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21. 发明申请

US20060014023A9 BIOABSORBABLE BRANCHED POLYMERS CONTAINING UNITS DERIVED FROM DIOXANONE AND MEDICAL/SURGICAL DEVICES MANUFACTURED THEREFROM 有权
标题翻译：包含二氧化钛衍生的单体的生物可分支聚合物及其制造的医疗/外科设备
公开(公告)号：US20060014023A9
公开(公告)日：2006-01-19
申请号：US10630945
申请日：2003-07-30
申请人： Steven Bennett , Kevin Connolly , Elliott Gruskin , Ying Jiang
发明人： Steven Bennett , Kevin Connolly , Elliott Gruskin , Ying Jiang
IPC分类号： B32B27/00
CPC分类号： C08G81/00 , A61L24/046 , C08G63/06 , C08G63/66 , C08G63/664 , C08G63/912 , Y10T428/31551 , C08L67/04
摘要： Star polymers of soft segment forming monomers are useful in forming surgical devices. The star polymers can be endcapped with isocyanate, mixed with a filler and/or cross-linked. The polymer compositions are useful, for example, as fiber coatings, surgical adhesives or bone putty, or tissue growth substrate.
摘要翻译：软链段形成单体的星形聚合物可用于形成外科装置。星形聚合物可以用异氰酸酯封端，与填料混合和/或交联。聚合物组合物可用作例如纤维涂层，手术粘合剂或骨腻子或组织生长底物。

22. 发明授权

US06339130B1 Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured therefrom 有权
标题翻译：含有衍生自二恶烷酮的单元的生物可吸收支化聚合物和由其制造的医疗/手术装置
公开(公告)号：US06339130B1
公开(公告)日：2002-01-15
申请号：US09282724
申请日：1999-03-31
申请人： Steven L. Bennett , Kevin Connolly , Elliott Gruskin , Ying Jiang
发明人： Steven L. Bennett , Kevin Connolly , Elliott Gruskin , Ying Jiang
IPC分类号： A61L2404
CPC分类号： C08G81/00 , A61L24/046 , C08G63/06 , C08G63/66 , C08G63/664 , C08G63/912 , Y10T428/31551 , C08L67/04
摘要： Star polymers of soft segment forming monomers are useful in forming surgical devices. The star polymers can be endcapped with isocyanate, mixed with a filler and/or cross-linked. The polymer compositions are useful, for example, as fiber coatings, surgical adhesives or bone putty, or tissue growth substrate.
摘要翻译：软链段形成单体的星形聚合物可用于形成外科装置。星形聚合物可以用异氰酸酯封端，与填料混合和/或交联。聚合物组合物可用作例如纤维涂层，手术粘合剂或骨腻子或组织生长底物。

23. 发明授权

US5939191A Coated gut suture 失效
标题翻译：涂层肠缝合
公开(公告)号：US5939191A
公开(公告)日：1999-08-17
申请号：US880303
申请日：1997-06-23
申请人： Steven L. Bennett , Ying Jiang , Mark S. Roby , Nagabhushanam Totakura
发明人： Steven L. Bennett , Ying Jiang , Mark S. Roby , Nagabhushanam Totakura
IPC分类号： A61L17/08 , A61L17/14 , C08G63/08 , C08G63/64 , C08G63/664 , C09D167/04 , B05D1/36 , A61B17/04
CPC分类号： A61L17/08 , A61L17/145 , C08G63/08 , C08G63/64 , C08G63/664 , C09D167/04 , Y10T428/2933 , Y10T428/2938 , Y10T428/2967
摘要： A gut suture is coated with a bioabsorbable copolymer obtained by polymerizing a major amount of .epsilon.-caprolactone and a minor amount of at least one other copolymerizable monomer in the presence of polyhydric alcohol as initiator. The coated gut suture can be packaged in the absence of conventional tubing fluid, i.e., in the dry state, while at the same time retaining flexibility, pliability and resistance to fray. In an alternative embodiment, a gut suture is coated with a pre-coating composition prior to being coated with the bioabsorbable copolymer.
摘要翻译：在多元醇作为引发剂的存在下，通过聚合主要量的ε-己内酯和少量的至少一种其它可共聚单体获得的生物可吸收共聚物涂布肠缝合线。涂覆的肠缝合线可以在不存在常规管道流体的情况下被包装，即处于干燥状态，同时保持柔韧性，柔韧性和抗磨损性。在替代实施例中，在用生物可吸收共聚物涂覆之前，用预涂组合物涂覆肠缝合线。

