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21. 发明授权

US06207638B1 Nutritional intervention composition for enhancing and extending satiety 有权
标题翻译：营养干预组合物用于增强和延长饱腹感
公开(公告)号：US06207638B1
公开(公告)日：2001-03-27
申请号：US09510809
申请日：2000-02-23
申请人： Robert Portman
发明人： Robert Portman
IPC分类号： A01N3718
CPC分类号： A23L33/21 , A23L33/12 , A23L33/18 , A23L33/185 , A23L33/19 , A23L33/40
摘要： The invention relates to a nutritional intervention composition that enhances and extends satiety in a calorically efficient manner. In particular, the invention contains protein, long chain fatty acids, calcium, soluble and insoluble fibers to stimulate CCK and prevent its subsequent inactivation and inhibition. By stimulating CCK and extending satiety the method is useful for the treatment of overweight individuals, individuals with Type II diabetes and individuals with bulimia.
摘要翻译：本发明涉及营养干预组合物，其以热量有效的方式增强和延长饱腹感。特别地，本发明包含蛋白质，长链脂肪酸，钙，可溶性和不溶性纤维，以刺激CCK并防止其随后的失活和抑制。通过刺激CCK并延长饱腹感，该方法可用于治疗超重型个体，II型糖尿病个体和贪食症患者。

22. 发明授权

US06177402B1 Method for regulating neuron development and maintenance 失效
标题翻译：调节神经元发育和维持的方法
公开(公告)号：US06177402B1
公开(公告)日：2001-01-23
申请号：US08410402
申请日：1995-03-27
申请人： Perry Bartlett , Mark Murphy
发明人： Perry Bartlett , Mark Murphy
IPC分类号： A01N3718
CPC分类号： A61K38/185 , A61K38/2093 , A61K2300/00
摘要： The present invention provides methods for regulating neuron development, regeneration and maintenance by administration of leukemia inhibitory factor (LIF). Pharmaceutical compositions containing LIF and one or more additional neuron stimulating factors are also provided.
摘要翻译：本发明提供了通过施用白血病抑制因子（LIF）来调节神经元发育，再生和维持的方法。还提供了含有LIF和一种或多种另外的神经元刺激因子的药物组合物。

23. 发明授权

US06809075B1 Elastin peptide analogs and uses of same incombination with skin enhancing agents 失效
标题翻译：弹性蛋白肽类似物和与皮肤增强剂相结合的用途
公开(公告)号：US06809075B1
公开(公告)日：2004-10-26
申请号：US09580110
申请日：2000-05-30
申请人： Thomas F. Mitts , Lawrence B. Sandberg
发明人： Thomas F. Mitts , Lawrence B. Sandberg
IPC分类号： A01N3718
CPC分类号： C07K14/78 , A61K8/64 , A61K8/671 , A61K38/39 , A61Q19/00 , C07K5/06034 , C07K5/0806 , C07K5/1008 , C07K5/101 , C07K5/1016 , Y10S514/844
摘要： The present invention is directed to a composition which is used to enhance the elasticity and/or appearance of tissue. Specifically, the present invention is directed to a composition formulated from peptides having low molecular weights and which substantially correspond to sequences found in elastin. These peptides are used in conjunction with or in combination with retinoids, preferably tretinoin.
摘要翻译：本发明涉及用于增强组织的弹性和/或外观的组合物。具体而言，本发明涉及由具有低分子量且基本对应于在弹性蛋白中发现的序列的肽配制的组合物。这些肽与维甲酸，优选维A酸联合使用或与维甲酸合用使用。

24. 发明授权

US06780838B2 Compounds for treating fungal pathologies of the oral cavity 失效
标题翻译：用于治疗口腔真菌病理的化合物
公开(公告)号：US06780838B2
公开(公告)日：2004-08-24
申请号：US09774282
申请日：2001-01-29
申请人： James M. Lipton , Anna P Catania
发明人： James M. Lipton , Anna P Catania
IPC分类号： A01N3718
CPC分类号： A61K45/06 , A61K9/006 , A61K31/00 , A61K38/34 , A61K38/35 , A61K2300/00
摘要： The broadest aspect of the invention is a composition and method of treatment of fungal pathologies of the oral cavity or fungal growth on the surface of dentures. A preferred embodiment of the is a pharmacologically effective amount of a peptide selected from the group of peptides with a C-terminal sequence consisting of KPV(SEQ ID NO: 1), HFRWGKPV(SEQ ID NO: 3), and SYSMEHFRWGKPV (SEQ ID NO: 4) in combination with a therapeutically effective amount of a fungicide selected from the group consisting of: itraconazole, econazole, ketoconazole, miconazole, imconazole and fluconazole. Another embodiment of the invention is a method for treating fungal pathologies of the oral cavity and dentures by application of a pharmacologically effective amount of a peptide selected from the group of peptides with a C-terminal sequence consisting of KPV (SEQ ID NO: 1), HFRWGKPV (SEQ ID NO: 3), and SYSMEHFRWGKPV (SEQ ID NO: 4) in combination with a therapeutically effective amount of a fungicide selected from the group consisting of: itraconazole, econazole, ketoconazole, miconazole and fluconazole. In yet another embodiment of the invention these peptides are used in combination with a therapeutically effective amount of gram positive and/or gram negative antibiotics.
摘要翻译：本发明的最广泛的方面是在假牙表面上治疗口腔真菌病理或真菌生长的组合物和方法。优选的实施方案是药理学有效量的肽，其选自具有由KPV（SEQ ID NO：1），HFRWGKPV（SEQ ID NO：3）和SYSMEHFRWGKPV（SEQ ID NO：3）组成的C末端序列的肽组 NO：4）与治疗有效量的选自伊曲康唑，益康唑，酮康唑，咪康唑，咪康唑和氟康唑的杀真菌剂组合。本发明的另一个实施方案是通过应用药理学有效量的选自下列肽的肽来治疗口腔和假牙的真菌病理学的方法：具有由KPV（SEQ ID NO：1）组成的C末端序列，，HFRWGKPV（SEQ ID NO：3）和SYSMEHFRWGKPV（SEQ ID NO：4）与治疗有效量的选自伊曲康唑，益康唑，酮康唑，咪康唑和氟康唑的杀真菌剂的组合。在本发明的另一个实施方案中，这些肽与治疗有效量的革兰氏阳性和/或革兰氏阴性抗生素组合使用。

