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21. 发明申请

US20100114232A1 INITIATION TESTS AND GUIDELINES FOR IMPLEMENTING CARDIAC THERAPY 有权
标题翻译：用于实施心脏病治疗的启动试验和指导
公开(公告)号：US20100114232A1
公开(公告)日：2010-05-06
申请号：US12264077
申请日：2008-11-03
申请人： Xiaoyi Min
发明人： Xiaoyi Min
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61N1/37247
摘要： An exemplary system includes a programmer configured to instruct an implantable device and a qualification module with instructions to call for tests performed by an implantable device configured for delivery of CRT, to receive results from the tests, to analyze the results and to decide, based on the analysis, if the patient qualifies for automatic, implantable device-based optimization of one or more CRT parameters and, only if the patient qualifies for automatic, implantable device-based optimization of one or more CRT parameters, presenting a graphical user interface that comprises a selectable control to enable an algorithm of an implantable device to automatically optimize at least one of the one or more cardiac resynchronization therapy parameters. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性系统包括编程器，其被配置为指示可植入装置和鉴定模块，其具有用于调用由配置用于输送CRT的可植入装置执行的测试的指令，以接收来自测试的结果，以分析结果并基于如果患者符合一个或多个CRT参数的自动植入式设备优化，并且仅当患者符合对一个或多个CRT参数进行自动可植入设备的优化时，呈现图形用户界面，该图形用户界面包括可选择的控制以使可植入装置的算法能够自动优化所述一个或多个心脏再同步治疗参数中的至少一个。还公开了其它示例性方法，装置，系统等。

22. 发明申请

US20100100145A1 MEASUREMENT OF CARDIAC INFORMATION FOR CRT OPTIMZIATION IN THE PRESENCE OF CONDUCTION DYSFUNCTION OR ATRIAL ARRHYTHMIA 有权
标题翻译：测量导管性功能障碍或ATRIAL ARRHYTHMIA存在CRT优化的心脏病信息
公开(公告)号：US20100100145A1
公开(公告)日：2010-04-22
申请号：US12255544
申请日：2008-10-21
申请人： Xiaoyi Min
发明人： Xiaoyi Min
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/368 , A61N1/3682
摘要： An exemplary method includes delivering a cardiac pacing therapy that includes an atrio-ventricular delay and an interventricular delay, providing a paced propagation delay associated with delivery of a stimulus to a ventricle, delivering a stimulus to the ventricle, sensing an event in the other ventricle caused by the stimulus, determining an interventricular conduction delay value based on the delivering and the sensing, determining a interventricular delay (ΔSur) based on the interventricular conduction delay and the paced propagation delay and determining an atrio-ventricular delay based at least in part on the interventricular delay (ΔSur). Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括递送心脏起搏疗法，其包括心室延迟和室间延迟，提供与将刺激递送到心室相关联的节奏传播延迟，向脑室递送刺激，感测另一脑室中的事件由刺激引起的，基于递送和感测来确定心室间传导延迟值，基于室间传导延迟和节奏传播延迟来确定心室间延迟（＆Dgr; Sur），并且基于至少在部分在室间延迟（＆Dgr; Sur）。还公开了其它示例性方法，装置，系统等。

23. 发明授权

US07643872B2 System and method for detecting cardiac ischemia based on T-Waves using an implantable medical device 有权
标题翻译：用于使用可植入医疗装置检测基于T波的心脏缺血的系统和方法
公开(公告)号：US07643872B2
公开(公告)日：2010-01-05
申请号：US11686784
申请日：2007-03-15
申请人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
发明人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
IPC分类号： A61B5/0452 , A61N1/36
CPC分类号： A61B5/0452 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7242 , A61N1/3627 , A61N1/3702
摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.
摘要翻译：提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发作的方法。简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

24. 发明授权

US07627366B1 Analysis of polarization information 有权
标题翻译：极化信息分析
公开(公告)号：US07627366B1
公开(公告)日：2009-12-01
申请号：US11123300
申请日：2005-05-06
申请人： Annapurna Karicherla , Xiaoyi Min , Xiaozheng Zhang , Jong Gill
发明人： Annapurna Karicherla , Xiaoyi Min , Xiaozheng Zhang , Jong Gill
IPC分类号： A61N1/37
CPC分类号： A61N1/36507
摘要： An exemplary method includes providing a first value indicative of electrode polarization, delivering a cardiac stimulus and determining a second value indicative of electrode polarization associated with the cardiac stimulus, comparing the second value to the first value to determine whether a change in cardiac condition has occurred and, based at least in part on the comparing, deciding whether to adjust a cardiac stimulation therapy.
摘要翻译：示例性方法包括提供指示电极极化的第一值，递送心脏刺激并确定指示与心脏刺激相关联的电极极化的第二值，将第二值与第一值进行比较，以确定心脏状态的变化是否已发生并且至少部分地基于比较，决定是否调整心脏刺激疗法。

