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21. 发明授权

US07033834B2 Methods and means for targeted gene delivery 失效
公开(公告)号：US07033834B2
公开(公告)日：2006-04-25
申请号：US09901836
申请日：2001-07-10
申请人： Domenico Valerio , Victor Willem Van Beusechem
发明人： Domenico Valerio , Victor Willem Van Beusechem
IPC分类号： A01N63/00 , A01N43/04 , C12N15/00 , C12N15/63 , C12N15/85
CPC分类号： C07K14/005 , A61K47/6898 , A61K47/6901 , A61K48/00 , B82Y5/00 , C07K14/70535 , C07K2319/32 , C12N7/00 , C12N15/86 , C12N15/87 , C12N2710/00088 , C12N2740/13043 , C12N2740/13045 , C12N2740/13052 , C12N2740/15022 , C12N2810/855 , C12N2810/859
摘要： A method for producing viral gene delivery vehicles which can be transferred to pre-selected cell types by using targeting conjugates. The gene delivery vehicles comprise: 1) the gene of interest; and 2) a viral capsid or envelope carrying a member of a specific binding pair, the counterpart of which is not directly associated with the surface of the target cell. These vehicles can be rendered unable to bind to their natural cell receptor. The targeting conjugates include the counterpart member of the specific binding pair, linked to a targeting moiety which is a cell-type specific ligand (or fragments thereof). The number of the specific binding pair present on the viral vehicles can be, for example, an immunoglobulin binding moiety (e.g., capable of binding to a Fc fragment, protein A, protein G, FcR or an anti-Ig antibody), or biotin, avidin or streptavidin. The virus' outer membrane or capsid may contain a substance which mediates entrance of the gene delivery vehicle into the target cell. Due to the specificity of the ligand, the binding pair's high affinity, and the gene delivery vehicle's inability to be targeted when used alone, the universality of the method for gene delivery, together with its high cell type selectively can be achieved by using various targeting conjugates.

22. 发明申请

US20010055791A1 Methods for enhancing the production of interferon in cell culture 失效
标题翻译：增强细胞培养中干扰素生产的方法
公开(公告)号：US20010055791A1
公开(公告)日：2001-12-27
申请号：US09906326
申请日：2001-07-16
发明人： Allan S. Lau
IPC分类号： C12P021/02
CPC分类号： C12N9/1205 , C07K14/555 , C12N7/00 , C12N15/67 , C12N2710/00088 , C12N2710/16643 , C12P21/02 , C12Q1/18
摘要： Methods for enhancing the production of interferons in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain inducers of interferon production, in particular cellular levels of double-stranded-RNA-dependent kinase (dsRNA-PKR, or PKR). In cell cultures that overproduce PKR, interferon synthesis is induced to high levels, and significant amounts of interferon can be recovered without conventional induction of interferon by virus.
摘要翻译：描述了用于增强动物细胞培养物中干扰素产生的方法。这些方法依赖于干扰素产生的某些诱导物的细胞水平的操作，特别是双链RNA依赖性激酶（dsRNA-PKR或PKR）的细胞水平。在过量产生PKR的细胞培养物中，干扰素合成被诱导为高水平，并且可以在不常规诱导病毒感染干扰素的情况下回收大量的干扰素。