25. 发明授权

US06716881B2 Carbanilides used as pesticides 失效
标题翻译： Carbanilides用作农药
公开(公告)号：US06716881B2
公开(公告)日：2004-04-06
申请号：US10158602
申请日：2002-05-30
申请人： Hans-Ludwig Elbe , Bernd-Wieland Krüger , Robert Markert , Ralf Tiemann , Dietmar Kuhnt , Stefan Dutzmann , Klaus Stenzel , Christoph Erdelen , Martin Kugler , Hans-Ulrich Buschhaus
发明人： Hans-Ludwig Elbe , Bernd-Wieland Krüger , Robert Markert , Ralf Tiemann , Dietmar Kuhnt , Stefan Dutzmann , Klaus Stenzel , Christoph Erdelen , Martin Kugler , Hans-Ulrich Buschhaus
IPC分类号： A01N3718
CPC分类号： C07D213/82 , A01N37/22 , A01N37/40 , A01N43/08 , A01N43/10 , A01N43/32 , A01N43/40 , A01N43/56 , A01N43/78 , C07C233/75 , C07C235/64 , C07C323/42 , C07D233/90 , C07D277/56 , C07D307/30 , C07D307/68 , C07D327/06 , C07D333/38 , C07D403/12
摘要： The present invention provides carbanilides of formula (I), wherein A, Q, R, X, Z and m are as defined herein. A plurality of processes for preparing these compounds is provided, along with methods of using the compounds to control microorganisms in crops and in the protection of materials. The compounds of the present invention also find use in controlling animal pests.
摘要翻译：本发明提供了式（I）的酰胺化物，其中A，Q，R，X，Z和m如本文所定义。提供了多种制备这些化合物的方法，以及使用化合物控制作物中的微生物和保护材料的方法。本发明的化合物也可用于控制动物害虫。

26. 发明授权

US06683050B1 Compounds with anti-KS and anti-HIV activity 有权
公开(公告)号：US06683050B1
公开(公告)日：2004-01-27
申请号：US09494500
申请日：2000-01-31
申请人： Tony Antakly , Ram M. Sairam
发明人： Tony Antakly , Ram M. Sairam
IPC分类号： A01N3718
CPC分类号： A61K31/00 , A61K38/00 , C07K14/59 , Y10S530/834
摘要： The present invention relates to a compound having anti-KS and anti-HIV pharmaceutical activity which comprises an HCG-like inhibitory protein and fragments or derivatives thereof, said protein and fragments thereof are isolated from a biologically active fraction of APL-HCG, wherein said protein has a molecular weight of about 3,500 or of about 13,000 Dalton, and wherein said protein and fragments thereof are adsorbed polypropylene plastic supports. A pharmaceutical composition for the prevention and/or treatment of Kaposi's sarcoma (KS) and HIV which comprises an therapeutically effective amount of at least one compound of the present invention in association with a pharmaceutically acceptable carrier. A method for the prevention, treatment and/or reduction of Kaposi's sarcoma and HIV expression in AIDS patients, which consists in administering the composition to the patient.

