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31. 发明申请

US20100119733A1 METHOD OF IMMOBILIZING ACTIVE MATERIAL ON SURFACE OF SUBSTRATE 审中-公开
标题翻译：基体表面活性材料的固定方法
公开(公告)号：US20100119733A1
公开(公告)日：2010-05-13
申请号：US12419527
申请日：2009-04-07
申请人： An-Soon KIM , Chil-Seong AH , Hye-Kyoung YANG , Chan-Woo PARK , Jong-Heon YANG , Chang-Geun AHN , In-Bok BAEK , Tae-Youb KIM , Gun-Yong SUNG , Seon-Hee PARK
发明人： An-Soon KIM , Chil-Seong AH , Hye-Kyoung YANG , Chan-Woo PARK , Jong-Heon YANG , Chang-Geun AHN , In-Bok BAEK , Tae-Youb KIM , Gun-Yong SUNG , Seon-Hee PARK
IPC分类号： C23C16/513 , B05D3/06
CPC分类号： G01N33/54353 , C12Q1/6834 , G01N33/551
摘要： Provided is a method of immobilizing an active material on a surface of a substrate. The method including cleaning a substrate, functionalizing a surface of the substrate using a hydroxyl group, functionalizing the surface of the substrate at atmospheric pressure using a vaporized organic silane compound, and immobilizing an active material to an end of the surface of the substrate. Therefore, since evacuation or the use of carrier gas is not necessary, a uniform, high-density, single-molecular, silane compound film can be formed inexpensively, simply, and reproducibly, and an active material can be immobilized to the single-molecular silane compound film.
摘要翻译：提供了将活性物质固定在基材表面上的方法。该方法包括清洗基材，使用羟基官能化基材的表面，使用蒸发的有机硅烷化合物在大气压下使基材的表面官能化，并将活性材料固定在基材的表面的末端。因此，由于不需要排气或使用载气，所以可以廉价地，简单地且可再现地形成均匀，高密度的单分子硅烷化合物膜，并且活性材料可以固定在单分子硅烷化合物膜。

32. 发明申请

US20100013030A1 BIOSENSOR, MANUFACTURING METHOD THEREOF, AND BIOSENSING APPARATUS INCLUDING THE SAME 审中-公开
标题翻译：生物传感器，其制造方法和包括其的生物传感装置
公开(公告)号：US20100013030A1
公开(公告)日：2010-01-21
申请号：US12443376
申请日：2007-08-30
申请人： Han-Young Yu , An-Soon Kim , Chil-Seong Ah , Jong-Heon Yang , In-Bok Baek , Chang-Geun Ahn , Seong-Jae Lee , Jin-Ho Yun
发明人： Han-Young Yu , An-Soon Kim , Chil-Seong Ah , Jong-Heon Yang , In-Bok Baek , Chang-Geun Ahn , Seong-Jae Lee , Jin-Ho Yun
IPC分类号： H01L29/66 , H01L21/30
CPC分类号： G01N33/54366 , B01L3/502707 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0887
摘要： Provided is a biosensor with a three-dimensional multi-layered structure, a method for manufacturing the biosensor, and a biosensing apparatus including the biosensor. The biosensing apparatus includes: a chamber having an inlet through which a fluid containing a biomaterial enters and an outlet through which the fluid exits; and a plurality of biosensors inserted and fixed in the chamber. Each biosensor includes: a support unit having a fluid channel through which a fluid containing a biomaterial flows; and a sensing unit disposed on the support unit in such a way that the sensing unit is exposed three-dimensionally in the fluid channel of the support unit, the sensing unit being surface-treated with a reactive material that is to react with the biomaterial flowing through the fluid channel.
摘要翻译：本发明提供具有三维多层结构的生物传感器，生物传感器的制造方法以及包括生物传感器的生物传感装置。所述生物传感装置包括：具有入口的腔室，含有生物材料的流体通过所述入口进入，所述流体通过所述出口流出; 以及插入并固定在所述室中的多个生物传感器。每个生物传感器包括：具有流体通道的支撑单元，含有生物材料的流体通过该流体通道流动; 以及感测单元，其以这样的方式设置在所述支撑单元上，使得所述感测单元在所述支撑单元的流体通道中三维地暴露，所述感测单元用反应性材料进行表面处理，所述反应性材料与所述生物材料流动通过流体通道。

