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1. 发明授权

US5500358A Antibody catalysis of cyclohexadienone rearrangments 失效
标题翻译：抗体催化环己二烯酮重排
公开(公告)号：US5500358A
公开(公告)日：1996-03-19
申请号：US292934
申请日：1994-08-18
申请人： Jean-Louis Reymond , Yuanwei Chen , Richard A. Lerner
发明人： Jean-Louis Reymond , Yuanwei Chen , Richard A. Lerner
IPC分类号： C12N9/00 , C12P7/22
CPC分类号： C12N9/0002 , C12P7/22
摘要： Catalytic antibodies are employed for catalyzing rearrangement reactions involving carbon-carbon bonds. The catalytic antibodies are generated using haptens that are transition state analogs of the such rearrangement reactions. More particularly, the haptens dispslay an electrostatic complementarity with the transition state. Since the formation of a transient positive charge in the migrating bond is a general feature of nucleophilic 1,2-shifts, it is disclosed that haptens for generating catalytic antibody directed to such reactions must incorporate such charge. Antibody catalysis of the dienone-phenol rearrangement is shown to catalyze both the hydronium ion promoted pathway and the spontaneous rearrangement pathway, indicating that the antibody stabilizes the localized positive charge of the transition state.
摘要翻译：催化抗体用于催化涉及碳 - 碳键的重排反应。使用作为这种重排反应的过渡态类似物的半抗原产生催化抗体。更具体地，半抗原与过渡态分解静电互补。由于迁移键中的瞬时正电荷的形成是亲核1,2-位移的一般特征，因此公开了用于产生针对这种反应的催化抗体的半抗原必须包含这种电荷。显示了二烯酮 - 苯酚重排的抗体催化催化水合氢离子促进途径和自发重排途径，表明抗体稳定了过渡态的局部正电荷。

2. 发明授权

US5576174A Catalytic antibody with primary amine cofactor 失效
标题翻译：具有伯胺辅因子的催化抗体
公开(公告)号：US5576174A
公开(公告)日：1996-11-19
申请号：US417370
申请日：1995-04-05
申请人： Jean-Louis Reymond , Yuanwei Chen
发明人： Jean-Louis Reymond , Yuanwei Chen
IPC分类号： C12N9/00 , C12N9/88 , C12P7/26 , C12Q1/25
CPC分类号： C12P7/26 , C12N9/0002 , C12N9/88 , G01N2333/901
摘要： Antibodies raised against the quaternary piperidinium haptens are shown to catalyze the aldol stereoselective addition of acetone to aldehydes using the primary benzylamine as a cofactor.
摘要翻译：显示针对四哌啶鎓半抗原产生的抗体催化丙酮立体选择性加成醛，使用伯胺作为辅因子。

3. 发明授权

US08129434B2 Benzylphenyl cyclohexane derivatives and methods of use 有权
标题翻译：苄基苯基环己烷衍生物和使用方法
公开(公告)号：US08129434B2
公开(公告)日：2012-03-06
申请号：US12333190
申请日：2008-12-11
申请人： Yuanwei Chen , Kun Peng , Lili Zhang , Binhua Lv , Baihua Xu , Jiajia Dong , Jiyan Du , Yan Feng , Ge Xu , Vasanthakumar Rajappan , Brian Seed
发明人： Yuanwei Chen , Kun Peng , Lili Zhang , Binhua Lv , Baihua Xu , Jiajia Dong , Jiyan Du , Yan Feng , Ge Xu , Vasanthakumar Rajappan , Brian Seed
IPC分类号： A61K31/015 , C07C15/12
CPC分类号： C07H7/04
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

4. 发明授权

US07795228B2 Spiroheterocyclic glycosides and methods of use 有权
标题翻译：螺杂环苷及其使用方法
公开(公告)号：US07795228B2
公开(公告)日：2010-09-14
申请号：US11964493
申请日：2007-12-26
申请人： Michael J. Hadd , Yuanwei Chen , Yan Feng , Sengen Sen , Brian Seed
发明人： Michael J. Hadd , Yuanwei Chen , Yan Feng , Sengen Sen , Brian Seed
IPC分类号： A01N43/04 , C07H1/00 , C07H3/00 , C08B37/00
CPC分类号： C07H17/04
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

