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21. 发明申请

US20100305402A1 METHOD AND APPARATUS FOR MAGNETIC WAVEGUIDE FORMING A SHAPED FIELD EMPLOYING A MAGNETIC APERTURE FOR GUIDING AND CONTROLLING A MEDICAL DEVICE 审中-公开
标题翻译：用于形成用于引导和控制医疗装置的磁性孔的形成磁场的方法和装置
公开(公告)号：US20100305402A1
公开(公告)日：2010-12-02
申请号：US12475370
申请日：2009-05-29
申请人： Yehoshua Shachar , Laszlo Farkas , Leslie Farkas
发明人： Yehoshua Shachar , Laszlo Farkas , Leslie Farkas
IPC分类号： A61B1/00 , H01F3/00
CPC分类号： A61B1/00158 , A61B5/05 , A61B5/062 , A61B34/73 , A61B2034/731 , A61M25/0127
摘要： A system that uses a magnetic aperture and electromagnets to configure a magnetic shaped field is described. In one embodiment, the system can be used for guiding a catheter or other devices through a patient's body. In further modification of the system, the waveguide field and field gradient is achieved by the use of varying the electromagnetic wave and its respective flux density axis. In one embodiment, one or more magnetic pole pieces (electromagnet cores) are configured with anisotropic permeability to control the shape of the resulting magnetic field. In one embodiment, the shape and permeability distribution in an electromagnet poleface is configured to produce the desired field distribution. In one embodiment, a number of electromagnets are arranged in a spherical pattern to produce a desired magnetic field in an enclosed spherical region. In one embodiment, a distal end of a catheter is provided with a plurality of magnets having different coercivity to allow improved control of the position and orientation of the distal end
摘要翻译：描述了使用磁性孔和电磁体来构造磁场的系统。在一个实施例中，系统可用于通过患者身体引导导管或其他装置。在系统的进一步修改中，通过使用改变电磁波及其各自的磁通密度轴来实现波导场和场梯度。在一个实施例中，一个或多个磁极片（电磁铁芯）被构造为具有各向异性磁导率以控制所得到的磁场的形状。在一个实施例中，电磁铁极面中的形状和磁导率分布被配置为产生所需的场分布。在一个实施例中，多个电磁体被布置成球形图案以在封闭的球形区域中产生期望的磁场。在一个实施例中，导管的远端设置有具有不同矫顽力的多个磁体，以允许改善对远端的位置和取向的控制

22. 发明授权

US07799016B2 Magnetic breather pump and a method for treating a brain tumor using the same 有权
标题翻译：磁性呼吸泵和使用其治疗脑肿瘤的方法
公开(公告)号：US07799016B2
公开(公告)日：2010-09-21
申请号：US12143720
申请日：2008-06-20
申请人： Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Bruce Marx , David Johnson , Laszlo Farkas
发明人： Yehoshua Shachar , Thomas C. Chen , Leslie Farkas , Bruce Marx , David Johnson , Laszlo Farkas
IPC分类号： A61K9/22
CPC分类号： A61M5/16827 , A61M5/14276 , A61M2210/0693
摘要： A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, a medicating agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.
摘要翻译：将磁力控制的泵植入患者的脑中，并以对应于患者的特定需要的受控速率递送多个治疗剂。本发明包括由两层聚合物形成的柔性双壁袋。该小袋由磁性螺线管交替地膨胀和收缩。当收缩时，通过多根针将药剂从袋中推出。当袋膨胀时，将周围的脑液吸入小袋的双壁之间的空间，通过导管将其从拉伸到分析器。分析从患者抽取的脑液。基于这些测量，该装置的操作以及因此的处理被远程控制并通过外部控制器显示。

