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21. 发明申请

US20030215499A1 Use of completely linear short chain alpha-glucans as a pharmaceutical excipient 审中-公开
标题翻译：使用完全线性的短链α-葡聚糖作为药物赋形剂
公开(公告)号：US20030215499A1
公开(公告)日：2003-11-20
申请号：US10298813
申请日：2002-11-18
发明人： Yong-Cheng Shi , Xiaoyuan Cui , Sibu Chakrabarti
IPC分类号： A61K031/716 , A61K009/48 , A61K009/20 , D04H001/00 , B27N003/00
CPC分类号： A61K9/2059
摘要： This patent pertains to a tablet comprising as a binder a low amylose starch, which has been fully debranched using isoamylase and the method of making such tablet. Such binders are useful in any tabletting method, including direct compression, and can be used as a replacement for microcrystalline cellulose.
摘要翻译：该专利涉及包含作为粘合剂的低直链淀粉的片剂，其使用异淀粉酶完全脱支，并制备这种片剂。这种粘合剂可用于任何压片方法，包括直接压片，并可用作微晶纤维素的替代物。

22. 发明申请

US20030215470A1 Compositions and methods for preparing dispersions of thickened oils 审中-公开
标题翻译：制备增稠油分散体的组合物和方法
公开(公告)号：US20030215470A1
公开(公告)日：2003-11-20
申请号：US10332392
申请日：2003-04-29
发明人： James M. Wilmott , Michael Ross , Duncan T. Aust , Timothy K. Crawford
IPC分类号： A61K031/716 , A61K009/00
CPC分类号： A61K8/895 , A61K8/062 , A61K8/8111 , A61K8/8117 , A61K2800/33 , A61Q17/04
摘要： Disclosed are methods for preparing surfactant free dispersions of hydrophobic fluids and hydrophobic rheological modifying agents which are used to modify the aesthetic properties of cosmetic and pharmaceutical topical compositions. The dispersions are prepared using high pressure/high shear methods. In particular, the dispersions comprise polyisobutene gel or silicone gel.
摘要翻译：公开了用于制备用于改变化妆品和药物局部组合物的美学性质的疏水性流体和疏水性流变改性剂的表面活性剂自由分散体的方法。使用高压/高剪切方法制备分散体。特别地，分散体包括聚异丁烯凝胶或硅凝胶。

23. 发明申请

US20030171333A1 Pharmaceutical composition containing at least a polymer combined with or conjugated to at least a phenylalkylcarboxylic acid salt, conjugate polymers and uses thereof 审中-公开
标题翻译：含有至少一种与至少一种苯基烷基羧酸盐结合或与至少一种苯基烷基羧酸盐共轭的聚合物的药物组合物及其用途
公开(公告)号：US20030171333A1
公开(公告)日：2003-09-11
申请号：US10297035
申请日：2003-05-02
发明人： Thierry Avramoglou , Rosita Bagheri , Frederic Chaubet , Michel Crepin , Latifa Dahri , Melanie Dibenedetto , Claudia Gervelas , Remi Huynh , Jacqueline Jozefonvicz
IPC分类号： A61K031/722 , A61K031/721 , A61K031/718 , A61K031/717 , A61K031/716
CPC分类号： C08B37/0021 , A61K9/0019 , A61K31/19 , A61K31/192 , A61K47/36 , A61K47/61
摘要： The invention concerns a pharmaceutical composition containing at least a polymer associated or conjugated with at least a phenylalkylcarboxylic acid derivative, novel polymers conjugated with at least a phenylalkylcarboxylic acid derivative and their uses in particular in cancer treatment.
摘要翻译：本发明涉及至少包含与至少一种苯基烷基羧酸衍生物缔合或共轭的聚合物的药物组合物，与至少一种苯基烷基羧酸衍生物共轭的新型聚合物及其用途，特别是在癌症治疗中。

24. 发明申请

US20030096791A1 Taste masking of highly water-soluble drugs 审中-公开
标题翻译：高度水溶性药物的味道掩蔽
公开(公告)号：US20030096791A1
公开(公告)日：2003-05-22
申请号：US10158715
申请日：2002-05-30
申请人： Cima Labs Inc.
发明人： Vijay V. Gupte , Walid Habib , Kris E. Holt , Rajendra K. Khankari , John Hontz
IPC分类号： A61K031/716 , A61K047/00 , A61K009/14
CPC分类号： A61K31/716 , A61K9/0056 , A61K9/5078 , A61K31/495
摘要： A taste-masked formulation which provides for effective taste-masking of an active ingredient such as cetirizine hydrochloride, while simultaneously providing a desired dissolution profile.
摘要翻译：一种掩味的制剂，其提供活性成分如盐酸西替利嗪的有效掩味，同时提供所需的溶出曲线。