24. 发明授权

US5641502A Biodegradable moldable surgical material 失效
标题翻译：可生物降解的可成型外科材料
公开(公告)号：US5641502A
公开(公告)日：1997-06-24
申请号：US480084
申请日：1995-06-07
申请人： Walter Skalla , Steven L. Bennett , Ying Jiang
发明人： Walter Skalla , Steven L. Bennett , Ying Jiang
IPC分类号： A61L24/00 , A61L24/04 , A61L27/18 , A61L27/26 , A61L27/56 , A61L31/04 , A61L31/06 , A61F2/00 , A61L15/64
CPC分类号： A61L31/041 , A61L24/0036 , A61L24/043 , A61L24/046 , A61L27/18 , A61L27/26 , A61L27/56 , A61L31/06
摘要： A moldable biodegradable surgical material is made of a bioabsorbable polymer derived from hydroxyacids, tactones, carbonates, etheresters, anhydrides, orthoesters and copolymers, terpolymers and/or blends thereof, the polymer blended with at least one surface active agent selected from the group consisting of fatty acid ester and poly(oxypropylene)/poly(oxyethylene) block copolymer. In one embodiment, a leaching agent is blended with the above-mentioned surgical material. Methods of making moldable biodegradable surgical material are provided. The surgical material may be used as a moldable bone wax in connection with repair of wounds and is an adaptable aid for any appropriate surgical use, e.g., hemostat, anchor, patch etc.
摘要翻译：可成型的可生物降解手术材料由衍生自羟基酸，触媒，碳酸酯，醚类，酸酐，原酸酯和共聚物的生物可吸收聚合物，三聚物和/或其共混物制成，所述聚合物与至少一种选自以下的表面活性剂共混脂肪酸酯和聚（氧丙烯）/聚（氧乙烯）嵌段共聚物。在一个实施方案中，将浸出剂与上述手术材料混合。提供可模制生物降解外科手术材料的制备方法。外科手术材料可以用作与伤口修复相关的可模制骨蜡，并且是用于任何合适手术用途的适应性辅助，例如止血剂，锚固剂，贴剂等。

25. 发明授权

US5483009A Polymer derived from cyclic amide and medical devices manufactured therefrom 失效
标题翻译：衍生自环状酰胺的聚合物和由其制造的医疗器械
公开(公告)号：US5483009A
公开(公告)日：1996-01-09
申请号：US423171
申请日：1995-04-18
申请人： Ying Jiang
发明人： Ying Jiang
IPC分类号： A61L17/10 , A61L31/06 , C08G69/14 , C08F267/10 , A61B19/00
CPC分类号： C08G69/14 , A61L17/10 , A61L31/06
摘要： A moldable and/or extrudable polymer which is useful for the manufacture of surgical devices such as sutures, staples, clips, etc., possesses structural units derived from a cyclic amide monomer containing oxygen, sulfur or nitrogen in the ring.
摘要翻译：可用于制造诸如缝合线，缝钉，夹子等的外科装置的可成型和/或可挤出的聚合物具有衍生自在环中含有氧，硫或氮的环酰胺单体的结构单元。

26. 发明授权

US5349045A Polymer derived from cyclic amide and medical devices manufactured therefrom 失效
标题翻译：衍生自环状酰胺的聚合物和由其制造的医疗器械
公开(公告)号：US5349045A
公开(公告)日：1994-09-20
申请号：US9122
申请日：1993-01-26
申请人： Ying Jiang
发明人： Ying Jiang
IPC分类号： A61L17/10 , A61L31/06 , C08G69/14
CPC分类号： C08G69/14 , A61L17/10 , A61L31/06
摘要： A moldable and/or extrudable polymer which is useful for the manufacture of surgical devices such as sutures, staples, clips, etc., possesses structural units derived from a cyclic amide monomer containing oxygen, sulfur or nitrogen in the ring.
摘要翻译：可用于制造诸如缝合线，缝钉，夹子等的外科装置的可成型和/或可挤出的聚合物具有衍生自在环中含有氧，硫或氮的环酰胺单体的结构单元。

27. 发明申请

US20060293406A1 Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured therefrom 失效
公开(公告)号：US20060293406A1
公开(公告)日：2006-12-28
申请号：US11511133
申请日：2006-08-28
申请人： Steven Bennett , Kevin Connolly , Elliott Gruskin , Ying Jiang
发明人： Steven Bennett , Kevin Connolly , Elliott Gruskin , Ying Jiang
IPC分类号： A61L17/00 , A61L27/00
CPC分类号： C08G81/00 , A61L24/046 , C08G63/06 , C08G63/66 , C08G63/664 , C08G63/912 , Y10T428/31551 , C08L67/04
摘要： Star polymers of soft segment forming monomers are useful in forming surgical devices. The star polymers can be endcapped with isocyanate, mixed with a filler and/or cross-linked. The polymer compositions are useful, for example, as fiber coatings, surgical adhesives or bone putty, or tissue growth substrate.