23. 发明申请

US20090275828A1 METHOD AND APPARATUS FOR CREATING A HIGH RESOLUTION MAP OF THE ELECTRICAL AND MECHANICAL PROPERTIES OF THE HEART 审中-公开
标题翻译：用于创建心脏电气和机械特性的高分辨率图的方法和装置
公开(公告)号：US20090275828A1
公开(公告)日：2009-11-05
申请号：US12113804
申请日：2008-05-01
申请人： Yehoshua Shachar , Bruce Marx , Laszlo Farkas , David Johnson , Leslie Farkas
发明人： Yehoshua Shachar , Bruce Marx , Laszlo Farkas , David Johnson , Leslie Farkas
IPC分类号： A61B5/00 , A61B5/053
CPC分类号： A61B5/0422 , A61B5/0452 , A61B5/053 , A61B5/0538 , A61B5/062 , A61B5/1107 , A61B5/6885 , A61B2034/2051
摘要： A system method that tracks one or more points on the surface of a cardiac tissue throughout a cardiac cycle and collect various types of data points which are then subsequently used to generate a corresponding model of the tissue and display the model as a 3D color coded image is described. In one embodiment, the system determines the position and orientation of a distal tip of a catheter, manipulates the catheter tip so as to maintain constant contact between the tip and a region of cardiac tissue using the impedance method, acquires positional and electrical data of the tip-tissue configuration through an entire heartbeat cycle, repeats the measurements as many times as needed in different tissue regions, and forms a 3D color coded map displaying various mechanical and electrical properties of the heart using the acquired data.
摘要翻译：一种跟踪心脏周围心脏组织表面上的一个或多个点的系统方法，并收集各种类型的数据点，然后随后使用这些数据点来生成组织的相应模型并将该模型显示为3D彩色编码图像被描述。在一个实施例中，系统确定导管的远侧末端的位置和取向，操纵导管尖端，以便使用阻抗方法保持尖端与心脏组织区域之间的恒定接触，获取位置和电气数据通过整个心跳周期的尖端组织配置，在不同组织区域中根据需要重复测量多次，并且使用获取的数据形成显示心脏的各种机械和电学性质的3D颜色编码图。

24. 发明申请

US20080249395A1 METHOD AND APPARATUS FOR CONTROLLING CATHETER POSITIONING AND ORIENTATION 审中-公开
标题翻译：用于控制导管定位和定向的方法和装置
公开(公告)号：US20080249395A1
公开(公告)日：2008-10-09
申请号：US11697690
申请日：2007-04-06
申请人： Yehoshua Shachar , Bruce Marx , Leslie Farkas
发明人： Yehoshua Shachar , Bruce Marx , Leslie Farkas
IPC分类号： A61B5/05
CPC分类号： A61B5/06 , A61B5/062 , A61B5/7285 , A61B34/20 , A61B34/25 , A61B34/76 , A61B90/36 , A61B2017/00703 , A61B2034/102 , A61B2034/105 , A61B2034/107 , A61B2034/2051
摘要： A method and apparatus for detecting position and orientation of catheter distal magnetic element end while moving in a patient's heart is described. The apparatus includes magnetic sensors for to detect the magnetic field of a generated by the catheter tip. Each sensor transmits the field magnitude and direction to a detection unit, which filters the signals and removes other field sources, such as generated by CGCI coils and external medical hardware. The method allows the measurements of magnitude corresponding to the catheter tip distance from the sensor and the orientation of the field showing the magnetic tip orientation. Since the tip's magnetic field is not necessarily symmetric, the position and orientation computation technique are not independent of each other. Hence, an iterative calculation is used to converge to a solution. The method of determining tip position is calculated by triangulation from each sensor. In one embodiment, the tip orientation is calculated by an intersecting-planes algorithm. The orientation is used to adjust the distances from each sensor, and the process is repeated until convergence for both position and orientation is achieved. The resultant value provides the actual catheter tip position and orientation (AP). The actual position is further filtered by synchronizing the AP measurements with the QRS signal of the heart, allowing the operator and CGCI controller to view the organ as a static object.
摘要翻译：描述了一种用于在患者心脏中移动时检测导管远侧磁性元件端部的位置和方向的方法和装置。该装置包括用于检测由导管尖端产生的磁场的磁传感器。每个传感器将场强和方向传送到检测单元，该检测单元对信号进行滤波并去除诸如由CGCI线圈和外部医疗硬件产生的其它场源。该方法允许测量对应于来自传感器的导管尖端距离的大小以及示出磁性尖端取向的场的取向。由于尖端的磁场不一定是对称的，因此位置和方向计算技术不是彼此独立的。因此，迭代计算用于收敛到解。通过每个传感器的三角测量来计算尖端位置的方法。在一个实施例中，通过相交平面算法来计算尖端取向。该方向用于调整每个传感器的距离，重复该过程，直到达到位置和方向的收敛。所得到的值提供实际的导管尖端位置和取向（AP）。通过将AP测量与心脏的QRS信号同步来进一步滤除实际位置，允许操作者和CGCI控制器将器官视为静态对象。

