专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20090053185A1 Coagulation factor x polypeptides with modified activation properties 有权
标题翻译：凝血因子x多肽具有修饰的活化特性
公开(公告)号：US20090053185A1
公开(公告)日：2009-02-26
申请号：US11921399
申请日：2006-05-30
申请人： Stefan Schulte , Hans-Peter Hauser , Uwe Kalina , Thomas Weimer
发明人： Stefan Schulte , Hans-Peter Hauser , Uwe Kalina , Thomas Weimer
IPC分类号： A61K48/00 , C07K2/00 , C07H21/04 , C12N15/63 , C12N5/00 , C12P21/06 , A61K38/00 , A61K31/7088
CPC分类号： C12N9/6432 , C12Y304/21006
摘要： The present invention relates to modified cDNA sequences coding for human Factor X and their derivatives with improved stability and modified activation sequences, recombinant expression vectors containing such cDNA sequences, and host cells transformed with such recombinant expression vectors. The invention also relates to recombinant factor X polypeptides and derivatives which have biological activities of the unmodified wild type protein but with improved stability and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises such modified DNA.
摘要翻译：本发明涉及编码具有改善的稳定性和修饰的活化序列的人因子X及其衍生物的修饰的cDNA序列，含有此类cDNA序列的重组表达载体和用这些重组表达载体转化的宿主细胞。本发明还涉及具有未修饰的野生型蛋白的生物活性但具有改进的稳定性的重组因子X多肽和衍生物，以及用于制备这些重组蛋白及其衍生物的方法。本发明还涵盖用于人基因治疗的转移载体，其包含这种修饰的DNA。

22. 发明授权

US07002694B2 Interferometer system and method for recording an interferogram using weighted averaging over multiple frequencies, and method for providing and manufacturing an object having a target surface 失效
标题翻译：使用多个频率上的加权平均来记录干涉图的干涉仪系统和方法以及用于提供和制造具有目标表面的物体的方法
公开(公告)号：US07002694B2
公开(公告)日：2006-02-21
申请号：US10743792
申请日：2003-12-24
申请人： Stefan Schulte , Bernd Dörband , Henriette Müller , Wolfgang Kähler
发明人： Stefan Schulte , Bernd Dörband , Henriette Müller , Wolfgang Kähler
IPC分类号： G01B9/02
CPC分类号： G01B9/02057 , G01B9/02004 , G01B9/02039 , G01B9/02059 , G01B9/02069 , G01B9/02072 , G01B11/2441 , G01B11/306
摘要： An interferometer system comprises a reference surface, a support for an object providing an object surface, a radiation source for emitting radiation of an adjustable frequency onto the reference surface and the object surface, a position-sensitive radiation detector, a controller for adjusting a plurality of different frequencies of the radiation emitted by the radiation source, and an integrator for averaging the interference patterns superposed on the radiation detector at different frequencies. Moreover, there is provided a method for recording an interferogram, a method for providing an object with a target surface as well as a method for manufacturing an object with a target surface.
摘要翻译：干涉仪系统包括参考表面，用于提供物体表面的物体的支撑件，用于将可调节频率的辐射发射到参考表面和物体表面上的辐射源，位置敏感放射线检测器，用于调整多个由辐射源发射的辐射的不同频率，以及用于平均叠加在不同频率上的辐射检测器上的干涉图案的积分器。此外，提供了一种用于记录干涉图的方法，用于向对象提供目标表面的方法以及用于制造具有目标表面的物体的方法。

23. 发明授权

US09695577B2 Method and device for automatic flushing 有权
公开(公告)号：US09695577B2
公开(公告)日：2017-07-04
申请号：US13414990
申请日：2012-03-08
申请人： Stefan Leymann , Oliver Cyliax , Christian Becker , Stefan Schulte
发明人： Stefan Leymann , Oliver Cyliax , Christian Becker , Stefan Schulte
IPC分类号： B08B9/032 , E03B7/00 , E03B7/08 , F24D17/00
CPC分类号： E03B7/006 , B08B9/0325 , E03B7/08 , F24D17/0073 , Y10T137/0424
摘要： The invention relates to a method for automatic flushing of fluid lines, in particular potable water lines. The invention further relates to a device for automatic flushing of fluid lines, in particular potable water lines. The invention is based on the technical problem to provide a method and a device for automatic flushing which allows a flushing behaviour that is better-suited to the circumstances and more reliable. The technical problem is solved by a method for automatic flushing of at least one fluid line, in particular a potable water line, in which a temperature profile of the fluid is measured, in which the measured data are evaluated and in which the automatic flushing of the at least one fluid line is influenced by an outcome of the evaluation.

