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21. 发明授权

US08410166B2 Fused bicyclic compound 有权
标题翻译：稠合双环化合物
公开(公告)号：US08410166B2
公开(公告)日：2013-04-02
申请号：US13561662
申请日：2012-07-30
申请人： Yoichi Takahashi , Nobumasa Awai , Hidenori Akatsuka , Takayuki Kawaguchi , Toru Iljima
发明人： Yoichi Takahashi , Nobumasa Awai , Hidenori Akatsuka , Takayuki Kawaguchi , Toru Iljima
IPC分类号： C07D265/00
CPC分类号： C07D265/16 , C07D311/20 , C07D311/58 , C07D311/96 , C07D405/14 , C07D413/04
摘要： Fused bicyclic compound having an affinity to mineral corticoid receptor (MR), of formula [I]: wherein ring A is benzene having a substituent R1, fused to an adjacent 6-membered heterocyclic ring and further optionally having a substituent(s) other than R1, R1 is alkylsulfonylamino, etc., R2 and R3 are (a) the same of different and are hydrogen, alkyl, or optionally substituted aryl, or (b) combined with each other to form an oxo group or (c) combined with each other at its terminal together with the adjacent carbon atom to form cycloalkyl, X is ═N—, ═C(R4)— or —CH(R4)—, R4 is (a) hydrogen, (b) cyano, (c) halogen, (d) alkyl, (e) alkenyl, (f) cycloalkyl, (g) alkanoyl, (h) carbamoyl, or (i) cycloalkenyl, Ar is an optionally substituted aromatic cyclic group and a dotted line means presence or absence of a double bond, or a pharmaceutically acceptable salt thereof, useful e.g. as an antihypertensive agent.
摘要翻译：具有式[I]的矿物质类皮质激素受体（MR）的亲和性的稠合双环化合物：其中环A是具有取代基R 1的苯，与相邻的6元杂环稠合，并且进一步任选具有除 R 1，R 1是烷基磺酰基氨基等，R 2和R 3是（a）不同的并且是氢，烷基或任选取代的芳基，或（b）彼此结合形成氧代基或（c）与 X是= N - ， - C（R4） - 或-CH（R4） - ，R4是（a）氢，（b）氰基，（c）卤素，（d）烷基，（e）烯基，（f）环烷基，（g）烷酰基，（h）氨基甲酰基或（i）环烯基，Ar是任选取代的芳族环状基团，虚线表示存在或不存在双键或其药学上可接受的盐，例如，作为抗高血压药。

22. 发明授权

US08258131B2 Fused bicyclic compound 有权
标题翻译：稠合双环化合物
公开(公告)号：US08258131B2
公开(公告)日：2012-09-04
申请号：US12671479
申请日：2008-07-21
申请人： Yoichi Takahashi , Nobumasa Awai , Hidenori Akatsuka , Takayuki Kawaguchi , Toru Iijima
发明人： Yoichi Takahashi , Nobumasa Awai , Hidenori Akatsuka , Takayuki Kawaguchi , Toru Iijima
IPC分类号： C07D265/16 , A61K31/352 , A61K31/353
CPC分类号： C07D265/16 , C07D311/20 , C07D311/58 , C07D311/96 , C07D405/14 , C07D413/04
摘要： The present invention provides a novel fused bicyclic compound having an affinity to a receptor of mineral corticoid (MR), shown by the formula [I]: wherein the ring A is a benzene ring having a substituent R1, fused to an adjacent 6-membered heterocyclic ring and further optionally having a substituent(s) other than R1, R1 is an alkylsulfonylamino group etc., R2 and R3 are (a) the same of different and a hydrogen atom, an alkyl group or a substituted or unsubstituted aryl group, (b) combined each other to form an oxo group or (c) combined each other at its terminal together with the adjacent carbon atom to form a cycloalkyl group, X is a group of ═N—, ═C(R4)— or —CH(R4)—, R4 is (a) a hydrogen atom, (b) a cyano group, (c) a halogen atom, (d) an alkyl group, (e) an alkenyl group, (f) a cycloalkyl group (g) an alkanoyl group, (h) a carbamoyl group or (i) a cycloalkenyl group, Ar is an optionally substituted aromatic cyclic group and a dotted line means presence or absence of a double bond, or a pharmaceutically acceptable salt thereof, which is useful as an antihypertensive agent etc.
摘要翻译：本发明提供了对式[I]所示的对矿物质类皮质激素（MR）的受体具有亲和性的新的稠合双环化合物：其中环A是具有取代基R 1的苯环，与相邻的6元杂环，并且还可任选地具有除R1以外的取代基，R 1是烷基磺酰基氨基等，R 2和R 3是（a）不同的，和氢原子，烷基或取代或未取代的芳基，（b）彼此组合以形成氧代基团，或（c）在其末端与相邻的碳原子一起相互结合形成环烷基，X是一个= N - ， - C（R 4） - 或 - CH（R4） - ，R4是（a）氢原子，（b）氰基，（c）卤原子，（d）烷基，（e）烯基，（f）环烷基 g）烷酰基，（h）氨基甲酰基或（i）环烯基，Ar是任选取代的芳环基，虚线表示存在或不存在双键或其药学上可接受的盐，其可用作抗高血压剂等。

