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21. 发明申请

US20110195929A1 COMPOUNDS FOR THE TREATMENT OF FLAVIVIRAL INFECTIONS 审中-公开
标题翻译：治疗感染病毒的化合物
公开(公告)号：US20110195929A1
公开(公告)日：2011-08-11
申请号：US13057557
申请日：2009-08-04
申请人： Olivier De Moor , Graeme Horne , Penny Jane Middleton , Frank Schroer , Stephen Paul Wren , Maria Ines Passos Eleuterio , Renate Van Well , Colin Richard Dorgan , Francis Xavier Wilson , Robert Nash , Richard Storer , Graham Michael Wynne , Alan Geoffrey Roach , Akane Kawamura , Jonathon Mark Tinsley
发明人： Olivier De Moor , Graeme Horne , Penny Jane Middleton , Frank Schroer , Stephen Paul Wren , Maria Ines Passos Eleuterio , Renate Van Well , Colin Richard Dorgan , Francis Xavier Wilson , Robert Nash , Richard Storer , Graham Michael Wynne , Alan Geoffrey Roach , Akane Kawamura , Jonathon Mark Tinsley
IPC分类号： A61K31/695 , C07D487/04 , A61K31/407 , C07D207/12 , A61K31/40 , C07D211/46 , A61K31/445 , C07D207/16 , C07D451/06 , A61K31/46 , C07D471/04 , A61K31/437 , C07D405/04 , A61K31/453 , C07D265/32 , A61K31/5375 , C07D491/113 , A61K31/438 , C07D223/08 , A61K31/55 , C07F7/18 , C07D491/056 , A61K31/397 , A61P31/14
CPC分类号： C07H19/16 , A61K31/40 , A61K31/445 , A61K31/70 , A61K31/7016 , A61K31/702
摘要： Described are various compounds and methods for the treatment of flaviviral infections. In particular, alkaloids and imino sugars in arabinose and/or lyxose stereochemical configuration with antiflaviviral activity are described.
摘要翻译：描述了用于治疗黄病毒感染的各种化合物和方法。特别地，描述了具有抗病毒活性的阿拉伯糖和/或赖索斯立体化学构型中的生物碱和亚氨基糖。

22. 发明申请

US20100168072A1 Drug Combinations for the Treatment of Duchenne Muscular Dystrophy 审中-公开
标题翻译：药物组合治疗杜氏肌营养不良症
公开(公告)号：US20100168072A1
公开(公告)日：2010-07-01
申请号：US12600240
申请日：2008-08-01
申请人： Graham Michael Wynne , Stephen Wren , Peter Johnson , Paul Price , Olivier De Moor , Gary Nugent , Richard Storer , Richard Joseph Pye , Colin Richard Dorgan
发明人： Graham Michael Wynne , Stephen Wren , Peter Johnson , Paul Price , Olivier De Moor , Gary Nugent , Richard Storer , Richard Joseph Pye , Colin Richard Dorgan
IPC分类号： A61K31/56 , A61K31/416 , A61K31/4192 , A61K31/454 , A61K31/5377
CPC分类号： A61K45/06 , A61K31/416 , A61K31/4192 , A61K2300/00
摘要： Combinations comprising (or consisting essentially of) one or more compounds of the formula (I) or (II) with one or more ancillary compounds, to processes for preparing the combinations, and to various therapeutic uses of the combinations. Also provided are pharmaceutical compositions containing the combinations as well as a method of treatment of Duchenne muscular dystrophy, Becker muscular dystrophy or cachexia using the combinations.
摘要翻译：包含（或基本上由）一种或多种式（I）或（II）化合物与一种或多种辅助化合物组合的组合，以及组合的各种治疗用途。还提供了含有组合的药物组合物以及使用这些组合治疗杜氏肌营养不良症，贝克肌营养不良症或恶病质的方法。

