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21. 发明授权

US4503251A Raney nickel catalysis of aromatic amines 失效
标题翻译：阮内镍催化芳香胺
公开(公告)号：US4503251A
公开(公告)日：1985-03-05
申请号：US365211
申请日：1982-04-05
申请人： Thomas J. Gray , Norman G. Masse , Richard A. Hagstrom
发明人： Thomas J. Gray , Norman G. Masse , Richard A. Hagstrom
IPC分类号： C07B61/00 , B01J25/02 , B01J35/10 , C07C67/00 , C07C209/00 , C07C211/35 , C07C211/36 , C07C85/24
CPC分类号： B01J25/02
摘要： Hydrogenation processes utilizing improved Raney nickel alloy catalysts are disclosed. The catalyst comprises a monolithic mesh type structure of a nickel alloy having an integral Beta phase Raney Ni.sub.x M.sub.1-x coating on its outer surfaces, where M is a catalytic activator selected from the group consisting of molybdenum, ruthenium, tantalum and titanium and where x, the weight fraction of nickel in the combined alloy, is between about 0.80 and about 0.95. The catalyst is effective in processes for hydrogenating an amine-substituted aromatic compound of the type ##STR1## wherein K is either benzene or naphthalene, R.sub.1 is a hydrogen atom or an aliphatic chain containing from about 1 to about 12 carbon atoms or a phenyl radical, R.sub.2 is a hydrogen atom, an amine group or an aliphatic chain containing from about 1 to about 3 carbon atoms, R.sub.3 is hydrogen or an amine group, and R.sub.4 is an amine group. When this catalyst is used, substantially higher reactant flow rates and lower operating temperatures are possible as compared to conventional fluidized bed granular catalysts.
摘要翻译：公开了利用改进的阮内镍合金催化剂的氢化方法。催化剂包括在其外表面上具有整体β相拉尼NixM1-x涂层的镍合金的整体网状结构，其中M是选自钼，钌，钽和钛的催化活化剂，其中x，合金中镍的重量分数在约0.80至约0.95之间。该催化剂在氢化胺取代的“IMAGE”类型的芳族化合物的方法中是有效的，其中K是苯或萘，R 1是氢原子或含有约1至约12个碳原子的脂族链或苯基 R2为氢原子，胺基或含有约1〜约3个碳原子的脂族链，R3为氢或胺基，R4为胺基。当使用该催化剂时，与常规流化床颗粒催化剂相比，可以实现更高的反应物流速和较低的操作温度。

22. 发明授权

US4443631A Selective halogenation of 2-fluoroaniline 失效
标题翻译： 2-氟苯胺的选择性卤化
公开(公告)号：US4443631A
公开(公告)日：1984-04-17
申请号：US340569
申请日：1982-01-18
申请人： Amphlett G. Padilla
发明人： Amphlett G. Padilla
IPC分类号： C07C85/24
摘要： Novel processes for making arylpropionic acids are described. One process comprises carboxylating particular Grignard compounds which are the products of a catalyzed reaction between corresponding arylmagnesium bromides and ethylene. Furthermore, the reaction making the particular Grignard compounds is itself novel. Also, an improved method is disclosed for making coupled aryl compounds useful as intermediates for making compounds having a pharmaceutical use. For example, particular biaryls may be used to make some of the Grignard compounds herein from which the arylpropionic acids are made. Finally, an improved bromination is disclosed giving high yields of 4-bromo-2-fluoroaniline, which is thereafter coupled with benzene, then used to make the arylmagnesium bromide reacted with ethylene to obtain the particular Grignard compound and subsequent desired arylpropionic acid, i.e. 2-(2-fluoro-4-biphenylyl)propionic acid.
摘要翻译：描述了制备芳基丙酸的新方法。一种方法包括羧化特定的格氏化合物，其是相应的芳基溴化镁和乙烯之间的催化反应的产物。此外，使特定格利雅化合物的反应本身是新颖的。此外，公开了一种改进的制备偶联芳基化合物的方法，其用作制备具有药物用途的化合物的中间体。例如，特定的联芳基可以用于制备一些本文的格利雅化合物，其中制备芳基丙酸。最后，公开了改进的溴化，得到高产量的4-溴-2-氟苯胺，然后与苯偶联，然后用于使芳基溴化镁与乙烯反应，得到特定的格利雅化合物和随后所需的芳基丙酸，即2 - （2-氟-4-联苯基）丙酸。

