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21. 发明申请

US20070106286A1 Side fire optical fiber for high power applications 审中-公开
标题翻译：侧火光纤适用于大功率应用
公开(公告)号：US20070106286A1
公开(公告)日：2007-05-10
申请号：US11592598
申请日：2006-11-03
申请人： Alexander Harschack , Wolfgang Neuberger , Kelly Moran
发明人： Alexander Harschack , Wolfgang Neuberger , Kelly Moran
IPC分类号： A61B18/18 , G02B6/028 , G02B6/02 , G02F1/295
摘要： An optical fiber treatment system is provided for high power laser transmission to an area of medical treatment. A side fire optical fiber tip for use in high power laser applications having outputs of greater than or equal to 50 Watts is a key to the system. Embodiments are particularly appropriate for the medical treatment of benign prostate hyperplasia (BPH) with a side fire optical fiber tip using a Holmium:YAG laser or a high power diode laser. Such procedures can be done with only local anesthesia A predetermined length of an output tip on the distal end of the optical fiber of the present invention is formed with an optical fiber core and cladding layer of preselected thickness wherein the cladding to core diameter ratio is at least as great as 1.2. A side fire surface is formed on the distal end of the core/clad output end. Over this optical fiber output end, a pure silica capillary tube is fused to the predetermined length of exposed cladding where the outermost cladding is also pure silica to reduce thermal mismatch during the fusion process. By having the refractive index at the fusing interface of the tube to the cladding matched, and bubbles or gaps eliminated or prevented, it is possible to substantially eliminate Fresnel reflection losses at this interface. Further, the outer surface area where the laser energy is exiting from the tube may be heat treated with a laser to increase durability for high power laser energy transmission in fluid environments. Germanium-doped silica as well as pure silica can be used as fiber core material.
摘要翻译：提供了一种用于大功率激光传输到医疗领域的光纤处理系统。用于具有大于或等于50瓦的输出的大功率激光应用的侧面火光光纤尖端是系统的关键。实施例特别适用于使用钬：YAG激光器或高功率二极管激光器的侧消光光纤尖端治疗良性前列腺增生（BPH）。这样的程序可以仅进行局部麻醉。本发明的光纤的远端上的输出端的预定长度形成有预定厚度的光纤芯和包层，其中包层与芯直径之比为至少高达1.2。侧面火表面形成在芯/包层输出端的远端。在该光纤输出端上，纯二氧化硅毛细管被熔化到预定长度的暴露的包层，其中最外包层也是纯二氧化硅，以减少融合过程中的热失配。通过使管的熔融界面处的折射率与包层匹配，并且消除或防止气泡或间隙，可以基本上消除该界面处的菲涅尔反射损失。此外，激光能量从管出射的外表面区域可以用激光进行热处理，以提高在流体环境中的高功率激光能量传输的耐久性。锗掺杂二氧化硅以及纯二氧化硅可用作纤维芯材料。

22. 发明申请

US20060111699A1 Medical device recognition system with write-back feature 审中-公开
标题翻译：具有回写功能的医疗器械识别系统
公开(公告)号：US20060111699A1
公开(公告)日：2006-05-25
申请号：US11320389
申请日：2005-12-28
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/18
CPC分类号： A61B18/22 , A61B90/90 , A61B2017/00482 , A61B2017/00725 , A61B2018/00988 , A61B2090/0803
摘要： A medical radiation treatment system is disclosed for identifying and monitoring the use of disposable or reusable optical fibers or other optical accessories. The treatment system comprises a radiation source unit connected to a recognition/control unit, and a medical radiation delivery system connected to an identification/recordation unit. This forms a read-write system to ensure that radiation parameters conform to delivery device characteristics, and to prevent the use of overused or incompatible delivery devices. This is achieved by reading previously encoded information in the identification/recordation unit that provides all usage history, including number of uses or total duration of use. The encoded information is updated after use, and preferably frequently or continuously during use, to guarantee a complete usage history even after an incomplete treatment. Additionally, the treatment system can differentiate between completed treatments, incomplete treatments and calibration, to retain an accurate record of all the stresses on a fiber. A transponder sends information to the source unit, and also receives and writes information to a non-volatile memory chip or other storage means. The identification/recordation unit, including the transponder and memory, is powered by sending/receiving means in the recognition/control unit without physical, optical or electrical connection between the source unit and delivery system.
摘要翻译：公开了用于识别和监测一次性或可重复使用的光纤或其他光学附件的使用的医疗辐射治疗系统。治疗系统包括连接到识别/控制单元的辐射源单元和连接到识别/记录单元的医疗辐射传送系统。这形成一个读写系统，以确保辐射参数符合传送设备特性，并防止使用过度使用或不兼容的传送设备。这是通过读取提供所有使用历史的识别/记录单元中的先前编码的信息来实现的，包括使用次数或使用总时间。编码信息在使用后被更新，并且优选地在使用期间经常或连续地更新，以保证即使在不完全处理之后的完整使用历史。此外，治疗系统可以区分完成的治疗，不完全的治疗和校准，以保持光纤上所有应力的准确记录。应答器向源单元发送信息，并且还向非易失性存储器芯片或其他存储装置接收和写入信息。识别/记录单元（包括应答器和存储器）由识别/控制单元中的发送/接收装置供电，而不需要源单元和传送系统之间的物理，光学或电气连接。

