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21. 发明申请

US20070009387A1 Chemical analysis apparatus and chemical analysis method 有权
标题翻译：化学分析仪器和化学分析方法
公开(公告)号：US20070009387A1
公开(公告)日：2007-01-11
申请号：US11522379
申请日：2006-09-18
申请人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
发明人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
IPC分类号： G01N33/00
CPC分类号： G01N35/1002 , B01F11/0283 , B01F2215/0037 , G01N35/025 , G01N2035/00554 , Y10S707/962 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99956
摘要： A chemical analysis apparatus in which a sample to be analyzed and a reagent are placed into a reaction container, and sound waves are irradiated to said reaction container so as to agitate them, wherein said chemical analysis apparatus comprises a piezoelectric element producing said sound waves, and drivers for driving said piezoelectric element, said sound waves being intermittently irradiated into said reaction container.
摘要翻译：一种化学分析装置，其中将待分析样品和试剂置于反应容器中，并且将声波照射到所述反应容器以搅拌它们，其中所述化学分析装置包括产生所述声波的压电元件，以及用于驱动所述压电元件的驱动器，所述声波被间歇地照射到所述反应容器中。

22. 发明申请

US20050060599A1 Distributed testing apparatus and host testing apparatus 失效
标题翻译：分布式测试仪器和主机测试仪器
公开(公告)号：US20050060599A1
公开(公告)日：2005-03-17
申请号：US10901965
申请日：2004-07-30
申请人： Hisao Inami , Yasuhiko Sasaki , Hajime Katou , Ryo Miyake
发明人： Hisao Inami , Yasuhiko Sasaki , Hajime Katou , Ryo Miyake
IPC分类号： G01N33/50 , G01N21/27 , G01N35/00 , G06F11/00 , G06F11/273 , G06F19/18 , G06Q50/00 , G06Q50/10 , G06Q50/22
CPC分类号： G06F11/2294
摘要： There is provided a group of testing apparatuses that realizes high-level testing and high quality medical treatment by conducting tests using apparatuses and facilities that are located in a distributed condition. A distributed testing apparatus is configured to be connectable to a network system to which a host testing apparatus is connected, wherein the distributed testing apparatus has a testing part that assays genetic information of a specimen, a transmission part that transmits test results information of the testing part and a specimen ID corresponding to the specimen to the host testing apparatus through the network, a receiver part that receives through the network assessment information from the host testing apparatus that corresponds to the transmitted test results information, and an output part that outputs the received information.
摘要翻译：提供了一组通过使用位于分布状态的设备和设施进行测试来实现高水平测试和高质量医疗的测试装置。分布式测试装置被配置为可连接到主机测试设备连接到的网络系统，其中分布式测试设备具有测试样本的遗传信息的测试部分，传送测试结果信息的传输部分通过网络向主机测试装置对应于样本的部分和样本ID，通过来自主机测试装置的与所发送的测试结果信息相对应的网络评估信息接收的接收机部分和输出所接收到的测试结果信息的输出部分信息。

23. 发明授权

US5690895A Flow cell apparatus 失效
标题翻译：流通池装置
公开(公告)号：US5690895A
公开(公告)日：1997-11-25
申请号：US761143
申请日：1996-12-06
申请人： Masaetsu Matsumoto , Isao Yamazaki , Ryo Miyake , Masaharu Ishii , Ryohei Yabe , Hiroshi Ohki , Hideyuki Horiuchi , Shinichi Sakuraba
发明人： Masaetsu Matsumoto , Isao Yamazaki , Ryo Miyake , Masaharu Ishii , Ryohei Yabe , Hiroshi Ohki , Hideyuki Horiuchi , Shinichi Sakuraba
IPC分类号： G01N15/00 , G01N15/02 , G01N15/06 , G01N15/14 , G01N21/05 , G01N33/49
CPC分类号： G01N21/05 , G01N15/1404 , G01N2021/0346
摘要： A flow cell apparatus, useful in an apparatus for measuring particles suspended in a liquid, comprises a sample liquid, supply device, a sheath liquid supply device, a flow cell which has a flow passage passing through a transparent measuring portion, and a nozzle for causing the sample liquid, from the supply device to flow in the flow passage of the flow cell. The nozzle has at least one discharge port which is disposed in the flow passage in a spaced relation from the inner wall of the flow cell flow passage. The sheath liquid supply device causes the sheath liquid to flow around the nozzle discharge port and surround the sample liquid flow to form a sheath flow. The flow passage of the flow cell and the nozzle are so formed as to ensure a sample liquid flow of a fixed width through the measuring portion. A stable sample flow having a fixed width can be formed in the measuring portion even when the flow is at a high velocity, and particles in the sample liquid can efficiently be photographed with high accuracy.
摘要翻译：一种用于测量悬浮在液体中的颗粒的装置中的流动池装置，包括样品液体，供给装置，皮肤液体供应装置，具有通过透明测量部分的流动通道的流动池，以及用于使来自供给装置的样品液体流入流动池的流路。喷嘴具有至少一个排出口，该排出口以与流动池流动通道的内壁隔开的关系设置在流动通道中。皮肤液体供给装置使皮肤液体在喷嘴排出口周围流动并且围绕样品液体流动形成鞘流。流动池和喷嘴的流动通道形成为确保通过测量部分具有固定宽度的样品液体流动。即使在流速高的情况下，也可以在测量部分形成具有固定宽度的稳定的样品流，并且可以高精度地有效地拍摄样品液体中的颗粒。

