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1. 发明授权

US06617456B1 Camptothecin derivatives 失效
标题翻译：喜树碱衍生物
公开(公告)号：US06617456B1
公开(公告)日：2003-09-09
申请号：US09624012
申请日：2000-07-21
申请人： Kenji Tsujihara , Takayuki Kawaguchi , Satoshi Okuno , Toshiro Yano
发明人： Kenji Tsujihara , Takayuki Kawaguchi , Satoshi Okuno , Toshiro Yano
IPC分类号： C07D49800
CPC分类号： C08B37/0018 , A61K47/61 , A61K47/65 , C08B37/0021
摘要： A camptothecin derivative comprising a compound of the formula [I]: wherein R1, R2, R3, R4 and R5 are (A) adjacent two groups combine to form alkylene, or both are H, and one of the remaining three groups is —Xn-Alkm-R6, and the other two are H, alkyl or halogen, or (B) adjacent two groups combine to form alkylene, and one of the carbon atoms of said alkylene group is substituted by —Xn-Alkm-R6, and the remaining three groups are H, alkyl or a halogen, and one or two —CH2— of the alkylene in (A) or (B) may optionally be replaced by —O—, —S— or —NH—, X is —O— or —NH—, Alk is alkylene, or —OH, m and n are both 0 or 1, or m is 1 and n is 0, which camptothecin compound is bound to a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable salt thereof. Said camptothecin derivatives show enhanced antitumor activities but few side effects and are useful as a medicament.
摘要翻译：包含式[I]化合物的喜树碱衍生物：其中R1，R2，R3，R4和R5是（A）相邻的两个基团结合形成亚烷基，或两者都是H，其余三个基团之一是-Xn -Alkm-R6，另外两个为H，烷基或卤素，或（B）相邻的两个基团结合形成亚烷基，所述亚烷基的一个碳原子被-Xn-Alkm-R6取代，并且剩余的三个基团是H，烷基或卤素，并且（A）或（B）中的一个或两个亚烷基的-CH 2可以任选地被-O - ， - S-或-NH-替代，X是-O - 或-NH-，Alk为亚烷基或-OH，m和n均为0或1，或m为1，n为0，喜树碱化合物通过氨基酸或肽与具有羧基的多糖结合，或其药学上可接受的盐。所述喜树碱衍生物显示出增强的抗肿瘤活性，但副作用很少，可用作药物。

2. 发明申请

US20200299118A1 TRANSPORT APPARATUS 审中-公开
公开(公告)号：US20200299118A1
公开(公告)日：2020-09-24
申请号：US16822156
申请日：2020-03-18
申请人： Satoru KURITA , Kazunori Bannai , Daisuke Maeda , Satoshi Okuno
发明人： Satoru KURITA , Kazunori Bannai , Daisuke Maeda , Satoshi Okuno
IPC分类号： B66F9/20 , B62B3/06 , B66F9/075 , B66F9/065
摘要： A transport apparatus includes a body; a fork having one portion supported by the body and another portion protruded from the body; a lifting unit; a control unit; a primary rotatable member mounted at a front end portion of the fork; an auxiliary rotatable member mounted at a rotatable-member-attaching position of the fork closer to a front end portion or a rear end portion of the fork compared to the primary rotatable member; and a step detection unit, disposed at a detection-unit-attaching position of the fork closer to the front end portion or closer to the rear end portion of the fork compared to the auxiliary rotatable member, and the step detection unit configured to detect a step member of a carriage base. The control unit lowers the fork using the lifting unit in response to a detection of the step member by the step detection unit.