5. 发明申请

US20090258888A1 Pyrimidine Derivatives 审中-公开
标题翻译：嘧啶衍生物
公开(公告)号：US20090258888A1
公开(公告)日：2009-10-15
申请号：US11918016
申请日：2006-04-07
申请人： Dhanapalan Nagarathnam , Yuanwei Chen , Wenlang Fu , Donald Bierer , Ming Wang , Michael Brands , Yamin Wang , Brian R. Bear , Aaron Schmitt , Eric Mull , David Miller , Jin Zhao
发明人： Dhanapalan Nagarathnam , Yuanwei Chen , Wenlang Fu , Donald Bierer , Ming Wang , Michael Brands , Yamin Wang , Brian R. Bear , Aaron Schmitt , Eric Mull , David Miller , Jin Zhao
IPC分类号： A61K31/506 , C07D239/46 , A61P35/00
CPC分类号： C07D401/12
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
摘要翻译：本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。

6. 发明授权

US06831096B2 Inhibitors of neuraminidases 有权
标题翻译：神经氨酸酶抑制剂
公开(公告)号：US06831096B2
公开(公告)日：2004-12-14
申请号：US10253152
申请日：2002-09-24
申请人： Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
发明人： Clarence J. Maring , Yu Gui Gu , Hui-Ju Chen , Yuanwei Chen , David A. Degoey , William J. Flosi , Vincent L. Giranda , David J. Grampovnik , Warren M. Kati , Dale J. Kempf , April Kennedy , Larry L. Klein , Allan C. Krueger , Zhen Lin , Darold L. Madigan , Keith F. McDaniel , Steven W. Muchmore , Hing L. Sham , Kent D. Stewart , Vincent S. Stoll , Minghua Sun , Noah P. Tu , Frank L. Wagenaar , Gary T. Wang , Sheldon Wang , Paul E. Wiedeman , Yibo Xu , Ming C. Yeung , Chen Zhao , Stephen Hanessian , Malken Bayrakdarian , Xuehong Luo
IPC分类号： A61K3140
CPC分类号： C07D207/16 , C07D207/26 , C07D207/327 , C07D207/38 , C07D207/46 , C07D231/12 , C07D233/56 , C07D249/08 , C07D303/16 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/04 , C07D417/04 , C07D417/06
摘要： Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
摘要翻译：公开了下式的化合物：其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶。还公开了用于预防和治疗由具有神经氨酸酶的微生物引起的疾病的组合物和方法，用于制备这些方法中使用的化合物和合成中间体的方法。

7. 发明授权

US08106021B2 Benzylbenzene derivatives and methods of use 有权
标题翻译：苄苯衍生物和使用方法
公开(公告)号：US08106021B2
公开(公告)日：2012-01-31
申请号：US12917367
申请日：2010-11-01
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

8. 发明授权

US08076488B2 Bicyclic urea derivatives useful in the treatment of cancer and other disorders 有权
标题翻译：用于治疗癌症和其他疾病的双环脲衍生物
公开(公告)号：US08076488B2
公开(公告)日：2011-12-13
申请号：US10788426
申请日：2004-03-01
申请人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger A. Smith , William J. Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
发明人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger A. Smith , William J. Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
IPC分类号： C07D213/62 , C07D401/00 , C07D417/00
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译：本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。

9. 发明授权

US07838499B2 Benzylbenzene derivatives and methods of use 有权
标题翻译：苄苯衍生物和使用方法
公开(公告)号：US07838499B2
公开(公告)日：2010-11-23
申请号：US12197095
申请日：2008-08-22
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael J. Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Y. Roberge
IPC分类号： A01N43/04 , A61K31/70 , C07H1/00 , C07H5/02
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

10. 发明授权

US07803778B2 Glucose transport inhibitors and methods of use 有权
标题翻译：葡萄糖转运抑制剂和使用方法
公开(公告)号：US07803778B2
公开(公告)日：2010-09-28
申请号：US11752226
申请日：2007-05-22
申请人： Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Jiajia Dong , Brian Seed , Michael J. Hadd
发明人： Yuanwei Chen , Yan Feng , Baihua Xu , Binhua Lv , Jiajia Dong , Brian Seed , Michael J. Hadd
IPC分类号： A01N43/04 , C07H1/00 , C07H3/00 , C08B37/00
CPC分类号： C07D311/96 , C07D407/12 , C07H7/04 , C07H19/00
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

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