33. 发明授权

US07537883B2 Method of manufacturing nano size-gap electrode device 有权
标题翻译：制造纳米尺寸间隙电极器件的方法
公开(公告)号：US07537883B2
公开(公告)日：2009-05-26
申请号：US11447820
申请日：2006-06-06
申请人： Han Young Yu , In Bok Baek , Chang Geun Ahn , Ki Ju Im , Jong Heon Yang , Ung Hwan Pi , Min Ki Ryu , Chan Woo Park , Sung Yool Choi , Seong Jae Lee
发明人： Han Young Yu , In Bok Baek , Chang Geun Ahn , Ki Ju Im , Jong Heon Yang , Ung Hwan Pi , Min Ki Ryu , Chan Woo Park , Sung Yool Choi , Seong Jae Lee
IPC分类号： G03F7/00 , H01L51/40 , C25D5/18
CPC分类号： H01L51/105 , B82Y10/00 , H01L51/0023 , H01L51/0595
摘要： Provided is a method of manufacturing a nano size-gap electrode device. The method includes the steps of: disposing a floated nano structure on a semiconductor layer; forming a mask layer having at least one opening pattern to intersect the nano structure; and depositing a metal on the semiconductor layer exposed through the opening pattern to form an electrode, such that a nano size-gap is provided under the nano structure by the nano structure.
摘要翻译：提供一种制造纳米尺寸间隙电极器件的方法。该方法包括以下步骤：在半导体层上设置漂浮的纳米结构; 形成具有至少一个开口图案以与纳米结构相交的掩模层; 以及在通过所述开口图案暴露的所述半导体层上沉积金属以形成电极，使得通过所述纳米结构在所述纳米结构下方提供纳米尺寸间隙。

34. 发明申请

US20130030288A1 IMAGE DIAGNOSIS APPARATUS INCLUDING X-RAY IMAGE TOMOSYNTHESIS DEVICE AND PHOTOACOUSTIC IMAGE DEVICE AND IMAGE DIAGNOSIS METHOD USING THE SAME 审中-公开
标题翻译：图像诊断装置，包括X射线图像形成装置和照相图像装置以及使用其的图像诊断方法
公开(公告)号：US20130030288A1
公开(公告)日：2013-01-31
申请号：US13557126
申请日：2012-07-24
申请人： Jeong Won LEE , Chang-Geun AHN , Sooyeul LEE , Donghoon YU , Seunghwan KIM
发明人： Jeong Won LEE , Chang-Geun AHN , Sooyeul LEE , Donghoon YU , Seunghwan KIM
IPC分类号： A61B6/02
CPC分类号： A61B6/025 , A61B5/0095 , A61B5/4312 , A61B6/0414 , A61B6/502 , A61B6/5247
摘要： Provided are an image diagnosis apparatus and an image diagnosis method using the same. The image diagnosis apparatus includes an X-ray image tomosynthesis device fixing an object using an object fixing unit, the X-ray image tomosynthesis device generating an image tomosynthesis signal by irradiating a plurality of X-rays into the object, a photoacoustic image device fixing the object using the object fixing unit, the photoacoustic image device generating an ultrasonic signal by scanning the object using a photoacoustic light source, an image processing device for processing image signals transmitted from the X-ray image tomosynthesis device and the photoacoustic image device to generate a three-dimensional (3D) image, and a display device for displaying the 3D image generated from the image processing device. The image diagnosis apparatus may realize internal tissues of the object into a clear 3D image.
摘要翻译：提供了一种图像诊断装置和使用其的图像诊断方法。图像诊断装置包括使用物体固定单元固定物体的X射线图像断层合成装置，通过将多个X射线照射到物体中而生成图像断层合成信号的X射线图像层析合成装置，固定使用对象固定单元的对象，通过使用光声光源扫描对象来生成超声波信号的光声图像装置，用于处理从X射线图像断层合成装置和光声图像装置发送的图像信号的图像处理装置，生成三维（3D）图像和用于显示从图像处理装置生成的3D图像的显示装置。图像诊断装置可以将物体的内部组织实现为清晰的3D图像。