23. 发明申请

US20060088584A1 Liposomal formulations of hydrophobic photosensitizer for photodynamic therapy 有权
标题翻译：用于光动力疗法的疏水性光敏剂的脂质体制剂
公开(公告)号：US20060088584A1
公开(公告)日：2006-04-27
申请号：US11298729
申请日：2005-12-09
申请人： Volker Albrecht , Alfred Fahr , Dietrich Scheglmann , Susanna Grafe , Wolfgang Neuberger
发明人： Volker Albrecht , Alfred Fahr , Dietrich Scheglmann , Susanna Grafe , Wolfgang Neuberger
IPC分类号： A61K9/127 , A61K31/70 , A61K31/409
CPC分类号： A61K41/0071 , A61K9/127
摘要： Pharmaceutical liposomal formulations are described for photodynamic therapy comprising a, hydrophobic porphyrin photosensitizer, a monosaccharide and one or more synthetic phospholipids, which are stable in storage especially through freeze-drying process. The liposomal formulations provide therapeutically effective amounts of the photosensitizer for intravenous administration. In particular derivatives of chlorins and bacteriochlorins, such as temoporfin, are, hydrophobic photosensitizers whose efficacy and safety are enhanced by such liposomal formulations. The formulation can be efficiently freeze-dried preserving the size of the liposomal vehicles, and the content of a therapeutically effective amount of the photosensitizer, due to the selection of phospholipids and monosaccharides. The invention also relates to liposome compositions formed upon reconstitution with an aqueous vehicle. The freeze-dried formulation upon reconstitution with a suitable aqueous vehicle forms liposomes that are useful for intravenous administration.
摘要翻译：描述了用于光动力学治疗的药物脂质体制剂，其包括疏水性卟啉光敏剂，单糖和一种或多种合成磷脂，其特别通过冷冻干燥方法在储存中稳定。脂质体制剂提供治疗有效量的用于静脉内给药的光敏剂。特别是二氢卟酚和细菌二氢卟酚的衍生物，如temoporfin，是通过这种脂质体制剂增强其功效和安全性的疏水性光敏剂。由于磷脂和单糖的选择，制剂可以有效地冷冻干燥，保持脂质体载体的大小和治疗有效量的光敏剂的含量。本发明还涉及在用水性载体重建时形成的脂质体组合物。用合适的水性载体重建后的冷冻干燥制剂形成可用于静脉内给药的脂质体。

24. 发明授权

US06948815B2 Laser safety contact lenses 失效
标题翻译：激光安全隐形眼镜
公开(公告)号：US06948815B2
公开(公告)日：2005-09-27
申请号：US10628522
申请日：2003-07-28
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61F9/02 , G02C7/04
CPC分类号： G02C7/021 , A61F9/022 , G02C7/04
摘要： Individually marked contact lenses for protection of one's eyes from harmful radiation are provided. Contact lenses are coated or treated to be absorptive or reflective to a preselected wavelength or wavelengths. The lenses contain one or more identification areas on each lens to demonstrate that the lenses are being worn and to indicate the proper applications with which the lenses should be used and/or the wavelengths for which the lens is protective. The identification area, which should be visible when worn to third parties and/or the person wearing the lenses, consists of markings such as colored bands or shaded areas in the region around the iris. Different colors or color patterns of the markings indicate which wavelengths the lens protects against. Other safety features may include fluorescent markers, added features and devices to facilitate placement and retention in the eye, pick-up or release.
摘要翻译：提供单独标记的隐形眼镜，用于保护人眼免受有害辐射。隐形眼镜被涂覆或处理以吸收或反射到预选的波长或波长。透镜在每个透镜上包含一个或多个识别区域以示出透镜被磨损并且指示应当使用透镜的适当应用和/或透镜保护的波长。当佩戴到第三方和/或戴着镜片的人员时，识别区域应该可见，包括虹膜周围区域的彩色条纹或阴影区域等标记。标记的不同颜色或颜色图案表示镜头防止哪些波长。其他安全特征可以包括荧光标记，添加的特征和装置，以便于在眼睛中的放置和保留，拾取或释放。