24. 发明授权

US4863264A Photoanalysis apparatus with means for correcting flow rate of fluid carrying particles and/or position of applied light beam for examination and photoanalysis method therefor 失效
标题翻译：具有用于校正流体携带颗粒的流速和/或施加的光束的位置用于检查和光分析方法的光分析装置
公开(公告)号：US4863264A
公开(公告)日：1989-09-05
申请号：US203457
申请日：1988-06-07
申请人： Ryo Miyake , Hiroshi Ohki , Isao Yamazaki
发明人： Ryo Miyake , Hiroshi Ohki , Isao Yamazaki
IPC分类号： G01N15/14 , G01N33/48
CPC分类号： G01N15/1404 , G01N2015/1409 , G01N2015/1452
摘要： A photoanalysis apparatus includes marker pouring device for pouring markers into one of sheath fluid and fluid carrying particles in a flow-cell device, second optical device for applying a light beam for correction to the markers in the flow-cell device to measure strength of fluorescence or light scattering caused by said markers to generate a signal for correction, second signal processing device for calculating from the signal for correction at least one of a difference in position between a center of the fluid carrying particles in the flow-cell device and a center of a light beam for examination and a difference in flow rate between a predetermined flow rate and an actual flow rate of the fluid carrying particles in the flow-cell device to generate correspondingly at least one of a first command signal for position correction and a second command signal for flow rate correction, and correspondingly at least one of first correcting device for shifting the center of the light beam for examination to the center of the flow of the fluid carrying particles in accordance with the first command signal and second correcting device for correcting the flow rate of the fluid carrying particles to the predetermined flow rate in accordance with the second command signal.

25. 发明授权

US08658102B2 Chemical analysis apparatus and chemical analysis method 有权
标题翻译：化学分析仪器和化学分析方法
公开(公告)号：US08658102B2
公开(公告)日：2014-02-25
申请号：US12785835
申请日：2010-05-24
申请人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
发明人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
IPC分类号： B06B1/06
CPC分类号： G01N35/1002 , B01F11/0283 , B01F2215/0037 , G01N35/025 , G01N2035/00554 , Y10S707/962 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99956
摘要： A chemical analysis apparatus comprising reaction containers containing therein a substance to be analyzed; an agitating mechanism spaced from the substance to be analyzed and agitating said substance to be analyzed with a liquid in said reaction container; and, a measuring portion for measuring physical properties of the substance to be analyzed, said agitating mechanism having a sound supply portion supplying sound waves to the substance to be analyzed, wherein said sound supply portion comprises a mechanism changing, in time, intensity of ultrasonic waves to be irradiated so as to apply pulsation to a swirl flow in the reaction container.
摘要翻译：一种化学分析装置，包括含有待分析物质的反应容器; 与待分析物质间隔开的搅拌机构，并在所述反应容器中用液体搅拌待分析物质; 以及用于测量被分析物质的物理性质的测量部分，所述搅拌机构具有向待分析物质供应声波的声音供给部分，其中所述声音供应部分包括时间上改变超声波强度的机构要被照射的波浪以便对反应容器中的涡流施加脉动。