3. 发明授权

US5892043A Camptothecin derivatives 失效
标题翻译：喜树碱衍生物
公开(公告)号：US5892043A
公开(公告)日：1999-04-06
申请号：US773182
申请日：1996-12-27
申请人： Kenji Tsujihara , Takayuki Kawaguchi , Satoshi Okuno , Toshiro Yano
发明人： Kenji Tsujihara , Takayuki Kawaguchi , Satoshi Okuno , Toshiro Yano
IPC分类号： A61K47/48 , C08B37/00 , C08B37/02 , C07D471/00
CPC分类号： C08B37/0018 , A61K47/4823 , A61K47/48338 , C08B37/0021
摘要： A camptothecin derivative comprising a compound of the formula �I!: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are (A) adjacent two groups combine to form alkylene, or both are H, and one of the remaining three groups is --X.sub.n --Alk.sub.m --R.sup.6, and the other two are H, alkyl or halogen, or (B) adjacent two groups combine to form alkylene, and one of the carbon atoms of said alkylene group is substituted by --X.sub.n --Alk.sub.m --R.sup.6, and the remaining three groups are H, alkyl or a halogen, and one or two --CH.sub.2 -- of the alkylene in (A) or (B) may optionally be replaced by --O--, --S-- or --NH--, X is --O-- or --NH--, Alk is alkylene, R.sup.6 is --NH.sub.2, ##STR2## or --OH, m and n are both 0 or 1, or m is 1 and n is 0, which camptothecin compound is bound to a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable salt thereof. Said camptothecin derivatives show enhanced antitumor activities but few side effects and are useful as a medicament.
摘要翻译：包含式[I]化合物的喜树碱衍生物：其中R 1，R 2，R 3，R 4和R 5是（A）相邻的两个基团结合形成亚烷基，或两者都是H，并且其中之一其余三个为-Xn-Alkm-R6，另外两个为H，烷基或卤素，或（B）相邻的两个基团结合形成亚烷基，所述亚烷基的一个碳原子被-Xn- Al-C-R6，其余三个基团是H，烷基或卤素，并且（A）或（B）中亚烷基的一个或两个-CH 2可以任选地被-O - ， - S-或-NH - ，X为-O-或-NH-，Alk为亚烷基，R6为-NH2，或IMA为-OH，m和n均为0或1，或m为1，n为0，喜树碱化合物为通过氨基酸或肽或其药学上可接受的盐与具有羧基的多糖结合。所述喜树碱衍生物显示出增强的抗肿瘤活性，但副作用很少，可用作药物。

4. 发明授权

US5863907A Carboxymethylmannoglucans and derivatives thereof 失效
公开(公告)号：US5863907A
公开(公告)日：1999-01-26
申请号：US681981
申请日：1996-07-30
申请人： Kazuhiro Inoue , Teruomi Ito , Takayuki Kawaguchi , Katsutoshi Aono , Satoshi Okuno , Toshiro Yano
发明人： Kazuhiro Inoue , Teruomi Ito , Takayuki Kawaguchi , Katsutoshi Aono , Satoshi Okuno , Toshiro Yano
IPC分类号： A61K47/36 , A61K47/48 , C08B15/00 , C08B37/00 , A61K31/725 , A61K31/715 , A61K31/72
CPC分类号： C08B37/0087 , A61K47/4823
摘要： A carboxymethylmannoglucan comprising tetrasaccharide units represented by the following general formula (I) and salt thereof. Further, the invention discloses a carboxymethylmannoglucan derivative and salt thereof produced by subjecting part or the whole of mannose of the tetrasaccharide units to ring opening and subjecting part or the whole of glucose which constitute the main chain but have no mannose as a branch ##STR1## wherein R.sup.1 to R.sup.12 each represent a hydrogen atom or a carboxymethyl group.The compounds are useful as carrier for delaying the disappearance of a drug in the blood and for enhancing the organotropism of the drug for a carcinoma.

5. 发明授权

US5863908A Carboxymethylmannoglucans and derivatives thereof 失效
标题翻译：羧甲基甘露糖葡聚糖及其衍生物
公开(公告)号：US5863908A
公开(公告)日：1999-01-26
申请号：US689095
申请日：1996-07-30
申请人： Kazuhiro Inoue , Teruomi Ito , Takayuki Kawaguchi , Katsutoshi Aono , Satoshi Okuno , Toshiro Yano
发明人： Kazuhiro Inoue , Teruomi Ito , Takayuki Kawaguchi , Katsutoshi Aono , Satoshi Okuno , Toshiro Yano
IPC分类号： A61K47/36 , A61K47/48 , C08B15/00 , C08B37/00 , A61K31/725 , A61K31/715 , A61K31/72
CPC分类号： C08B37/0087 , A61K47/4823
摘要： A carboxymethylmannoglucan comprising tetrasaccharide units represented by the following general formula (I) and salt thereof. Further, the invention discloses a carboxymethylmannoglucan derivative and salt thereof produced by subjecting part or the whole of mannose of the tetrasaccharide units to ring opening and subjecting part or the whole of glucose which constitute the main chain but have no mannose as a branch ##STR1## wherein R.sup.1 to R.sup.12 each represent a hydrogen atom or a carboxymethyl group.The compounds are useful as carrier for delaying the disappearance of a drug in the blood and for enhancing the organotropism of the drug for a carcinoma.
摘要翻译：包含由以下通式（I）表示的四糖单元及其盐的羧甲基甘露糖葡聚糖。此外，本发明公开了通过使四糖单元的一部分或全部甘露糖开环并使构成主链但不具有甘露糖的部分或全部葡萄糖作为分支而制备的羧甲基葡萄糖聚糖衍生物及其盐。（I）其中R 1至R 12各自表示氢原子或羧甲基。这些化合物可用作延迟药物在血液中消失并用于增强癌症药物的有机性的载体。