35. 发明申请

US20120258882A1 METHOD FOR QUANTITATIVELY DETECTING BIOMOLECULES 审中-公开
标题翻译：用于定量检测生物分子的方法
公开(公告)号：US20120258882A1
公开(公告)日：2012-10-11
申请号：US13443833
申请日：2012-04-10
申请人： Chil Seong Ah , Chang Geun Ahn , Tae Youb Kim , Gun Yong Sung
发明人： Chil Seong Ah , Chang Geun Ahn , Tae Youb Kim , Gun Yong Sung
IPC分类号： C40B30/04 , B82Y15/00
CPC分类号： B82Y15/00 , G01N33/54306 , G01N33/54346 , G01N33/544 , G01N33/585
摘要： Provided is a method for quantitatively detecting biomolecules with high sensitivity for a short time by using nanoparticles and a metal deposition method in an immuno-detection using a well-type plastic substrate.
摘要翻译：本发明提供一种通过使用纳米颗粒和金属沉积方法在使用良好型塑料基材进行免疫检测的方法来定期检测短时间内具有高灵敏度的生物分子的方法。

36. 发明授权

US08263964B2 Three-dimensional nanodevices including nanostructures 有权
标题翻译：包括纳米结构在内的三维纳米器件
公开(公告)号：US08263964B2
公开(公告)日：2012-09-11
申请号：US12672995
申请日：2008-05-19
申请人： Han Young Yu , Byung Hoon Kim , An Soon Kim , In Bok Baek , Chil Seong Ah , Jong Heon Yang , Chan Woo Park , Chang Geun Ahn
发明人： Han Young Yu , Byung Hoon Kim , An Soon Kim , In Bok Baek , Chil Seong Ah , Jong Heon Yang , Chan Woo Park , Chang Geun Ahn
IPC分类号： H01L29/06
CPC分类号： H01J49/4205 , B81B7/0025 , B81B2201/0214 , B81B2201/0271 , B82Y10/00 , B82Y40/00 , G01N2291/0257 , H01J49/0018 , H01L29/0673 , H01L29/7613 , H01L29/775 , H03H2009/02314
摘要： Provided are three-dimensional (3D) nanodevices including 3D nanostructures. The 3D nanodevice includes at least one nanostructure, each nanostructure including an oscillation portion floating over a substrate and support portions for supporting both lengthwise end portions of the oscillation portion, supports disposed on the substrate to support the support portions of each of the nanostructures, at least one controller disposed at an upper portion of the substrate, a lower portion of the substrate, or both the upper and lower portions of the substrate to control each of the nanostructures, and a sensing unit disposed on each of the oscillation portions to sense an externally supplied adsorption material. Thus, unlike in a typical planar device, generation of impurities between a nanodevice and a substrate can be reduced, and mechanical vibration can be caused. In particular, since 3D nanostructures have mechanical and electrical characteristics, 3D nanodevices including new 3D nanostructures can be provided using nano-electro-mechanical systems (NEMS). Also, a single electron device, a spin device, or a single electron transistor (SET)-field effect transistor (FET) hybrid device can be formed using a simple process unlike in planar devices.
摘要翻译：提供了三维（3D）纳米器件，包括3D纳米结构。 3D纳米装置包括至少一个纳米结构，每个纳米结构包括漂浮在基板上的振荡部分和支撑部分，用于支撑振荡部分的两个纵向端部，支撑件设置在基板上以支撑每个纳米结构的支撑部分，设置在基板的上部，基板的下部或基板的上部和下部的至少一个控制器，以控制每个纳米结构;以及感测单元，设置在每个振荡部分上以感测外部供应的吸附材料。因此，与典型的平面器件不同，可以减少纳米器件与衬底之间的杂质的产生，并且可能引起机械振动。特别地，由于3D纳米结构具有机械和电学特性，可以使用纳米机电系统（NEMS）提供包括新的3D纳米结构的3D纳米器件。此外，可以使用与平面器件不同的简单工艺来形成单电子器件，自旋器件或单电子晶体管（SET）场效应晶体管（FET）混合器件。

