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    • 4. 发明授权
    • Biocompatible hydrogels made with small molecule precursors
    • 用小分子前体制备的生物相容性水凝胶
    • US08003705B2
    • 2011-08-23
    • US12156085
    • 2008-05-29
    • Amarpreet S. SawhneySteven BennettPeter G. Edelman
    • Amarpreet S. SawhneySteven BennettPeter G. Edelman
    • A61K47/30A61K47/32A61K47/34
    • A61K47/42A61K9/0014A61K9/0019A61L27/52A61L27/58A61L31/145A61L31/148C07K14/75C08L89/00C08L2666/02
    • Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable, or not, are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers. Embodiments that include hydrogels having isolated hydrolytically degradable esters are set forth. Embodiments including the use of low molecular weight amines to make degradable hydrogels are also set forth.
    • 公开了生物相容的交联聚合物及其制备和使用的方法,其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子和亲核官能团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解的方法也可以提供,以及用于控制降解速率的方法。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送,术后粘连的预防,医疗装置如血管移植物,伤口敷料和手术密封剂的涂覆。 可交联剂可以与交联聚合物一起包含。 阐述包括具有分离的水解可降解酯的水凝胶的实施方案。 还阐述了包括使用低分子量胺来制备可降解水凝胶的实施方案。