23. 发明授权

US06261554B1 Compositions for targeted gene delivery 失效
标题翻译：用于靶基因递送的组合物
公开(公告)号：US06261554B1
公开(公告)日：2001-07-17
申请号：US09000133
申请日：1998-02-24
申请人： Domenico Valerio , Victor Willem van Beusechem
发明人： Domenico Valerio , Victor Willem van Beusechem
IPC分类号： A61K3500
CPC分类号： C07K14/005 , A61K47/6898 , A61K47/6901 , A61K48/00 , B82Y5/00 , C07K14/70535 , C07K2319/32 , C12N7/00 , C12N15/86 , C12N15/87 , C12N2710/00088 , C12N2740/13043 , C12N2740/13045 , C12N2740/13052 , C12N2740/15022 , C12N2810/855 , C12N2810/859
摘要： A method of producing viral gene delivery vehicles which can be transferred to pre-selected cell types by using targeting conjugates. The gene delivery vehicles comprise: 1) the gene of interest; 2) a viral capsid or envelope carrying a member of a specific binding pair, the counterpart of which is not directly associated with the surface of the target cell. These vehicles can be made unable to bind to their natural receptor on the cell. The targeting conjugates are composed of the counterpart member of the specific binding pair linked to a targeting moiety which is a cell-type specific ligand. The number of the specific binding pair present on the viral vehicles can be, for example, an immunoglobulin binding moiety, biotin, avidin, or streptavidin. The outer membrane or capsid of the virus may contain a substance which mediates entrance of the gene delivery vehicle into the target cell. Due to the specificity of the ligand, the high affinity of the binding pair and to the inability of the gene delivery vehicle to be targeted when used alone, the universality of the method for gene delivery, together with its high cell type selectively can easily be achieved by the use of various adequate targeting conjugates.
摘要翻译：一种生产病毒基因递送载体的方法，其可以通过使用靶向缀合物转移到预先选择的细胞类型。基因递送载体包括：1）感兴趣的基因; 2）携带特异性结合对的成员的病毒衣壳或信封，其对应物不与靶细胞的表面直接相关。这些载体可能不能与细胞上的天然受体结合。靶向缀合物由与作为细胞型特异性配体的靶向部分连接的特异性结合对的对应成员组成。存在于病毒载体上的特异性结合对的数目可以是例如免疫球蛋白结合部分，生物素，抗生物素蛋白或链霉亲和素。病毒的外膜或衣壳可以含有介导基因递送载体进入靶细胞的入口的物质。由于配体的特异性，当单独使用时，结合对的高亲和力和基因递送载体的靶向性不足，基因递送方法的普及性及其高细胞型选择性可以容易地通过使用各种适当的靶向缀合物实现。

24. 发明授权

US09340577B2 HLA binding motifs and peptides and their uses 有权
标题翻译： HLA结合基序和肽及其用途
公开(公告)号：US09340577B2
公开(公告)日：2016-05-17
申请号：US10817970
申请日：2004-04-06
申请人： Howard M. Grey , Alessandro Sette , John Sidney , Scott Southwood , Ralph T. Kubo , Esteban Celis , Robert Chesnut , W. Martin Kast
发明人： Howard M. Grey , Alessandro Sette , John Sidney , Scott Southwood , Ralph T. Kubo , Esteban Celis , Robert Chesnut , W. Martin Kast
IPC分类号： A61K38/10 , A61K39/145 , C07K7/08 , C07K7/06 , A61K39/02 , A61K39/12 , C07K14/74 , A61K38/00 , A61K39/00
CPC分类号： A61K38/00 , A61K38/10 , A61K39/00 , A61K39/0011 , A61K39/02 , A61K39/12 , A61K39/145 , A61K2039/5158 , A61K2039/55516 , A61K2039/55566 , A61K2039/572 , C07K7/06 , C07K14/70539 , C07K2319/01 , C07K2319/33 , C07K2319/40 , C12N2710/00088 , C12N2710/20034 , C12N2730/10134 , C12N2740/16034 , C12N2770/24234
摘要： The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. One such peptide, NMLSTVLGV (SEQ ID NO: 183) is useful to elicit an immune response against influenza. The present invention also provides a heteropolymer of an isolated immunogenic peptide less than 15 amino acids in length comprising the oligopeptide NMLSTVLGV (SEQ ID NO: 183) and at least one different peptide.
摘要翻译：本发明提供了选择免疫原性肽的方法和方法以及能够特异性结合由HLA等位基因编码的糖蛋白并诱导由等位基因限制的T细胞中的T细胞活化的免疫原性肽组合物。一种这样的肽NMLSTVLGV（SEQ ID NO：183）可用于引发针对流感的免疫应答。本发明还提供了长度小于15个氨基酸的分离的免疫原性肽的杂聚物，其包含寡肽NMLSTVLGV（SEQ ID NO：183）和至少一种不同的肽。

