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21. 发明授权

EP0699758B1 Prototype felv isolates for use in disease models and vaccines 失效
标题翻译：原型的FeLV株用作疾病模型或疫苗
公开(公告)号：EP0699758B1
公开(公告)日：2002-07-24
申请号：EP95100871.3
申请日：1989-12-12
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
发明人： Hoover, Edward A. , Mullins, James I.
IPC分类号： C12N7/00 , C12N15/48 , A61K39/21
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/525 , C12N7/00 , C12N2740/13021 , C12N2740/13022 , C12N2740/13061 , Y10S424/819

22. 发明公开

EP0044920A3 Veterinary rabies vaccine 有权转让
标题翻译：兽医疫苗
公开(公告)号：EP0044920A3
公开(公告)日：1982-02-17
申请号：EP81104298
申请日：1981-06-04
申请人： NORDEN LABORATORIES, INC.
发明人： Bass, Edmund Paul , Sharpee, Richard Leroy
IPC分类号： A61K39/205 , A61K39/295 , C12N07/00
CPC分类号： A61K39/205 , A61K39/12 , A61K2039/5252 , A61K2039/552 , A61K2039/55505 , C12N2760/20134 , Y10S424/818 , Y10S424/819
摘要： Inactivated rabies virus vaccine is prepared by propagation of rabies virus in a swine testicle cell culture, inactivation with an inactivating agent which does not destroy the virus particles or antigenicity and combination with an adjuvant and a carrier. The inactivated rabies vaccine is eventually combined with one or more vaccinal canine viruses or bacteria.

23. 发明授权

US06042835A Prototype FelV isolates for use in disease models and vaccines 失效
标题翻译：用于疾病模型和疫苗的原型FelV分离物
公开(公告)号：US06042835A
公开(公告)日：2000-03-28
申请号：US233004
申请日：1994-04-22
申请人： Edward A. Hoover , James I. Mullins
发明人： Edward A. Hoover , James I. Mullins
IPC分类号： C12N15/09 , A61K39/00 , A61K39/21 , A61P31/18 , C07K14/15 , C12N5/10 , C12N7/00 , C12N7/04 , C12N15/48 , C12P21/02 , C12R1/91 , A01N63/00 , A61K39/12 , C12P21/06
CPC分类号： C07K14/005 , C12N7/00 , A61K2039/525 , A61K39/00 , C12N2740/13021 , C12N2740/13022 , C12N2740/13061 , Y10S424/819
摘要： Molecular clones of feline leukemia virus isolates that encode (a) a prototype highly infectious, minimally pathogenic virus, (b) a variant genome that is replication-defective and associated with a fatal immunodeficiency in cats similar to AIDS (FAIDS) or (c) a chimeric genome that is replication-competent and induces FAIDS. These molecular clones may be used to generate cell lines producing infectious virus which is useful in the preparation of vaccines or in the generation of viremia or disease challenge systems.
摘要翻译：编码（a）原型感染性极低的病原体病毒的猫白血病病毒分离株的分子克隆，（b）与艾滋病相似的猫（FAIDS）中复制缺陷并与致命免疫缺陷相关的变异基因组，或（c）具有复制能力并诱导FAIDS的嵌合基因组。这些分子克隆可用于产生产生感染性病毒的细胞系，其可用于制备疫苗或产生病毒血症或疾病挑战系统。

24. 发明授权

US5820869A Recombinant raccoon pox viruses and their use as an effective vaccine against feline immunodeficiency virus infection 失效
标题翻译：重组浣熊痘病毒及其作为针对猫免疫缺陷病毒感染的有效疫苗的用途
公开(公告)号：US5820869A
公开(公告)日：1998-10-13
申请号：US482090
申请日：1995-06-07
申请人： Terri Wasmoen , Hsien-Jue Chu , Lloyd Chavez
发明人： Terri Wasmoen , Hsien-Jue Chu , Lloyd Chavez
IPC分类号： A61K48/00 , C12N15/09 , A61K35/76 , A61K39/00 , A61K39/21 , A61K39/275 , A61K39/295 , A61P31/12 , A61P31/18 , C07K14/15 , C07K14/155 , C12N7/00 , C12N15/49 , C12N15/863 , C12R1/92 , A61K39/12 , A01N43/04 , A61K39/215
CPC分类号： C12N7/00 , A61K39/12 , A61K39/21 , C07K14/005 , C12N15/86 , A61K2039/5256 , A61K39/00 , C12N2710/24043 , C12N2710/24143 , C12N2740/15022 , C12N2740/15034 , Y10S424/819
摘要： This invention provides a recombinant raccoon poxvirus that express the envelope protein of Feline Immunodeficiency Virus. The recombinant viruses are useful as vaccines, either alone or in combination with carries and adjuvants.
摘要翻译：本发明提供了表达猫免疫缺陷病毒包膜蛋白的重组浣熊痘病毒。重组病毒可单独或与携带和佐剂组合用作疫苗。

