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21. 发明授权

US08034395B2 Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof 有权
标题翻译：除了使用有机磷酸和有机膦酸的单层和多层及其盐的沉淀方法
公开(公告)号：US08034395B2
公开(公告)日：2011-10-11
申请号：US12662932
申请日：2010-05-12
申请人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
发明人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
IPC分类号： G01N1/28 , G02B6/00
CPC分类号： C23F11/1676 , A61B5/14546 , A61B5/415 , A61B17/68 , A61F2/30767 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00215 , A61F2310/00227 , A61F2310/00239 , A61F2310/00251 , A61F2310/00281 , A61F2310/00317 , A61F2310/00323 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00646 , A61F2310/00652 , A61F2310/00658 , A61F2310/00664 , A61F2310/00742 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/00778 , A61F2310/00784 , A61F2310/00874 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61F2310/00904 , A61F2310/0091 , A61F2310/00976 , A61L27/34 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C04B41/009 , C04B41/4994 , C04B41/84 , C04B2111/00836 , Y10T428/31678 , C04B35/01
摘要： The invention relates to a method for precipitating mono or multiple layers of a mixture of organophosphoric acids of the general formula I (A) Y—B—OPO3H2 (IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2 (IB) and the salts thereof, wherein Y and B are defined in the specification. According to the invention, precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices.
摘要翻译：本发明涉及使通式I（A）Y-B-OPO 3 H 2（IA）的有机磷酸或通式I（B）Y-B-的有机膦酸的混合物的单层或多层沉淀的方法， PO 3 H 2（IB）及其盐，其中Y和B在说明书中定义。根据本发明，在金属和半导体的纯或混合氧化物，氮化物或碳化物的基材表面上，特别是作为传感器平台，植入物和医疗附件装置的表面，发生沉淀。本发明还涉及其作为涂覆的传感器平台，植入物和医疗附件装置的一部分的用途。

22. 发明授权

US07740896B2 Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof 失效
公开(公告)号：US07740896B2
公开(公告)日：2010-06-22
申请号：US12230915
申请日：2008-09-08
申请人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
发明人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schürmann-Mader , Markus Ehrat , Samuele Tosatti
IPC分类号： G01N1/28 , G02B6/00
CPC分类号： C23F11/1676 , A61B5/14546 , A61B5/415 , A61B17/68 , A61F2/30767 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00215 , A61F2310/00227 , A61F2310/00239 , A61F2310/00251 , A61F2310/00281 , A61F2310/00317 , A61F2310/00323 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00646 , A61F2310/00652 , A61F2310/00658 , A61F2310/00664 , A61F2310/00742 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/00778 , A61F2310/00784 , A61F2310/00874 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61F2310/00904 , A61F2310/0091 , A61F2310/00976 , A61L27/34 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C04B41/009 , C04B41/4994 , C04B41/84 , C04B2111/00836 , Y10T428/31678 , C04B35/01
摘要： The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A) Y—B—OPO3H2 (IA) or of organophosphonic acids of the general formula I (B) Y—B—PO3H2 (IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more —CH2— groups. According to the invention, said precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, comprising the use of water-soluble salts of a compound of formula (IA) or (IB) for the treatment of these surfaces, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices in addition to new organophosphoric acids and organophosphonic acids themselves. The optionally substituted compounds of formulae (IA) and (IB) wherein the B and Y groups have the above-mentioned designations, i.e. optionally substituted alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetaryl, are hereinafter referred to as organophosphoric acids and organophosphonic acids.

23. 发明申请

US20030186914A1 Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof 失效
公开(公告)号：US20030186914A1
公开(公告)日：2003-10-02
申请号：US10363555
申请日：2003-03-05
发明人： Rolf Hofer , Michael Pawlak , Marcus Textor , Eveline Schurmann-Mader , Markus Ehrat , Samuele Tosatti
IPC分类号： A61K048/00 , A61K009/32
CPC分类号： C23F11/1676 , A61B5/14546 , A61B5/415 , A61B17/68 , A61F2/30767 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00215 , A61F2310/00227 , A61F2310/00239 , A61F2310/00251 , A61F2310/00281 , A61F2310/00317 , A61F2310/00323 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00646 , A61F2310/00652 , A61F2310/00658 , A61F2310/00664 , A61F2310/00742 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/00778 , A61F2310/00784 , A61F2310/00874 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61F2310/00904 , A61F2310/0091 , A61F2310/00976 , A61L27/34 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C04B41/009 , C04B41/4994 , C04B41/84 , C04B2111/00836 , Y10T428/31678 , C04B35/01
摘要： The invention relates to a method for precipitating mono or multiple layers of organophosphoric acids of the general formula I (A)YnullBnullOPO3 H2 nullnull(IA)or of organophosphonic acids of the general formula I (B)YnullBnullPO3 H2 nullnull(IB)and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetarylalkyl residue and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl-substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulfate, sulfonate, maleimide, succinimydyl, epoxy, acrylate series, wherein a biological, biochemical or synthetic indicator element may be coupled to B or Y by addition or substitution reaction, wherein compounds may also be added conferring the substrate surface a resistance to protein adsorption and/or to cell adhesion and in the B chain may optionally be comprised one or more ethylene oxide groups, rather than one or more nullCH2null groups. According to the invention, said precipitation occurs on substrate surfaces of pure or mixed oxides, nitrides or carbides of metals and semiconductors, comprising the use of water-soluble salts of a compound of formula (IA) or (IB) for the treatment of these surfaces, in particular as surfaces of sensor platforms, implants and medical accessory devices. The invention also relates to the use thereof as part of coated sensor platforms, implants and medical accessory devices in addition to new organophosphoric acids and organophosphonic acids themselves. The optionally substituted compounds of formulae (IA) and (IB) wherein the B and Y groups have the above-mentioned designations, i.e. optionally substituted alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetaryl, are hereinafter referred to as organophosphoric acids and organophosphonic acids.