25. 发明申请

US20110135685A1 Edible Vaccines Expressed in Soybeans 审中-公开
标题翻译：在大豆中表达的食用疫苗
公开(公告)号：US20110135685A1
公开(公告)日：2011-06-09
申请号：US12692722
申请日：2010-01-25
申请人： Kenneth John Piller , Kenneth Lee Bost
发明人： Kenneth John Piller , Kenneth Lee Bost
IPC分类号： A61K39/108 , A61K39/07 , A61K39/08 , A61K39/245 , A61K39/285 , A61K39/12 , A61K39/21 , A61K39/215 , A61P31/04 , A61P31/18 , A61P31/22 , A61P31/14
CPC分类号： C12N15/8258 , A61K39/0005 , A61K39/02 , A61K39/0258 , A61K39/35 , A61K2039/517 , A61K2039/55544 , C12N2710/00088 , Y02A50/469 , Y02A50/474
摘要： The present invention relates to vaccines that are made in transgenic soybeans for use in humans, animals of agricultural importance, pets, and wildlife. These vaccines are used as vaccines against viral, bacterial, fungal, parasitic or prion related diseases, cancer antigens, toxins, and autologous or self proteins. The transgenic soybeans of the instant invention also can be used for inducing tolerance to allergens or tolerance to autoimmune antigens, wherein an individual shows hypersensitivity to said allergen or has developed autoimmunity to autologous or self proteins, respectively. The invention also relates to prophylactically treating individuals and/or populations prior to showing hypersensitivity to allergens. Other aspects of the invention include using the transgenic soybeans as an oral contraceptive, and the expression of protein adjuvants in transgenic soybeans.
摘要翻译：本发明涉及用于人类的转基因大豆，具有农业重要性的动物，宠物和野生动物的疫苗。这些疫苗用作抗病毒，细菌，真菌，寄生或朊病毒相关疾病，癌症抗原，毒素和自体或自身蛋白的疫苗。本发明的转基因大豆还可用于诱导对变应原的耐受性或对自身免疫抗原的耐受性，其中个体对所述变应原显示过敏反应或分别对自体或自身蛋白产生自身免疫性。本发明还涉及在对过敏原显示过敏之前预防性地治疗个体和/或群体。本发明的其它方面包括使用转基因大豆作为口服避孕药，以及在转基因大豆中表达蛋白佐剂。

26. 发明申请

US20070192905A1 Edible vaccines expressed in soybeans 有权
标题翻译：在大豆中表达的食用疫苗
公开(公告)号：US20070192905A1
公开(公告)日：2007-08-16
申请号：US11249182
申请日：2005-10-12
申请人： Kenneth Piller , Kenneth Bost
发明人： Kenneth Piller , Kenneth Bost
IPC分类号： A01H5/00 , A61K39/00 , A61K39/12 , A61K39/02
CPC分类号： C12N15/8258 , A61K39/0005 , A61K39/02 , A61K39/0258 , A61K39/35 , A61K2039/517 , A61K2039/55544 , C12N2710/00088 , Y02A50/469 , Y02A50/474
摘要： The present invention relates to vaccines that are made in transgenic soybeans for use in humans, animals of agricultural importance, pets, and wildlife. These vaccines are used as vaccines against viral, bacterial, fungal, parasitic or prion related diseases, cancer antigens, toxins, and autologous or self proteins. The transgenic soybeans of the instant invention also can be used for inducing tolerance to allergens or tolerance to autoimmune antigens, wherein an individual shows hypersensitivity to said allergen or has developed autoimmunity to autologous or self proteins, respectively. The invention also relates to prophylatically treating individuals and/or populations prior to showing hypersensitivity to allergens. Other aspects of the invention include using the transgenic soybeans as an oral contraceptive, and the expression of protein adjuvants in transgenic soybeans.
摘要翻译：本发明涉及用于人类的转基因大豆，具有农业重要性的动物，宠物和野生动物的疫苗。这些疫苗用作抗病毒，细菌，真菌，寄生或朊病毒相关疾病，癌症抗原，毒素和自体或自身蛋白的疫苗。本发明的转基因大豆还可用于诱导对变应原的耐受性或对自身免疫抗原的耐受性，其中个体对所述变应原显示过敏反应或分别对自体或自身蛋白产生自身免疫性。本发明还涉及在对过敏原显示过敏之前预防性地治疗个体和/或群体。本发明的其它方面包括使用转基因大豆作为口服避孕药，以及在转基因大豆中表达蛋白佐剂。

