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    • 29. 发明申请
    • Targeted Vectors
    • 目标向量
    • US20070202524A1
    • 2007-08-30
    • US11694683
    • 2007-03-30
    • Richard Murphy
    • Richard Murphy
    • C12Q1/68C12P19/34
    • C12N15/86A61K31/70A61K47/6901A61K48/00C07K16/00C12N2710/10343C12N2710/10345C12N2810/859C12P19/34
    • This invention provides therapeutic and diagnostic agent delivery vehicles, including viral vectors, that are complexed to a targeting moiety by coordinate covalent linkages mediated by a transition metal ion. The complex is typically formed with a transition metal ion that is in a kinetically labile oxidation state; after the complex is formed, the oxidation state of the transition metal ion is changed to one that renders the complex kinetically stable. The use of a coordinate covalent linkage to attach the targeting moiety to the delivery vehicle provides advantages such as the ability to readily attach a different targeting moiety to a delivery vehicle without modifying the delivery vehicle itself. This flexibility is achieved without sacrificing stability of the complex.
    • 本发明提供了通过由过渡金属离子介导的配位共价键与靶向部分复合的治疗和诊断剂递送载体,包括病毒载体。 络合物通常形成为具有动态不稳定氧化态的过渡金属离子; 复合物形成后,过渡金属离子的氧化态变为使复合物动力学稳定的氧化态。 使用坐标共价连接将靶向部分连接到递送载体提供了诸如在不改变递送载体本身的情况下容易地将不同靶向部分附着到递送载体的能力的优点。 在不牺牲复合物的稳定性的情况下实现这种灵活性。