24. 发明申请

US20150150911A2 METHODS TO REDUCE ADVERSE EVENTS CAUSED BY PHARMACEUTICAL PREPARATIONS COMPRISING PLASMA DERIVED PROTEINS 审中-公开
标题翻译：减少包含等离子体衍生蛋白质的药物制剂引起的不良事件的方法
公开(公告)号：US20150150911A2
公开(公告)日：2015-06-04
申请号：US14116491
申请日：2012-05-14
申请人： Stefan Schulte , Uwe Kalina , Michael Moses , Annette Feussner
发明人： Stefan Schulte , Uwe Kalina , Michael Moses , Annette Feussner
IPC分类号： A61K35/16
CPC分类号： A61K35/16 , A61K31/727 , A61K38/385 , A61K38/57 , C12Y304/21008 , C12Y304/21027 , C12Y304/21038
摘要： The instant invention provides a method to reduce adverse events caused by a pharmaceutical preparation derived from a plasma fraction said plasma fraction comprising antithrombin III wherein the method comprises contacting the plasma fraction with heparin or a heparin-like substance thereby reducing the activity of at least one activated serine protease per ml of the plasma fraction.
摘要翻译：本发明提供了一种减少由衍生自血浆级分的药物制剂引起的不良事件的方法，所述血浆级分包含抗凝血酶III，其中所述方法包括使血浆级分与肝素或肝素样物质接触，从而降低至少一种每毫升血浆级分活化丝氨酸蛋白酶。

25. 发明授权

US08754194B2 Modified coagulation factors with prolonged in vivo half-life 有权
标题翻译：改性凝血因子具有延长的体内半衰期
公开(公告)号：US08754194B2
公开(公告)日：2014-06-17
申请号：US12520840
申请日：2007-12-21
申请人： Stefan Schulte , Thomas Weimer , Hubert Metzner
发明人： Stefan Schulte , Thomas Weimer , Hubert Metzner
IPC分类号： A61K38/37 , C07K1/00
CPC分类号： C07K14/755 , C07K14/745 , C07K14/765 , C07K16/18 , C07K2319/31
摘要： The present invention relates to nucleic acid sequences coding for modified coagulation factors, preferably coagulation factor VIII, and their derivatives; recombinant expression vectors containing such nucleic acid sequences; host cells transformed with such recombinant expression vectors; and recombinant polypeptides and derivatives coded for by said nucleic acid sequences, whereby said recombinant polypeptides and derivatives have biological activities and prolonged in vivo half-lives compared to the unmodified wild-type proteins. The invention also relates to corresponding sequences that result in improved in vitro stability. The present invention further relates to processes for the manufacture of such recombinant proteins and their derivatives. The invention also relates to a transfer vector for use in human gene therapy, which comprises such nucleic acid sequences.
摘要翻译：本发明涉及编码改性凝血因子，优选凝血因子VIII及其衍生物的核酸序列; 含有该核酸序列的重组表达载体; 用这些重组表达载体转化的宿主细胞; 和由所述核酸序列编码的重组多肽和衍生物，其中与未修饰的野生型蛋白相比，所述重组多肽和衍生物具有生物活性和延长的体内半衰期。本发明还涉及导致体外稳定性改善的相应序列。本发明还涉及制备这些重组蛋白及其衍生物的方法。本发明还涉及用于人基因治疗的转移载体，其包含这样的核酸序列。

26. 发明授权

US08575104B2 Factor VIII, von willebrand factor or complexes thereof with prolonged in vivo half-life 有权
标题翻译：因子VIII，血管性血友病因子或其复合物具有延长的体内半衰期
公开(公告)号：US08575104B2
公开(公告)日：2013-11-05
申请号：US13000938
申请日：2009-06-24
申请人： Thomas Weimer , Stefan Schulte , Hubert Metzner , Ulrich Kronthaler , Holger Lind , Wiegand Lang
发明人： Thomas Weimer , Stefan Schulte , Hubert Metzner , Ulrich Kronthaler , Holger Lind , Wiegand Lang
IPC分类号： A61K38/37 , A61K38/36 , A61K38/16 , A61K35/14 , C07K1/00 , C12N5/00
CPC分类号： C07K14/76 , A61K38/00 , C07K14/755 , C07K2319/31
摘要： The present invention relates to modified nucleic acid sequences coding for coagulation factor VIII (FVIII) and for von Willebrand factor (VWF) as well as complexes thereof and their derivatives, recombinant expression vectors containing such nucleic acid sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives coded for by said nucleic acid sequences which recombinant polypeptides and derivatives do have biological activities together with prolonged in vivo half-life and/or improved in vivo recovery compared to the unmodified wild-type protein. The invention also relates to corresponding FVIII sequences that result in improved expression yield. The present invention further relates to processes for the manufacture of such recombinant proteins and their derivatives. The invention also relates to a transfer vector for use in human gene therapy, which comprises such modified nucleic acid sequences.
摘要翻译：本发明涉及编码凝血因子VIII（FVIII）和von Willebrand因子（VWF）的修饰的核酸序列及其复合物及其衍生物，含有此类核酸序列的重组表达载体，用这种重组表达转化的宿主细胞载体，重组多肽和由所述核酸序列编码的衍生物，所述重组多肽和衍生物与未修饰的野生型蛋白质相比具有生物活性以及延长的体内半衰期和/或改善的体内恢复。本发明还涉及导致表达产量提高的相应FVIII序列。本发明还涉及制备这些重组蛋白及其衍生物的方法。本发明还涉及用于人基因治疗的转移载体，其包含这种修饰的核酸序列。

