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21. 发明授权

US5135864A Human Immunodeficiency Virus (HIV) associated with Acquired Immunual Deficiency Syndrome (AIDS), a diagnostic method for aids and pre-aids, and a kit therefor 失效
标题翻译：与获得性免疫缺陷综合征（AIDS）相关的人类免疫缺陷病毒（HIV），辅助和预辅助的诊断方法及其工具包
公开(公告)号：US5135864A
公开(公告)日：1992-08-04
申请号：US117937
申请日：1987-11-05
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
IPC分类号： C07K14/16 , C12N7/02
CPC分类号： C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222 , Y10S435/974
摘要： Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS), including Lymphadenopathy Associated Virus (LAV), are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. LAV is a Human Immunodeficiency Virus (HIV). Viral extract, structural proteins and other fractions of the retrovirus immunologically recognize the sera of such patients. Immunological reaction is used to detect antibodies that specifically bind to antigenic sites of the retrovirus in samples of body fluids from patients with AIDS or risk of AIDS. A kit for in vitro assay of LAS or AIDS is provided.
摘要翻译：与获得性免疫缺陷综合征（AIDS）相关的逆转录病毒，包括淋巴结病相关病毒（LAV），从患有淋巴结病综合征（LAS）或AIDS的患者血清中分离。 LAV是人类免疫缺陷病毒（HIV）。病毒提取物，结构蛋白和其他部分的逆转录病毒免疫识别这些患者的血清。免疫反应用于检测具有艾滋病或艾滋病风险的患者体液样品中特异性结合逆转录病毒抗原位点的抗体。提供了用于LAS或AIDS的体外测定的试剂盒。

22. 发明授权

US06428952B1 Methods and kits employing LAV antigens for the detection of HIV-1-specific antibodies 失效
标题翻译：用于检测针对HIV变体的抗体的方法和试剂盒
公开(公告)号：US06428952B1
公开(公告)日：2002-08-06
申请号：US08424631
申请日：1995-04-19
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , G. Sarngadharan
IPC分类号： C12Q170
CPC分类号： C07K16/1045 , G01N2333/16
摘要： Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS), including Lymphadenopathy Associated Virus (LAV), are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. LAV is a Human Immunodeficiency Virus (HIV). Viral extract, structural proteins and other fractions of the retrovirus immunologically recongize the sera of such patients. Immunological reaction is used to detect antibodies that specifically bind to antigenic sites of the retrovirus in samples of body fluids from patients with AIDS or risk of AIDS.
摘要翻译：与获得性免疫缺陷综合征（AIDS）相关的逆转录病毒，包括淋巴结病相关病毒（LAV），从患有淋巴结病综合征（LAS）或AIDS的患者血清中分离。 LAV是人类免疫缺陷病毒（HIV）。病毒提取物，结构蛋白和其他部分的逆转录病毒免疫学上述了这些患者的血清。免疫反应用于检测具有艾滋病或艾滋病风险的患者体液样品中特异性结合逆转录病毒抗原位点的抗体。

23. 发明授权

US5420030A Molecular clones of HIV-1 viral strains MN-ST1 and BA-L and uses thereof 失效
标题翻译： HIV-1病毒株MN-ST1和BA-L的分子克隆及其用途
公开(公告)号：US5420030A
公开(公告)日：1995-05-30
申请号：US22835
申请日：1993-02-25
申请人： Marvin S. Reitz, Jr. , Genoveffa Franchini , Phillip D. Markham , Robert C. Gallo , Franco C. Lori , Mikulas Popovic , Suzanne Gartner
发明人： Marvin S. Reitz, Jr. , Genoveffa Franchini , Phillip D. Markham , Robert C. Gallo , Franco C. Lori , Mikulas Popovic , Suzanne Gartner
IPC分类号： A61K39/00 , A61K39/21 , A61P31/12 , C07K14/00 , C07K14/155 , C07K14/16 , C07K14/705 , C07K17/00 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/49 , C12P21/02 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122 , Y10S435/974
摘要： The present invention relates to the HIV-1 strains MN-ST1 and BA-L which are typical United States HIV-1 isotypes. The present invention relates to DNA segments encoding the envelope protein of MN-ST1 or BA-L, to DNA constructs containing such DNA segments and to host cells transformed with such constructs. The viral isolates and envelope proteins of the present invention are of value for use in vaccines and bioassays for the detection of HIV-1 infection in biological samples, such as blood bank samples.
摘要翻译：本发明涉及作为典型的美国HIV-1同种型的HIV-1株MN-ST1和BA-L。本发明涉及编码MN-ST1或BA-L的包膜蛋白的DNA片段，涉及含有这些DNA片段的DNA构建体和用这些构建体转化的宿主细胞。本发明的病毒分离物和包膜蛋白在用于检测生物样品例如血库样品中的HIV-1感染的疫苗和生物测定中是有价值的。

