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21. 发明授权

US4888417A Therapeutic and prophylactic agents for peptic ulcer 失效
标题翻译：消化性溃疡的治疗和预防剂
公开(公告)号：US4888417A
公开(公告)日：1989-12-19
申请号：US867169
申请日：1986-05-27
申请人： Yusei Shiraga , Chikara Fukaya , Toshiaki Akira , Masakazu Iwai , Kazumasa Yokoyama , Mamoru Tabata , Hiroshi Fukui , Shigeo Tanaka , Yoshiro Iga , Tadakazu Suyama , Kanemichi Okano
发明人： Yusei Shiraga , Chikara Fukaya , Toshiaki Akira , Masakazu Iwai , Kazumasa Yokoyama , Mamoru Tabata , Hiroshi Fukui , Shigeo Tanaka , Yoshiro Iga , Tadakazu Suyama , Kanemichi Okano
IPC分类号： A61K31/12 , A61K31/70 , A61K36/54 , C07C49/242 , C07C49/255 , C07C49/647 , C07C49/743 , C07H15/18 , C07H15/203 , C07H15/207
CPC分类号： C07C403/08 , C07C403/10 , C07C403/12 , C07H15/18 , C07H15/203 , C07C2101/16 , Y10S514/927
摘要： A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I): ##STR1## wherein R.sub.1 represents hydrogen or =O; R.sub.2 represents hydrogen or --OR.sub.5 ; R.sub.3 represents hydrogen or --OR.sub.6 ; R.sub.4 represents --OR.sub.7 in the case of the absence of double bond; R.sub.5, R.sub.6 and R.sub.7 each represents hydrogen or an organic residue;X represents group (A):.dbd.C.dbd.CH--COR.sub.8 (A) or group (B): ##STR2## wherein R.sub.8 represents alkyl, and R.sub.9 and R.sub.10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R.sub.1 and R.sub.3 both represent hydrogen, R.sub.2 represents --OR.sub.5 ; R.sub.4 represents OR.sub.7 and the bond between the carbon atoms to which X is attached and the carbon atom to which R.sub.4 is attached is a single bond, and when X represents group (B), then R.sub.1 represents .dbd.O, R.sub.2 represents hydrogen, R.sub.3 represents --OR.sub.6 and the bond between the carbon atom to which X is attached and the carbon atom to which R.sub.4 is attached is a double bond, or a pharmaceutically acceptable salt thereof, or a compound of the general formula (II): ##STR3## wherein R.sub.11 represents hydrogen or an organic residue, and R.sub.12, R.sub.13 and R.sub.14 each represents an organic residue, or a pharmaceutically acceptable salt thereof. The compounds of the general formulae (I) and (II) can be derived from compounds contained in a hot water extract of cinnamon.
摘要翻译：含有作为活性成分的通式（I）的化合物的消化性溃疡的治疗和预防剂：其中R1表示氢或= O; R2代表氢或-OR5; R3表示氢或-OR6; 在不存在双键的情况下，R4代表-OR7; R5，R6和R7各自表示氢或有机残基; X表示基团（A）：= C = CH-COR 8（A）或基团（B）：其中R 8表示烷基，R 9和R 10各自表示氢或有机残基; 条件是当X表示基团（A）时，则R1和R3都表示氢，R2表示-OR5; R4表示OR7，X所连接的碳原子和与R4连接的碳原子之间的键为单键，当X表示基团（B）时，则R 1表示= O，R 2表示氢，R 3表示 -OR 6和X所连接的碳原子和与R 4连接的碳原子之间的键是双键，或其药学上可接受的盐或通式（II）的化合物：（ II）其中R 11表示氢或有机残基，R 12，R 13和R 14各自表示有机残基或其药学上可接受的盐。通式（I）和（II）的化合物可以衍生自肉桂热水提取物中所含的化合物。