23. 发明授权

US08501713B2 Drug combinations for the treatment of duchenne muscular dystrophy 有权
标题翻译：药物组合治疗杜氏肌营养不良症
公开(公告)号：US08501713B2
公开(公告)日：2013-08-06
申请号：US12600242
申请日：2008-08-01
申请人： Graham Michael Wynne , Stephen Paul Wren , Peter David Johnson , Paul Damien Price , Olivier De Moor , Gary Nugent , Richard Storer , Richard Joseph Pye , Colin Richard Dorgan
发明人： Graham Michael Wynne , Stephen Paul Wren , Peter David Johnson , Paul Damien Price , Olivier De Moor , Gary Nugent , Richard Storer , Richard Joseph Pye , Colin Richard Dorgan
IPC分类号： A01N57/00 , A61K31/675 , C07F9/28 , C07D209/48 , C07D307/00
CPC分类号： A61K31/573 , A61K31/423 , A61K45/06 , C07D263/58 , A61K2300/00
摘要： Combinations comprising (or consisting essentially of) one or more compounds of formula (1) with one or more ancillary agents, to processes for preparing the combinations, and to various therapeutic uses of the combinations. Also provided are pharmaceutical compositions containing the combinations as well as a method of treatment of Duchenne muscular dystrophy, Becker muscular dystrophy or cachexia using the combinations.
摘要翻译：包含（或基本上由）一种或多种式（1）化合物与一种或多种辅助试剂组合的组合，以及组合的各种治疗用途。还提供了含有组合的药物组合物以及使用这些组合治疗杜氏肌营养不良症，贝克肌营养不良症或恶病质的方法。

24. 发明申请

US20120020950A1 ANTIBACTERIAL COMPOUNDS 有权
标题翻译：抗菌化合物
公开(公告)号：US20120020950A1
公开(公告)日：2012-01-26
申请号：US13131469
申请日：2009-12-01
申请人： Paul James Davis , Olivier De Moor , Colin Richard Dorgan , Peter David Johnson , Alan Geoffrey Roach , Richard Storer , Richard John Vickers , Francis Xavier Wilson , Graham Michael Wynne
发明人： Paul James Davis , Olivier De Moor , Colin Richard Dorgan , Peter David Johnson , Alan Geoffrey Roach , Richard Storer , Richard John Vickers , Francis Xavier Wilson , Graham Michael Wynne
IPC分类号： A61K31/4184 , C07D401/14 , A61K31/444 , A61K35/74 , A61K39/40 , A61P31/04 , A01P1/00 , A01N43/52 , A01N43/40 , A61K38/12 , C07D403/10 , A01N63/02
CPC分类号： A61K31/444 , A61K31/4439 , C07D235/18 , C07D401/14 , Y02A50/473
摘要： Disclosed are compounds of formula (I), which are of use in the treatment of bacterial diseases and infections, to compositions containing those compounds and to methods of treating bacterial diseases and infections using the compounds. In particular, the compounds are useful for the treatment of infection with, and diseases caused by, Clostridium difficile.
摘要翻译：公开了用于治疗细菌性疾病和感染的式（I）化合物，含有这些化合物的组合物以及使用该化合物治疗细菌性疾病和感染的方法。特别地，这些化合物可用于治疗由艰难梭菌引起的感染和疾病。

