housing; (iv) a heater pan providing an upper surface of the housing, the heater pan cooperating with the at least one heater element to provide heat to a container of peritoneal dialysis fluid placed onto the heater pan, the container being part of or in communication with the peritoneal dialysis fluid carrying disposable; and (iv) a weight sensor cooperating with the heater pan to sense the weight of the peritoneal dialysis fluid located within the container.
摘要翻译：腹膜透析机包括：（i）外壳; （ii）由壳体承载的致动器，以能够与携带一次性的腹膜透析液相互作用; （iii）由壳体承载的至少一个加热元件; （iv）提供所述壳体的上表面的加热器盘，所述加热器盘与所述至少一个加热器元件配合以向放置在所述加热器盘上的腹膜透析液体的容器提供热量，所述容器是与所述加热器的一部分或与其连通的腹膜透析液携带一次性; 和（iv）与加热器盘配合的重量传感器，以感测位于容器内的腹膜透析液的重量。

37. 发明申请

US20130314085A1 Interface for Medical Imaging Device 有权
标题翻译：医疗成像装置接口
公开(公告)号：US20130314085A1
公开(公告)日：2013-11-28
申请号：US13480214
申请日：2012-05-24
申请人： Junichi Tokuda , Li Pan , Christine Lorenz
发明人： Junichi Tokuda , Li Pan , Christine Lorenz
IPC分类号： G01R33/48
CPC分类号： G01R33/546 , A61B10/0233 , G01R33/285 , G01R33/543
摘要： A system and method for modifying an imaging plane of a medical imaging device is presented. An electronic device includes a tilt sensor. The electronic device is configured to monitor a tilt of the electronic device. A computer is configured to receive an indication of the tilt of the electronic device, translate the indication of the tilt of the electronic device into a corresponding movement of the imaging plane of the medical imaging device, and transmit an instruction to the medical imaging device to cause the corresponding movement of the imaging plane. The medical imaging device may include an magnetic resonance imaging (MRI) system.
摘要翻译：提出了一种用于修改医学成像装置的成像平面的系统和方法。电子设备包括倾斜传感器。电子设备被配置为监视电子设备的倾斜。计算机被配置为接收电子设备的倾斜的指示，将电子设备的倾斜指示转换成医疗成像设备的成像平面的相应运动，并将指令发送到医疗成像设备导致成像平面的相应运动。医学成像装置可以包括磁共振成像（MRI）系统。

38. 发明申请

US20130267918A1 Negative Pressure Wound Therapy Pump with Tilt and Fill Sensors 审中-公开
标题翻译：负压伤口治疗泵与倾斜和填充传感器
公开(公告)号：US20130267918A1
公开(公告)日：2013-10-10
申请号：US13584441
申请日：2012-08-13
申请人： Li Pan , Jiang Li , Huiyong Lin , Tongfeng Yang
发明人： Li Pan , Jiang Li , Huiyong Lin , Tongfeng Yang
IPC分类号： A61M1/00
CPC分类号： A61M1/0088 , A61M1/0023 , A61M1/0066 , A61M2205/18 , A61M2205/215 , A61M2205/3306 , A61M2205/3331 , A61M2205/3382 , A61M2205/8206 , A61M2209/084
摘要： A pump includes a canister for collecting fluids from a negative pressure wound therapy bandage in which the canister incorporates both tilt and fill sensors operatively connected to a microprocessor to control the operation of the pump in drawing fluids from the negative pressure bandage. The fill sensors include a pair of spaced sensor pins that convey a filled signal when fluid within the canister interconnects the two sensor pins. The tilt sensor is housed within the pump housing. The canister is also formed with an optical sensor that provides an indication of proper alignment of the canister on the pump housing. The optical sensor includes a reflector in the canister that reflects an infrared light emanating from the pump housing. When the light reflection is received properly within the pump housing, the canister is properly aligned and mounted on the pump housing.
摘要翻译：泵包括用于从负压伤口治疗绷带收集流体的罐，其中罐结合了可操作地连接到微处理器的倾斜和填充传感器，以控制泵从负压绷带抽取流体的操作。填充传感器包括一对间隔开的传感器销，当罐内的流体互连两个传感器销时，该传感器销传送填充信号。倾斜传感器安装在泵壳体内。罐也形成有光学传感器，其提供罐在泵壳体上的适当对准的指示。光学传感器包括反射器，其反射从泵壳体发出的红外光。当光反射在泵壳体内正确接收时，罐体正确对准并安装在泵壳体上。