23. 发明授权

US07605158B2 Carbamoyl-type benzofuran derivatives 失效
标题翻译：氨基甲酰型苯并呋喃衍生物
公开(公告)号：US07605158B2
公开(公告)日：2009-10-20
申请号：US10571904
申请日：2004-09-24
申请人： Takayuki Kawaguchi , Hidenori Akatsuka , Masamichi Morimoto , Tatsuya Watanabe , Toru Iijima , Jun Murakami
发明人： Takayuki Kawaguchi , Hidenori Akatsuka , Masamichi Morimoto , Tatsuya Watanabe , Toru Iijima , Jun Murakami
IPC分类号： A61K31/5355 , A61K31/443 , C07D413/04 , C07D401/12 , C07D307/85
CPC分类号： C07D405/12 , C07D405/14
摘要： The present invention provides a carbamoyl-type benzofuran derivative of the formula [1]: wherein Ring Z is a group of the formula: etc.; A is a single bond, and the like; Y is a cycloalkanediyl group, etc.; R4 and R5 are the same or different and each is an optionally substituted lower alkyl group, etc.; R1 is a halogen atom, etc.; Ring B of the formula: is an optionally substituted benzene ring; and R3 is a hydrogen atom. etc., or a pharmaceutically acceptable salt thereof, which is useful as an FXa inhibitor.
摘要翻译：本发明提供式[1]的氨基甲酰基型苯并呋喃衍生物：其中环Z是下式的基团：等等; A是单键等; Y是环烷二基等; R4和R5相同或不同，各自为任选取代的低级烷基等; R1是卤素原子等; 下式的环B是任选取代的苯环; R3为氢原子。等等，或其药学上可接受的盐，其可用作FXa抑制剂。

24. 发明授权

US07456217B2 Inhibitors of alpha4 mediated cell adhesion 失效
标题翻译： α4介导的细胞粘附抑制剂
公开(公告)号：US07456217B2
公开(公告)日：2008-11-25
申请号：US11179729
申请日：2005-07-13
申请人： Takayuki Kawaguchi , Sumihiro Nomura , Mikiko Tsukimoto , Toshiyuki Kume , Ila Sircar
发明人： Takayuki Kawaguchi , Sumihiro Nomura , Mikiko Tsukimoto , Toshiyuki Kume , Ila Sircar
IPC分类号： A61K31/195 , C07C229/00
CPC分类号： C07C233/87 , A61K31/198
摘要： The present invention relates to a phenylalanine derivative of Formula (I) wherein X1 is a halogen atom, X2 is a halogen atom, Q is a CH2R— is a carboxyl group which may be esterified; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及式（I）的苯丙氨酸衍生物，其中X 1是卤原子，X 2是卤素原子，Q是CH 2 R-是可被酯化的羧基; 或其药学上可接受的盐。

25. 发明授权

US07026501B2 Inhibitors of α4 mediated cell adhesion 失效
标题翻译： α4介导的细胞粘附抑制剂
公开(公告)号：US07026501B2
公开(公告)日：2006-04-11
申请号：US10333985
申请日：2001-08-27
申请人： Takayuki Kawaguchi , Sumihiro Nomura , Mikiko Tsukimoto , Toshiyuki Kume
发明人： Takayuki Kawaguchi , Sumihiro Nomura , Mikiko Tsukimoto , Toshiyuki Kume
IPC分类号： C07C229/00 , A61K31/24 , A61K31/198
CPC分类号： C07C233/87 , A61K31/198
摘要： The present invention relates to a phenylalanine derivative of Formula (I) wherein X1 is a halogen atom, X2 is a halogen atom, Q is a CH2R— is a carboxyl group which may be esterified; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及式（I）的苯丙氨酸衍生物，其中X 1是卤原子，X 2是卤素原子，Q是CH 2 R-是可被酯化的羧基; 或其药学上可接受的盐。