24. 发明授权

US06534197B2 Biomedical implant material and method of producing the same 失效
标题翻译：生物医学植入材料及其制造方法
公开(公告)号：US06534197B2
公开(公告)日：2003-03-18
申请号：US09818054
申请日：2001-03-26
申请人： Iwao Noda , Junji Ikeda , Takefumi Nakanishi , Hiroyuki Kitano , Shingo Masuda
发明人： Iwao Noda , Junji Ikeda , Takefumi Nakanishi , Hiroyuki Kitano , Shingo Masuda
IPC分类号： B32B900
CPC分类号： C04B41/90 , A61C13/0003 , A61C13/0006 , A61F2/30767 , A61F2/3094 , A61F2002/30929 , A61F2002/3098 , A61F2002/30981 , A61F2310/00203 , A61F2310/00227 , A61F2310/00239 , A61F2310/00281 , A61F2310/00311 , A61F2310/00317 , A61F2310/00323 , A61F2310/00401 , A61F2310/00407 , A61F2310/00413 , A61F2310/00431 , A61F2310/00437 , A61F2310/00485 , A61F2310/00491 , A61F2310/00497 , A61F2310/00514 , A61F2310/0052 , A61F2310/00544 , A61F2310/0055 , A61F2310/00568 , A61F2310/00604 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/00742 , A61F2310/00796 , A61F2310/00868 , A61F2310/00874 , A61F2310/0088 , A61F2310/00928 , A61L27/04 , A61L27/10 , A61L27/105 , A61L27/306 , A61L27/42 , A61L2420/08 , C04B41/009 , C04B41/52 , C04B2111/00405 , C04B2111/00836 , Y10T428/2405 , C04B41/4529 , C04B41/5133 , C04B41/5068 , C04B41/522 , C04B41/4527 , C04B41/5048 , C04B35/10 , C04B35/00 , C04B35/48
摘要： The present invention provides a biomedical implant material comprising a substrate for biomedical implant made of a ceramic material, a first coating layer formed on the surface of said substrate by low-thermal impact coating process, and a second coating layer formed on said first coating layer via a metallic layer formed by thermal spraying process, and a method of producing the same. According to the biomedical implant material, it is made possible to prevent cracks from occurring in the ceramic substrate, and to secure sufficient bonding strength between the thermal-sprayed layer of titanium or the like onto the ceramic substrate.
摘要翻译：本发明提供了一种生物医学植入材料，其包括由陶瓷材料制成的用于生物医学植入物的基底，通过低热冲击涂覆法形成在所述基底的表面上的第一涂层，以及形成在所述第一涂层上的第二涂层通过热喷涂法形成的金属层及其制造方法。根据生物医学植入材料，可以防止在陶瓷基板中发生裂纹，并且确保钛等的热喷涂层在陶瓷基板上的充分的接合强度。