27. 发明授权

US06646011B2 Insect repellant compositions 失效
标题翻译：驱虫剂组合物
公开(公告)号：US06646011B2
公开(公告)日：2003-11-11
申请号：US09089762
申请日：1998-06-03
申请人： Danilo L. Lambino , Kennie U. Dee , Susan M. Niemiec
发明人： Danilo L. Lambino , Kennie U. Dee , Susan M. Niemiec
IPC分类号： A01N3718
CPC分类号： A01N37/18 , A01N25/22 , A01N37/46 , F41A17/32 , Y10S424/10 , Y10S514/873 , Y10S514/885 , Y10S514/886 , Y10S514/887 , Y10S514/904 , Y10S514/918 , Y10S514/919 , Y10S514/97 , Y10S514/975 , Y10S977/775 , Y10S977/926 , A01N31/08 , A01N31/02 , A01N25/30 , A01N2300/00
摘要： The present invention relates to insect repellant compositions containing, based upon the total weight of the composition, from about 6 to about 30 percent by weight of insect repellant active material having functionality selected from ester, amide, urethane or combinations thereof; from about 5 to about 30 percent by weight of alcohol, and from about 1 to about 10 percent by weight of nonionic surfactant. The compositions of the invention exhibit reduced rates of degradation of the active material in solution and are less drying and irritating to sensitive skin.
摘要翻译：本发明涉及基于组合物总重量计含有约6至约30重量％的具有选自酯，酰胺，氨基甲酸酯或其组合的官能团的驱虫剂活性物质的驱虫剂组合物; 约5至约30重量％的醇和约1至约10重量％的非离子表面活性剂。本发明的组合物表现出降低溶液中活性物质的降解速率，并且对敏感皮肤的干燥和刺激性降低。

28. 发明授权

US06635615B1 Stable salts of S-adenosyl-l-methionine 有权
标题翻译： S-腺苷-1-甲硫氨酸的稳定盐
公开(公告)号：US06635615B1
公开(公告)日：2003-10-21
申请号：US09713896
申请日：2000-11-16
申请人： Rolland F. Hebert
发明人： Rolland F. Hebert
IPC分类号： A01N3718
CPC分类号： A61K31/7076 , A61K31/722 , A61K2300/00
摘要： Stable salts of S-adenosyl-1-methionine with polycations such as chitosan are described. The salts according to the invention are very stable and are valuable for use as active constituents in pharmaceutical compositions.
摘要翻译：描述了S-腺苷-1-甲硫氨酸与聚阳离子如壳聚糖的稳定盐。根据本发明的盐非常稳定，对于用作药物组合物中的活性成分是有价值的。

29. 发明授权

US06573240B1 Bacillus thuringiensis isolated active against lepidopteran pests, and genes encoding novel lepidopteran-active toxins 失效
标题翻译：针对鳞翅目害虫的新型苏云金芽孢杆菌分离株和编码新型鳞翅目昆虫活性毒素的基因
公开(公告)号：US06573240B1
公开(公告)日：2003-06-03
申请号：US09521344
申请日：2000-03-09
申请人： Jewel Payne , August J. Sick
发明人： Jewel Payne , August J. Sick
IPC分类号： A01N3718
CPC分类号： C12N15/8286 , A01N63/00 , C07K14/325 , C12R1/075 , Y02A40/162 , Y10S435/832 , Y10S530/825
摘要： Novel Bacillus thuringiensis genes encoding toxins which are active against lepidopteran insects have been cloned from novel lepidopteran-active B. thuringiensis microbes. The DNA encoding the B. thuringiensis toxins can be used to transform various prokaryotic and eukaryotic microbes to express the B. thuringiensis toxins. These recombinant microbes can be used to control lepidopteran insects in various environments.
摘要翻译：编码对鳞翅目昆虫有活性的毒素的新型苏云金芽孢杆菌基因已经从新型鳞翅目昆虫激活的苏云金芽孢杆菌微生物中克隆出来。编码苏云金芽孢杆菌毒素的DNA可用于转化各种原核和真核微生物，以表达苏云金芽孢杆菌毒素。这些重组微生物可用于控制各种环境中的鳞翅目昆虫。

30. 发明授权

US06548475B1 Use of the KAL protein and treatment with the KAL protein in treatment of retinal, renal, neuronal and neural injury 失效
标题翻译：使用KAL蛋白并用KAL蛋白处理视网膜，肾，神经元和神经损伤
公开(公告)号：US06548475B1
公开(公告)日：2003-04-15
申请号：US09576967
申请日：2000-05-24
申请人： Christine Petit , Nadia Soussi-Yanticostas , Jean-Pierre Hardelin , Catherine Sarailh , Genevieve Rougon , Renaud Legouis , Olivier Ardouin , Jean-Claude Mazie
发明人： Christine Petit , Nadia Soussi-Yanticostas , Jean-Pierre Hardelin , Catherine Sarailh , Genevieve Rougon , Renaud Legouis , Olivier Ardouin , Jean-Claude Mazie
IPC分类号： A01N3718
CPC分类号： C07K14/475 , A61K38/1709 , C07K14/78 , C07K16/22
摘要： KAL protein is identified as the active agent in a therapeutic composition for treatment of injury to nerve tissue, including spinal cord tissue, as well as support of treatment for renal grafts. Additionally, therapeutic treatment of renal injury, and kidney transplantation and renal surgery, is effected by administration of KAL protein. The therapeutic agent may be administered locally, or intravenously. Retinal disorders may be similarly treated.
摘要翻译： KAL蛋白被鉴定为用于治疗包括脊髓组织在内的神经组织损伤的治疗组合物中的活性剂，以及对肾移植物的治疗的支持。此外，通过施用KAL蛋白来实现肾损伤和肾移植和肾脏手术的治疗。治疗剂可以局部施用或静脉内施用。视网膜疾病也可以同样治疗。

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