23. 发明授权

US4435599A Para-nitrodiphenylamine synthesis 失效
标题翻译：对硝基二苯胺合成
公开(公告)号：US4435599A
公开(公告)日：1984-03-06
申请号：US444633
申请日：1982-11-26
申请人： Budd H. Sturm
发明人： Budd H. Sturm
IPC分类号： C07B61/00 , B01J23/72 , B01J23/80 , B01J27/00 , B01J31/00 , B01J31/02 , B01J31/04 , B01J31/12 , C07C67/00 , C07C209/00 , C07C209/10 , C07C211/56 , C07C213/00 , C07C213/02 , C07C217/92 , C07C85/18 , C07C85/24
CPC分类号： C07C209/10
摘要： There is disclosed a process for the synthesis of para-nitrodiphenylamines wherein the improvement is characterized in that a specific co-catalyst system is utilized. More specifically, a zinc (II) compound (zinc in the plus two oxidation or valence state), is used in conjunction with copper or a copper compound as a co-catalyst system in the preparation of para-nitrodiphenylamines.
摘要翻译：公开了用于合成对硝基二苯胺的方法，其中改进的特征在于使用特定的助催化剂体系。更具体地说，在制备对硝基二苯胺时，将锌（II）化合物（加二氧化或价态的锌）与铜或铜化合物一起用作助催化剂体系。

24. 发明授权

US4429155A Preparation of aromatic amines 失效
标题翻译：芳香胺的制备
公开(公告)号：US4429155A
公开(公告)日：1984-01-31
申请号：US326419
申请日：1981-12-01
申请人： Norbert Goetz , Peter Jacobs , Leopold Hupfer , Herbert Toussaint , Wolfgang Reiss
发明人： Norbert Goetz , Peter Jacobs , Leopold Hupfer , Herbert Toussaint , Wolfgang Reiss
IPC分类号： C07B61/00 , B01J21/00 , B01J23/00 , B01J23/44 , B01J23/56 , B01J23/58 , B01J23/63 , B01J23/89 , B01J27/00 , B01J29/00 , C07C67/00 , C07C209/00 , C07C209/16 , C07C209/18 , C07C209/26 , C07C209/68 , C07C209/72 , C07C211/16 , C07C211/46 , C07C211/47 , C07C213/02 , C07C85/00 , C07C85/06 , C07C85/24
CPC分类号： C07C209/18 , C07C209/72 , B01J21/005 , B01J23/005 , B01J23/44 , B01J23/58 , B01J23/63 , B01J23/89
摘要： Aromatic amines (anilines) are obtained directly or via the corresponding cycloaliphatic amines by an aminating/hydrogenating reaction of phenols with ammonia and hydrogen over a supported palladium catalyst which also contains elements from group 1b, 2b or 7b of the periodic table as well as iron, cobalt or nickel, as such or in the form of their compounds, and, preferably, an inorganic base, said catalysts also having dehydrogenating properties.
摘要翻译：芳族胺（苯胺）直接或通过相应的脂环族胺通过苯酚与氨和氢的氨化/氢化反应在负载的钯催化剂上得到，其还含有元素周期表第1b，2b或7b族元素以及铁，钴或镍，或其化合物的形式，优选无机碱，所述催化剂也具有脱氢性能。

25. 发明授权

US4414415A Process for the manufacture of 2,6-dichloro-4-nitroaniline, and the compound obtained by this process 失效
标题翻译：制备2,6-二氯-4-硝基苯胺的方法，以及通过该方法获得的化合物
公开(公告)号：US4414415A
公开(公告)日：1983-11-08
申请号：US263131
申请日：1981-05-13
申请人： Michel Aubouy , Pierre Hamel , Marc Molin
发明人： Michel Aubouy , Pierre Hamel , Marc Molin
IPC分类号： C07C209/74 , C07C20060101 , C07C67/00 , C07C209/00 , C07C211/46 , C07C211/52 , C07C85/24
CPC分类号： C07C209/74
摘要： (1) Process for the manufacture of 2,6-dichloro-4-nitroaniline.(2) This process consists in chlorinating paranitroaniline, with chlorine gas, in an aqueous solution of hydrochloric acid having a concentration of between 4 and 7.5 N, at the boil, at a temperature between 95.degree. and 110.degree. C.(3) This process makes it possible to obtain 2,6-dichloro-4-nitroaniline with an improved yield and an improved quality of product.
摘要翻译：（1）制备2,6-二氯-4-硝基苯胺的方法。（2）该方法在于在沸点为95〜110℃的温度下，在浓度为4〜7.5N的盐酸水溶液中用氯气氯化对硝基苯胺。（3）方法可以获得2,6-二氯-4-硝基苯胺，其产率提高，产品质量提高。