25. 发明申请

US20110237538A1 TREATMENT OF LYSOSOMAL STORAGE DISORDERS AND OTHER PROTEOSTATIC DISEASES 审中-公开
标题翻译：治疗淋巴结储存障碍和其他预防性疾病
公开(公告)号：US20110237538A1
公开(公告)日：2011-09-29
申请号：US13057654
申请日：2009-08-04
申请人： Olivier De Moor , Graeme Horne , Penny Jane Middleton , Frank Schroer , Stephen Paul Wren , Maria Ines Passos Eleuterio , Renate Van Well , Colin Richard Dorgan , Francis Xavier Wilson , Robert Nash , Richard Storer , Graham Michael Wynne , Alan Geoffrey Roach , Akane Kawamura , Jonathon Mark Tinsley
发明人： Olivier De Moor , Graeme Horne , Penny Jane Middleton , Frank Schroer , Stephen Paul Wren , Maria Ines Passos Eleuterio , Renate Van Well , Colin Richard Dorgan , Francis Xavier Wilson , Robert Nash , Richard Storer , Graham Michael Wynne , Alan Geoffrey Roach , Akane Kawamura , Jonathon Mark Tinsley
IPC分类号： A61K31/7028 , A61K31/407 , A61K31/445 , A61K31/439 , A61K31/55 , A61K31/40 , A61K31/404 , A61K31/47 , A61K31/495 , A61P3/10 , A61P9/00 , A61P25/00 , A61P19/02 , A61P35/00
CPC分类号： A61K31/40 , A61K31/445 , A61K31/70 , A61K31/7016 , A61K31/702
摘要： Described are various compounds, in particular iminosugars, and methods for the treatment of proteostatic diseases, in particular lysosomal storage disorders. The compound may be a pharmacoperone of an enzyme selected from: (a) Acid alpha-glucosidase; (b) Acid beta-glucosidase; (c) glucocerebrosidase; (d) alpha-Galactosidase A; (e) Acid beta-galactosidase; (f) beta-Hexosaminidase A; (g) beta-Hexosaminidase B; (h) Acid sphingomyelinase; (i) Galactocerebrosidase; (j) Acid ceramidase; (k) Arylsulfatase A; (l) alpha-L-Iduronidase; (m) Iduronate-2-sulfatase; (n) Heparan N-sulfatase; (o) alpha-N-Acetylglucosaminidase; (p) Acetyl-CoA: alpha-glucosaminide N-acetyltransferase; (q) N-Acetylglucosamine-6-sulfate sulfatase; (r) N-Acetylgalactosamine-6-sulfate sulfatase; (s) Acid beta-galactosidase; (t) Arylsulfatase B; (u) beta-Glucuronidase; (v) Acid alpha-mannosidase; (w) Acid beta-mannosidase; (x) Acid alpha-L-fucosidase; (y) Sialidase; and (z) alpha-N-acetylgalactosaminidase.
摘要翻译：描述了各种化合物，特别是亚氨基糖苷，以及用于治疗蛋白酶抑制疾病，特别是溶酶体储存障碍的方法。该化合物可以是选自以下的酶的药代动力学：（a）酸性α-葡糖苷酶; （b）酸性β-葡糖苷酶; （c）葡糖脑苷脂酶; （d）α-半乳糖苷酶A; （e）酸性β-半乳糖苷酶; （f）β-己糖胺酶A; （g）β-己糖淀粉酶B; （h）酸性鞘磷脂酶; （i）半乳糖脑苷脂酶; （j）酸性神经酰胺酶; （k）芳基硫酸酯酶A; （1）α-L-阿索非糖苷酶; （m）伊曲红素-2-硫酸酯酶; （n）肝素N-硫酸酯酶; （o）α-N-乙酰葡糖胺酶; （p）乙酰CoA：α-葡糖胺N-乙酰转移酶; （q）N-乙酰葡糖胺-6-硫酸酯硫酸酯酶; （r）N-乙酰基半乳糖胺-6-硫酸酯硫酸酯酶; 酸性β-半乳糖苷酶; （t）芳基硫酸酯酶B; （u）β-葡糖苷酸酶; （v）酸性α-甘露糖苷酶; （w）酸性β-甘露糖苷酶; （x）酸性α-L-岩藻糖苷酶; （y）唾液酸酶; 和（z）α-N-乙酰半乳糖胺酶。