24. 发明授权

US4708818A Human immunodeficiency viruses associated with Acquired Immune Deficiency Syndrome (AIDS), a diagnostic method for AIDS and pre-AIDS, and a kit therefor 失效
标题翻译：与获得性免疫缺陷综合征（AIDS）相关的人体免疫机能丧失病毒，艾滋病和艾滋病前期的诊断方法及其试剂盒
公开(公告)号：US4708818A
公开(公告)日：1987-11-24
申请号：US785638
申请日：1985-10-08
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
IPC分类号： A61K35/76 , A61K35/12 , A61K35/28 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/005 , C07K14/155 , C07K14/16 , C07K14/195 , C12N5/10 , C12N7/00 , C12N7/02 , C12N15/09 , C12Q1/70 , C12R1/92 , G01N33/569 , G01N33/535 , G01N33/543
CPC分类号： C07K14/005 , C12N7/00 , G01N33/56988 , C12N2740/16021 , C12N2740/16051 , C12N2740/16222 , Y10S435/81 , Y10S435/948 , Y10S435/974 , Y10S436/804 , Y10S436/808 , Y10S436/811
摘要： Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS), including Lymphadenopathy Associated Virus (LAV), are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. LAV is a Human Immunodeficiency Virus (HIV). Viral extract, structural proteins and other fractions of the retrovirus immunologically recognize the sera of such patients. Immunological reaction is used to detect antibodies that specifically bind to antigenic sites of the retrovirus in samples of body fluids from patients with AIDS or risk of AIDS. A kit for in vitro assay of LAS or AIDS is provided.
摘要翻译：与获得性免疫缺陷综合征（AIDS）相关的逆转录病毒，包括淋巴结病相关病毒（LAV），从患有淋巴结病综合征（LAS）或AIDS的患者血清中分离。 LAV是人类免疫缺陷病毒（HIV）。病毒提取物，结构蛋白和其他部分的逆转录病毒免疫识别这些患者的血清。免疫反应用于检测具有艾滋病或艾滋病风险的患者体液样品中特异性结合逆转录病毒抗原位点的抗体。提供了用于LAS或AIDS的体外测定的试剂盒。

25. 发明授权

US4520113A Serological detection of antibodies to HTLV-III in sera of patients with AIDS and pre-AIDS conditions 失效
标题翻译：血清学检测艾滋病和艾滋病前期患者血清中HTLV-III的抗体
公开(公告)号：US4520113A
公开(公告)日：1985-05-28
申请号：US602945
申请日：1984-04-23
申请人： Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
IPC分类号： G01N33/543 , A61K39/00 , C12N7/04 , C12Q1/70 , G01N33/569 , G01N33/54 , G01N33/56
CPC分类号： G01N33/56988 , Y10S435/81 , Y10S435/948 , Y10S435/974 , Y10S435/975 , Y10S436/804 , Y10S436/808 , Y10S436/809 , Y10S436/811
摘要： This invention relates to the detection of antibodies in sera of AIDS and pre-AIDS patients and describes the biochemical and immunological analysis of antigens associated with the virus HTLV-III Human T-Cell Leukemia Virus. It is shown that antigens associated with the infection of human cells by this virus are specifically recognized by antibodies from AIDS patients. Specifically, HTLV-III isolated from AIDS patients and transmitted by cocultivation with an HT cell line is specifically detected by antibodies from human sera taken from AIDS patients. The method of detection of antibodies preferred is a strip radioimmunoassay (RIA) based on the Western Blot technique or an ELISA (an enzyme-linked immunosorbent assay) or an indirect immunofluorescence assay.
摘要翻译：本发明涉及艾滋病和艾滋病前期患者血清中抗体的检测，并描述了与病毒HTLV-III人T细胞白血病病毒相关的抗原的生物化学和免疫学分析。显示出与该病毒感染人细胞相关的抗原由AIDS患者的抗体特异性地识别。具体来说，艾滋病患者分离出来的并通过HT细胞系共培养传播的HTLV-III由来自艾滋病患者的人血清的抗体特异性检测。检测抗体的方法优选是基于Western Blot技术或ELISA（酶联免疫吸附测定）或间接免疫荧光测定的条带放射免疫测定（RIA）。

