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1. 发明申请

WO1992015684A1 RECOMBINANT FIV GLYCOPROTEIN 160 AND p24 GAG PROTEIN 审中-公开
标题翻译：重组FIV GLYCOPROTEIN 160和p24 GAG蛋白
公开(公告)号：WO1992015684A1
公开(公告)日：1992-09-17
申请号：PCT/US1992001421
申请日：1992-02-27
申请人： CAMBRIDGE BIOTECH CORPORATION
发明人： CAMBRIDGE BIOTECH CORPORATION , YOUNG, Eli , DAVIS, Deborah , STOREY, James, R. , BELTZ, Gerald
IPC分类号： C12N15/49
CPC分类号： C07K14/005 , C07K16/1054 , C07K16/1063 , C12N2740/15022 , Y10S424/819 , Y10S530/826
摘要： Feline immunodeficiency virus antigens from gp160 envelope protein, gp120 envelope protein and p24 gag protein, useful for the diagnosis, treatment, and prevention of FIV. The invention may also be used to purify FIV.
摘要翻译：来自gp160包膜蛋白的猫免疫缺陷病毒抗原，gp120包膜蛋白和p24 gag蛋白，用于FIV的诊断，治疗和预防。本发明也可用于净化FIV。

2. 发明申请

WO1997014435A1 FeLV THERAPEUTIC AGENT, METHOD OF ITS PREPARATION, AND METHOD OF TREATING FeLV INFECTION THEREWITH 审中-公开
标题翻译： FeLV治疗剂，其制备方法及其治疗感染的方法
公开(公告)号：WO1997014435A1
公开(公告)日：1997-04-24
申请号：PCT/US1996016394
申请日：1996-10-15
申请人： PARHELION CORPORATION
发明人： PARHELION CORPORATION , OLSEN, Richard, G. , RIDIHALGH, John, L.
IPC分类号： A61K39/21
CPC分类号： A61K35/26 , A61K2035/124 , A61K2039/5158 , C12N5/0651 , C12N2501/23 , Y10S424/819
摘要： The present invention broadly relates to a therapeutic agent effective in mitigating disease associated with Feline Leukemia Virus (FeLV) in a feline infected with FeLV. A feline is an animal of the family Felidae. The novel therapeutic agent is composed of feline excised lymph nodes which have been subjected to mitogenic stimulation for their expansion dispersed in a pharmaceutically-acceptable carrier. Mitogenic stimulation conditions include culturing the excised lymph nodes in the presence of Interleukin-2. Optionally, culture conditions can include the presence of allogeneic or autologous FeLV tumor. The inventive therapeutic agent is prepared by excising lymph nodes from a feline infected with FeLV, mitogenically stimulating said excised lymph nodes for their expansion, and administering to the infected feline the expanded lymph nodes. Multidose regimens can be used as is necessary or desirable in convenient fashion. The method for mitigating disease associated with Feline Leukemia Virus (FeLV) in a feline infected with FeLV is composed of administering to the diseased feline the therapeutic agent composed of feline excised lymph nodes which have been subjected to mitogenic stimulation for their expansion dispersed in a pharmaceutically-acceptable carrier.
摘要翻译：本发明广泛地涉及有效减轻感染FeLV的猫的猫白血病病毒（FeLV）相关疾病的治疗剂。猫是猫科动物。该新型治疗剂由已经进行有丝分裂刺激扩散分散在药学上可接受的载体中的猫切除的淋巴结组成。有丝分裂刺激条件包括在白细胞介素-2存在下培养切除的淋巴结。任选地，培养条件可以包括同种异体或自体FeLV肿瘤的存在。本发明的治疗剂通过从感染FeLV的猫科切除淋巴结来制备，有丝分裂刺激所述切除的淋巴结进行扩增，以及向感染的猫科管理扩大的淋巴结。可以以方便的方式使用多药方案作为必要或需要的。用于减轻感染FeLV的猫的猫白血病病毒（FeLV）相关疾病的方法包括向患病猫施用由已经进行有丝分裂刺激扩散分散在药物中的猫切除的淋巴结组成的治疗剂可接受的载体。