25. 发明授权

US08986214B2 System and method for using tissue contact information in an automated mapping of cardiac chambers employing magnetically shaped fields 有权
标题翻译：在使用磁性场的心室的自动测绘中使用组织接触信息的系统和方法
公开(公告)号：US08986214B2
公开(公告)日：2015-03-24
申请号：US12707085
申请日：2010-02-17
申请人： Yehoshua Shachar , Bruce Marx , Leslie Farkas , Eli Gang , Laszlo Farkas
发明人： Yehoshua Shachar , Bruce Marx , Leslie Farkas , Eli Gang , Laszlo Farkas
IPC分类号： A61B5/02 , A61B5/053 , A61B5/06 , A61B5/107 , A61B5/00 , A61B5/0402
CPC分类号： A61B5/0538 , A61B5/0402 , A61B5/06 , A61B5/062 , A61B5/1075 , A61B5/6851 , A61B5/6852 , A61B5/6869 , A61B5/6885
摘要： The invention relates to a method for using tissue contact technology to optimize automated cardiac chamber mapping algorithms to both speed up the mapping process and guarantee the definition of the actual chamber limits. The invention further comprises a method for conveying tissue type information to such automatic mapping algorithms so as to allow them to adapt their point collection density within areas of particular interest. The method is enhanced by the use of a magnetic chamber that employs electromagnetic coils configured as a waveguide that radiate magnetic fields by shaping the necessary flux density axis on and around the catheter distal tip so as to push, pull and rotate the tip on demand and as defined by such automatic mapping algorithms.
摘要翻译：本发明涉及一种使用组织接触技术来优化自动心室映射算法以加速映射过程并保证实际室限定义的方法。本发明还包括一种用于将组织类型信息传送到这种自动映射算法的方法，以便使它们能够将它们的点收集密度调整到特别感兴趣的区域内。该方法通过使用磁场室来增强，该磁室采用被配置为波导的电磁线圈，其通过在导管远端顶端上和周围形成必要的通量密度轴而辐射磁场，以便按需推动，拉动和旋转尖端，如这种自动映射算法所定义的。

26. 发明申请

US20120310066A1 METHOD AND APPARATUS FOR CREATING A HIGH RESOLUTION MAP OF THE ELECTRICAL AND MECHANICAL PROPERTIES OF THE HEART 审中-公开
标题翻译：用于创建心脏电气和机械特性的高分辨率图的方法和装置
公开(公告)号：US20120310066A1
公开(公告)日：2012-12-06
申请号：US13491300
申请日：2012-06-07
申请人： Yehoshua Shachar , Bruce Marx , Laszlo Farkas , David Johnson , Leslie Farkas
发明人： Yehoshua Shachar , Bruce Marx , Laszlo Farkas , David Johnson , Leslie Farkas
IPC分类号： A61B5/042 , A61B5/053 , A61B5/0402 , A61M25/095
CPC分类号： A61B5/0422 , A61B5/0452 , A61B5/053 , A61B5/0538 , A61B5/062 , A61B5/1107 , A61B5/6885 , A61B2034/2051
摘要： A system method that tracks one or more points on the surface of a cardiac tissue throughout a cardiac cycle and collect various types of data points which are then subsequently used to generate a corresponding model of the tissue and display the model as a 3D color coded image is described. In one embodiment, the system determines the position and orientation of a distal tip of a catheter, manipulates the catheter tip so as to maintain constant contact between the tip and a region of cardiac tissue using the impedance method, acquires positional and electrical data of the tip-tissue configuration through an entire heartbeat cycle, repeats the measurements as many times as needed in different tissue regions, and forms a 3D color coded map displaying various mechanical and electrical properties of the heart using the acquired data.
摘要翻译：一种跟踪心脏周围心脏组织表面上的一个或多个点的系统方法，并收集各种类型的数据点，然后随后使用这些数据点来生成组织的相应模型并将该模型显示为3D彩色编码图像被描述。在一个实施例中，系统确定导管的远侧末端的位置和取向，操纵导管尖端，以便使用阻抗方法保持尖端与心脏组织区域之间的恒定接触，获取位置和电气数据通过整个心跳周期的尖端组织配置，在不同组织区域中根据需要重复测量多次，并且使用获取的数据形成显示心脏的各种机械和电学性质的3D颜色编码图。