26. 发明授权

US4351958A Process for producing orthoalkylated aromatic amine 失效
标题翻译：生产原烷基芳香胺的方法
公开(公告)号：US4351958A
公开(公告)日：1982-09-28
申请号：US297166
申请日：1981-08-28
申请人： Kazunori Takahata , Katsuo Taniguchi
发明人： Kazunori Takahata , Katsuo Taniguchi
IPC分类号： C07C209/68 , C07C85/24
CPC分类号： C07C209/68
摘要： An orthoalkylated aromatic amine is produced at a high selectivity from the reaction of an aromatic amine having at least one hydrogen atom at the ortho-positions and a primary or secondary alcohol under heating in the presence of a catalyst containing, as a main constituent, iron oxides.
摘要翻译：在邻位上具有至少一个氢原子的芳族胺与原醇或仲醇在加热下，在含有作为主要成分的铁的催化剂存在下，以高选择性制备原烷基化芳族胺氧化物。

27. 发明授权

US4331817A Process for the preparation of 4-arylthioanilines 失效
标题翻译： 4-芳基硫代苯胺的制备方法
公开(公告)号：US4331817A
公开(公告)日：1982-05-25
申请号：US225739
申请日：1981-01-16
申请人： James R. Throckmorton
发明人： James R. Throckmorton
IPC分类号： C07C85/00 , C07C85/24
CPC分类号： C07C319/14
摘要： A process for the preparation of a 4-arylthioaniline from the corresponding 4-unsubstituted aniline which comprises reacting the latter with an alkali metal thiocyanate in the presence of halogen to provide the 4-thiocyanoaniline, reacting it with an alkali metal sulfide to convert the thiocyano moiety to an alkali metal mercaptide group followed by heating with cuprous oxide then with an aryl halide to form the desired product.
摘要翻译：从相应的4-未取代的苯胺制备4-芳基硫代苯胺的方法，包括在卤素存在下使后者与碱金属硫氰酸盐反应，得到4-氰基氰胺，与碱金属硫化物反应，将硫氰酸部分与碱金属硫醇盐基团接触，随后用氧化亚铜加热，然后用芳基卤化物加热形成所需产物。

28. 发明授权

US4304934A Synthesis of amino hydroxy cyclopentenones 失效
标题翻译：氨基羟基环戊烯酮的合成
公开(公告)号：US4304934A
公开(公告)日：1981-12-08
申请号：US221523
申请日：1980-12-30
申请人： James R. Bartels-Keith , Eva R. Karger , Jean B. Rogers
发明人： James R. Bartels-Keith , Eva R. Karger , Jean B. Rogers
IPC分类号： C07C45/51 , C07C55/02 , C07F7/18 , G03C5/30 , C07C85/00 , C07C85/11 , C07C85/24
CPC分类号： G03C5/30 , C07C45/511 , C07C55/02 , C07F7/1856
摘要： This invention relates to a method of synthesizing 3-amino-2-hydroxy-2-cyclopentenones possessing an aliphatic substituent in the 4-position which comprises reacting cyanoacetamide with an aliphatic aldehyde to yield the corresponding .beta.-substituted-.alpha.,.alpha.'-dicyanoglutaramide, hydrolyzing the amide to the corresponding .beta.-substituted glutaric acid, esterifying the acid to the corresponding dialkyl diester, converting the diester to a 1,2-bis(trimethylsiloxy)-4-substituted cyclopentene by reductive cyclization using chlorotrimethylsilane in the presence of sodium, hydrolyzing and oxidizing the bis(trimethylsiloxy) compound to the 2-hydroxy-4-substituted-2-cyclopentenone in the presence of a cupric salt, nitrosating the 2-cyclopentenone to the 2-hydroxy-4-substituted-5-oximino-2-cyclopentenone, converting the oxime to the 2-acetoxy-3-amino-4-substituted-2-cyclopentenone by reductive acetylation and removing the acetyl group by alkanolysis to yield the 3-amino-2-hydroxy-4-substituted-2-cyclopentenone product.
摘要翻译：本发明涉及在4-位上合成具有脂肪族取代基的3-氨基-2-羟基-2-环戊烯酮的方法，该方法包括使氰基乙酰胺与脂族醛反应，得到相应的β-取代-α，α'-二氰基戊酰胺，将酰胺水解成相应的β-取代戊二酸，将酸酯化成相应的二烷基二酯，通过在钠存在下使用氯代三甲基硅烷进行还原环化将二酯转化成1,2-双（三甲基甲硅烷氧基）-4-取代的环戊烯，在铜盐存在下将双（三甲基甲硅烷氧基）化合物水解和氧化成2-羟基-4-取代-2-环戊烯酮，将2-环戊烯酮亚硝化为2-羟基-4-取代-2-环戊烯-2-酮， 2-环戊烯酮，通过还原乙酰化将肟转化为2-乙酰氧基-3-氨基-4-取代-2-环戊烯酮，通过链烷分解除去乙酰基，得到3-氨基-2-羟基-4- 取代-2-环戊烯酮产物。