27. 发明申请

US20120234398A1 Method and Device for Automatic Flushing 有权
标题翻译：自动冲洗的方法和装置
公开(公告)号：US20120234398A1
公开(公告)日：2012-09-20
申请号：US13414990
申请日：2012-03-08
申请人： Stefan Leymann , Oliver Cyliax , Christian Becker , Stefan Schulte
发明人： Stefan Leymann , Oliver Cyliax , Christian Becker , Stefan Schulte
IPC分类号： B08B9/032
CPC分类号： E03B7/006 , B08B9/0325 , E03B7/08 , F24D17/0073 , Y10T137/0424
摘要： The invention relates to a method for automatic flushing of fluid lines, in particular potable water lines. The invention further relates to a device for automatic flushing of fluid lines, in particular potable water lines. The invention is based on the technical problem to provide a method and a device for automatic flushing which allows a flushing behaviour that is better-suited to the circumstances and more reliable. The technical problem is solved by a method for automatic flushing of at least one fluid line, in particular a potable water line, in which a temperature profile of the fluid is measured, in which the measured data are evaluated and in which the automatic flushing of the at least one fluid line is influenced by an outcome of the evaluation.
摘要翻译：本发明涉及一种用于自动冲洗流体管线，特别是饮用水管线的方法。本发明还涉及一种用于自动冲洗流体管线，特别是饮用水管线的装置。本发明基于技术问题，提供一种自动冲洗的方法和装置，其允许更适合于环境和更可靠的冲洗行为。技术问题通过一种用于自动冲洗至少一条流体管线，特别是饮用水管线的方法来解决，其中测量流体的温度分布，其中评估测量数据，并且其中自动冲洗至少一条流体管线受到评估结果的影响。

28. 发明授权

US08264695B2 Method of measuring a deviation of an optical surface from a target shape 有权
标题翻译：测量光学表面与目标形状的偏差的方法
公开(公告)号：US08264695B2
公开(公告)日：2012-09-11
申请号：US13030748
申请日：2011-02-18
申请人： Ralf Arnold , Stefan Schulte , Bernd Doerband
发明人： Ralf Arnold , Stefan Schulte , Bernd Doerband
IPC分类号： G01B11/02
CPC分类号： G01B9/021 , G01B9/02039 , G01B11/2441 , G01M11/025 , G01M11/0271 , Y10T29/49771
摘要： A method of aligning at least two wave shaping elements, a method of measuring a deviation of an optical surface from a target shape and a measuring apparatus for interferometrically measuring a deviation of an optical surface from a target shape. The method of aligning at least two wave shaping elements, each of which wave shaping elements has a diffractive measurement structure for adapting part of a wave front of incoming light to a respective portion of the target shape, includes: providing a first one of the wave shaping elements with a diffractive alignment structure, arranging the wave shaping elements relative to each other such that each of the diffractive measurement structures is traversed by a separate subset of rays of the incoming light during operation of the measuring apparatus, and aligning the first wave shaping element and a second one of the wave shaping elements relative to each other by evaluating alignment light having consecutively interacted with the diffractive alignment structure and with the second wave shaping element.
摘要翻译：对准至少两个波形整形元件的方法，测量光学表面与目标形状的偏差的方法和用于干涉测量光学表面与目标形状的偏差的测量装置。对准至少两个波形整形元件的方法，其中每个波形整形元件具有衍射测量结构，用于将入射光的一部分波前适应到目标形状的相应部分，包括：提供第一波具有衍射对准结构的成形元件，将波形整形元件相对于彼此布置，使得每个衍射测量结构在测量设备的操作期间被入射光的单独的子集子穿过，并且对准第一波形整形元件和第二波形成形元件相对于彼此，通过评估与衍射对准结构和第二波形整形元件连续相互作用的对准光。