26. 发明授权

US06875984B2 Bio electron microscope and observation method of specimen 失效
标题翻译：生物电子显微镜和样品观察方法
公开(公告)号：US06875984B2
公开(公告)日：2005-04-05
申请号：US10621444
申请日：2003-07-18
申请人： Hiroshi Kakibayashi , Shigeyuki Hosoki , Yuji Takagi , Ryo Miyake , Kuniyasu Nakamura , Mitsugu Sato , Hiroyuki Kobayashi
发明人： Hiroshi Kakibayashi , Shigeyuki Hosoki , Yuji Takagi , Ryo Miyake , Kuniyasu Nakamura , Mitsugu Sato , Hiroyuki Kobayashi
IPC分类号： G01N23/04 , G01N1/28 , G01N23/225 , G01N33/483 , G01N37/00 , H01J37/20 , H01J37/22 , H01J37/26 , H01J37/28 , H01J49/44
CPC分类号： H01J37/22 , H01J37/26 , H01J2237/05 , H01J2237/2809 , H01J2237/2813
摘要： A bio electron microscope and an observation method which can observe a bio specimen by low damage and high contrast to perform high-accuracy image analysis, and conduct high-throughput specimen preparation. 1) A specimen is observed at an accelerating voltage 1.2 to 4.2 times a critical electron accelerating voltage possible to transmit a specimen obtained under predetermined conditions. 2) An electron energy filter of small and simplified construction is provided between the specimen and an electron detector for imaging by the electron beam in a specified energy region of the electron beams transmitting the specimen. 3) Similarity between an observed image such as virus or protein in the specimen and a reference image such as known virus or protein is subjected to quantitative analysis by image processing. 4) A preparation protocol of the bio specimen is made into a chip using an MEMS technique, which is then mounted on a specimen stage part of an electron microscope to conduct specimen introduction, preparation and transfer onto a specimen holder.
摘要翻译：一种生物电子显微镜和观察方法，可以通过低损伤和高对比度观察生物样品，进行高精度图像分析，并进行高通量样品制备。 1）在可能传输在预定条件下获得的样品的临界电子加速电压的1.2至4.2倍的加速电压下观察样品。 2）在样品和电子检测器之间提供小而简化结构的电子能过滤器，用于通过电子束在传输样品的电子束的规定能量区域内的电子束进行成像。 3）通过图像处理对样本中的观察图像（例如病毒或蛋白质）与已知病毒或蛋白质等参考图像之间的相似性进行定量分析。 4）使用MEMS技术将生物样品的制备方案制成芯片，然后将其安装在电子显微镜的样品台部分上，以将样品引入，准备和转移到样品架上。

27. 发明申请

US20050004765A1 Method for estimating effect of working substance and screening method 审中-公开
标题翻译：估算工作物质影响的方法和筛选方法
公开(公告)号：US20050004765A1
公开(公告)日：2005-01-06
申请号：US10859143
申请日：2004-06-03
申请人： Tetsuro Miyamoto , Shigenori Togashi , Ryo Miyake , Naoya Sasaki
发明人： Tetsuro Miyamoto , Shigenori Togashi , Ryo Miyake , Naoya Sasaki
IPC分类号： G01N33/48 , C12Q1/02 , G01N33/15 , G01N33/50 , G06F17/30 , G06F19/00 , G06F19/12
CPC分类号： G01N33/502 , G01N33/5008 , G01N33/5082
摘要： The object of the present invention is to estimate the effect of working substances on actual living organisms such as cells and tissues. The present invention provides a method for estimation of the effect of working substance which includes the following steps (a) and (b): (a) a step of contacting a working substance with a model cell to measure a cell activity value of the model cell, and (b) a step of estimating the effect of the working substance on the target living organism when the working substance is allowed to act on the target living organism, using the cell activity value measured at the step (a) as an input value.
摘要翻译：本发明的目的是估计工作物质对细胞和组织等实际生物体的影响。本发明提供一种估计工作物质影响的方法，其包括以下步骤（a）和（b）：（a）使工作物质与模型细胞接触以测量模型的细胞活性值的步骤（b）当使用步骤（a）测量的细胞活性值作为输入时，估计工作物质对目标生物体的影响的步骤，当使所述工作物质作用于所述目标生物体时，值。

