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21. 发明授权

US07582645B2 Pyrimidine derivatives for treatment of hyperproliferative disorders 失效
标题翻译：嘧啶衍生物用于治疗过度增殖性疾病
公开(公告)号：US07582645B2
公开(公告)日：2009-09-01
申请号：US10573227
申请日：2004-10-08
申请人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion
发明人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion
IPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , A61K31/506 , A61K31/505 , A61P35/00
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译：式（I）的嘧啶衍生物，其中J和Y代表芳族或杂芳族环; R2，G，G'和G“表示取代基，R2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法。

22. 发明授权

US07557129B2 Cyanopyridine derivatives useful in the treatment of cancer and other disorders 有权
标题翻译：可用于治疗癌症和其他疾病的氰基吡啶衍生物
公开(公告)号：US07557129B2
公开(公告)日：2009-07-07
申请号：US10788029
申请日：2004-02-27
申请人： William J. Scott , Jacques Dumas , Stephen Boyer , Wendy Lee , Yuanwei Chen , Barton Phillips , Sharad Verma , Jianqing Chen , Zhi Chen , Jianmei Fan , Brian Raudenbush , Aniko Redman , Lin Yi , Qingming Zhu , Lila Adnane
发明人： William J. Scott , Jacques Dumas , Stephen Boyer , Wendy Lee , Yuanwei Chen , Barton Phillips , Sharad Verma , Jianqing Chen , Zhi Chen , Jianmei Fan , Brian Raudenbush , Aniko Redman , Lin Yi , Qingming Zhu , Lila Adnane
IPC分类号： A61K31/4433 , C07D405/12
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译：本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。

23. 发明授权

US06849638B2 4-AMINO-5,6-SUBSTITUTED THIOPHENO [2,3-D] PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND THEIR USE IN THE TREATMENT OR PREVENTION OF PDE7B-MEDIATED DISEASES AND CONDITIONS 失效
标题翻译： 4-氨基-5,6-取代的噻吩并[2,3-D]嘧啶，含有它们的药物组合物及其在治疗或预防PDE7B介导的疾病和病症中的用途
公开(公告)号：US06849638B2
公开(公告)日：2005-02-01
申请号：US10136575
申请日：2002-04-29
申请人： Andreas Stolle , Donald E. Bierer , Yuanwei Chen , Dongping Fan , Barry Hart , Mary Katherine Monahan , William J. Scott
发明人： Andreas Stolle , Donald E. Bierer , Yuanwei Chen , Dongping Fan , Barry Hart , Mary Katherine Monahan , William J. Scott
IPC分类号： A61K31/4365 , A61K31/519 , A61K31/5377 , A61K31/541 , A61P1/04 , A61P1/18 , A61P3/10 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/08 , A61P25/24 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D495/04 , C07D495/14 , C07D521/00
CPC分类号： C07D231/12 , A61K31/4365 , A61K31/519 , A61K31/5377 , A61K31/541 , C07D233/56 , C07D249/08 , C07D495/04 , C07D495/14
摘要： The invention relates to 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same and their use to treat or prevent diseases and conditions mediated by the phosphodiesterase enzyme 7B (PDE7B). Diseases and conditions mediated by PDE7B include osteoporosis, osteopenia and asthma.
摘要翻译：本发明涉及4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶，含有它们的药物组合物及其用于治疗或预防由磷酸二酯酶7B（PDE7B）介导的疾病和病症的用途。 PDE7B介导的疾病和病症包括骨质疏松症，骨质减少和哮喘。

24. 发明授权

US06518305B1 Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases 失效
标题翻译：神经氨酸酶的五元碳环和杂环抑制剂
公开(公告)号：US06518305B1
公开(公告)日：2003-02-11
申请号：US09422093
申请日：1999-10-19
申请人： Clarence J. Maring , Yuanwei Chen , David A. Degoey , Vincent L. Giranda , David J. Grampovnik , Yu Gui Gu , Warren M. Kati , Dale J. Kempf , April Kennedy , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Gary T. Wang , Sheldon Wang , Ming C. Yeung , Chen Zhao
发明人： Clarence J. Maring , Yuanwei Chen , David A. Degoey , Vincent L. Giranda , David J. Grampovnik , Yu Gui Gu , Warren M. Kati , Dale J. Kempf , April Kennedy , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Gary T. Wang , Sheldon Wang , Ming C. Yeung , Chen Zhao
IPC分类号： A61K31195
CPC分类号： C07D233/64 , C07B2200/07 , C07B2200/09 , C07C233/48 , C07C237/24 , C07C271/22 , C07C271/24 , C07C279/16 , C07C2601/08 , C07C2601/10 , C07D263/32 , C07D307/24 , C07D317/30 , C07D405/04
摘要： Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
摘要翻译：公开了下式的化合物：其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶。还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。

25. 发明授权

US5576174A Catalytic antibody with primary amine cofactor 失效
标题翻译：具有伯胺辅因子的催化抗体
公开(公告)号：US5576174A
公开(公告)日：1996-11-19
申请号：US417370
申请日：1995-04-05
申请人： Jean-Louis Reymond , Yuanwei Chen
发明人： Jean-Louis Reymond , Yuanwei Chen
IPC分类号： C12N9/00 , C12N9/88 , C12P7/26 , C12Q1/25
CPC分类号： C12P7/26 , C12N9/0002 , C12N9/88 , G01N2333/901
摘要： Antibodies raised against the quaternary piperidinium haptens are shown to catalyze the aldol stereoselective addition of acetone to aldehydes using the primary benzylamine as a cofactor.
摘要翻译：显示针对四哌啶鎓半抗原产生的抗体催化丙酮立体选择性加成醛，使用伯胺作为辅因子。