29. 发明申请

US20110189182A1 PROTEOLYTICALLY CLEAVABLE FUSION PROTEINS WITH HIGH MOLAR SPECIFIC ACTIVITY 审中-公开
标题翻译：具有高度特异性活性的蛋白质可溶蛋白融合蛋白
公开(公告)号：US20110189182A1
公开(公告)日：2011-08-04
申请号：US13074153
申请日：2011-03-29
申请人： Hubert METZNER , Thomas Weimer , Stefan Schulte
发明人： Hubert METZNER , Thomas Weimer , Stefan Schulte
IPC分类号： A61K39/395 , C07K19/00 , C12N9/64 , C07H21/00 , C12N15/63 , C12P21/00 , A61K48/00 , C12N5/10 , A61P7/00 , A61P7/04
CPC分类号： C12N9/6437 , A61K38/00 , A61K48/00 , C07K14/745 , C07K14/755 , C07K14/76 , C07K14/765 , C07K2319/31 , C07K2319/50 , C12N9/6424 , C12N9/6443 , C12N9/6472 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to therapeutic fusion proteins in which a coagulation factor is fused to a half-life enhancing polypeptide, and in which both are connected by a linker peptide that is proteolytically cleavable. The cleavage of such linkers liberates the coagulation factor from activity-compromising steric hindrance caused by the half-life enhancing polypeptide and thereby allows the generation of fusion proteins may show relatively high molar specific activity when tested in coagulation-related assays. Furthermore, the fact that the linker is cleavable can enhance the rates of inactivation and/or elimination after proteolytic cleavage of the peptide linker compared to the rates measured for corresponding therapeutic fusion proteins linked by the non-cleavable linker having the amino acid sequence GGGGGGV.
摘要翻译：本发明涉及治疗融合蛋白，其中凝血因子与半衰期增强多肽融合，并且其中两者通过可蛋白水解切割的接头肽连接。这种接头的切割将凝血因子从半衰期增强多肽引起的活性损害的空间位阻释放，从而允许融合蛋白的产生在凝血相关测定中测试时可显示相对高的摩尔比活性。此外，与通过具有氨基酸序列GGGGGGV的不可切割接头连接的相应治疗性融合蛋白测量的速率相比，接头可切割的事实可增加肽接头的蛋白水解切割后的失活和/或消除速率。

30. 发明授权

US07936521B2 Method of measuring a deviation of an optical surface from a target shape 有权
标题翻译：测量光学表面与目标形状的偏差的方法
公开(公告)号：US07936521B2
公开(公告)日：2011-05-03
申请号：US12684600
申请日：2010-01-08
申请人： Ralf Arnold , Stefan Schulte , Bernd Doerband
发明人： Ralf Arnold , Stefan Schulte , Bernd Doerband
IPC分类号： G02B13/18
CPC分类号： G01B9/021 , G01B9/02039 , G01B11/2441 , G01M11/025 , G01M11/0271 , Y10T29/49771
摘要： A method of aligning at least two wave shaping elements, a method of measuring a deviation of an optical surface from a target shape and a measuring apparatus for interferometrically measuring a deviation of an optical surface from a target shape. The method of aligning at least two wave shaping elements, each of which wave shaping elements has a diffractive measurement structure for adapting part of a wave front of incoming light to a respective portion of the target shape, includes: providing a first one of the wave shaping elements with a diffractive alignment structure, arranging the wave shaping elements relative to each other such that each of the diffractive measurement structures is traversed by a separate subset of rays of the incoming light during operation of the measuring apparatus, and aligning the first wave shaping element and a second one of the wave shaping elements relative to each other by evaluating alignment light having consecutively interacted with the diffractive alignment structure and with the second wave shaping element.
摘要翻译：对准至少两个波形整形元件的方法，测量光学表面与目标形状的偏差的方法和用于干涉测量光学表面与目标形状的偏差的测量装置。对准至少两个波形整形元件的方法，其中每个波形整形元件具有衍射测量结构，用于将入射光的一部分波前适应到目标形状的相应部分，包括：提供第一波具有衍射对准结构的成形元件，将波形整形元件相对于彼此布置，使得每个衍射测量结构在测量设备的操作期间被入射光的单独的子集子穿过，并且对准第一波形整形元件和第二波形成形元件相对于彼此，通过评估与衍射对准结构和第二波形整形元件连续相互作用的对准光。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式