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31. 发明授权

US08753315B2 Manual basal bolus drug delivery device 有权
标题翻译：手动基础药物输送装置
公开(公告)号：US08753315B2
公开(公告)日：2014-06-17
申请号：US13360485
申请日：2012-01-27
申请人： Clifton A. Alferness , John M. Adams
发明人： Clifton A. Alferness , John M. Adams
IPC分类号： A61M5/142 , A61M5/145 , A61M5/14
CPC分类号： A61M5/1424 , A61M5/1454 , A61M2005/1405
摘要： A fully manually powered infusion device provides both basal and bolus delivery of a liquid medicament to a patient. In some embodiments, the device includes a main reservoir that supplies the liquid medicament, an outlet port that delivers the liquid medicament to the patient, a basal dispenser that delivers a substantially constant flow of the liquid medicament to the outlet port, and a manually actuated bolus pump that delivers a bolus dose of the liquid medicament from the main reservoir to the outlet when actuated. The basal medicament supply delivers a volume of the liquid medicament from the main reservoir to the basal dispenser consonant with each actuation of the bolus pump.
摘要翻译：完全手动输液装置提供液体药物到患者的基础和推注。在一些实施例中，该装置包括供给液体药物的主储存器，将液体药物输送给患者的出口端口，将液体药物的基本上恒定的流量输送到出口的基础分配器，以及手动致动推动泵，其在致动时将液体药物从主容器输送到出口。基础药物供应器通过每次推动推注泵将一定体积的液体药物从主储存器输送到基础分配器辅助器。

32. 发明授权

US08657837B2 Tissue fixation devices and a transoral endoscopic gastroesophageal flap valve restoration device and assembly using same 有权
标题翻译：组织固定装置和经口内镜胃食管瓣瓣修复装置及组装使用方法
公开(公告)号：US08657837B2
公开(公告)日：2014-02-25
申请号：US12460510
申请日：2009-07-18
申请人： Steve G. Baker , Brett J. Carter , Stefan J.M. Kraemer , Clifton A. Alferness , John M. Adams
发明人： Steve G. Baker , Brett J. Carter , Stefan J.M. Kraemer , Clifton A. Alferness , John M. Adams
IPC分类号： A61B17/08
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/064 , A61B17/068 , A61B2017/00827 , A61B2017/0409 , A61B2017/0414 , A61B2017/0419
摘要： Tissue fasteners carried on a tissue piercing deployment wire fasten tissue layers of a mammalian body together. The fasteners include a first member, a second member, and a connecting member extending between the first and second members. The first and second members are substantially parallel to each other. The fasteners may be deployed in limited spaces and in various applications including the restoration of a gastroesophageal flap valve.
摘要翻译：携带在组织穿刺部署线上的组织紧固件将哺乳动物身体的组织层紧固在一起。紧固件包括第一构件，第二构件和在第一构件和第二构件之间延伸的连接构件。第一和第二构件基本上彼此平行。紧固件可以在有限的空间和各种应用中部署，包括恢复胃食管瓣阀。

33. 发明授权

US08277372B2 Cardiac support device with differential compliance 有权
标题翻译：心脏支持装置符合差异
公开(公告)号：US08277372B2
公开(公告)日：2012-10-02
申请号：US12719553
申请日：2010-03-08
申请人： Clifton A. Alferness , Jai Shankar Raman , John Melmouth Power
发明人： Clifton A. Alferness , Jai Shankar Raman , John Melmouth Power
IPC分类号： A61F2/02
CPC分类号： A61F2/2481 , A61F2002/0068
摘要： A cardiac support device comprising a jacket of flexible and biocompatible material having a first axis for alignment generally parallel to a longitudinal axis of a patient's heart and a second axis that is transverse to the first axis. The material exhibits an amount of expansion in response to a force applied to the material along the first axis that is different than an amount of expansion in response to the force applied to the material along the second axis.
摘要翻译：一种心脏支持装置，其包括柔性和生物相容性材料的护套，其具有大致平行于患者心脏的纵向轴线的对准的第一轴线和横向于第一轴线的第二轴线。该材料响应于沿着第一轴施加到材料上的力而响应于沿着沿着第二轴施加到材料的力而产生的膨胀量不同的膨胀量。

34. 发明申请

US20120165856A1 REMOVABLE ANCHORED LUNG VOLUME REDUCTION DEVICES AND METHODS 有权
标题翻译：可拆卸的锚定式减压装置及方法
公开(公告)号：US20120165856A1
公开(公告)日：2012-06-28
申请号：US13415616
申请日：2012-03-08
申请人： Clifton A. Alferness
发明人： Clifton A. Alferness
IPC分类号： A61M29/00
CPC分类号： A61B17/12104 , A61B17/12022 , A61B17/1204 , A61B17/12159 , A61B17/12172 , A61B2017/1205 , A61B2017/22051 , A61B2017/22067 , A61F2002/043
摘要： An intra-bronchial device may be placed and anchored in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes an obstructing member that prevents air from being inhaled into the lung portion, and an anchor that anchors the obstruction device within the air passageway. The anchor may piercingly engage the air passageway wall. The anchor may be releasable from the air passageway for removal of the obstructing member. The anchor may be releasable by collapsing a portion of the obstructing member, or by drawing the obstructing member toward the larynx. The obstructing member may be a one-way valve.
摘要翻译：可以将支气管内装置放置并锚定在患者的空气通道中以折叠与空气通道相关联的肺部分。该装置包括防止空气被吸入肺部的阻塞构件，以及将阻塞装置固定在空气通道内的锚固件。锚固件可以穿透空气通道壁。锚固件可以从空气通道释放以去除阻塞构件。锚固件可以通过塌缩阻塞构件的一部分，或者通过将阻塞构件拉向喉部来释放。阻塞构件可以是单向阀。