28. 发明授权

US07097907B2 Bioabsorbable branched polymers containing units derived from dioxanone and medical/surgical devices manufactured therefrom 有权
公开(公告)号：US07097907B2
公开(公告)日：2006-08-29
申请号：US10630945
申请日：2003-07-30
申请人： Steven L. Bennett , Kevin Connolly , Elliott Gruskin , Ying Jiang
发明人： Steven L. Bennett , Kevin Connolly , Elliott Gruskin , Ying Jiang
IPC分类号： A61L31/10 , C09D167/04
CPC分类号： C08G81/00 , A61L24/046 , C08G63/06 , C08G63/66 , C08G63/664 , C08G63/912 , Y10T428/31551 , C08L67/04
摘要： Star polymers of soft segment forming monomers are useful in forming surgical devices. The star polymers can be endcapped with isocyanate, mixed with a filler and/or cross-linked. The polymer compositions are useful, for example, as fiber coatings, surgical adhesives or bone putty, or tissue growth substrate.

29. 发明授权

US06277927B1 Absorbable block copolymers and surgical articles fabricated therefrom 有权
标题翻译：可吸收嵌段共聚物和由其制造的外科用品
公开(公告)号：US06277927B1
公开(公告)日：2001-08-21
申请号：US09198035
申请日：1998-11-23
申请人： Mark S. Roby , Ying Jiang
发明人： Mark S. Roby , Ying Jiang
IPC分类号： C08G6308
CPC分类号： A61L17/12 , C08G63/08
摘要： Block copolymers wherein the first block contains from about 20 to about 80 mole percent of repeating units derived from lactide randomly combined with from about 20 to 80 mole percent of repeating units derived from glycolide and the second block contains repeating units derived from lactide and repeating units derived from other bioabsorbable monomeric units, such as glycolide, the second block containing a higher proportion of repeating units derived from lactide than the first block, with units derived from lactide constituting from about 40 to about 90 mole percent of the entire block copolymer are useful in forming surgical articles, including sutures.
摘要翻译：嵌段共聚物，其中第一嵌段含有约20至约80摩尔％的衍生自丙交酯的重复单元与约20至80摩尔％的衍生自乙交酯的重复单元随机组合，第二嵌段含有衍生自丙交酯和重复单元的重复单元衍生自其它生物可吸收单体单元如乙交酯，第二嵌段含有比第一嵌段衍生自丙交酯的更高比例的重复单元，衍生自构成整个嵌段共聚物的约40至约90摩尔％的丙交酯的单元是有用的在形成外科用品时，包括缝线。

30. 发明授权

US06177094B1 Bioabsorbable blends and coating composition containing same 有权
标题翻译：生物可吸收的混合物和含有它们的涂料组合物
公开(公告)号：US06177094B1
公开(公告)日：2001-01-23
申请号：US09243123
申请日：1999-01-29
申请人： Ying Jiang
发明人： Ying Jiang
IPC分类号： A61F202
CPC分类号： A61L17/145 , A61B17/06166 , A61B2017/00004
摘要： A bioabsorbable blend is provided which comprises the reaction product of 1) a bioabsorbable copolymer obtained by polymerizing a major amount of epsilon-caprolactone and a minor amount of at least one other copolymerizable monomer in the presence of a polyhydric alcohol initiator and 2) the reaction product obtained by mixing polyalkylene glycol and a coplymer of glycolide/lactide copolymer. The blend has many uses, including that of a coating for a surgical suture.
摘要翻译：提供了一种生物可吸收的共混物，其包含以下反应产物：1）通过在多元醇引发剂的存在下聚合主要量的ε-己内酯和少量至少一种其它可共聚单体获得的生物可吸收共聚物和2）反应通过混合聚亚烷基二醇和乙交酯/丙交酯共聚物的共聚物获得的产物。该混合物具有许多用途，包括用于外科缝合线的涂层。

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