26. 发明授权

US06927558B2 Power supply voltage lowering circuit used in semiconductor device 失效
公开(公告)号：US06927558B2
公开(公告)日：2005-08-09
申请号：US10671339
申请日：2003-09-25
申请人： Takayuki Kawaguchi , Jin Kashiwagi
发明人： Takayuki Kawaguchi , Jin Kashiwagi
IPC分类号： G11C11/413 , G05F1/46 , G05F3/24 , H01L21/822 , H01L27/04 , G05F3/16
CPC分类号： G05F1/465
摘要： A reference voltage generating circuit generates reference voltage and outputs the thus generated reference voltage from an output terminal thereof. A voltage generating circuit lowers external power supply voltage according to the reference voltage supplied from the reference voltage generating circuit to output internal power supply voltage from an output terminal thereof. A transistor has a current path connected between a terminal to which the external power supply voltage is supplied and the output terminal of the voltage generating circuit or between the terminal to which the external power supply voltage is supplied and the output terminal of the reference voltage generating circuit and a gate supplied with constant voltage and has negative threshold voltage.

27. 发明授权

US06729565B2 Process for reusing waste paint and processor therefor 失效
标题翻译：废旧油漆及其处理器的再利用过程
公开(公告)号：US06729565B2
公开(公告)日：2004-05-04
申请号：US09968525
申请日：2001-10-02
申请人： Tomihisa Yamakawa , Kuniya Sonehara , Takayuki Kawaguchi
发明人： Tomihisa Yamakawa , Kuniya Sonehara , Takayuki Kawaguchi
IPC分类号： B02C1912
CPC分类号： B02C4/04 , B02C4/44 , B02C17/16 , B02C21/00 , B02C21/005 , C08J11/00 , F26B11/14 , F26B17/20 , F26B17/284
摘要： The present invention provides a process and processor for reusing waste paint (i.e., a process and processor for converting waste paint into resources) which bring about efficient processing of the waste paint. In the process for reusing the waste paint, the waste paint is rolled between a pair of heated rotating drums disposed opposite to each other, to dehydrate and dry the waste paint (rough drying step); and the dehydrated and dried waste paint is ground by a rotating grinding rotor of which axial is perpendicularly arranged in a processing tank and further the dehydrated and dried waste paint is dehydrated, dried and pulverized (main drying step).
摘要翻译：本发明提供了一种用于使废漆（即，用于将废漆转化为资源的方法和处理器）再利用的方法和处理器，其实现废涂料的有效处理。在重新使用废涂料的过程中，废漆在彼此相对设置的一对加热的旋转鼓之间滚动，以使废漆脱水并干燥（粗糙干燥步骤）; 脱水干燥后的废漆通过旋转的研磨转子研磨，其轴向垂直设置在处理槽中，脱水干燥并粉碎（主干燥步骤）。

28. 发明授权

US06617456B1 Camptothecin derivatives 失效
标题翻译：喜树碱衍生物
公开(公告)号：US06617456B1
公开(公告)日：2003-09-09
申请号：US09624012
申请日：2000-07-21
申请人： Kenji Tsujihara , Takayuki Kawaguchi , Satoshi Okuno , Toshiro Yano
发明人： Kenji Tsujihara , Takayuki Kawaguchi , Satoshi Okuno , Toshiro Yano
IPC分类号： C07D49800
CPC分类号： C08B37/0018 , A61K47/61 , A61K47/65 , C08B37/0021
摘要： A camptothecin derivative comprising a compound of the formula [I]: wherein R1, R2, R3, R4 and R5 are (A) adjacent two groups combine to form alkylene, or both are H, and one of the remaining three groups is —Xn-Alkm-R6, and the other two are H, alkyl or halogen, or (B) adjacent two groups combine to form alkylene, and one of the carbon atoms of said alkylene group is substituted by —Xn-Alkm-R6, and the remaining three groups are H, alkyl or a halogen, and one or two —CH2— of the alkylene in (A) or (B) may optionally be replaced by —O—, —S— or —NH—, X is —O— or —NH—, Alk is alkylene, or —OH, m and n are both 0 or 1, or m is 1 and n is 0, which camptothecin compound is bound to a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable salt thereof. Said camptothecin derivatives show enhanced antitumor activities but few side effects and are useful as a medicament.
摘要翻译：包含式[I]化合物的喜树碱衍生物：其中R1，R2，R3，R4和R5是（A）相邻的两个基团结合形成亚烷基，或两者都是H，其余三个基团之一是-Xn -Alkm-R6，另外两个为H，烷基或卤素，或（B）相邻的两个基团结合形成亚烷基，所述亚烷基的一个碳原子被-Xn-Alkm-R6取代，并且剩余的三个基团是H，烷基或卤素，并且（A）或（B）中的一个或两个亚烷基的-CH 2可以任选地被-O - ， - S-或-NH-替代，X是-O - 或-NH-，Alk为亚烷基或-OH，m和n均为0或1，或m为1，n为0，喜树碱化合物通过氨基酸或肽与具有羧基的多糖结合，或其药学上可接受的盐。所述喜树碱衍生物显示出增强的抗肿瘤活性，但副作用很少，可用作药物。