26. 发明授权

US06600023B1 Antibody directed against HIV-1 P25 antigen 失效
标题翻译：针对HIV-1 P25抗原的抗体
公开(公告)号：US06600023B1
公开(公告)日：2003-07-29
申请号：US08019297
申请日：1993-02-18
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
IPC分类号： C07K1600
CPC分类号： C07K16/1045 , C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222 , G01N2333/16
摘要： Antibodies which bind with antigens of human immunodeficiency virus type 1 (HIV-1), such as Lymphadenopathy Associated Virus (LAV), are disclosed. Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS) are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. Viral extracts, structural proteins and other fractions of the retrovirus immunologically recognize the sera of such patients.
摘要翻译：公开了与人类免疫缺陷病毒1型（HIV-1）的抗原结合的抗体，例如淋巴结病相关病毒（LAV）。与获得性免疫缺陷综合征（AIDS）相关的逆转录病毒从患有淋巴结病综合征（LAS）或AIDS的患者的血清中分离。逆转录病毒的病毒提取物，结构蛋白和其他部分免疫识别这些患者的血清。

27. 发明授权

US5576000A Molecular clones of HIV-1 viral strains MH-ST1 and BA-L, and uses thereof 失效
标题翻译： HIV-1病毒株MH-ST1和BA-L的分子克隆及其用途
公开(公告)号：US5576000A
公开(公告)日：1996-11-19
申请号：US388809
申请日：1995-02-15
申请人： Marvin S. Reitz, Jr. , Genoveffa Franchini , Phillip D. Markham , Robert C. Gallo , Franco C. Lori , Mikulas Popovic , Suzanne Gartner
发明人： Marvin S. Reitz, Jr. , Genoveffa Franchini , Phillip D. Markham , Robert C. Gallo , Franco C. Lori , Mikulas Popovic , Suzanne Gartner
IPC分类号： A61K39/00 , A61K39/21 , A61P31/12 , C07K14/00 , C07K14/155 , C07K14/16 , C07K14/705 , C07K17/00 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/49 , C12P21/02 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122 , Y10S435/974
摘要： The present invention relates to the HIV-1 strains MN-ST1 and BA-L which are typical United States HIV-1 isotypes. The present invention relates to DNA segments encoding the envelope protein of MN-ST 1 or BA-L, to DNA constructs containing such DNA segments and to host cells transformed with such constructs. The viral isolates and envelope proteins of the present invention are of value for use in vaccines and bioassays for the detection of HIV-1 infection in biological samples, such as blood bank samples.
摘要翻译：本发明涉及作为典型的美国HIV-1同种型的HIV-1株MN-ST1和BA-L。本发明涉及编码MN-ST1或BA-L的包膜蛋白的DNA片段，涉及含有这些DNA片段的DNA构建体和用这些构建体转化的宿主细胞。本发明的病毒分离物和包膜蛋白在用于检测生物样品例如血库样品中的HIV-1感染的疫苗和生物测定中是有价值的。