25. 发明授权

US5849206A Method of producing a biocompatible prosthesis 失效
标题翻译：制备生物相容性假体的方法
公开(公告)号：US5849206A
公开(公告)日：1998-12-15
申请号：US794375
申请日：1997-02-04
申请人： Michael Amon , Armin Bolz
发明人： Michael Amon , Armin Bolz
IPC分类号： A61F2/00 , A61F2/82 , A61L27/30 , A61L31/08 , A61L33/02 , C23C16/02 , C23C16/32 , H01L21/308
CPC分类号： A61F2/82 , A61L27/306 , A61L31/088 , A61L33/027 , C23C16/0245 , C23C16/0272 , C23C16/325 , A61F2/0077 , A61F2240/001 , A61F2310/00742
摘要： A method of producing a biocompatible prosthesis based on a substrate made essentially of metal or ceramic. The substrate is placed into a reactor chamber of a cathodic vapor deposition arrangement and the chamber is evacuated to a predetermined pressure. A predetermined, negative bias voltage is then applied to the substrate and the substrate is surface treated by adding an etching gas to the reactor chamber, at a predetermined, first flow rate and coupling in a high frequency power with a first, predetermined power density for ionic etching for a first, predetermined period of time. The surface treated substrate is separated from the negative bias voltage and a semiconductor cover layer is chemical vapor-phase deposited on the substrate by adding to the reactor chamber a multi-component mixture of process gases containing a semiconductor element in bound form at a second, predetermined flow rate and coupling-in of HF power with a predetermined, second power density, for a second, predetermined time period.
摘要翻译：一种生产基于由金属或陶瓷制成的基底的生物相容性假体的方法。将衬底放置在阴极气相沉积装置的反应室中，并将室抽真空至预定压力。然后将预定的负偏置电压施加到衬底，并且通过以预定的第一流量向反应器室中加入蚀刻气体并以高频功率与第一预定功率密度耦合来对衬底进行表面处理，用于离子蚀刻第一预定时间段。将经表面处理的衬底与负偏压分离，并且半导体覆盖层通过向反应器室中加入含有在第二个结合形式的半导体元件的工艺气体的多组分混合物而化学气相沉积在衬底上，预定的流量和具有预定的第二功率密度的HF功率的耦合进入第二预定时间段。

26. 发明授权

US5735896A Biocompatible prosthesis 失效
标题翻译：生物相容性假体
公开(公告)号：US5735896A
公开(公告)日：1998-04-07
申请号：US417966
申请日：1995-04-06
申请人： Michael Amon , Armin Bolz
发明人： Michael Amon , Armin Bolz
IPC分类号： A61F2/00 , A61F2/82 , A61L27/30 , A61L31/08 , A61L33/02 , C23C16/02 , C23C16/32 , A61F2/02 , A61F2/04
CPC分类号： A61F2/82 , A61L27/306 , A61L31/088 , A61L33/027 , C23C16/0245 , C23C16/0272 , C23C16/325 , A61F2/0077 , A61F2240/001 , A61F2310/00742
摘要： A method of producing a biocompatible prosthesis based on a substrate made essentially of metal or ceramic. The substrate is placed into a reactor chamber of a cathodic vapor deposition arrangement and the chamber is evacuated to a predetermined pressure. A predetermined, negative bias voltage is then applied to the substrate and the substrate is surface treated by adding an etching gas to the reactor chamber, at a predetermined, first flow rate and coupling in a high frequency power with a first, predetermined power density for ionic etching for a first, predetermined period of time. The surface treated substrate is separated from the negative bias voltage and a semiconductor cover layer is chemical vapor-phase deposited on the substrate by adding to the reactor chamber a multi-component mixture of process gases containing a semiconductor element in bound format a second, predetermined flow rate and coupling-in of HF power with a predetermined, second power density, for a second, predetermined time period.
摘要翻译：一种生产基于由金属或陶瓷制成的基底的生物相容性假体的方法。将衬底放置在阴极气相沉积装置的反应室中，并将室抽真空至预定压力。然后将预定的负偏置电压施加到衬底，并且通过以预定的第一流量向反应器室中加入蚀刻气体并以高频功率与第一预定功率密度耦合来对衬底进行表面处理，用于离子蚀刻第一预定时间段。将经表面处理的衬底与负偏压分离，并且半导体覆盖层通过向反应器室中加入含有结合形式的第二预定的半导体元件的工艺气体的多组分混合物而化学气相沉积在衬底上流量和具有预定的第二功率密度的HF功率的耦合进入第二预定时间段。

27. 发明公开

EP2651461A4 METHOD AND APPARATUS FOR A POROUS ORTHOPEDIC IMPLANT 审中-公开
标题翻译：方法和装置的多孔整形外科植入物
公开(公告)号：EP2651461A4
公开(公告)日：2014-06-18
申请号：EP11848047
申请日：2011-12-15
申请人： BIO2 TECHNOLOGIES INC
发明人： LIU JAMES JENQ
IPC分类号： A61L27/08 , A61F5/01 , A61L27/14
CPC分类号： A61F2/30767 , A61F2/30907 , A61F2/4241 , A61F2002/30929 , A61F2002/30968 , A61F2002/4256 , A61F2310/00161 , A61F2310/00742 , A61F2310/00796 , A61L27/08 , A61L27/30 , A61L27/306 , A61L27/32 , A61L27/56 , A61L2430/02