25. 发明授权

US06942656B2 Method for accurate optical treatment of an eye's fundus 失效
标题翻译：精确光学治疗眼底的方法
公开(公告)号：US06942656B2
公开(公告)日：2005-09-13
申请号：US10208218
申请日：2002-07-30
申请人： Dirk Pawlowski , Wolfgang Neuberger
发明人： Dirk Pawlowski , Wolfgang Neuberger
IPC分类号： A61B3/135 , A61F9/008 , A61F9/009 , A61K41/00 , A61B18/18
CPC分类号： A61F9/008 , A61B3/135 , A61F9/009 , A61F2009/00846 , A61F2009/00863 , A61K41/0042
摘要： A system and method is provided to accurately treat sites on an eye's retina employing computer based image generation, processing and central control means in conjunction with diode laser sources and optical fibers. The system and method accurately determine geometry of a treatment zone of a specific eye's fundus and adjust a treatment beam to irradiate the treatment zone with minimal coverage of adjacent well tissue. The treatment zone or zone is accurately determined with digital processing of angiographic data and slit lamp image data. This information is integrated with information on the treatment beam characteristics to better match treatment beam coverage with minimal overlap with healthy areas of the fundus. Additionally preferred embodiments also have the ability to automatically track eye movement and switch the beam source depending on eye movement, adjusting the beam spot area in real time.
摘要翻译：提供了一种使用基于计算机的图像生成，处理和与二极管激光源和光纤结合的中央控制装置来精确地治疗眼睛视网膜上的部位的系统和方法。该系统和方法准确地确定特定眼底的治疗区的几何形状，并调整治疗束以相邻的井组织的最小覆盖面照射治疗区。通过血管造影数据和裂隙灯图像数据的数字处理准确地确定治疗区域或区域。该信息与治疗波束特征的信息相结合，以更好地匹配治疗波束覆盖，同时与眼底健康区域的重叠最小。另外，优选实施例还具有根据眼睛移动自动跟踪眼睛移动和切换束源的能力，实时调整束斑区域。

26. 发明申请

US20050159794A1 Multiple port photodynamic therapy irradiation system 审中-公开
标题翻译：多端口光动力治疗照射系统
公开(公告)号：US20050159794A1
公开(公告)日：2005-07-21
申请号：US10757910
申请日：2004-01-15
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/20 , A61N5/06 , A61N5/00 , A61N1/00
CPC分类号： A61N5/062 , A61B2018/208 , A61N5/0601 , A61N2005/0612 , A61N2005/0651
摘要： A diode-based radiation source is disclosed, having multiple output ports for delivery of radiation to multiple delivery devices such as optical fibers. The radiation source, useful especially for photodynamic therapy and interstitial tumor therapy, contains a number of diode units, wherein a number of individual emitters' output powers are combined to each output port. A computer or other control unit enables the desired output power to be adjusted separately for each port and enables each delivery system to be calibrated individually. In this way, multiple delivery devices can be inserted into a treatment area from a single source and be individually adjusted to provide a desired distribution of radiation power in the treatment area.
摘要翻译：公开了一种基于二极管的辐射源，具有用于将辐射传送到诸如光纤之类的多个输送装置的多个输出端口。特别用于光动力治疗和间质肿瘤治疗的辐射源包含多个二极管单元，其中多个单个发射器的输出功率被组合到每个输出端口。计算机或其他控制单元能够为每个端口分别调整所需的输出功率，并使每个传送系统能够单独校准。以这种方式，可以将多个递送装置从单个源插入到治疗区域中并且被单独调整以在治疗区域中提供期望的辐射功率分布。