25. 发明授权

US5705162A FeLV therapeutic agent, method of its preparation, and method of treating FeLV infection therewith 失效
标题翻译： FeLV治疗剂，其制备方法及其治疗FeLV感染的方法
公开(公告)号：US5705162A
公开(公告)日：1998-01-06
申请号：US543820
申请日：1995-10-16
申请人： Richard G. Olsen , John L. Ridihalgh
发明人： Richard G. Olsen , John L. Ridihalgh
IPC分类号： A61K35/12 , A61K35/26 , A61K39/00 , C12N5/078 , A61K39/21
CPC分类号： A61K35/26 , C12N5/0651 , A61K2035/124 , A61K2039/5158 , C12N2501/23 , Y10S424/819
摘要： The present invention broadly relates to a therapeutic agent effective in mitigating disease associated with Feline Leukemia Virus (FeLV) in a feline infected with FeLV. A feline is an animal of the family Felidae. The novel therapeutic agent is composed of feline excised lymph nodes which have been subjected to mitogenic stimulation for their expansion dispersed in a pharmaceutically-acceptable carrier. Mitogenic stimulation conditions include culturing the excised lymph nodes in the presence of Interleukin-2. Optionally, culture conditions can include the presence of allogeneic or autologous FeLV tumor. The inventive therapeutic agent is prepared by excising lymph nodes from a feline infected the FeLV, mitogenically stimulating said excised lymph nodes for their expansion, and administering to the infected feline the expanded lymph nodes. Multidose regimens can be used as is necessary or desirable in convenient fashion. The method for mitigating disease associated with Feline Leukemia Virus (FeLV) in a feline infected with FeLV is composed of administering to the diseased feline the therapeutic agent composed of feline excised lymph nodes which have been subjected to mitogenic stimulation for their expansion dispersed in a pharmaceutically-acceptable carrier.
摘要翻译：本发明广泛地涉及有效减轻感染FeLV的猫的猫白血病病毒（FeLV）相关疾病的治疗剂。猫是猫科动物。该新型治疗剂由已经进行有丝分裂刺激扩散分散在药学上可接受的载体中的猫切除的淋巴结组成。有丝分裂刺激条件包括在白细胞介素-2存在下培养切除的淋巴结。任选地，培养条件可以包括同种异体或自体FeLV肿瘤的存在。本发明的治疗剂通过从感染了FeLV的猫科的淋巴结中切除，有丝分裂刺激所述切除的淋巴结进行扩增，以及向感染的猫科管理扩大的淋巴结来制备。可以以方便的方式使用多药方案作为必要或需要的。用于减轻感染FeLV的猫的猫白血病病毒（FeLV）相关疾病的方法包括向患病猫施用由已经进行有丝分裂刺激扩散分散在药物中的猫切除的淋巴结组成的治疗剂可接受的载体。

26. 发明授权

US4933179A Feline leukemia virus antigen vaccines 失效
标题翻译：猫白血病病毒抗原疫苗
公开(公告)号：US4933179A
公开(公告)日：1990-06-12
申请号：US703837
申请日：1985-02-21
申请人： Anthony C. Allison , Noelene E. Byars
发明人： Anthony C. Allison , Noelene E. Byars
IPC分类号： A61K9/00 , A61K9/107 , A61K39/39
CPC分类号： A61K39/39 , A61K9/1075 , A61K2039/5555 , A61K2039/55555 , A61K2039/55566 , Y10S424/819 , Y10S435/948 , Y10S514/908 , Y10S514/941 , Y10S514/975 , Y10S516/01 , Y10S516/02 , Y10S530/806
摘要： A vaccine for immunizing animals against Feline Leukemia Virus (FeLV) infections contains an FeLV antigen emulsified with a polyoxypropylene-polyoxyethylene block polymer, a glycol ether-based surfactant, an immunopotentiating amount of an immunostimulating glycopeptide, and, optionally, a metabolizable non-toxic oil.
摘要翻译：用于针对猫白血病病毒（FeLV）感染免疫动物的疫苗含有用聚氧丙烯 - 聚氧乙烯嵌段聚合物乳化的FeLV抗原，二醇醚类表面活性剂，免疫增强量的免疫刺激性糖肽，以及任选的可代谢无毒的油。