22. 发明授权

US4748157A Composition for gastrointestinal ulcers 失效
标题翻译：胃肠溃疡的成分
公开(公告)号：US4748157A
公开(公告)日：1988-05-31
申请号：US827209
申请日：1986-02-04
申请人： Masakazu Iwai , Kazumasa Yokoyama , Tsunekazu Fukushima
发明人： Masakazu Iwai , Kazumasa Yokoyama , Tsunekazu Fukushima
IPC分类号： A61K38/00 , C07K16/18 , A61K37/00 , C07G7/00
CPC分类号： C07K16/18 , A61K38/00 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/929 , Y10S530/866
摘要： Fab or Fc fragment of human IgG which is obtainable by enzymatic digestion of the human IgG is reduced by a reducing agent to sever an interchain of disulfide bonds therein and then blocked the SH radicals formed with alkyl group which may contain other group. The resulting alkylated Fab and Fc fragments display therapeutic and prophylactic action for gastrointestinal ulcers by the oral or parenteral administration.
摘要翻译：通过人IgG的酶消化可获得的人IgG的Fab或Fc片段被还原剂还原，以切断其中二硫键的链间，然后封闭由可能含有其它基团的烷基形成的SH自由基。所得到的烷基化Fab和Fc片段通过口服或肠胃外给药显示对胃肠溃疡的治疗和预防作用。

23. 发明授权

US4687762A Water soluble drug complex and method for production of same 失效
标题翻译：水溶性药物复合物及其制备方法
公开(公告)号：US4687762A
公开(公告)日：1987-08-18
申请号：US716436
申请日：1985-03-27
申请人： Tsunekazu Fukushima , Hiroshi Emoto , Yoshio Kagitani , Kazumasa Yokoyama , Masayuki Nishida , Tadakazu Suyama
发明人： Tsunekazu Fukushima , Hiroshi Emoto , Yoshio Kagitani , Kazumasa Yokoyama , Masayuki Nishida , Tadakazu Suyama
IPC分类号： B01J13/02 , A61K9/00 , A61K9/127 , A61K9/50 , A61K31/70 , A61K31/545 , A61K31/685
CPC分类号： A61K47/48053 , A61K9/1277
摘要： The invention provides a method of producing a water-soluble complex comprising a water-insoluble drug and a phospholipid, comprising the steps of (1) dissolving a water-insoluble drug and a phospholipid in an organic solvent, (2) removing the solvent to leave behind a drug-containing phospholipid film, (3) suspending the resulting film in an aqueous solution, (4) ultrasonicating the film, (5) centrifuging the resulting suspension, and (6) recovering the lowermost layer of the resulting sediment to yield the water-soluble complex. The above complex can be administered parenterally as well as by the oral and other routes, and is so rich in the drug component that a remarkably increased drug activity can be realized.
摘要翻译：本发明提供一种生产包含水不溶性药物和磷脂的水溶性络合物的方法，包括以下步骤：（1）将水不溶性药物和磷脂溶于有机溶剂中，（2）除去溶剂至留下含药磷脂膜，（3）将所得膜悬浮在水溶液中，（4）使膜超声波化，（5）离心所得悬浮液，（6）回收所得沉淀物的最下层，得到水溶性复合物。上述复合物可以肠胃外给药，口服给药或其他途径给药，药物成分丰富，药物活性显着提高。

24. 发明授权

US4613614A Prostaglandin I.sub.2 ester and fat emulsion containing the same 失效
标题翻译：前列腺素I2酯和脂肪乳剂含有相同的
公开(公告)号：US4613614A
公开(公告)日：1986-09-23
申请号：US626422
申请日：1984-06-29
申请人： Chikara Fukaya , Youichiro Naito , Kazumasa Yokoyama
发明人： Chikara Fukaya , Youichiro Naito , Kazumasa Yokoyama
IPC分类号： C07D307/935 , A61K9/107 , A61K31/557 , A61P43/00 , C07D307/937 , A61K31/74 , C07D307/93
CPC分类号： C07D307/937
摘要： There is provided a new ester of prostaglandin of the formula ##STR1## wherein R.sub.1 denotes an alkyl group having 1 to 20 carbon atoms; R.sub.2 denotes a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms; and X denotes a group represented by the formula ##STR2## The new ester dissolves in oil easier than prostaglandin I.sub.2 itself and can easily be emulsified in the form of particles of solution in a vegetable oil. The ester in the fat emulsion is more stable than prostaglandin I.sub.2 and its physiological acts which are the same as prostaglandin I.sub.2 are prolonged.
摘要翻译：提供了一种新型的具有式“IMAGE”的前列腺素酯，其中R 1表示具有1至20个碳原子的烷基; R2表示氢原子或碳原子数1〜4的低级烷基，并且X表示由下式表示的基团。新的酯比前列腺素I2本身容易溶于油中，并且可以容易地以植物油中的溶液颗粒的形式乳化。脂肪乳剂中的酯比前列腺素I2更稳定，其与前列腺素I2相同的生理作用延长。