27. 发明授权

US06918905B2 Monolithic irradiation handpiece 失效
标题翻译：单片照射手机
公开(公告)号：US06918905B2
公开(公告)日：2005-07-19
申请号：US10103261
申请日：2002-03-21
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/20 , A61B19/00
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/2025 , A61B2090/0454
摘要： A handpiece for topical application of electromagnetic radiation is disclosed, consisting of a single monolithic transparent block covered by a semitransparent coating on the faces of the block not directed toward a treatment site. The block and coating are transparent to visible radiation, allowing the user a direct view of the treatment site. At the same time, for the safety of the user and a patient, the monolithic block has a coating of radiation blocking or absorbing material to selectively prevent treatment radiation from harming a user or patient. In a preferred embodiment, an optical fiber or fiber bundle coupled to a suitable power source is directly molded into the monolithic block. This invention is useful for a broad variety of laser applications, including the treatment of dermatological diseases and paint removal. The simple monolithic structure allows the device to be portable and practical in open environments. Optionally, the handpiece may contain cooling mechanisms to alleviate overheating of the treated site in high power situations. Other embodiments contain further safeguards including sensors to provide feedback to the power source for more precise control of radiation and thus are available in preferred embodiments.
摘要翻译：公开了一种用于局部施用电磁辐射的手机，由单块整体式透明块组成，该单块整体式透明块被块体表面上没有指向治疗部位的半透明涂层覆盖。块和涂层对可见辐射是透明的，允许用户直接观察治疗部位。同时，为了用户和患者的安全，整体块具有辐射阻挡或吸收材料的涂层，以选择性地防止治疗辐射伤害使用者或患者。在优选实施例中，将耦合到合适电源的光纤或光纤束直接模制到单片块中。本发明可用于各种各样的激光应用，包括治疗皮肤病和除漆。简单的单片结构允许设备在开放环境中是便携式和实用的。可选地，手持件可以包含冷却机构，以在大功率情况下减轻处理部位的过热。其他实施例包含进一步的保护措施，包括向电源提供反馈以用于更精确地控制辐射的传感器，因此在优选实施例中可用。

28. 发明申请

US20050000429A1 Spiral gas flow plasma reactor 审中-公开
标题翻译：螺旋气流等离子体反应器
公开(公告)号：US20050000429A1
公开(公告)日：2005-01-06
申请号：US10847012
申请日：2004-05-17
申请人： Wolfgang Neuberger , Alexei Solomatine
发明人： Wolfgang Neuberger , Alexei Solomatine
IPC分类号： C23C16/44 , C23C16/455 , C23C16/511 , H01J37/32 , C23C16/00
CPC分类号： C23C16/45502 , C23C16/455 , C23C16/511 , H01J37/3244 , H01J37/32834
摘要： A plasma reactor and accompanying method for thin film deposition is disclosed, comprising a system of input means and exhaust means that produce an adjustable spiral flow of precursor gas used in creating a spatially stable plasma over large substrate surface areas. The flow of gas created by this configuration of input and exhaust means results in a plasma that remains uniform as it extends radially from the center to the edges of the substrate and is capable of high quality depositions and high deposition rates. In a preferred embodiment, the input means is in the form of a ring jet with a tangential flow component surrounding the substrate. Gas exhausts through exhaust means located at a preselected distance above the substrate. In a preferred embodiment, gas exhausts through a central exhaust aperture and a number of surrounding apertures located at a preselected distance from the central exhaust aperture. Both the central and surrounding exhaust apertures may be connected by an adjustable manifold to allow for coordinated positioning of the central and surrounding apertures. Additionally, apertures located at the bottom of the cavity can be used to input additional precursor gas so as to maintain the spiral flow over the substrate.
摘要翻译：公开了一种用于薄膜沉积的等离子体反应器和相关方法，其包括输入装置和排气装置的系统，该系统产生用于在大的基板表面区域上产生空间上稳定的等离子体的前驱气体的可调螺旋流。由这种构造的输入和排出装置产生的气体的流动导致等离子体从中心到基板的边缘径向延伸而保持均匀，并且能够进行高质量的沉积和高沉积速率。在优选实施例中，输入装置是环形喷射的形式，其具有环绕衬底的切向流动分量。气体通过位于衬底上方预选距离处的排气装置排出。在优选实施例中，气体通过中心排气孔和位于距离中心排气孔预选距离的多个周围孔排出。中央和周围排气孔都可以通过可调整的歧管连接，以允许中心和周围孔的协调定位。此外，位于空腔底部的孔可以用于输入额外的前体气体，以便保持螺旋流过衬底。