25. 发明申请

US20020143174A1 Very high molecular weight beta-glucans 有权
公开(公告)号：US20020143174A1
公开(公告)日：2002-10-03
申请号：US10094686
申请日：2002-03-07
申请人： Biopolymer Engineering, Inc.
发明人： Myra L. Patchen , Spiros Jamas , D. Davidson Easson JR. , Gary R. Ostroff
IPC分类号： A61K031/716 , C07H001/00
CPC分类号： A61K31/716 , C08B37/0024 , C08L5/00 , Y10S514/885 , Y10S514/944 , Y10S514/951 , Y10S514/959 , Y10S514/962
摘要： The invention pertains to compositions and therapeutic and prophylatic methods for treating/preventing infections in an animal or human by administering a soluble null-glucan composition comprising null-glucan molecules having an average molecular weight of at least 1,000,000 daltons, as determined by multi-angle laser light scattering (VHMW-glucan).

26. 发明申请

US20020041871A1 Genomeceutical and/or enzymatic composition and method for treating autism 失效
标题翻译：用于治疗自闭症的基因组学和/或酶组合物和方法
公开(公告)号：US20020041871A1
公开(公告)日：2002-04-11
申请号：US09872615
申请日：2001-06-01
发明人： Mark A. Brudnak
IPC分类号： A61K038/46 , A61K031/70 , A61K031/716
CPC分类号： A61K45/06 , A61K31/00 , A61K38/465 , A61K38/48 , A61K38/4873 , A61K2300/00
摘要： A composition for use in treating autism spectrum disorders. The composition preferably includes a genomeceutical type compound that increases the user's expression of DPPIV or like substances. The genomeceutical compound may include a sugar (such as a milk sugar), glucans, galactose and/or related material. The composition may also include one or more of a protease, peptidase or phytase. The inclusion of phospholipids, disaccharides, lipases and/or related substances in a composition for treating autism spectrum disorders and the function they provide is also disclosed.
摘要翻译：用于治疗孤独症谱系障碍的组合物。组合物优选包括增加用户对DPPIV或类似物质的表达的基因组合型化合物。基因组合物可以包括糖（例如乳糖），葡聚糖，半乳糖和/或相关材料。组合物还可以包括一种或多种蛋白酶，肽酶或植酸酶。还公开了将磷脂，二糖，脂肪酶和/或相关物质包含在用于治疗自闭症谱系障碍的组合物中以及它们提供的功能。

27. 发明申请

US20040266727A1 Nutritional supplement having a unique soluble and insoluble fiber blend and method of making the same 审中-公开
标题翻译：营养补充剂具有独特的可溶性和不溶性纤维混合物及其制备方法
公开(公告)号：US20040266727A1
公开(公告)日：2004-12-30
申请号：US10877300
申请日：2004-06-25
发明人： Steve F. Brandon
IPC分类号： A61K031/716 , A61K031/715
CPC分类号： A61K31/715 , A23L33/21 , A23V2002/00 , A61K31/716 , A23V2250/5108 , A23V2250/5062 , A23V2250/5086
摘要： A nutritional supplement that includes a natural soluble fiber and a natural insoluble fiber is disclosed. The nutritional supplement includes an amount of a natural soluble fiber from 30% to 70% by weight, and an amount of a natural insoluble fiber from 30% to 70% by weight. The natural soluble fiber that is used is inulin, and the insoluble fiber that is used is cellulose. Xanthan gum is added in a negligible amount and serves as a stabilizer and to improve shelf life by helping to resist enzymatic degradation. A method of preparing a nutritional supplement is also disclosed. The insoluble fiber and the soluble fiber are blended to form a substantially homogenous, quickly dispersing powder blend. The powder blend can then be formed into a capsule, tablet, or wafer, or alternatively can be used as a food or drink additive.
摘要翻译：公开了包含天然可溶性纤维和天然不溶性纤维的营养补充剂。营养补充剂包括一定量的30重量％至70重量％的天然可溶性纤维，以及30重量％至70重量％的天然不溶性纤维的量。使用的天然可溶性纤维是菊粉，所用的不溶性纤维是纤维素。以可忽略的量加入黄原胶，并且通过有助于抵抗酶降解而用作稳定剂并改善保质期。还公开了一种制备营养补充剂的方法。将不溶性纤维和可溶性纤维混合以形成基本均匀的快速分散粉末混合物。然后将粉末混合物形成胶囊，片剂或晶片，或者可以用作食品或饮料添加剂。