27. 发明授权

US4347239A Inactivated rabies vaccine for veterinary use 失效
公开(公告)号：US4347239A
公开(公告)日：1982-08-31
申请号：US174306
申请日：1980-07-30
申请人： Edmund P. Bass , Richard L. Sharpee
发明人： Edmund P. Bass , Richard L. Sharpee
IPC分类号： A61K39/12 , A61K39/155 , A61K39/175 , A61K39/205 , A61K39/23 , A61K39/235 , A61K39/295 , A61P31/12
CPC分类号： A61K39/205 , A61K39/12 , A61K2039/5252 , A61K2039/552 , A61K2039/55505 , C12N2760/20134 , Y10S424/818 , Y10S424/819
摘要： The preparation of a vaccine for immunization of canine and feline animals from inactivated HCP-SAD strain of rabies virus is disclosed.

28. 发明授权

US4303644A Feline infectious peritonitis virus vaccines 失效
标题翻译：猫传染性腹膜炎病毒疫苗
公开(公告)号：US4303644A
公开(公告)日：1981-12-01
申请号：US85435
申请日：1979-10-16
申请人： Eldon Davis
发明人： Eldon Davis
IPC分类号： A61K39/215 , C12N7/08 , A61K39/12
CPC分类号： C12N7/00 , A61K39/12 , A61K39/215 , A61K2039/5254 , A61K2039/542 , A61K2039/552 , C12N2770/20034 , C12N2770/20064 , Y10S424/819
摘要： The isolation, identification and in vitro propagation of feline infectious peritonitis virus and preparation of vaccines for immunization of animals of the genus Felis, family felidae therefrom are disclosed.
摘要翻译：公开了猫感染性腹膜炎病毒的分离，鉴定和体外繁殖以及用于免疫来自其家系的猫科动物的疫苗的疫苗的制备。

29. 发明授权

US4117112A Vaccine for prevention of feline leukemia 失效
标题翻译：用于预防流感病毒的疫苗
公开(公告)号：US4117112A
公开(公告)日：1978-09-26
申请号：US798509
申请日：1977-05-19
申请人： William Fleming Hoggan Jarrett , James Oswald Jarrett , Lindsay Joan Mackey
发明人： William Fleming Hoggan Jarrett , James Oswald Jarrett , Lindsay Joan Mackey
IPC分类号： A61K39/00 , C07K14/15 , A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/13022 , Y10S424/819
摘要： The present invention encompasses a vaccine for the prevention of disease associated with feline leukemia virus which comprises an effective amount of an adjuvant and about 10.sup.5 -10.sup.7 feline lymphoblastoid cells chronically infected with feline leukemia virus and having viral associated antigen on their surface wherein the virus and cells are inactivated by chemical or physical means without destroying immunogenicity.

30. 发明授权

US4034081A Vaccines against feline leukemia 失效
标题翻译：针对猫白血病的疫苗
公开(公告)号：US4034081A
公开(公告)日：1977-07-05
申请号：US668110
申请日：1976-03-18
申请人： William Fleming Hoggan Jarrett , James Oswald Jarrett , Lindsay Joan Mackey
发明人： William Fleming Hoggan Jarrett , James Oswald Jarrett , Lindsay Joan Mackey
IPC分类号： A61K39/00 , C07K14/15
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/13022 , Y10S424/819
摘要： Vaccines affording protection against the diseases resulting from infection of cats with feline leukemia virus are produced from cells infected with that virus or from the virus alone.
摘要翻译：提供针对猫类白血病病毒感染所致疾病的疫苗的疫苗由感染该病毒的细胞或单独的病毒产生。

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