27. 发明申请

US20120296200A1 SYSTEM AND METHOD FOR TARGETING CATHETER ELECTRODES 审中-公开
标题翻译：用于引导电极电极的系统和方法
公开(公告)号：US20120296200A1
公开(公告)日：2012-11-22
申请号：US13450831
申请日：2012-04-19
申请人： Yehoshua Shachar , Bruce Marx , David Johnson , Leslie Farkas , Steven Kim
发明人： Yehoshua Shachar , Bruce Marx , David Johnson , Leslie Farkas , Steven Kim
IPC分类号： A61M25/095
CPC分类号： A61B5/042 , A61B18/1492 , A61B34/70 , A61B34/73 , A61B2018/00577 , A61B2018/00839 , A61B2562/0209 , A61B2562/043
摘要： A system and method is described for a catheter guidance system which allows an operator to use a mapping catheter to specify tissue target locations for the automatic guidance of a second therapeutic catheter. The operator places a mapping catheter at a desired location, and commands the catheter guidance system by either selecting a point on that catheter or one of the catheter electrode electrocardiograms. The operator may target the selected dynamic location, or tissue contact beyond that location on a specific side of the mapping catheter.
摘要翻译：描述了一种用于导管引导系统的系统和方法，其允许操作者使用映射导管来指定用于第二治疗导管的自动引导的组织靶位置。操作者将映射导管放置在所需位置，并通过选择导管上的点或导管电极心电图之一来命令导管引导系统。操作者可以瞄准所选择的动态位置或组织接触超过该映射导管的特定侧上的该位置。

28. 发明申请

US20120289822A1 APPARATUS AND METHOD FOR LORENTZ-ACTIVE SHEATH DISPLAY AND CONTROL OF SURGICAL TOOLS 审中-公开
标题翻译：用于LORENTZ主动式显示和手术工具控制的装置和方法
公开(公告)号：US20120289822A1
公开(公告)日：2012-11-15
申请号：US13450148
申请日：2012-04-18
申请人： Yehoshua Shachar , Bruce Marx , Leslie Farkas , David Johnson , Laszlo Farkas
发明人： Yehoshua Shachar , Bruce Marx , Leslie Farkas , David Johnson , Laszlo Farkas
IPC分类号： A61B1/32 , A61B6/00
CPC分类号： A61B5/06 , A61B1/018 , A61B5/061 , A61B5/062 , A61B5/064 , A61B5/065
摘要： The Lorentz-Active Sheath (LAS) serves as a conduit for other medical devices such as catheters, balloons, biopsy needles, etc. The sheath is inserted through a vein or other body orifice and is guided into the area of the patient where the operation is to be performed. The position and orientation of the LAS is tracked via an industry standard position detection system which senses electrical signals that are emitted from several electrodes coupled to the LAS. The signals received from the LAS are used to calculate an accurate and reliable assessment of the actual position of the LAS within the patient. The electrode signals also serve to create a reference frame which is then used to act as a motion compensation filter and fiducial alignment system for the movement of the LAS-hosted medical tool.
摘要翻译：洛伦兹活性护套（LAS）用作导管，气球，活检针等其他医疗设备的导管。鞘通过静脉或其他体孔插入，并被引导到患者的手术区域将被执行。 LAS的位置和方向通过工业标准位置检测系统来跟踪，该系统检测从耦合到LAS的多个电极发射的电信号。从LAS接收的信号用于计算对患者体内LAS的实际位置的准确可靠的评估。电极信号还用于创建参考框架，然后将其用作运动补偿滤波器和用于LAS托管的医疗工具运动的基准对准系统。