3. 发明申请

WO1996040268A1 RECOMBINANT RACCOON POX VIRUSES AND THEIR USE AS AN EFFECTIVE VACCINE AGAINST FELINE IMMUNODEFICIENCY VIRUS INFECTION 审中-公开
标题翻译：重组RACCOON POX病毒及其作为有效疫苗使用免疫缺陷病毒感染
公开(公告)号：WO1996040268A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008508
申请日：1996-06-03
申请人： AMERICAN HOME PRODUCTS CORPORATION
发明人： AMERICAN HOME PRODUCTS CORPORATION , WASMOEN, Terri , CHU, Hsien-Jue , CHAVEZ, Lloyd, George, Jr.
IPC分类号： A61K48/00
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2710/24043 , C12N2710/24143 , C12N2740/15022 , C12N2740/15034 , Y10S424/819
摘要： The present invention provides recombinant raccoon poxviruses (RRPVs) useful in vaccines for the prophylaxis of disease caused by feline immunodeficiency virus (FIV). RRPVs according to the invention have at least one internal gene comprising a DNA sequence that encodes FIV gag protein (gag), FIV enveloppe protein (env), a polypeptide consisting of amino acids 1-735 of FIV env, or immunogenic fragments of any of the foregoing. The vaccines that comprise one or more of the FIV-expressing recombinant raccoon poxviruses described above may also comprise a pharmaceutically acceptable carrier or diluent and a pharmaceutically acceptable adjuvant. The invention also provides methods for preventing or lessening disease caused by FIV, which is carried out by administering to a feline in need of such treatment the vaccines described above.
摘要翻译：本发明提供了用于疫苗预防猫免疫缺陷病毒（FIV）引起的疾病的重组浣熊痘病毒（RRPV）。根据本发明的RRPV具有至少一个内部基因，其包含编码FIV gag蛋白（gag），FIV包膜蛋白（env），由FIV env的氨基酸1-735组成的多肽的DNA序列或任何以上。包含一种或多种上述表达FIV的重组浣熊痘病毒的疫苗也可以包含药学上可接受的载体或稀释剂和药学上可接受的佐剂。本发明还提供了用于预防或减轻由FIV引起的疾病的方法，其通过向需要这种治疗的猫科动物施用上述疫苗来进行。

4. 发明申请

WO1993002405A1 ADAPTIVE CONTROL SYSTEM INPUT LIMITING 审中-公开
标题翻译：自适应控制系统输入限制
公开(公告)号：WO1993002405A1
公开(公告)日：1993-02-04
申请号：PCT/US1992005742
申请日：1992-07-09
申请人： UNITED TECHNOLOGIES CORPORATION
发明人： UNITED TECHNOLOGIES CORPORATION , ADAMS, Donald, L., Jr. , WRIGHT, Stuart, C. , VERZELLA, David, J. , LAMONTAGNE, Troy, J.
IPC分类号： G05B13/02
CPC分类号： G05B5/01 , G05D1/0061 , Y10S424/819
摘要： A control system, having an input command signal and driving a prime mover, is provided with variable magnitude and/or rate input signal limiting that is adjusted by maps (68, 70, 72, 74) which set the limits for a variable magnitude limiter (14) and a variable rate limiter (22) as a function of the prime mover rate. The limiting is adjusted dynamically as the prime mover rate changes. When the prime mover enters an undesirable operating condition, the maps only limit the command signal in the direction of such condition. The adjustable limiting is enabled or disabled based on the position, rate, and/or acceleration of the prime mover.

6. 发明专利

JPS5732227A Hydrophobia vaccine 失效
标题翻译： HYDROPHOBIA VACCINE
公开(公告)号：JPS5732227A
公开(公告)日：1982-02-20
申请号：JP2416581
申请日：1981-02-19
申请人： Norden Lab Inc
发明人： EDOMONDO POORU BASU , RICHIYAADO REROI SHIYAAPII
IPC分类号： A61K39/12 , A61K39/155 , A61K39/175 , A61K39/205 , A61K39/23 , A61K39/235 , A61K39/295 , A61P31/12
CPC分类号： A61K39/205 , A61K39/12 , A61K2039/5252 , A61K2039/552 , A61K2039/55505 , C12N2760/20134 , Y10S424/818 , Y10S424/819