25. 发明授权

US4605650A Perfluoro-1-azatricyclic amine compounds useful as oxygen carriers in artificial blood and infusion fluids 失效
标题翻译：全氟-1-氮杂环胺化合物可用作人造血液和输注液中的氧载体
公开(公告)号：US4605650A
公开(公告)日：1986-08-12
申请号：US751850
申请日：1983-07-05
申请人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
发明人： Kazumasa Yokoyama , Chikara Fukaya , Yoshio Tsuda , Taizo Ono , Yoshio Arakawa , Yoshihisa Inoue , Youichiro Naito , Tadakazu Suyama
IPC分类号： A61K9/00 , C07D453/02 , C07D471/08 , C07D487/08 , C25B3/08 , A61K31/40
CPC分类号： A61K9/0026 , C07D453/02 , C07D471/08 , C07D487/08 , C25B3/08 , Y10S514/832 , Y10S514/833
摘要： A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 to 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.

26. 发明授权

US4186253A Perfusate for preserving organ to be transplanted and preserving method 失效
标题翻译：用于保存器官的移植和保存方法
公开(公告)号：US4186253A
公开(公告)日：1980-01-29
申请号：US950071
申请日：1978-10-10
申请人： Kazumasa Yokoyama , Masakazu Iwai , Hiroyuki Okamoto , Noboru Yamada
发明人： Kazumasa Yokoyama , Masakazu Iwai , Hiroyuki Okamoto , Noboru Yamada
IPC分类号： A01N1/00 , A01N1/02 , C12B3/00 , A61K31/025
CPC分类号： A01N1/02 , A01N1/0226
摘要： An organ to be transplanted, such as kidney, can effectively be preserved by perfusion for a considerably long time by the use of a perfusate which is made by mixing a Ringer's solution modified by increasing potassium ion to 8-20 meq/l, a stable perfluorocarbon compound emulsion and albumin, so that the concentration of the perfluorocarbon compound is 7.5 to 12.5% (W/V) and that of albumin is 1-8% (W/V) based on the perfusate.
摘要翻译：通过使用通过将通过增加钾离子修饰的林格氏溶液混合至8-20meq / l而制成的灌注液，可以通过灌注相当长的时间来有效地保存要移植的器官，例如肾脏，稳定的全氟化碳化合物乳液和白蛋白，使得全氟化碳化合物的浓度为7.5至12.5％（W / V），而白蛋白的浓度为基于灌注液的1-8％（W / V）。

27. 发明授权

US3993581A Process for preparing stable oxygen transferable emulsion 失效
标题翻译：制备稳定的可转印乳液的方法
公开(公告)号：US3993581A
公开(公告)日：1976-11-23
申请号：US485318
申请日：1974-07-02
申请人： Kazumasa Yokoyama , Koichi Yamanouchi , Ryoichiro Murashima , Ryozo Watanabe
发明人： Kazumasa Yokoyama , Koichi Yamanouchi , Ryoichiro Murashima , Ryozo Watanabe
IPC分类号： A61K9/00 , A61K31/02 , B01J13/00
CPC分类号： A61K9/0026 , A61K31/02 , Y10S516/06
摘要： Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C.sub.3.sub.-5 -alkylcyclohexanes), perfluoro(C.sub.4.sub.-6 -alkyl tetrahydropyrans), perfluoro(C.sub.5.sub.-7 -alkyltetrahydrofurans), perfluoro(C.sub.5.sub.-7 -alkylmorpholins) and perfluoro(C.sub.9.sub.-11 -trialkylamines) are emulsified in a physiologically acceptable aqueous solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 .mu.. It is usable as a blood substitute or a perfurate for preservation of the internal organs.
摘要翻译：可全氟（C 5-8 - 烷基环己烷），全氟（C 5-6 - 烷基四氢吡喃），全氟（C 5-7 - 烷基四氢呋喃），全氟（C 5-7 - 烷基四氢呋喃），全氟）和全氟（C9-11-三烷基胺）在生理学上可接受的水溶液如林格氏溶液中借助于磷脂作为乳化剂和8-22个碳原子的脂肪酸，其碱金属盐或其单甘油酯作为乳化助剂乳化。该乳液在相当长的一段时间内是稳定的并且含有粒度范围为0.05-0.3μm的颗粒。它可用作血液替代物或用于保存内脏的胃酸。