29. 发明申请

US20120288838A1 METHOD FOR SIMULATING A CATHETER GUIDANCE SYSTEM FOR CONTROL, DEVELOPMENT AND TRAINING APPLICATIONS 审中-公开
标题翻译：用于模拟控制，开发和培训应用的导管指导系统的方法
公开(公告)号：US20120288838A1
公开(公告)日：2012-11-15
申请号：US13450323
申请日：2012-04-18
申请人： Yehoshua Shachar , Bruce Marx , David Johnson , Leslie Farkas , Steven Kim
发明人： Yehoshua Shachar , Bruce Marx , David Johnson , Leslie Farkas , Steven Kim
IPC分类号： G09B23/28
CPC分类号： G09B23/285 , A61B5/061 , A61B34/20 , A61B34/35 , A61B2034/2051 , G05B13/048
摘要： A system is disclosed for incorporating a realistic simulated catheter or catheters within a catheter guidance and control system that operate from the same closed-loop position control feedback and geometric mapping data as the real position control system and are able to make contact with real and simulated datasets. These catheters may be operated in a pure simulation mode without interacting with real catheters and position control hardware, or may be used as control cursors to enhance the placement of catheter positioning targets. The catheter tip, which is focus of magnetic control, is realistically guided by the control system parameters, while the remainder of the catheter line is realistically constrained by the mapped chamber geometry and introducer sheath.
摘要翻译：公开了一种用于将真实的模拟导管或导管结合在导管引导和控制系统内的系统，其从与实际位置控制系统相同的闭环位置控制反馈和几何映射数据操作并且能够与实际和模拟的数据集。这些导管可以以纯仿真模式操作，而不与实际导管和位置控制硬件相互作用，或者可以用作控制光标以增强导管定位目标的放置。作为磁控制焦点的导管尖端由控制系统参数实际引导，而导管线的其余部分实际上受到映射室几何形状和引导器护套的约束。

30. 发明申请

US20110112396A1 SYSTEM AND METHOD FOR TARGETING CATHETER ELECTRODES 审中-公开
标题翻译：用于引导电极电极的系统和方法
公开(公告)号：US20110112396A1
公开(公告)日：2011-05-12
申请号：US12615176
申请日：2009-11-09
申请人： Yehoshua Shachar , Bruce Marx , David Johnson , Leslie Farkas , Steven Kim
发明人： Yehoshua Shachar , Bruce Marx , David Johnson , Leslie Farkas , Steven Kim
IPC分类号： A61B5/05
CPC分类号： A61B5/042 , A61B18/1492 , A61B34/70 , A61B34/73 , A61B2018/00577 , A61B2018/00839 , A61B2562/043
摘要： A system and method is described for a catheter guidance system which allows an operator to use a mapping catheter to specify tissue target locations for the automatic guidance of a second therapeutic catheter. The operator places a mapping catheter at a desired location, and commands the catheter guidance system by either selecting a point on that catheter or one of the catheter electrode electrocardiograms. The operator may target the selected dynamic location, or tissue contact beyond that location on a specific side of the mapping catheter.
摘要翻译：描述了一种用于导管引导系统的系统和方法，其允许操作者使用映射导管来指定用于第二治疗导管的自动引导的组织靶位置。操作者将映射导管放置在所需位置，并通过选择导管上的点或导管电极心电图之一来命令导管引导系统。操作者可以瞄准所选择的动态位置或组织接触超过该映射导管的特定侧上的该位置。

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