29. 发明授权

US4247482A Process for producing bis(N,N-dialkylamino)alkyl ethers employing sulfur trioxide vapor 失效
标题翻译：使用三氧化硫蒸气生产双（N，N-二烷基氨基）烷基醚的方法
公开(公告)号：US4247482A
公开(公告)日：1981-01-27
申请号：US103210
申请日：1979-12-13
申请人： Fedor Poppelsdorf
发明人： Fedor Poppelsdorf
IPC分类号： C08G18/18 , C08G18/20 , C07C85/24 , C07C89/00
CPC分类号： C08G18/1833 , C08G18/2081
摘要： A process is provided for producing bis-(N,N-dialkylamino)alkyl ethers of the formula (R.sub.2 NR').sub.2 O, wherein R is a methyl or ethyl group and R' is a bivalent alkylene group having from 2 to 3 carbon atoms. The novel process is effected by a two-step, preferably "one pot," reaction that utilizes SO.sub.3 vapor and R.sub.2 NR'ONa as reactants, wherein R and R' are defined above. The resulting bis-ethers are useful as catalysts in the production of polyurethanes, especially cellular polyurethanes.
摘要翻译：提供了制备式（R2NR'）2O的二 - （N，N-二烷基氨基）烷基醚的方法，其中R是甲基或乙基，R'是具有2至3个碳原子的二价亚烷基。该新方法通过利用SO 3蒸气和R2NR'ONa作为反应物的两步优选“一锅”反应实现，其中R和R'如上定义。所得双醚可用作生产聚氨酯，特别是细胞聚氨酯的催化剂。

30. 发明授权

US4231963A Process for producing aminophenol ether 失效
标题翻译：生产氨基苯酚醚的方法
公开(公告)号：US4231963A
公开(公告)日：1980-11-04
申请号：US81460
申请日：1979-10-03
申请人： Akira Shinohara , Nobuhide Wada , Yukio Tokunaga , Chihiro Yazawa
发明人： Akira Shinohara , Nobuhide Wada , Yukio Tokunaga , Chihiro Yazawa
IPC分类号： C07B61/00 , B01J23/00 , B01J23/04 , B01J27/00 , B01J27/24 , B01J31/00 , B01J31/18 , C07C20060101 , C07C67/00 , C07C213/00 , C07C213/06 , C07C217/82 , C07C217/84 , C07C85/24
CPC分类号： C07C213/06
摘要： An aminophenol ether having the formula ##STR1## is produced by reacting an alkali aminophenolate having the formula ##STR2## wherein M represents an alkali metal atom; with an organic halide having the formulaR-Xwherein R represents a lower alkyl group, a lower alkenyl group or benzyl group; and X represents a halogen atom in substantially anhydrous condition in the presence of an alkali metal hydroxide and a quaternary salt selected from the group consisting of quaternary ammonium salts and quaternary phosphonium salts.
摘要翻译：具有式“IMAGE”的氨基苯酚醚通过使具有式“IMAGE”的碱式氨基苯甲酸酯反应，其中M表示碱金属原子; 具有式R-X的有机卤化物，其中R表示低级烷基，低级烯基或苄基; 在碱金属氢氧化物和选自季铵盐和季鏻盐的季盐的存在下，X代表基本上无水条件下的卤素原子。

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