29. 发明授权

US6044037A Semiconductor device 失效
标题翻译：半导体器件
公开(公告)号：US6044037A
公开(公告)日：2000-03-28
申请号：US103234
申请日：1998-06-23
申请人： Takayuki Kawaguchi
发明人： Takayuki Kawaguchi
IPC分类号： G11C11/41 , G11C8/18 , G11C8/00
CPC分类号： G11C8/18
摘要： A semiconductor device which enables quick and reliable adjustment of the address transition detection pulse width has an address transition detector (ATD) and n PMOS transistors connected in parallel to an output terminal, the PMOS transistors behaving as pull-up transistors for the ATD. The PMOS transistors are controlled by controlling outputs of n controllers which generate the outputs from a pulse-like waveform applied to an input terminal thereof, thus the size of the PMOS transistors are substantially changed.
摘要翻译：能够快速可靠地调整地址转换检测脉冲宽度的半导体器件具有与输出端并联连接的地址转换检测器（ATD）和n个PMOS晶体管，PMOS晶体管作为ATD的上拉晶体管。通过控制从施加到其输入端的脉冲状波形产生输出的n个控制器的输出来控制PMOS晶体管，因此PMOS晶体管的尺寸基本上改变。

30. 发明授权

US5068831A Data read circuit for semiconductor storage device 失效
标题翻译：半导体存储器件的数据读取电路
公开(公告)号：US5068831A
公开(公告)日：1991-11-26
申请号：US550025
申请日：1990-07-09
申请人： Satoru Hoshi , Masami Masuda , Takayuki Kawaguchi
发明人： Satoru Hoshi , Masami Masuda , Takayuki Kawaguchi
IPC分类号： G11C11/41 , G11C7/06 , G11C7/12 , G11C7/22 , G11C11/409 , G11C11/417 , H01L21/8242 , H01L27/10 , H01L27/108
CPC分类号： G11C7/12 , G11C7/06 , G11C7/22
摘要： In a data read circuit, for a semiconductor storage device, data of a memory cell (11) selected according to an address is inputted to a sense amplifier (22) via a pair of complementary first data lines (N1 to N6). The sense amplifier outputs the inputted and amplified data to a pair of complementary second data lines (N7, N8). First switching means (Tr3) equalizes the pair of complementary first data lines (N5, N6) at the input side of the sense amplifier (22) by making the first data lines conductive with respect to each other. Second switching means (Tr4) equalizes the pair of complementary second data lines (N7, N8) by making the second data lines conductive with respect to each other. Third switching means (Tr5, Tr6) equalizes by making the pair of first data lines (N5, N6) at the input side of the sense amplifier (22) and corresponding ones of the pair of second data lines (N7, N8) conductive with respect to each other. Second equalizing pulse generator means (42) generates a second equalizing pulse (.PHI..sub.eq ') when the address is changed, and turns on the first switch means (Tr3) by applying the second equalizing pulse to a control terminal of the first switch means. First equalizing pulse generator means (41) generates a first equalizing pulse (.PHI..sub.eq) when the address is changed, and turns on the second and third switching means (Tr4, Tr5, Tr6) by applying the second equalizing pulse to gate terminals of the second and third switching means. The load capacitance ]C(.PHI..sub.eq ')] connected to an output terminal of the second equalizing pulse generating means (42) is set smaller than the load capacitance [C(.PHI..sub.eq)] connected to an output terminal of the first equalizing pulse generator means (41). The number of stages of logical circuits constituting the second equalizing pulse generator means (42) is smaller than the number of stages of logical circuits constituting the first equalizing pulse generator means (41). Accordingly, with this data read circuit for a semiconductor storage device, the second equalizing pulse (.PHI..sub.eq ') from the second equalizing pulse generator means (42) is established earlier than the first equalizing pulse (.PHI..sub.eq) from the first equalizing pulse generator means (41).

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