26. 发明授权

US5500358A Antibody catalysis of cyclohexadienone rearrangments 失效
标题翻译：抗体催化环己二烯酮重排
公开(公告)号：US5500358A
公开(公告)日：1996-03-19
申请号：US292934
申请日：1994-08-18
申请人： Jean-Louis Reymond , Yuanwei Chen , Richard A. Lerner
发明人： Jean-Louis Reymond , Yuanwei Chen , Richard A. Lerner
IPC分类号： C12N9/00 , C12P7/22
CPC分类号： C12N9/0002 , C12P7/22
摘要： Catalytic antibodies are employed for catalyzing rearrangement reactions involving carbon-carbon bonds. The catalytic antibodies are generated using haptens that are transition state analogs of the such rearrangement reactions. More particularly, the haptens dispslay an electrostatic complementarity with the transition state. Since the formation of a transient positive charge in the migrating bond is a general feature of nucleophilic 1,2-shifts, it is disclosed that haptens for generating catalytic antibody directed to such reactions must incorporate such charge. Antibody catalysis of the dienone-phenol rearrangement is shown to catalyze both the hydronium ion promoted pathway and the spontaneous rearrangement pathway, indicating that the antibody stabilizes the localized positive charge of the transition state.
摘要翻译：催化抗体用于催化涉及碳 - 碳键的重排反应。使用作为这种重排反应的过渡态类似物的半抗原产生催化抗体。更具体地，半抗原与过渡态分解静电互补。由于迁移键中的瞬时正电荷的形成是亲核1,2-位移的一般特征，因此公开了用于产生针对这种反应的催化抗体的半抗原必须包含这种电荷。显示了二烯酮 - 苯酚重排的抗体催化催化水合氢离子促进途径和自发重排途径，表明抗体稳定了过渡态的局部正电荷。

27. 发明申请

US20110098301A1 Pyrimidine Derivatives for Treatment of Hyperproliferative Disorders 审中-公开
标题翻译：嘧啶衍生物治疗过度增殖性疾病
公开(公告)号：US20110098301A1
公开(公告)日：2011-04-28
申请号：US11886132
申请日：2006-03-09
申请人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu
发明人： Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu
IPC分类号： A61K31/5377 , C07D401/12 , A61K31/506 , C07D401/14 , C07D239/48 , C07D403/12 , C07D413/14 , A61K31/496 , A61P35/00
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14
摘要： Pyrimidine derivatives of formula pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are disclosed and claimed.
摘要翻译：公开并要求保护含有这些化合物的配方药物组合物的嘧啶衍生物和使用这些化合物治疗过度增殖性疾病如癌症的方法。

28. 发明申请

US20090286785A1 Pyrimidine Derivatives 审中-公开
标题翻译：嘧啶衍生物
公开(公告)号：US20090286785A1
公开(公告)日：2009-11-19
申请号：US11887976
申请日：2006-04-07
申请人： Dhanapalan Nagarathnam , Yuanwei Chen , Wenlang Fu , Donald Bierer , Ming Wang , Michael Brands , Yamin Wang , Brian R. Bear
发明人： Dhanapalan Nagarathnam , Yuanwei Chen , Wenlang Fu , Donald Bierer , Ming Wang , Michael Brands , Yamin Wang , Brian R. Bear
IPC分类号： A61K31/5377 , C07D413/14 , A61P35/00 , C07D401/14 , A61K31/506
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14
摘要： This invention relates to novel compounds (I) and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
摘要翻译：本发明涉及新化合物（I）及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。

29. 发明申请

US20050277640A1 Pyrimidine derivatives for treatment of hyperproliferative disorders 失效
标题翻译：嘧啶衍生物用于治疗过度增殖性疾病
公开(公告)号：US20050277640A1
公开(公告)日：2005-12-15
申请号：US11078681
申请日：2005-03-10
申请人： Julie Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin Hentemann , Ann-Marie Bullion , Manoj Patel
发明人： Julie Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin Hentemann , Ann-Marie Bullion , Manoj Patel
IPC分类号： A61K31/506 , A61K31/5377 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D453/02 , C07D43/02
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译：式（I）的嘧啶衍生物，其中J和Y代表芳族或杂芳族环; R 2，G，G'和G“表示取代基，R 2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法。

30. 发明申请

US20050038031A1 Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders 有权
标题翻译：用于治疗癌症和其他疾病的新型双环脲衍生物
公开(公告)号：US20050038031A1
公开(公告)日：2005-02-17
申请号：US10788426
申请日：2004-03-01
申请人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger Smith , William Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
发明人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger Smith , William Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
IPC分类号： A61K31/335 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/444 , A61K31/4709 , A61K31/498 , A61K31/53 , A61K31/538 , A61K31/5415 , A61P35/00 , C07D213/68 , C07D213/79 , C07D213/84 , C07D251/02 , C07D333/66 , C07D401/12 , C07D405/12 , C07D417/12
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译：本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。

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