6. 发明授权

US5837673A Camptothecin derivatives 失效
标题翻译：喜树碱衍生物
公开(公告)号：US5837673A
公开(公告)日：1998-11-17
申请号：US689018
申请日：1996-07-30
申请人： Kenji Tsujihara , Takayuki Kawaguchi , Satoshi Okuno , Toshiro Yano
发明人： Kenji Tsujihara , Takayuki Kawaguchi , Satoshi Okuno , Toshiro Yano
IPC分类号： A61K9/00 , A61K31/4745 , A61K38/00 , A61K47/48 , A61P35/00 , C07D491/22 , C07K5/065 , C07K5/103 , C07K9/00 , A61K31/00 , A61K38/14
CPC分类号： C07D491/22 , A61K47/4823 , A61K47/48338 , C07K5/06078 , C07K5/1008 , C07K9/003 , A61K38/00
摘要： A camptothecin derivative comprising a compound of the formula �I!: ##STR1## wherein R.sup.1 is a substituted or unsubstituted lower alkyl group, X.sup.1 is a group of the formula: --NHR.sup.2 (R.sup.2 is a hydrogen atom or a lower alkyl group) or a group of --OH, and Alk is a straight chain or branched chain alkylene group having optionally an oxygen atom in the chain thereof, bound to a polysaccharide having carboxyl groups via an amino acid or a peptide, or a pharmaceutically acceptable salt thereof. Said camptothecin derivatives show enhanced antitumor activities but few side effects unlike conventional anticancer agents, and hence, these compounds are extremely useful as a medicament.
摘要翻译：包含式[I]化合物的喜树碱衍生物：其中R1是取代或未取代的低级烷基，X1是下式的基团：-NHR2（R2是氢原子或低级烷基基团）或一组-OH，Alk是其链中任选具有氧原子的直链或支链亚烷基，经由氨基酸或肽与具有羧基的多糖结合，或其药学上可接受的盐其中。所述喜树碱衍生物显示增强的抗肿瘤活性，但与常规抗癌剂不同的副作用很少，因此这些化合物作为药物是非常有用的。

7. 发明授权

US5688931A Polysaccharide derivatives and drug carriers 失效
标题翻译：多糖衍生物和药物载体
公开(公告)号：US5688931A
公开(公告)日：1997-11-18
申请号：US325296
申请日：1994-12-28
申请人： Hideo Nogusa , Hiroshi Hamana , Toshiro Yano , Masahiro Kajiki , Keiji Yamamoto , Satoshi Okuno , Shuichi Sugawara , Nobukazu Kashima , Kazuhiro Inoue
发明人： Hideo Nogusa , Hiroshi Hamana , Toshiro Yano , Masahiro Kajiki , Keiji Yamamoto , Satoshi Okuno , Shuichi Sugawara , Nobukazu Kashima , Kazuhiro Inoue
IPC分类号： A61K47/48 , C08B37/00 , C08B37/02 , C07H13/02 , C07K5/00 , C08B37/08
CPC分类号： C08B37/0063 , A61K47/48338 , C08B37/00 , C08B37/0006
摘要： A novel polysaccharide derivative, a drug carrier comprising a novel polysaccharide derivative, and a drug complex are disclosed. The polysaccharide derivative according to the present invention comprises a polysaccharide having a carboxyl group in which a peptide chain is introduced at a part or all of the carboxyl groups of the polysaccharide. The peptide chain comprises 1-8 amino acids which may be the same or different. A part or all of the amino groups in the peptide chain which are not involved in the linkages with the carboxyl groups of the polysaccharide or the carboxyl groups in the peptide chain may form an acid amide linkage or an ester linkage with a carboxyl group, an amino group or a hydroxyl group of a third compound such as drugs. The polysaccharide derivative has a property of accumulating in a high amount at a tumor, and thus can deliver efficiently a drug which has a side-effect or a limited sustainment of the drug efficacy to the tumor.
摘要翻译： PCT No.PCT / JP94 / 00322 Sec。 371日期1994年12月28日第 102（e）日期1994年12月28日PCT 1994年2月28日PCT PCT。第WO94 / 19376号公报日期1994年9月1日公开了一种新型多糖衍生物，包含新型多糖衍生物的药物载体和药物复合物。本发明的多糖衍生物含有在多糖的一部分或全部羧基上引入肽链的具有羧基的多糖。肽链包含1-8个氨基酸，其可以相同或不同。不参与与肽链中的多糖或羧基的羧基的连接的肽链中的一部分或全部氨基可以与羧基形成酸酰胺键或酯键，氨基或第三化合物如药物的羟基。多糖衍生物具有在肿瘤中高度积累的性质，因此能够有效地递送对肿瘤具有药效的副作用或有限维持性的药物。