27. 发明授权

US07232566B2 Methods for treating HIV infected subjects 有权
标题翻译：治疗艾滋病毒感染者的方法
公开(公告)号：US07232566B2
公开(公告)日：2007-06-19
申请号：US11029188
申请日：2005-01-04
申请人： Carl H. June , Craig B. Thompson , Gary J. Nabel , Gary S. Gray , Paul D. Rennert
发明人： Carl H. June , Craig B. Thompson , Gary J. Nabel , Gary S. Gray , Paul D. Rennert
IPC分类号： A61K35/14 , A61K35/26 , A61K35/28
CPC分类号： C12N5/0636 , A61K35/17 , A61K38/00 , A61K39/02 , A61K39/12 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/5158 , C07K14/705 , C07K14/70521 , C07K14/70532 , C07K16/00 , C07K16/2806 , C07K16/2809 , C07K16/2812 , C07K16/2815 , C07K16/2818 , C07K16/2833 , C07K16/2866 , C07K16/289 , C07K16/2896 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/73 , C07K2317/74 , C07K2319/00 , C07K2319/30 , C12N2501/51 , C12N2501/515 , C12N2501/599 , C12N2710/00088 , C12N2740/16011
摘要： Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
摘要翻译：描述了通过激活T细胞群并用结合附属分子的配体刺激T细胞表面上的辅助分子来诱导T细胞群体增殖的方法。 T细胞增殖发生在没有外源生长因子或附属细胞的情况下。通过刺激T细胞受体（TCR）/ CD3复合物或CD2表面蛋白来完成T细胞活化。为了诱导活化的群体T细胞的增殖，T细胞表面上的辅助分子如CD28被与配合分子结合的配体刺激。通过本发明的方法扩增的T细胞群体可以被遗传转导并用于免疫治疗，或可用于诊断方法。

28. 发明申请

US20060013832A1 Methods for treating HIV infected subjects 有权
标题翻译：治疗艾滋病毒感染者的方法
公开(公告)号：US20060013832A1
公开(公告)日：2006-01-19
申请号：US11029188
申请日：2005-01-04
申请人： Carl June , Craig Thompson , Gary Nabel , Gary Gray , Paul Rennert
发明人： Carl June , Craig Thompson , Gary Nabel , Gary Gray , Paul Rennert
IPC分类号： A61K39/21 , C12N15/86
CPC分类号： C12N5/0636 , A61K35/17 , A61K38/00 , A61K39/02 , A61K39/12 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/5158 , C07K14/705 , C07K14/70521 , C07K14/70532 , C07K16/00 , C07K16/2806 , C07K16/2809 , C07K16/2812 , C07K16/2815 , C07K16/2818 , C07K16/2833 , C07K16/2866 , C07K16/289 , C07K16/2896 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/73 , C07K2317/74 , C07K2319/00 , C07K2319/30 , C12N2501/51 , C12N2501/515 , C12N2501/599 , C12N2710/00088 , C12N2740/16011
摘要： Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
摘要翻译：描述了通过激活T细胞群并用结合附属分子的配体刺激T细胞表面上的辅助分子来诱导T细胞群体增殖的方法。 T细胞增殖发生在没有外源生长因子或附属细胞的情况下。通过刺激T细胞受体（TCR）/ CD3复合物或CD2表面蛋白来完成T细胞活化。为了诱导活化的群体T细胞的增殖，T细胞表面上的辅助分子如CD28被与配合分子结合的配体刺激。通过本发明的方法扩增的T细胞群体可以被遗传转导并用于免疫治疗，或可用于诊断方法。