37. 发明授权

US08164123B2 Biosensor and method of driving the same 失效
标题翻译：生物传感器及其驱动方法
公开(公告)号：US08164123B2
公开(公告)日：2012-04-24
申请号：US12703939
申请日：2010-02-11
申请人： Chan Woo Park , Chang Geun Ahn , Chil Seong Ah , Tae Youb Kim , An Soon Kim , Jong Heon Yang , Gun Yong Sung
发明人： Chan Woo Park , Chang Geun Ahn , Chil Seong Ah , Tae Youb Kim , An Soon Kim , Jong Heon Yang , Gun Yong Sung
IPC分类号： H01L29/78 , H01L29/772
CPC分类号： G01N27/4145
摘要： Provided are a biosensor and a method of driving the same. The biosensor includes a transistor including a substrate including a source, a drain, and a channel formed between the source and the drain, a gate insulating layer formed on the channel, and a source electrode and a drain electrode respectively connected with the source and the drain, a fluid line for covering the transistor to have an inner space together with the transistor and in which a sample solution including target molecules flows, a reference electrode formed on an inner wall of the fluid line, and a probe molecule layer attached on the reference electrode and reacting with the target molecules. Accordingly, the reference electrode is formed on the inner wall of the fluid line, enabling miniaturization of the bio device. Also, the probe molecules are formed on the reference electrode to measure a change in threshold voltage according to a change in electric potential between the reference electrode and the gate insulating layer, such that the sensitivity and reaction rate can be remarkably improved.
摘要翻译：提供了一种生物传感器及其驱动方法。生物传感器包括晶体管，其包括基板，该基板包括源极，漏极和形成在源极和漏极之间的沟道，形成在沟道上的栅极绝缘层以及分别与源极和漏极连接的源极和漏极漏极，用于覆盖晶体管的流体线，其与晶体管一起具有内部空间，并且其中包含目标分子的样品溶液流动，形成在流体管线的内壁上的参考电极和附着在该流体管线上的探针分子层参考电极并与靶分子反应。因此，参考电极形成在流体管线的内壁上，使生物装置能够小型化。此外，探针分子形成在参考电极上，以根据参考电极和栅极绝缘层之间的电位的变化来测量阈值电压的变化，从而可以显着提高灵敏度和反应速率。

38. 发明授权

US08163240B2 Detection device and system 有权
标题翻译：检测装置和系统
公开(公告)号：US08163240B2
公开(公告)日：2012-04-24
申请号：US12682545
申请日：2008-06-13
申请人： Chang Geun Ahn , Chan Woo Park , Jong Heon Yang , In Bok Baek , Chil Seong Ah , Han Young Yu , An Soon Kim , Tae Youb Kim , Moon Gyu Jang , Seon Hee Park
发明人： Chang Geun Ahn , Chan Woo Park , Jong Heon Yang , In Bok Baek , Chil Seong Ah , Han Young Yu , An Soon Kim , Tae Youb Kim , Moon Gyu Jang , Seon Hee Park
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , G01N27/00
CPC分类号： G01N27/4145 , Y10T436/11
摘要： A detection device and system are provided. The detection device includes a detection capacitor and a Field Effect Transistor (FET). The detection capacitor has a reactive material layer reacting to a specific functional group in a fluid, and first and second electrodes disposed on the both surfaces of an insulating layer, and the FET has a source electrode connected with the second electrode, a gate electrode connected with the first electrode, and a drain electrode. Here, the insulating layer of the detection capacitor is thicker than a gate insulating layer of the FET.
摘要翻译：提供检测装置和系统。检测装置包括检测电容器和场效应晶体管（FET）。检测电容器具有与流体中的特定官能团反应的反应性物质层，以及设置在绝缘层两面的第一和第二电极，并且所述FET具有与所述第二电极连接的源电极，连接有栅电极与第一电极和漏电极。这里，检测电容器的绝缘层比FET的栅极绝缘层厚。