28. 发明申请

US20090032993A1 SOLUTION CASTING METHOD AND DEPOSIT REMOVING DEVICE 审中-公开
标题翻译：解决方案和沉积物去除装置
公开(公告)号：US20090032993A1
公开(公告)日：2009-02-05
申请号：US12282409
申请日：2007-03-07
申请人： Kazumasa Yokoyama
发明人： Kazumasa Yokoyama
IPC分类号： B29D7/00 , B29C39/16
CPC分类号： G02B5/3083 , B29C41/26 , B29C41/34 , B29K2001/00 , B29K2001/12
摘要： A drum cleaning device (65) has a nozzle (66). The drum cleaning device (65) is disposed in the upstream from a peel roller (34). A dope (21) is cast onto a surface of the casting drum(32) by using a casting die (30). The casting drum(32) is rotated to form a casting film(33) on the surface. The casting film(33) is cooled by the casting drum(32). Deposits containing fatty acid ester as a main component are precipitated from the casting film(33) onto the surface. The peel roller (34) peels off the casting film(33) as a wet film(38). The drum cleaning device (65) blasts gas mixture containing air and dry ice particles from the nozzle (66) onto the surface.
摘要翻译：鼓清洁装置（65）具有喷嘴（66）。滚筒清洁装置（65）设置在剥离辊（34）的上游。通过使用铸模（30）将涂料（21）浇铸到流延鼓（32）的表面上。铸塑滚筒（32）旋转以在表面上形成流延膜（33）。流延膜（33）由流延鼓（32）冷却。含有脂肪酸酯作为主要成分的沉淀物从浇铸膜（33）沉淀到表面上。剥离辊（34）作为湿膜（38）剥离流延薄膜（33）。鼓清洁装置（65）将含有空气和干冰颗粒的气体混合物从喷嘴（66）喷射到表面上。

29. 发明授权

US06617133B1 Process for purifying recombinant human serum albumin 有权
标题翻译：重组人血清白蛋白纯化方法
公开(公告)号：US06617133B1
公开(公告)日：2003-09-09
申请号：US09317214
申请日：1999-05-24
申请人： Munehiro Noda , Akinori Sumi , Takao Ohmura , Kazumasa Yokoyama
发明人： Munehiro Noda , Akinori Sumi , Takao Ohmura , Kazumasa Yokoyama
IPC分类号： C12P2100
CPC分类号： C07K14/765
摘要： The invention provides a process for purifying recombinant human serum albumin (rHSA) by heating a-culture medium containing rHSA and the rHSA-producing host cells, feeding said heated solution upwardly into a fluidized bed in which adsorbent particles are suspended to effect contacting with the adsorbent particles and then recovering the adsorbed fraction containing the rHSA, and a composition comprising rHSA which shows a A350/A280 ratio of below 0.015, when formulated into a 25% solution of said albumin.
摘要翻译：本发明提供了通过加热含有rHSA和产生rHSA的宿主细胞的培养基来纯化重组人血清白蛋白（rHSA）的方法，将所述加热溶液向上加入流化床中，其中吸附剂颗粒悬浮以实现与吸附剂颗粒，然后回收含有rHSA的吸附级分，以及包含rHSA的组合物，其在配制成所述白蛋白的25％溶液时显示A350 / A280比率低于0.015。

30. 发明授权

US5962649A Process for purifying recombinant human serum albumin 失效
标题翻译：重组人血清白蛋白纯化方法
公开(公告)号：US5962649A
公开(公告)日：1999-10-05
申请号：US522089
申请日：1995-08-31
申请人： Munehiro Noda , Akinori Sumi , Takao Ohmura , Kazumasa Yokoyama
发明人： Munehiro Noda , Akinori Sumi , Takao Ohmura , Kazumasa Yokoyama
IPC分类号： C07K14/765 , C07K1/16
CPC分类号： C07K14/765
摘要： The invention provides a process for purifying recombinant human serum albumin (rHSA) by heating a culture medium containing rHSA and the rHSA-producing host cello, feeding said heated solution upwardly into a fluidized bed in which adsorbent particles are suspended to effect contacting with the adsorbent particles and then recovering the adsorbed fraction containing the rHSA, and a composition comprising rHSA which shows a A35D/A280 ratio of below 0.015, when formulated into a 25% solution of said albumin.
摘要翻译：本发明提供了通过加热含有rHSA和产生rHSA的宿主大肠杆菌的培养基来纯化重组人血清白蛋白（rHSA）的方法，将所述加热溶液向上加入到流化床中，其中吸附剂颗粒悬浮以与吸附剂接触颗粒，然后回收含有rHSA的吸附级分，以及包含rHSA的组合物，其在配制成所述白蛋白的25％溶液时显示A35D / A280比率低于0.015。

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