29. 发明申请

US20010055586A1 Methods and means for targeted gene delivery 失效
标题翻译：靶向基因传递的方法和手段
公开(公告)号：US20010055586A1
公开(公告)日：2001-12-27
申请号：US09901836
申请日：2001-07-10
发明人： Domenico Valerio , Victor Willem Van Beusechem
IPC分类号： A61K048/00
CPC分类号： C07K14/005 , A61K47/6898 , A61K47/6901 , A61K48/00 , B82Y5/00 , C07K14/70535 , C07K2319/32 , C12N7/00 , C12N15/86 , C12N15/87 , C12N2710/00088 , C12N2740/13043 , C12N2740/13045 , C12N2740/13052 , C12N2740/15022 , C12N2810/855 , C12N2810/859
摘要： A method for producing viral gene delivery vehicles which can be transferred to pre-selected cell types by using targeting conjugates. The gene delivery vehicles comprise: 1) the gene of interest; and 2) a viral capsid or envelope carrying a member of a specific binding pair, the counterpart of which is not directly associated with the surface of the target cell. These vehicles can be rendered unable to bind to their natural cell receptor. The targeting conjugates include the counterpart member of the specific binding pair, linked to a targeting moiety which is a cell-type specific ligand (or fragments thereof). The number of the specific binding pair present on the viral vehicles can be, for example, an immunoglobulin binding moiety (e.g., capable of binding to a Fc fragment, protein A, protein G, FcR or an anti-Ig antibody), or biotin, avidin or streptavidin. The virus' outer membrane or capsid may contain a substance which mediates entrance of the gene delivery vehicle into the target cell. Due to the specificity of the ligand, the binding pair's high affinity, and the gene delivery vehicle's inability to be targeted when used alone, the universality of the method for gene delivery, together with its high cell type selectively can be achieved by using various targeting conjugates.
摘要翻译：用于产生病毒基因递送载体的方法，其可以通过使用靶向缀合物转移到预先选择的细胞类型。基因递送载体包括：1）感兴趣的基因; 和2）携带特异性结合对的成员的病毒衣壳或信封，其对应物不与靶细胞的表面直接相关。这些载体可能不能与其天然细胞受体结合。靶向缀合物包括与作为细胞型特异性配体（或其片段）的靶向部分连接的特异性结合对的对应成员。存在于病毒载体上的特异性结合对的数目可以是例如免疫球蛋白结合部分（例如，能够结合Fc片段，蛋白A，蛋白G，FcR或抗-Ig抗体）或生物素，抗生物素蛋白或链霉亲和素。病毒的外膜或衣壳可以含有介导基因递送载体进入靶细胞的入口的物质。由于配体的特异性，结合对的高亲和力和基因递送载体在单独使用时不能被靶向，所以基因递送方法的普及性及其高细胞类型选择性可以通过使用各种靶向共轭物

30. 发明申请

US20100221282A1 RECOMBINANT VACCINE AGAINST WEST NILE VIRUS 有权
标题翻译：重组疫苗对西尼病毒
公开(公告)号：US20100221282A1
公开(公告)日：2010-09-02
申请号：US12758500
申请日：2010-04-12
申请人： SHEENA MAY LOOSMORE , JEAN-CHRISTOPHE FRANCIS AUDONNET , JULES MAARTEN MINKE
发明人： SHEENA MAY LOOSMORE , JEAN-CHRISTOPHE FRANCIS AUDONNET , JULES MAARTEN MINKE
IPC分类号： A61K39/12 , C12N15/63 , C12N15/34 , C12N15/39
CPC分类号： A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/552 , A61K2039/55511 , A61K2039/55522 , A61K2039/55555 , C07K14/005 , C12N15/86 , C12N2710/00088 , C12N2710/24043 , C12N2770/24122 , C12N2770/24134 , C12N2770/24143 , C12N2799/023
摘要： An immunogenic or vaccine composition to induce an immune response or protective immune response against West Nile virus (WNV) in an animal susceptible to WNV. The composition includes a pharmaceutically or veterinarily acceptable vehicle or excipient, and a vector. The vector contains heterologous nucleic acid molecule(s), expresses in vivo in the animal WNV antigen, immunogen or epitope thereof, e.g., WNV E; WNV prM and E; WNV M and E; WNV prM, WNV M and E, WNV polyprotein prM-E, WNV polyprotein M-E, or WNV polyprotein prM-M-E. The composition can contain an adjuvant, such as carbomer. Methods for making and using such a composition, including prime-boost regimes and including as to differential diagnosis, are also contemplated.
摘要翻译：用于在易感WNV的动物中诱导针对西尼罗病毒（WNV）的免疫应答或保护性免疫应答的免疫原性或疫苗组合物。组合物包括药学上或兽医学上可接受的载体或赋形剂和载体。载体含有异源核酸分子，在体内在动物WNV抗原中表达，其免疫原或其表位，例如WNV E; WNV prM和E; WNV M和E; WNV prM，WNV M和E，WNV多聚蛋白prM-E，WNV多聚蛋白M-E或WNV多聚蛋白prM-M-E。组合物可以含有佐剂，如卡波姆。还考虑制备和使用这种组合物的方法，包括初始 - 加强方案和包括鉴别诊断。

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