39. 发明授权

US08133722B2 Cell culture compartment unit and array including the same 失效
标题翻译：细胞培养室单元和包括其的阵列
公开(公告)号：US08133722B2
公开(公告)日：2012-03-13
申请号：US12635682
申请日：2009-12-10
申请人： Sanghee Kim , Chul Am Kim , Chang-Geun Ahn , Moon Youn Jung
发明人： Sanghee Kim , Chul Am Kim , Chang-Geun Ahn , Moon Youn Jung
IPC分类号： C12M1/12
CPC分类号： C12M25/02 , C12M23/34 , C12M35/04
摘要： Provided are a cell culture compartment unit and an array including the same. The cell culture compartment unit includes: a cell culture region and a bio material emission region including a cell culture fluid, which are separated with a porous membrane therebetween; a piezoelectric device on the porous membrane of the cell culture region; a thin layer for cell attachment being on the piezoelectric device and having at least one surface on which cells are attachable; and a first power supply applying a first electric field to the piezoelectric device.
摘要翻译：提供了细胞培养室单元和包括其的阵列。细胞培养室单元包括：细胞培养区域和包括细胞培养液的生物材料发射区域，其间以多孔膜分离; 在细胞培养区的多孔膜上的压电元件; 用于细胞附着的薄层在压电装置上并且具有可附接细胞的至少一个表面; 以及向压电器件施加第一电场的第一电源。

40. 发明申请

US20110193052A1 THREE-DIMENSIONAL NANODEVICES INCLUDING NANOSTRUCTURES 有权
标题翻译：包括纳米结构的三维纳米器件
公开(公告)号：US20110193052A1
公开(公告)日：2011-08-11
申请号：US12672995
申请日：2008-05-19
申请人： Han Young Yu , Byung Hoon Kim , An Soon Kim , In Bok Baek , Chil Seong Ah , Jong Heon Yang , Chan Woo Park , Chang Geun Ahn
发明人： Han Young Yu , Byung Hoon Kim , An Soon Kim , In Bok Baek , Chil Seong Ah , Jong Heon Yang , Chan Woo Park , Chang Geun Ahn
IPC分类号： H01L29/06 , B82Y99/00
CPC分类号： H01J49/4205 , B81B7/0025 , B81B2201/0214 , B81B2201/0271 , B82Y10/00 , B82Y40/00 , G01N2291/0257 , H01J49/0018 , H01L29/0673 , H01L29/7613 , H01L29/775 , H03H2009/02314
摘要： Provided are three-dimensional (3D) nanodevices including 3D nanostructures. The 3D nanodevice includes at least one nanostructure, each nanostructure including an oscillation portion floating over a substrate and support portions for supporting both lengthwise end portions of the oscillation portion, supports disposed on the substrate to support the support portions of each of the nanostructures, at least one controller disposed at an upper portion of the substrate, a lower portion of the substrate, or both the upper and lower portions of the substrate to control each of the nanostructures, and a sensing unit disposed on each of the oscillation portions to sense an externally supplied adsorption material. Thus, unlike in a typical planar device, generation of impurities between a nanodevice and a substrate can be reduced, and mechanical vibration can be caused. In particular, since 3D nanostructures have mechanical and electrical characteristics, 3D nanodevices including new 3D nanostructures can be provided using nano-electro-mechanical systems (NEMS). Also, a single electron device, a spin device, or a single electron transistor (SET)-field effect transistor (FET) hybrid device can be formed using a simple process unlike in planar devices.
摘要翻译：提供了三维（3D）纳米器件，包括3D纳米结构。 3D纳米装置包括至少一个纳米结构，每个纳米结构包括漂浮在基板上的振荡部分和支撑部分，用于支撑振荡部分的两个纵向端部，支撑件设置在基板上以支撑每个纳米结构的支撑部分，设置在基板的上部，基板的下部或基板的上部和下部的至少一个控制器，以控制每个纳米结构;以及感测单元，设置在每个振荡部分上以感测外部供应的吸附材料。因此，与典型的平面器件不同，可以减少纳米器件与衬底之间的杂质的产生，并且可能引起机械振动。特别地，由于3D纳米结构具有机械和电学特性，可以使用纳米机电系统（NEMS）提供包括新的3D纳米结构的3D纳米器件。此外，可以使用与平面器件不同的简单工艺来形成单电子器件，自旋器件或单电子晶体管（SET）场效应晶体管（FET）混合器件。

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