28. 发明申请

US20040208906A1 Pharmaceutical composition for topical administration 审中-公开
标题翻译：用于局部给药的药物组合物
公开(公告)号：US20040208906A1
公开(公告)日：2004-10-21
申请号：US10750947
申请日：2004-01-05
申请人： Daiichi Suntory Pharma Co., Ltd.
发明人： Mitsutoshi Tatara , Toshihito Shimizu , Ryoichi Fukumoto , Masaaki Nomura
IPC分类号： A61K031/56 , A61K031/716
CPC分类号： A61K47/38 , A61K9/0014 , A61K47/14 , A61K47/34
摘要： A pharmaceutical composition for topical administration, which resides at a topical site of application for a long period and can control the release rate of an active agent, is provided. The present invention is a pharmaceutical composition for topical administration comprising an active ingredient, a water insoluble polymer, and a solvent capable dissolving the water insoluble polymer and compatible with water, and optionally containing other additive.
摘要翻译：提供一种用于局部给药的药物组合物，其驻留在长时间的局部应用部位并且可以控制活性剂的释放速率。本发明是用于局部给药的药物组合物，其包含活性成分，水不溶性聚合物和能够溶解水不溶性聚合物并与水相容并且任选地含有其它添加剂的溶剂。

29. 发明申请

US20040101561A1 Combinations of viscoelastics for use during surgery 审中-公开
标题翻译：手术中使用的粘弹胶组合
公开(公告)号：US20040101561A1
公开(公告)日：2004-05-27
申请号：US10381861
申请日：2003-03-28
发明人： Masoud R. Jafari , Uday Doshi , Kerry L. Markwardt
IPC分类号： A61K031/737 , A61K031/728 , A61K031/716 , A61K009/14
CPC分类号： A61K31/737 , A61K9/0048 , A61K31/716 , A61K31/728 , A61L24/001 , A61L24/043 , A61L2430/16 , A61K2300/00 , C08L5/08
摘要： Systems for performing surgery, especially ophthalmic surgery, utilizing multiple viscoelastic agents with differing physicochemical properties are disclosed. The systems enable the skilled surgeon to perform certain steps of a surgical procedure with viscoelastic agents that are particularly well suited for such steps.
摘要翻译：公开了用于进行手术的系统，特别是眼科手术，利用具有不同物理化学性质的多种粘弹性体。这些系统使得熟练的外科医生能够使用特别适合于这些步骤的粘弹剂来执行外科手术的某些步骤。

30. 发明申请

US20040101548A1 Hemostatic wound dressing containing aldehyde-modified polysaccharide 审中-公开
标题翻译：含醛改性多糖的止血伤口敷料
公开(公告)号：US20040101548A1
公开(公告)日：2004-05-27
申请号：US10305040
申请日：2002-11-26
发明人： Sanyog Manohar Pendharkar
IPC分类号： A61K031/737 , A61K031/728 , A61K031/716 , A61K031/715 , A61K009/70
CPC分类号： A61L15/28 , A61L2400/04 , Y10T442/2525 , C08L1/04 , C08L5/00
摘要： The present invention is directed to hemostatic wound dressings that include a substrate for contacting and/or covering a wound, where the substrate includes a wound-contacting surface, and which substrate contains or is fabricated at least in part from a biocompatible, aldehyde-modified polysaccharide, preferably biodegradable polysaccharides and to methods of providing hemostasis to a wound, which method includes applying to a wound requiring hemostasis the hemostatic wound dressing of the present invention.
摘要翻译：本发明涉及止血伤口敷料，其包括用于接触和/或覆盖伤口的基底，其中所述基底包括伤口接触表面，并且所述基底至少部分地由生物相容的醛修饰的多糖，优选可生物降解的多糖，以及向伤口提供止血的方法，该方法包括应用于需要止血的本发明止血伤口敷料的伤口。

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