28. 发明授权

US07994278B1 Biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA) 有权
标题翻译：衍生自命名为雌激素（MA）的新型早期妊娠因子的生物活性多肽
公开(公告)号：US07994278B1
公开(公告)日：2011-08-09
申请号：US09632831
申请日：2000-08-04
申请人： Robert C. Gallo , Joseph Bryant , Yanto Lundardi-Iskandar
发明人： Robert C. Gallo , Joseph Bryant , Yanto Lundardi-Iskandar
IPC分类号： A61K38/00 , A61K38/04
CPC分类号： C07K16/26 , A61K38/00 , A61K48/00 , C07K14/59 , C07K2319/00
摘要： The invention relates to therapeutic polypeptides isolated from beta-human chorionic gonadotropin (β-hCG) found in human early pregnancy urine, now synthetically produced and designated Maternin. The therapeutic polypeptides and their functional equivalents are useful in treating and/or preventing various medical conditions. Examples of therapeutic effects of the therapeutic polypeptides include anti-HIV, anti-cancer, anti-wasting, prohematopoietic (e.g., anemias, radiation-mediated bone marrow damage, and trauma-mediated blood loss), and anti-angiogenic effects. The invention also provides pharmaceutical compositions comprising the therapeutic polypeptides, as well as methods for using the therapeutic polypeptides, functional equivalents and/or pharmaceutical compositions in the treatment and/or prevention of such medical conditions.
摘要翻译：本发明涉及从人类早孕尿中发现的β-人绒毛膜促性腺激素（＆bgr--hCG）分离的治疗性多肽，现在合成产生并命名为Maternin。治疗性多肽及其功能等同物可用于治疗和/或预防各种医疗状况。治疗性多肽的治疗效果的实例包括抗HIV，抗癌，抗浪费，造血（例如，贫血，辐射介导的骨髓损伤和创伤介导的失血）和抗血管生成作用。本发明还提供了包含治疗性多肽的药物组合物，以及使用治疗性多肽，功能等同物和/或药物组合物治疗和/或预防这些医学病症的方法。

29. 发明授权

US06290963B1 Anti-HIV compositions containing native and recombinant peptides 失效
标题翻译：含有天然和重组肽的抗HIV组合物
公开(公告)号：US06290963B1
公开(公告)日：2001-09-18
申请号：US07314664
申请日：1989-02-23
申请人： Peter J. Fischinger , Flossie Wong-Stall , Robert C. Gallo , Thomas J. Matthews , Dani P. Bolognesi , Gerard W. Robey , Kai Krohn , Annamarie Ranki
发明人： Peter J. Fischinger , Flossie Wong-Stall , Robert C. Gallo , Thomas J. Matthews , Dani P. Bolognesi , Gerard W. Robey , Kai Krohn , Annamarie Ranki
IPC分类号： A61K3921
CPC分类号： C07K14/005 , A61K2039/5156 , A61K2039/57 , C12N2740/16122
摘要： Native and recombinant peptides which elicit anti-HIV immune response are provided.
摘要翻译：提供引起抗HIV免疫应答的天然和重组肽

30. 发明授权

US5968513A Method of promoting hematopoiesis using derivatives of human chorionic gonadotropin 失效
标题翻译：使用人绒毛膜促性腺激素衍生物促进造血的方法
公开(公告)号：US5968513A
公开(公告)日：1999-10-19
申请号：US709924
申请日：1996-09-09
申请人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
发明人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
IPC分类号： A61K38/00 , A61K38/24 , A61K48/00 , A61K38/12 , C07K7/64
CPC分类号： A61K38/24 , A61K48/00 , Y10S514/885
摘要： The present invention relates to methods of treating or preventing diseases or disorders associated with hematopoietic deficiency by administration of human chorionic gonadotropin, .beta.-human chorionic gonadotropin or a peptide containing a sequence of a portion of .beta.-human chorionic gonadotropin. The invention also relates to methods of treating or preventing diseases or disorders associated with hematopoietic deficiency by administration of hematopoietic cells, the numbers of which have been increased by contacting the cells with human chorionic gonadotropin, .beta.-human chorionic gonadotropin or a peptide containing a sequence of a portion of .beta.-human chorionic gonadotropin. The invention also provides assays for the utility of particular human chorionic gonadotropin preparations in the treatment or prevention of hematopoietic deficiencies or in the increasing of hematopoietic cell numbers in vitro. Pharmaceutical compositions and methods of administration of are also provided.
摘要翻译：本发明涉及通过施用人绒毛膜促性腺激素，β-人绒毛膜促性腺激素或含有一部分β-人绒毛膜促性腺激素序列的肽来治疗或预防与造血缺陷相关的疾病或病症的方法。本发明还涉及通过给予造血细胞来治疗或预防与造血缺陷相关的疾病或病症的方法，所述造血细胞的数量通过使细胞与人绒毛膜促性腺激素接触而增加，β-人绒毛膜促性腺激素或含有序列的肽的一部分β-人绒毛膜促性腺激素。本发明还提供特异性人绒毛膜促性腺激素制剂用于治疗或预防造血缺陷或增加体外造血细胞数量的测定。还提供了药物组合物和给药方法。

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