26. 发明申请

US20100022613A1 Compounds Having CRTH2 Antagonist Activity 审中-公开
标题翻译：具有CRTH2拮抗作用的化合物
公开(公告)号：US20100022613A1
公开(公告)日：2010-01-28
申请号：US12357792
申请日：2009-01-22
申请人： Richard Edward Armer , Graham Michael Wynne
发明人： Richard Edward Armer , Graham Michael Wynne
IPC分类号： A61K31/405 , C07D209/04
CPC分类号： C07D209/10
摘要： Compounds of general formula (I) W is chloro or fluoro; Z is a —SO2YR1 group wherein R1 is C3-C8 heterocyclyl, aryl or heteroaryl any of which may optionally be substituted with one or more substituents selected from halo, —CN, —C1-C6 alkyl, —SOR3, —SO2R3, —SO2N(R2)2, —N(R2)2, —NR2C(O)R3, —CO2R2, —CONR2R3, —NO2, —OR2, —SR2, —O(CH2)pOR2, and —O(CH2)pO(CH2)qOR2 wherein each R2 is independently hydrogen, —C1-C6 alkyl, —C3-C8 cycloalkyl, aryl or heteroaryl; each R3 is independently, —C1-C6 alkyl, —C3-C8 cycloalkyl, aryl or heteroaryl; p and q are each independently an integer from 1 to 3; Y is a straight or branched C1-C4 alkylene chain; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.
摘要翻译：通式（I）的化合物W是氯或氟; Z是-SO 2 YR1基团，其中R 1是C 3 -C 8杂环基，芳基或杂芳基，其中任何一个可以任选被一个或多个选自卤素，-CN，-C 1 -C 6烷基，-SOR 3，-SO 2 R 3，-SO 2 N （R 2）2，-N（R 2）2，-NR 2 C（O）R 3，-CO 2 R 2，-CONR 2 R 3，-NO 2，-OR 2，-SR 2，-O（CH 2）pOR 2和-O（CH 2））qOR 2，其中每个R 2独立地是氢，-C 1 -C 6烷基，-C 3 -C 8环烷基，芳基或杂芳基; 每个R 3独立地是-C 1 -C 6烷基，-C 3 -C 8环烷基，芳基或杂芳基; p和q各自独立地为1至3的整数; Y是直链或支链C 1 -C 4亚烷基链; 其药学上可接受的盐，水合物，溶剂合物，复合物或前药可用于口服给药的组合物中，用于治疗过敏性疾病如哮喘，过敏性鼻炎和特应性皮炎。

27. 发明申请

US20100305120A1 COMPOUNDS FOR TREATING MUSCULAR DYSTROPHY 审中-公开
标题翻译：用于治疗肌肉晶状体的化合物
公开(公告)号：US20100305120A1
公开(公告)日：2010-12-02
申请号：US12599963
申请日：2009-04-03
申请人： Graham Michael Wynne , Stephen Paul Wren , Renate Maria Van Well , Daniel Robert Chancellor , Frank Schroer , Francis Xavier Wilson
发明人： Graham Michael Wynne , Stephen Paul Wren , Renate Maria Van Well , Daniel Robert Chancellor , Frank Schroer , Francis Xavier Wilson
IPC分类号： A61K31/5377 , A61K31/498 , A61K31/4709 , A61K31/454 , A61K31/4439 , A61K31/433 , A61K31/4245 , A61K31/428 , A61K31/427 , A61K31/423 , A61K31/422 , A61K31/416 , C07D413/10 , C07D231/56 , A61P21/00
CPC分类号： A61K31/428 , A61K31/404 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/422 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/498 , A61K31/5377 , C07D231/56 , C07D405/12
摘要： Compounds of formula (I): wherein X, L1, R1, L2, R2, R3, and R4 are as defined herein, are useful in the treatment or prophylaxis of Duchenne muscular dystrophy, Becker muscular dystrophy, or cachexia.
摘要翻译：式（I）化合物：其中X，L1，R1，L2，R2，R3和R4如本文所定义，可用于治疗或预防杜氏肌营养不良症，贝克肌营养不良症或恶病质。