35. 发明授权

US08177805B2 Removable anchored lung volume reduction devices and methods 有权
标题翻译：可拆卸锚固肺体积减少装置及方法
公开(公告)号：US08177805B2
公开(公告)日：2012-05-15
申请号：US13198546
申请日：2011-08-04
申请人： Clifton A. Alferness
发明人： Clifton A. Alferness
IPC分类号： A61M29/00
CPC分类号： A61B17/12104 , A61B17/12022 , A61B17/1204 , A61B17/12159 , A61B17/12172 , A61B2017/1205 , A61B2017/22051 , A61B2017/22067 , A61F2002/043
摘要： An intra-bronchial device may be placed and anchored in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes an obstructing member that prevents air from being inhaled into the lung portion, and an anchor that anchors the obstruction device within the air passageway. The anchor may piercingly engage the air passageway wall. The anchor may be releasable from the air passageway for removal of the obstructing member. The anchor may be releasable by collapsing a portion of the obstructing member, or by drawing the obstructing member toward the larynx. The obstructing member may be a one-way valve.
摘要翻译：可以将支气管内装置放置并锚定在患者的空气通道中以折叠与空气通道相关联的肺部分。该装置包括防止空气被吸入肺部的阻塞构件，以及将阻塞装置固定在空气通道内的锚固件。锚固件可以穿透空气通道壁。锚固件可以从空气通道释放以去除阻塞构件。锚固件可以通过塌缩阻塞构件的一部分，或者通过将阻塞构件拉向喉部来释放。阻塞构件可以是单向阀。

36. 发明授权

US08172898B2 Device and method for modifying the shape of a body organ 有权
标题翻译：用于改变身体器官形状的装置和方法
公开(公告)号：US08172898B2
公开(公告)日：2012-05-08
申请号：US12719758
申请日：2010-03-08
申请人： Clifton A. Alferness , John M. Adams , Mark L. Mathis , David G. Reuter , Cruz Beeson , Leonard Kowalsky
发明人： Clifton A. Alferness , John M. Adams , Mark L. Mathis , David G. Reuter , Cruz Beeson , Leonard Kowalsky
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2451 , A61F2250/001 , A61F2250/0059
摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.
摘要翻译：血管内支持装置包括支撑件或再生线，近端锚和远端锚。支撑线接合血管壁以改变邻近其中放置血管内支架的血管的组织的形状。锚和支撑线被设计成使得放置支撑件的容器保持打开，并且如果需要可以被其他装置访问。该装置为在血管内流动的血液提供最小的金属表面积，以限制血栓形成。锚固件可以锁定到位以将支撑件固定在容器内。

37. 发明申请

US20110283998A1 REMOVABLE ANCHORED LUNG VOLUME REDUCTION DEVICES AND METHODS 有权
标题翻译：可拆卸的锚定式减压装置及方法
公开(公告)号：US20110283998A1
公开(公告)日：2011-11-24
申请号：US13198546
申请日：2011-08-04
申请人： CLIFTON A. ALFERNESS
发明人： CLIFTON A. ALFERNESS
IPC分类号： A61M16/00
CPC分类号： A61B17/12104 , A61B17/12022 , A61B17/1204 , A61B17/12159 , A61B17/12172 , A61B2017/1205 , A61B2017/22051 , A61B2017/22067 , A61F2002/043
摘要： An intra-bronchial device may be placed and anchored in an air passageway of a patient to collapse a lung portion associated with the air passageway. The device includes an obstructing member that prevents air from being inhaled into the lung portion, and an anchor that anchors the obstruction device within the air passageway. The anchor may piercingly engage the air passageway wall. The anchor may be releasable from the air passageway for removal of the obstructing member. The anchor may be releasable by collapsing a portion of the obstructing member, or by drawing the obstructing member toward the larynx. The obstructing member may be a one-way valve.
摘要翻译：可以将支气管内装置放置并锚定在患者的空气通道中以折叠与空气通道相关联的肺部分。该装置包括防止空气被吸入肺部的阻塞构件，以及将阻塞装置固定在空气通道内的锚固件。锚固件可以穿透空气通道壁。锚固件可以从空气通道释放以去除阻塞构件。锚固件可以通过塌缩阻塞构件的一部分，或者通过将阻塞构件拉向喉部来释放。阻塞构件可以是单向阀。