29. 发明授权

US06724963B2 Method and apparatus for manufacturing partially diffusing optical fibers 失效
标题翻译：用于制造部分扩散光纤的方法和装置
公开(公告)号：US06724963B2
公开(公告)日：2004-04-20
申请号：US10022053
申请日：2001-12-17
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： G02B602
CPC分类号： C03C25/6286 , B29C35/0866 , B29C35/10 , B29C59/165 , B29C2035/0838 , B29C2035/0872 , B29D11/00682 , B29L2011/0075 , C03B37/02718 , C03B2203/18 , C03B2205/20 , C03B2205/56 , C03C25/005 , C03C25/104 , C03C25/62 , C03C25/626 , G02B6/02 , G02B6/02038 , G02B6/02052
摘要： The present invention provides for an apparatus and method to manufacture optical fiber in a way that produces controlled and patterned diffusion of optical radiation along its length. The novelty of the described invention is that the patterns of diffusion are produced at the time the optical fiber is manufactured. The “in-line” manufacturing method avoids the need for post-production treatment of the fiber, which makes the process highly efficient and economical. Light diffusing optical fibers of significant length can be produced. Several manufacturing configurations to achieve the desired effects and their inclusion in the fiber production process are described. The processes can be configured to process optical fibers constructed from a wide variety of known glass, polymeric or other materials. The partially diffusing optical fibers of this invention have applications ranging from illuminated fabrics and toys and to lighting systems and medical instruments. A distributed sensor comprising a light detector coupled to a partially diffusing fiber is also disclosed.
摘要翻译：本发明提供一种制造光纤的装置和方法，其方式是沿其长度产生光辐射的受控和图案化扩散。所述发明的新颖之处在于，在制造光纤时产生扩散图案。 “在线”制造方法避免了对纤维的后期处理的需要，这使得该方法高效和经济。可以生产具有相当长度的光漫射光纤。描述了实现所需效果的几种制造构造及其包含在纤维生产过程中。这些工艺可以被配置为处理由各种已知的玻璃，聚合物或其它材料构成的光纤。本发明的部分扩散光纤具有从照明织物和玩具以及照明系统和医疗仪器的应用。还公开了一种包括耦合到部分漫射光纤的光检测器的分布式传感器。

30. 发明授权

US06685927B2 Topical application of chromophores for hair removal 失效
标题翻译：用于脱毛的发色团的局部应用
公开(公告)号：US06685927B2
公开(公告)日：2004-02-03
申请号：US09965354
申请日：2001-09-27
申请人： Chryslain Sumian , Wolfgang Neuberger , Serge Mordon
发明人： Chryslain Sumian , Wolfgang Neuberger , Serge Mordon
IPC分类号： A61K715
CPC分类号： A61Q9/04 , A61K8/0241 , A61K8/49 , A61K2800/412 , A61K2800/438 , A61K2800/56 , A61K2800/81 , A61K2800/82 , A61K2800/83 , A61Q9/00
摘要： A device and method is disclosed for permanent or semi-permanent removal of hair through the activation of microparticles introduced into hair follicles. Microparticles are incorporated into a composition that is topically applied to the skin. These microparticles containing or consisting of chromophores or chemically activated molecules are of a variety of shapes and sizes. Microparticles are within a size range of 1 micron to 70 microns, and preferably between 10 and 50 microns. Microparticles of this size and variety of shapes enter hair follicles on all areas of the skin without entering other areas of the skin, such as the stratum corneum or sweat gland channels. Treatment of the skin with electromagnetic radiation, ultrasonic radiation or chemical means activates the chromophore or chemically activated compounds, thus destroying the hair follicle without damaging other areas of the skin. In another embodiment, microparticles further contain nanoparticles released further into the hair follicle by use of a solvent or other method, allowing chromophores or chemically activated molecules to penetrate deeper into the follicle and avoid structures such as the sebaceous gland.
摘要翻译：公开了通过引入毛囊的微粒的活化来永久或半永久性去除毛发的装置和方法。将微粒掺入局部施用于皮肤的组合物中。含有或由发色团或化学活化分子组成的这些微粒具有各种形状和尺寸。微粒的尺寸范围为1微米至70微米，优选为10至50微米。这种尺寸和各种形状的微粒在皮肤的所有区域都进入毛囊，而不会进入皮肤的其他区域，例如角质层或汗腺通道。用电磁辐射，超声辐射或化学方法治疗皮肤会激活发色团或化学活化的化合物，从而破坏毛囊而不损害皮肤的其他部位。在另一个实施方案中，微粒还包含通过使用溶剂或其它方法进一步释放到毛囊中的纳米颗粒，使得发色团或化学活化分子能够更深地渗入毛囊并避免诸如皮脂腺的结构。

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