25. 发明申请

US20090287267A1 System and Method for Estimating Cardiac Pressure Based on Cardiac Electrical Conduction Delays Using an Implantable Medical Device 有权
标题翻译：使用可植入医疗器械的基于心电导通延迟的估计心脏压力的系统和方法
公开(公告)号：US20090287267A1
公开(公告)日：2009-11-19
申请号：US11779380
申请日：2007-07-18
申请人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
发明人： Brian Jeffrey Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
IPC分类号： A61N1/36
CPC分类号： A61B5/02156 , A61B5/0215 , A61B5/72 , A61N1/365 , A61N1/36564 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/37258
摘要： Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.
摘要翻译：提供了基于测量的传导延迟来估计左心房压力（LAP）或其他心脏性能参数的技术。特别地，LAP是基于室间传导延迟估计的。存储在装置内的预定转换因子用于将各种导通延迟转换为LAP值或其他适当的心脏性能参数。转换因子可以是例如由外部系统（诸如外部编程器）执行的初始校准过程期间导出的斜率和基线值。在一些示例中，可以通过可植入装置本身周期性地重新校准斜率和基线值。还描述了基于估计的LAP或其他心脏性能参数自适应地调整起搏参数的技术。此外，描述了用于基于阻抗或导纳值估计导通延迟并用于跟踪其心力衰竭的技术。

26. 发明申请

US20090270746A1 CRITERIA FOR MONITORING INTRATHORACIC IMPEDANCE 有权
标题翻译：监测静脉阻力的标准
公开(公告)号：US20090270746A1
公开(公告)日：2009-10-29
申请号：US12498948
申请日：2009-07-07
申请人： Xiaoyi Min
发明人： Xiaoyi Min
IPC分类号： A61B5/02 , A61B5/053
CPC分类号： A61B5/053 , A61B5/02028 , A61B5/0205 , A61B5/0538 , A61B5/4878 , A61N1/36521 , A61N1/3702 , A61N1/3943 , A61N1/3962 , A61N2001/083
摘要： An exemplary method includes providing information (e.g., a left atrial pressure, a NYHA class, echocardiographic information, etc.), based at least in part on the information, determining a weight and, based at least in part on the weight, determining a threshold for use in intrathoracic impedance monitoring. Such an exemplary method may include comparing an intrathoracic impedance to the threshold, comparing an intrathoracic impedance change to the threshold, or comparing a product of intrathoracic impedance and time to the threshold. Various exemplary methods, devices, systems, etc., are disclosed.
摘要翻译：至少部分地基于信息来确定重量并且至少部分地基于重量来确定一个重量，一个示例性的方法包括提供信息（例如，左心房压力，NYHA类，超声心动图信息等）用于胸腔内阻抗监测的阈值。这种示例性方法可以包括将胸内阻抗与阈值进行比较，将胸内阻抗变化与阈值进行比较，或将胸腔内阻抗和时间的乘积与阈值进行比较。公开了各种示例性方法，装置，系统等。

27. 发明申请

US20090177105A1 System and Method for Distinguishing Among Cardiac Ischemia, Hypoglycemia and Hyperglycemia Using an Implantable Medical Device 有权
公开(公告)号：US20090177105A1
公开(公告)日：2009-07-09
申请号：US12360826
申请日：2009-01-27
申请人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael E. Benser , Gene A. Bornzin
发明人： Jong Gill , Peter Boileau , Rupinder Bharmi , Xiaoyi Min , Joseph J. Florio , Michael E. Benser , Gene A. Bornzin
IPC分类号： A61B5/04
CPC分类号： A61N1/3962 , A61B5/0452 , A61B5/0468 , A61B5/14532 , A61N1/3621 , A61N1/3627 , A61N1/36557 , A61N1/3925
摘要： Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.