28. 发明授权

US5270212A Cell analysis apparatus 失效
标题翻译：细胞分析仪
公开(公告)号：US5270212A
公开(公告)日：1993-12-14
申请号：US841487
申请日：1992-02-26
申请人： Hideyuki Horiuchi , Shinichi Sakuraba , Toshio Kaneko , Nobuyuki Tatara , Ryohei Yabe , Hiroshi Ohki , Isao Yamazaki , Ryo Miyake
发明人： Hideyuki Horiuchi , Shinichi Sakuraba , Toshio Kaneko , Nobuyuki Tatara , Ryohei Yabe , Hiroshi Ohki , Isao Yamazaki , Ryo Miyake
IPC分类号： G01N1/00 , G01N1/28 , G01N15/00 , G01N15/14 , G01N33/48 , G01N35/00
CPC分类号： G01N35/1095 , G01N1/28 , G01N2015/0069 , G01N2015/0076 , G01N2015/1409 , G01N2021/6439 , Y10T436/111666
摘要： This invention relates to an apparatus for analyzing cells in a biological liquid sample, such as blood, in which apparatus a flow passage in a sample pretreatment system can be shortened with a simple construction. A sample metering chamber, a mixing chamber and a measurement liquid extracting chamber are formed in a rotary sliding member of a pretreatment portion. The rotary sliding member is intermittently rotated so as to shift a sample from one chamber to another to perform a necessary treatment. Fluorescence or scattering light with respect to the sample, mixed with a reagent in the pretreatment portion, is detected by a flow cell.
摘要翻译：本发明涉及用于分析生物液体样品如血液中的细胞的装置，其中可以用简单的结构缩短样品预处理系统中的流动通道。样品计量室，混合室和测量液体提取室形成在预处理部分的旋转滑动构件中。旋转滑动构件间歇地旋转，以将样品从一个室移动到另一个室进行必要的处理。通过流动池检测相对于样品的荧光或散射光与预处理部分中的试剂混合。

29. 发明授权

US5174162A Pipetter, pipette tube, sample analyzing apparatus including them and method of mixing and pipetting liquids 失效
标题翻译：管，管管，样品分析装置及其混合和管道液体的方法
公开(公告)号：US5174162A
公开(公告)日：1992-12-29
申请号：US550543
申请日：1990-07-10
申请人： Ryo Miyake , Hiroshi Ohki , Hideo Enoki , Toshio Kaneko , Hideyuki Horiuchi
发明人： Ryo Miyake , Hiroshi Ohki , Hideo Enoki , Toshio Kaneko , Hideyuki Horiuchi
IPC分类号： B01F5/06 , B01F11/00 , B01F13/00 , B01L3/02 , G01N1/00 , G01N21/78 , G01N33/543 , G01N35/02 , G01N35/10
CPC分类号： B01F11/0071 , B01F11/0074 , B01F13/00 , B01F5/0609 , B01L3/021 , G01N35/10 , G01N2035/1058
摘要： A pipetter capable of mixing liquids and dispensing the mixed liquid has a pipetting tube, an actuating device connected to the tube for sucking liquid into and discharging liquid from the tube, and a flow disturbance device in the tube spaced from the discharge and suction end thereof and adapted to cause longitudinal mixing of liquid in the tube when liquid is moved along the tube in at least one direction. Mixing is effected in the tube by causing a liquid body to move repeatedly to and fro along the tube so that during each such movement at least a portion of the liquid body passes the flow disturbance device and the liquid body is not discharged from the first end of the tube. The pipetter is useful for example in mixing a suspension of blood cells with a reagent prior to analysis.
摘要翻译：能够混合液体并分配混合液体的移液器具有移液管，连接到管的致动装置，用于将液体从管吸入和排出液体，以及与排出和吸入端隔开的管中的流动扰动装置并且适于当液体沿着至少一个方向移动时引起液体在管中的纵向混合。通过使液体沿着管道来回重复地在管中进行混合，使得在每次这样的移动期间，液体的至少一部分通过流动扰动装置，液体不从第一端排出的管。移液器可用于例如在分析之前将血细胞悬浮液与试剂混合。

30. 发明授权

US5007732A Flow-cell device 失效
标题翻译：流通池装置
公开(公告)号：US5007732A
公开(公告)日：1991-04-16
申请号：US182430
申请日：1988-04-18
申请人： Hiroshi Ohki , Hideaki Kamohara , Ryo Miyake
发明人： Hiroshi Ohki , Hideaki Kamohara , Ryo Miyake
IPC分类号： G01N33/483 , C12M1/34 , G01N15/14
CPC分类号： G01N15/1404
摘要： A sheath flow type flow-cell device for plow-cytometer which comprises a first inlet for sheath fluid, a flow passage communicated with the first inlet and contracted toward downstream, the flow passage having a substantially rectangular cross section, a straight capillary flow passage connected to the flow passage downstream thereof, the capillary flow passage having a substantially rectangular cross section, a second inlet for sample fluid, a nozzle communicating with the second inlet and opened within the flow passage in the same direction as the flow direction of the straight capillary flow passage, a discharge port provided at a terminal end of the straight capillary flow passage, and flow regulating means for regulating the flow of the sheath fluid in the straight capillary flow passage to be a laminar flow having a gradient of flow velocity.

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