39. 发明授权

US07444132B2 Apparatus, and associated method, for facilitating dynamic filtering of a receive signal 有权
标题翻译：装置和相关方法，用于促进接收信号的动态滤波
公开(公告)号：US07444132B2
公开(公告)日：2008-10-28
申请号：US10407931
申请日：2003-04-04
申请人： Li Pan , Rakesh Agrawal
发明人： Li Pan , Rakesh Agrawal
IPC分类号： H04M11/00
CPC分类号： H04B1/123
摘要： Apparatus, and an associated method, for adaptively controlling filter characteristics of a filter forming part of a receive station, such as a mobile station operable in a cellular communication system. An adaptive parameter unit is provided with signal representations of signals that are to be applied to the filter element. The adaptive parameter unit, responsive to measurement or other analysis of the signal indicia, selects the filter characteristics to be exhibited by the filter. And, the filter characteristics are caused to be selected responsive thereto. Dynamic selection and reselection of the filter characteristics is effectuated in which the response time of the filter is minimized during good signal conditions and increased, to permit increased filter operations, during weak signal conditions.
摘要翻译：用于自适应地控制形成诸如在蜂窝通信系统中操作的移动站的接收站的一部分的滤波器的滤波器特性的装置和相关联的方法。自适应参数单元被提供有要施加到滤波器元件的信号的信号表示。响应于信号标记的测量或其他分析的自适应参数单元选择滤波器要呈现的滤波器特性。并且，响应于此而选择滤波器特性。实现了滤波器特性的动态选择和重新选择，其中滤波器的响应时间在良好的信号条件下被最小化并且在弱信号条件下增加以允许增加的滤波器操作。

40. 发明申请

US20060023774A1 Apparatus and method for hybrid traffic and pilot signal quality determination of finger lock status of rake receiver correlators 失效
标题翻译：混合业务的装置和方法以及耙式接收机相关器的手指锁状态的导频信号质量确定
公开(公告)号：US20060023774A1
公开(公告)日：2006-02-02
申请号：US10899846
申请日：2004-07-27
申请人： Li Pan , Jigneshkumar Shah , Fenghua Liu
发明人： Li Pan , Jigneshkumar Shah , Fenghua Liu
IPC分类号： H04B1/707
CPC分类号： H04B1/7115 , H04B1/712 , H04B2201/70701
摘要： Provided are improved systems and methods for spread spectrum communication employing hybrid Eb/No and pilot-based finger lock determination for RAKE receivers. Finger lock thresholds are periodically set using an extended time-averaged Eb/No traffic signal estimate for each finger mapped to an Ec/No pilot level, where the extended time-averaged Eb/No estimate is inversely proportional to the mapped Ec/No level, thus, decreasing the required Ec/No level when the Eb/No estimate increases and increasing the required Ec/No level when the Eb/No estimate decreases. Existing pilot-based finger lock algorithms may be used with the Ec/No threshold set using the extended time-averaged Eb/No estimate. When pilot signals are weak but traffic signals remain strong, fingers will remain locked to increase the combiner output signal-to-noise ratio.
摘要翻译：提供了用于RAKE接收机的混合Eb / No和基于导频的手指锁确定的扩频通信的改进的系统和方法。手指锁定阈值使用针对映射到Ec / No导频电平的每个手指的扩展时间平均Eb / No业务信号估计来定期设置，其中扩展的时间平均Eb / No估计与映射的Ec / No电平成反比因此，当Eb / No估计值增加时，减少所需的Ec / No电平，并且当Eb / No估计值降低时增加所需的Ec / No电平。可以使用现有的基于导频的手指锁算法，使用扩展的时间平均Eb / No估计值设置Ec / No阈值。当导频信号较弱但业务信号保持较强时，手指将保持锁定，以提高组合器的输出信噪比。

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