28. 发明授权

US07440804B1 System and method for measuring ventricular evoked response using an implantable medical device 有权
标题翻译：使用可植入医疗装置测量心室诱发反应的系统和方法
公开(公告)号：US07440804B1
公开(公告)日：2008-10-21
申请号：US11025220
申请日：2004-12-28
申请人： Xiaoyi Min , Steve Koh
发明人： Xiaoyi Min , Steve Koh
IPC分类号： A61N1/378
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3627
摘要： Techniques are provided for measuring ventricular evoked response within the heart of a patient during atrial fibrillation. An intrinsic ventricular depolarization (i.e. a QRS complex) is sensed within the right ventricle and then a pacing pulse is applied to the left ventricle prior to intrinsic depolarization thereof. In this manner, the left ventricle contracts solely in response to the pacing pulse and possible fusion between the pacing pulse and a conducted P-wave/A-pulse from the atria is avoided. The evoked response generated in the left ventricle is then measured by the pacemaker. The technique permits reliable detection of left ventricular evoked response, even during atrial fibrillation when atrial contractions are frequent and erratic, but the technique may also be employed during normal sinus rhythm. Features of the evoked response are analyzed to detect heart failure, evaluate its severity and track its progression. Appropriate therapy is then automatically delivered to the patient.
摘要翻译：提供了用于在心房颤动期间测量患者心脏内心室诱发反应的技术。在右心室内检测到内部心室去极化（即QRS复合物），然后在其内部去极化之前将起搏脉冲施加到左心室。以这种方式，左心室仅响应于起搏脉冲而收缩，并避免起搏脉冲与从心房传导的P波/ A脉冲之间的融合。然后由起搏器测量在左心室产生的诱发反应。该技术允许可靠地检测左心室诱发反应，即使在心房收缩频繁且不稳定的心房颤动期间，该技术也可在正常窦性心律中使用。分析诱发反应的特征以检测心力衰竭，评估其严重程度并跟踪其进展。然后将适当的治疗自动递送给患者。

29. 发明申请

US20070027489A1 Characterization of a patient's condition by evaluating electrical and mechanical properties of the heart 审中-公开
标题翻译：通过评估心脏的电气和机械性质来描述患者状况
公开(公告)号：US20070027489A1
公开(公告)日：2007-02-01
申请号：US11192538
申请日：2005-07-28
申请人： Jong Gill , Xiaoyi Min
发明人： Jong Gill , Xiaoyi Min
IPC分类号： A61N1/00
CPC分类号： A61N1/365 , A61B5/0031 , A61B5/0215 , A61B5/0452 , A61N1/36521 , A61N1/36578 , A61N1/3682 , A61N1/3684
摘要： A method and device for evaluating the progression of a patient's condition, which in certain applications can include heart failure, on an ongoing manner which reduces the need for immediate attention from skilled clinicians or expensive diagnostic equipment. The method and device analyze relative timing between electrical and mechanical properties of the heart. Detection of an elongated delay between corresponding electrical and mechanical activity is interpreted as indicating a worsening heart failure condition. The analysis and data corresponding thereto can be stored for further analysis and/or telemetrically communicated to an external device. Therapy provided by the device can be altered based on the evaluation of the patient's condition.
摘要翻译：一种用于评估患者状况进展的方法和装置，其在某些应用中可以包括心力衰竭，以持续的方式减少熟练临床医生或昂贵诊断设备立即关注的需要。该方法和装置分析心脏的电气和机械性质之间的相对时间。在对应的电和机械活动之间的延长延迟的检测被解释为指示恶化的心力衰竭状况。可以存储对应于其的分析和数据用于进一步分析和/或遥测地传送到外部设备。可以根据对患者状况的评估来改变设备提供的治疗。

30. 发明授权

US07155282B1 Automatic sensitivity control and method for use in an implantable cardiac stimulation device 有权
标题翻译：自动灵敏度控制和用于可植入心脏刺激装置的方法
公开(公告)号：US07155282B1
公开(公告)日：2006-12-26
申请号：US10719307
申请日：2003-11-21
申请人： Xiaoyi Min , Gene A. Bornzin , Jeffery D. Snell
发明人： Xiaoyi Min , Gene A. Bornzin , Jeffery D. Snell
IPC分类号： A61N1/362
CPC分类号： A61N1/3704 , A61B5/0452 , A61B5/0456
摘要： A threshold sensing control for use in an implantable cardiac stimulation device controls the sensing of cardiac activity during a current cardiac cycle of a heart while avoiding sensing a T wave. The system includes a sensing circuit that senses cardiac activity of the heart during a cardiac cycle preceding the current cardiac cycle, a detector that measures selected T wave and R wave characteristics of the cardiac activity and a control circuit that varies the sensing threshold based upon the measured selected R wave and T wave characteristics. The sensing threshold control may be implemented for both intrinsic and paced beats.
摘要翻译：用于可植入心脏刺激装置的阈值感测控制器控制在心脏的当前心动周期期间对心脏活动的感测，同时避免感测T波。该系统包括感测电路，该感测电路在当前心动周期之前的心动周期期间感测心脏的心脏活动，测量心脏活动的所选T波和R波特征的检测器以及基于测量选定的R波和T波特性。感测阈值控制可以针对内部节奏和节奏节拍实现。

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