8. 发明授权

US5567690A Carboxymethylmannoglucans and derivatives thereof 失效
公开(公告)号：US5567690A
公开(公告)日：1996-10-22
申请号：US397560
申请日：1995-03-02
申请人： Kazuhiro Inoue , Teruomi Ito , Takayuki Kawaguchi , Katsutoshi Aono , Satoshi Okuno , Toshiro Yano
发明人： Kazuhiro Inoue , Teruomi Ito , Takayuki Kawaguchi , Katsutoshi Aono , Satoshi Okuno , Toshiro Yano
IPC分类号： A61K47/36 , A61K47/48 , C08B15/00 , C08B37/00 , A61K31/725 , A61K31/715 , A61K31/72
CPC分类号： C08B37/0087 , A61K47/4823
摘要： A carboxymethylmannoglucan comprising tetrasaccharide units represented by the following general formula (I) and salt thereof. Further, the invention discloses a carboxymethylmannoglucan derivative and salt thereof produced by subjecting part or the whole of mannose of the tetrasaccharide units to ring opening and subjecting part or the whole of glucose which constitute the main chain but have no mannose as a branch ##STR1## wherein R.sup.1 to R.sup.12 each represent a hydrogen atom or a carboxymethyl group.The compounds are useful as carrier for delaying the disappearance of a drug in the blood and for enhancing the organotropism of the drug for a carcinoma.

9. 发明授权

US5269236A Method and apparatus for preventing the adhesion of dust in an incinerator or melting furnace 失效
标题翻译：用于防止灰尘在焚化炉或熔化炉中粘附的方法和装置
公开(公告)号：US5269236A
公开(公告)日：1993-12-14
申请号：US886248
申请日：1992-05-21
申请人： Satoshi Okuno , Toshihisa Gouda , Kazuo Sato , Shizuo Yasuda , Hiroki Honda , Susumu Nishikawa
发明人： Satoshi Okuno , Toshihisa Gouda , Kazuo Sato , Shizuo Yasuda , Hiroki Honda , Susumu Nishikawa
IPC分类号： F23L7/00 , F23M5/08 , F27B3/08 , F27D1/00 , F27D21/02 , F27D25/00
CPC分类号： F27D25/008 , F23L7/002 , F23M5/085 , F27D21/02 , F27B3/085 , F27D1/003
摘要： A method of preventing dust from adhering to a wall of a combustion apparatus, such as a furnace wall or exhaust duct, is carried out by forcing gas through a porous refractory member forming the wall. Specifically, the furnace wall or exhaust duct wall to which dust might otherwise adhere is made of a porous refractory member and gas is injected through the pores of the refractory member. In an incinerator, the refractory porous member extends around the periphery of a liquid injection nozzle, so that gas fed to the inside of the incinerator through the refractory porous member prevents flower from accumulating at the periphery of the end of the nozzle and attenuates the wake of the injected liquid so as to suppress the entrainment of dust in the liquid. In a melting furnace, the refractory porous members provide the ceiling of a slag separating chamber and the entrance of an exhaust gas duct open to the upper portion of the slag separating chamber. Plate-like members form wind chambers with the porous refractory members so that cooling gas fed into the wind chambers is forced into the slag separating chamber and exhaust duct through the pores in the refractory porous members.
摘要翻译：通过迫使气体通过形成壁的多孔耐火材料来进行防止灰尘附着在诸如炉壁或排气管的燃烧装置的壁上的方法。具体地，灰尘可能附着的炉壁或排气管道壁由多孔耐火构件制成，并且气体通过耐火构件的孔注入。在焚烧炉中，耐火多孔构件围绕液体喷嘴的周边延伸，使得通过耐火多孔构件供给到焚烧炉内部的气体防止花在喷嘴端部的周边积聚，并且使尾迹以抑制灰尘在液体中的夹带。在熔炉中，耐火多孔构件提供炉渣分离室的顶板和与渣分离室的上部开口的废气管道的入口。板状构件与多孔耐火构件形成风室，使得进入风室的冷却气体通过耐火多孔构件中的孔被迫进入炉渣分离室和排气管道。

10. 发明申请

US20060052288A1 Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor 审中-公开
公开(公告)号：US20060052288A1
公开(公告)日：2006-03-09
申请号：US11265266
申请日：2005-11-03
申请人： Takayuki Kawaguchi , Satoshi Okuno , Toshiro Yano
发明人： Takayuki Kawaguchi , Satoshi Okuno , Toshiro Yano
IPC分类号： A61K38/16 , A61K38/14
CPC分类号： A61K47/61 , A61K47/65
摘要： A pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of a malignant tumor, which comprises as the active ingredient a polysaccharide derivative comprising a polysaccharide having a carboxyl group bound to an active substance having an anti-tumor activity via an amino acid or a peptide consisting of 2 to 8 amino acids which are the same or different, or a salt thereof.

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