38. 发明申请

US20110166413A1 COMPLIANT CARDIAC SUPPORT DEVICE 审中-公开
标题翻译：合规心脏辅助装置
公开(公告)号：US20110166413A1
公开(公告)日：2011-07-07
申请号：US13049499
申请日：2011-03-16
申请人： Clifton A. ALFERNESS , Donald G. ROHRBAUGH , James Edward SHAPLAND , Michael J. GIRARD , Donald F. PALME, II , James E. COX
发明人： Clifton A. ALFERNESS , Donald G. ROHRBAUGH , James Edward SHAPLAND , Michael J. GIRARD , Donald F. PALME, II , James E. COX
IPC分类号： A61F2/00
CPC分类号： A61F2/2481 , Y10S623/904
摘要： A jacket of biological compatible material has an internal volume dimensioned for an apex of the heart to be inserted into the volume and for the jacket to be slipped over the heart. The jacket has a longitudinal dimension between upper and lower ends sufficient for the jacket to surround a lower portion of the heart with the jacket surrounding a valvular annulus of the heart and further surrounding the lower portion to cover at least the ventricular lower extremities of the heart. The jacket is adapted to be secured to the heart with the jacket surrounding at least the valvular annulus and the ventricular lower extremities. The jacket is adjustable on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole.
摘要翻译：生物相容材料的护套具有尺寸设计用于心脏顶点的内部容积，以将其插入体积中并使护套滑过心脏。护套具有在上下端之间的纵向尺寸，足以使护套围绕心脏的下部围绕心脏的瓣膜环并且进一步围绕下部以至少覆盖心脏的心室下端。护套适于固定在心脏上，护套至少围绕瓣膜环和心室下肢。护套在心脏上是可调节的，以贴合地符合心脏的外部几何形状，并假设护套的最大调节体积以约束舒张期心脏超过最大调节体积的周向扩张，并允许心脏收缩期间不受阻碍的收缩。

39. 发明申请

US20100198020A1 System And Method For Computer-Implemented Method For Actively Managing Increased Insulin Resistance In Type 2 Diabetes Mellitus 审中-公开
标题翻译：计算机实施方法的系统和方法，用于积极管理2型糖尿病中增加的胰岛素抵抗
公开(公告)号：US20100198020A1
公开(公告)日：2010-08-05
申请号：US12757920
申请日：2010-04-09
申请人： Clifton A. Alferness , Gust H. Bardy
发明人： Clifton A. Alferness , Gust H. Bardy
IPC分类号： A61B5/00
CPC分类号： G06F19/3475 , G06F19/3456 , G06F19/3481 , G16H15/00 , G16H50/50
摘要： A computer-implemented method for actively managing increased insulin resistance in Type 2 diabetes mellitus is provided. A computer-generated model of glycemic effect for a Type 2 diabetic patient for digestive response is established on a computer workstation. A rise in postprandial blood glucose from a meal planned for ingestion by the patients estimated as displayed through the digestive response model. A coefficient applied to the digestive response model for an initial degree of insulin resistance experienced by the patient is adjusted. Following a physiologic increase in insulin resistance, a rise in postprandial blood glucose from a subsequent meal planned for ingestion by the patient is estimated as displayed through the digestive response model. The coefficient applied to the digestive response model for a subsequent degree of insulin resistance experienced by the patient is adjusted.
摘要翻译：提供了一种主动管理2型糖尿病胰岛素抵抗增加的计算机实现方法。在计算机工作站上建立了计算机生成的2型糖尿病患者消化反应的血糖效应模型。膳食中餐后血糖升高，计划由通过消化反应模型显示的患者进行摄入。调整用于患者经历的初始胰岛素抵抗程度的消化反应模型的系数。在胰岛素抵抗的生理上升后，通过消化反应模型估计出计划由患者摄取的随后的膳食中餐后血糖的升高。调整用于患者经历的随后的胰岛素抵抗程度的消化反应模型的系数。

40. 发明申请

US20100168847A1 Device and Method for Modifying the Shape of a Body Organ 有权
标题翻译：修饰身体器官形状的装置和方法
公开(公告)号：US20100168847A1
公开(公告)日：2010-07-01
申请号：US12719758
申请日：2010-03-08
申请人： Clifton A. Alferness , John M. Adams , Mark L. Mathis , David G. Reuter , Cruz Beeson , Leonard Kowalsky
发明人： Clifton A. Alferness , John M. Adams , Mark L. Mathis , David G. Reuter , Cruz Beeson , Leonard Kowalsky
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61F2250/001 , A61F2250/0059
摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.
摘要翻译：血管内支持装置包括支撑件或再生线，近端锚和远端锚。支撑线接合血管壁以改变邻近其中放置血管内支架的血管的组织的形状。锚和支撑线被设计成使得放置支撑件的容器保持打开，并且如果需要可以被其他装置访问。该装置为在血管内流动的血液提供最小的金属表面积，以限制血栓形成。锚固件可以锁定到位以将支撑件固定在容器内。

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