28. 发明授权

EP1315968B1 VERFAHREN ZUR ABSCHEIDUNG VON MONO- UND MEHRFACHSCHICHTEN VON ORGANOPHOSPHOR- UND -PHOSPHONSÄUREN UND DEREN SALZEN SOWIE DEREN VERWENDUNG 有权
标题翻译：工艺单声道和有机磷和膦多层及其盐，以及它们的使用分离
公开(公告)号：EP1315968B1
公开(公告)日：2008-02-13
申请号：EP01969680.6
申请日：2001-08-31
申请人： Bayer Technology Services GmbH
发明人： HOFER, Rolf , PAWLAK, Michael , TEXTOR, Marcus , SCHÜRMANN-MADER, Eveline , EHRAT, Markus , TOSATTI, Samuele
IPC分类号： G01N33/544 , G01N33/551 , A61L27/30 , A61L29/10 , A61L31/08 , A61L33/00
CPC分类号： C23F11/1676 , A61B5/14546 , A61B5/415 , A61B17/68 , A61F2/30767 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00215 , A61F2310/00227 , A61F2310/00239 , A61F2310/00251 , A61F2310/00281 , A61F2310/00317 , A61F2310/00323 , A61F2310/0061 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00646 , A61F2310/00652 , A61F2310/00658 , A61F2310/00664 , A61F2310/00742 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/00778 , A61F2310/00784 , A61F2310/00874 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61F2310/00904 , A61F2310/0091 , A61F2310/00976 , A61L27/34 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C04B41/009 , C04B41/4994 , C04B41/84 , C04B2111/00836 , Y10T428/31678 , C04B35/01
摘要： The invention relates to a method for precipitating mono or multiple layers of organophosphosphoric acids of general formula (I(A)) Y-B-OPO3 H2 (IA) or organophosphonic acids of general formula (I(B)) Y-B-PO3 H2 (IB) and the salts thereof, wherein B is an alkyl, alkenyl, alkinyl, aryl, aralkyl, hetaryl or hetaryl alkyl radical and Y is hydrogen or a functional group from the hydroxy, carboxy, amino, optionally low-alkyl- substituted mono or dialkylamino series, thiol, or a negative acid group from the ester, phosphate, phosphonate, sulphate, sulphonate, maleimide, succinimydyl, epoxy, acrylate series. A biological, biochemical or synthetic indicator element can be coupled to B or Y as addition or substitution reaction, whereby compounds can also be added imparting on the substrate surface a resistance against protein absorption and/or cell adhesion and in the B chain can be, optionally, composed of one or more ethylene oxide groups rather than one or more CH2 groups. According to the invention, said precipitation occurs on the surfaces of the substrates of pure or mixed oxides, nitrides or carbides of metals and semi-conductors. The invention is characterised in that the water-soluble salts composed of formula (IA) or (IB) are used to treat said surfaces, especially the surfaces of sensor platforms, implants and medical accessory devices.

29. 发明授权

EP0712943B1 Verfahren zur Herstellung einer nichtkollabierenden intravasalen Gefässprothese (Stent) 失效
标题翻译：用于制备nichtkollabierenden血管内血管假体的方法（支架）
公开(公告)号：EP0712943B1
公开(公告)日：2003-06-18
申请号：EP95250199.7
申请日：1995-08-15
申请人： BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro Berlin
发明人： Amon, Michael , Bolz, Armin
IPC分类号： C23C16/32 , C23C16/02 , A61L31/00 , A61L27/00 , A61L33/00
CPC分类号： A61F2/82 , A61F2/0077 , A61F2240/001 , A61F2310/00742 , A61L27/306 , A61L31/088 , A61L33/027 , C23C16/0245 , C23C16/0272 , C23C16/325

30. 发明公开

EP0884987A1 EXPANDIERBARE INTRALUMINALE VORRICHTUNG 失效
标题翻译：可膨胀腔内装置
公开(公告)号：EP0884987A1
公开(公告)日：1998-12-23
申请号：EP97949871.0
申请日：1997-10-28
申请人： BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro Berlin
发明人： SCHMITZ, Klaus-Peter , BEHREND, Detlef
IPC分类号： A61F2
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2002/91566 , A61F2310/00742
摘要： The invention relates to an expandable interluminal device (1) for widening a receptacle, and has substantially the shape of a hollow cylinder with thin walls, the surface area of which is shaped like a net and bounded by segments (4,5). It has expandable stay configurations (3), each enclosing a recess. The rows, which extend axially (2), are connected to each other by segment-shaped coupling links (6) which extend in circumferential direction. The coupling links (6) are in each case fixed in the centre of the axially extending segments (4) by the segment configurations (3), which are adjacently arranged in circumferential direction and each enclose a recess. The expandable segment configurations (3, 12), which are arranged in rows (2, 13) and each enclose a recess, have a constriction (7, 7') substantially directed perpendicularly to their longitudinal axis.

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