7. 发明授权

US5037753B2 Feline t-lymphotrophic lentivirus 失效
标题翻译：卵清淋巴细胞性慢病毒
公开(公告)号：US5037753B2
公开(公告)日：1998-06-16
申请号：US61803090
申请日：1990-11-16
申请人： UNIV CALIFORNIA
发明人： PEDERSEN NIELS C , YAMAMOTO JANET K
IPC分类号： A61K39/00 , A61K39/21 , C07K14/155 , C12N7/00 , C07K16/00 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/5252 , C12N7/00 , C12N2740/15021 , C12N2740/15022 , C12N2740/15034 , Y10S424/819 , Y10S435/948

8. 发明授权

US5656275A Recombinant raccoon pox virus comprising the DNA encoding the nucleocapsid protein of feline infectious peritonitis virus 失效
标题翻译：重组浣熊痘病毒，其包含编码猫感染性腹膜炎病毒核衣壳蛋白的DNA
公开(公告)号：US5656275A
公开(公告)日：1997-08-12
申请号：US480882
申请日：1995-06-07
申请人： Terri Wasmoen , Lloyd Chavez , Hsien-Jue Chu
发明人： Terri Wasmoen , Lloyd Chavez , Hsien-Jue Chu
IPC分类号： C12N15/09 , A61K39/00 , A61K39/118 , A61K39/12 , A61K39/21 , A61K39/215 , A61K39/23 , A61K39/245 , A61K39/275 , A61K39/295 , A61K39/39 , A61P31/12 , C07K14/065 , C07K14/165 , C12N7/00 , C12N7/01 , C12N15/35 , C12N15/863 , A61K39/125 , A61K39/155 , A61K39/265 , C12N15/00
CPC分类号： C12N15/86 , C07K14/005 , A61K39/00 , C07K2319/00 , C12N2710/24022 , C12N2710/24143 , C12N2770/20022 , Y10S424/819
摘要： This invention provides a recombinant raccoon poxvirus that expresses the nucleocapsid and transmembrane proteins of Feline Infectious Peritionitis Virus. The recombinant viruses are useful as vaccines, either alone or in combination with carriers and adjuvants.
摘要翻译：本发明提供了表达猫传染性肠炎病毒的核衣壳和跨膜蛋白的重组浣熊痘病毒。重组病毒可单独或与载体和佐剂组合用作疫苗。

9. 发明授权

US4791062A FVR vaccine 失效
标题翻译： FVR疫苗
公开(公告)号：US4791062A
公开(公告)日：1988-12-13
申请号：US70201
申请日：1987-07-06
申请人： Gary P. Wiesehahn , Richard E. Giles , David R. Stevens
发明人： Gary P. Wiesehahn , Richard E. Giles , David R. Stevens
IPC分类号： A61K39/265 , A61K39/12 , A61K39/245
CPC分类号： A61K39/265 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N2710/16734 , Y10S424/819
摘要： Novel vaccines for feline viral rhinotracheitis are prepared by psoralen inactivation of live Feline Herpesvirus I by exposure to ultraviolet radiation in the presence of an inactivating furocoumarin. The resulting inactivated viruses are suitable as the immunogenic substances in vaccines, which vaccines are useful for inoculation of hosts susceptible to feline virus rhinotracheitis.
摘要翻译：通过在灭活的呋喃香豆素的存在下通过暴露于紫外线辐射的活的猫疱疹病毒I的补骨脂素灭活来制备用于猫病毒性鼻气管炎的新型疫苗。所得的灭活病毒适用于疫苗中的免疫原性物质，该疫苗可用于接种猫病毒性鼻气管炎易感的宿主。

10. 发明授权

US4264587A Vaccine for preventing persistent feline leukemia viremia in cats 失效
标题翻译：用于预防猫中持续性猫白血病病毒血症的疫苗
公开(公告)号：US4264587A
公开(公告)日：1981-04-28
申请号：US62737
申请日：1979-08-01
申请人： Niels C. Pedersen , Gordon H. Theilen
发明人： Niels C. Pedersen , Gordon H. Theilen
IPC分类号： A61K39/00 , C07K14/15 , A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/13022 , Y10S424/819
摘要： A vaccine in parenteral dose form for preventing persistent feline leukemia viremia in cats is characterized by containing as the immunizing agent inactivated feline leukemia virus (FeLV) derived from the FL74 feline lymphoblastoid cell line.
摘要翻译：用于预防猫中持续性猫白血病病毒血症的肠胃外剂量形式的疫苗的特征在于含有来自FL74猫科淋巴母细胞细胞系的灭活的猫白血病病毒（FeLV）作为免疫剂。

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