28. 发明授权

US06949563B2 (2-carboxamido)(3-amino)thiophene compounds 有权
标题翻译：（2-甲酰氨基）（3-氨基）噻吩化合物
公开(公告)号：US06949563B2
公开(公告)日：2005-09-27
申请号：US10752342
申请日：2004-01-06
申请人： Graham Michael Wynne , Kevin Doyle , Saleh Ahmed , An-Hu Li , John Fraser Keily , Chrystelle Marie Rasamison , Neil Anthony Pegg , Imaad Saba , Claire Thomas , Don Smyth , Shazia Sadiq , Gary Newton , Graham Dawson , Andrew Phillip Crew , Arlindo Lucas Castelhano
发明人： Graham Michael Wynne , Kevin Doyle , Saleh Ahmed , An-Hu Li , John Fraser Keily , Chrystelle Marie Rasamison , Neil Anthony Pegg , Imaad Saba , Claire Thomas , Don Smyth , Shazia Sadiq , Gary Newton , Graham Dawson , Andrew Phillip Crew , Arlindo Lucas Castelhano
IPC分类号： A61K31/381 , A61K31/437 , A61K31/4436 , A61K31/4709 , A61K31/4745 , A61K45/06 , C07D409/12 , C07D409/14 , C07D471/04 , C07D49/02
CPC分类号： C07D409/12 , A61K31/165 , A61K31/22 , A61K31/277 , A61K31/381 , A61K31/437 , A61K31/4436 , A61K31/444 , A61K31/4709 , A61K31/4745 , A61K45/06 , C07D409/14 , C07D471/04 , A61K2300/00
摘要： Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1 is R2 is and R3 is C0-4alkyl, are useful in the treatment of cancer.
摘要翻译：由式（I）表示的化合物或其药学上可接受的盐或N-氧化物，其中R1是R2，R3是C0-4-4烷基，可用于治疗癌症。

29. 发明授权

US08138351B2 Treatment of duchenne muscular dystrophy 有权
标题翻译：杜氏肌营养不良症的治疗
公开(公告)号：US08138351B2
公开(公告)日：2012-03-20
申请号：US12599970
申请日：2008-08-14
申请人： Graham Michael Wynne , Alexander Charles Weymouth-Wilson , Robert Clarkson , Renate Van Well , Stephen Paul Wren , Olivier De Moor
发明人： Graham Michael Wynne , Alexander Charles Weymouth-Wilson , Robert Clarkson , Renate Van Well , Stephen Paul Wren , Olivier De Moor
IPC分类号： C07D263/57
CPC分类号： C07D263/57
摘要： Provided is a process for the preparation of 5-(ethylsulfonyl)-2-(naphthalen-2-yl) benzo[d] oxazole useful in the treatment of Duchenne muscular dystrophy.
摘要翻译：提供了一种制备可用于治疗杜氏肌营养不良症的5-（乙基磺酰基）-2-（萘-2-基）苯并[d]恶唑的方法。

30. 发明授权

US06504037B2 Process for preparing resorcinol derivatives 失效
公开(公告)号：US06504037B2
公开(公告)日：2003-01-07
申请号：US09801999
申请日：2001-03-08
申请人： Stuart Edward Bradley , John Kitchin , Graham Michael Wynne
发明人： Stuart Edward Bradley , John Kitchin , Graham Michael Wynne
IPC分类号： C07D31100
CPC分类号： C07D317/72 , C07C37/07 , C07C45/59 , C07C45/71 , C07C49/747 , C07C2601/14 , C07C2601/18 , Y02P20/55 , Y10S977/926 , C07C49/753 , C07C39/17
摘要： The present invention relates to an improved process for preparing 4-substituted resorcinol derivatives, and intermediate compounds useful in the preparation of such resorcinol derivatives.

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