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21. 发明授权

US07892221B2 Method of controlled drug delivery from implant device 有权
标题翻译：从植入装置控制药物递送的方法
公开(公告)号：US07892221B2
公开(公告)日：2011-02-22
申请号：US11041161
申请日：2005-01-21
申请人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Achim Göpferich
发明人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Achim Göpferich
IPC分类号： A61K9/22
CPC分类号： A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M37/00 , A61M2205/0244 , C25F5/00 , C25F7/00 , Y10T137/8242
摘要： Reservoir-based medical devices are provided. In one embodiment, the medical device comprises a substrate; at least two discrete, microfabricated reservoirs provided in spaced positions across at least one surface of the substrate; discrete reservoir caps covering the at least two reservoirs; and control circuitry for selectively disintegrating the reservoir caps to open the reservoirs. The reservoirs of the device can include a diagnostic reagent or other molecules useful in medical diagnostics. In one embodiment, the reservoir cap comprises an anode and the control circuitry comprises a cathode and a power source for creating an electric potential between the cathode and the anode. Application of the electric potential causes the reservoir cap to disintegrate, thereby opening the reservoir.
摘要翻译：提供了基于水库的医疗设备。在一个实施例中，医疗装置包括基底; 至少两个离散的，微制造的储存器，跨过衬底的至少一个表面设置在间隔位置; 覆盖至少两个储存器的分立贮存器盖; 以及用于选择性地分解储存器盖以打开储存器的控制电路。装置的储存器可以包括诊断试剂或用于医学诊断的其它分子。在一个实施例中，储存器盖包括阳极，并且控制电路包括用于在阴极和阳极之间产生电位的阴极和电源。施加电势会导致储存器盖分解，从而打开储存器。

22. 发明授权

US07070592B2 Medical device with array of electrode-containing reservoirs 有权
标题翻译：带有电极储存器阵列的医疗器械
公开(公告)号：US07070592B2
公开(公告)日：2006-07-04
申请号：US10886405
申请日：2004-07-07
申请人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer
发明人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer
IPC分类号： A61K9/22 , A61N1/30
CPC分类号： A61K9/0097 , A61K9/0009 , A61K9/0024 , Y10T436/25
摘要： Devices are provided for medical diagnostics comprising a substrate; an array of reservoirs; one or more electrodes located at least partially inside the reservoirs; a plurality of discrete reservoir caps covering openings in the plurality reservoirs; control circuitry for selectively disintegrating or permeabilizing the reservoir cap over a reservoir opening; and, optionally, a diagnostic reagent in the reservoirs. Devices also are provided for the controlled delivery of molecules comprising a substrate; an array of reservoirs; a release system in the reservoirs comprising molecules for release; one or more electrodes attached to the substrate inside the reservoirs or to a surface outside of the reservoirs, wherein the electrodes are not reservoir caps; and means for applying an electric current or potential across the electrodes effective to activate release of the molecules from the reservoirs. The devices can be adapted for implantation for in vivo diagnostics or drug delivery.
摘要翻译：提供用于医疗诊断的装置，包括基底; 一系列水库; 一个或多个电极至少部分地位于储存器内部; 多个分立储存器盖，覆盖多个储存器中的开口; 用于选择性地将储存器盖分解或渗透在储存器开口上的控制电路; 和任选地，在储存器中的诊断试剂。还提供了用于受控输送包含基底的分子的装置; 一系列水库; 储存器中的释放系统包括用于释放的分子; 一个或多个电极附着到储存器内的基底或储存器外部的表面，其中电极不是储存器盖; 以及用于施加跨过电极的电流或电位的装置，有效地激活分子从储存器的释放。该装置可适于植入用于体内诊断或药物递送。

23. 发明申请

US20090112188A1 DEVICE FOR CONTROLLING EXPOSURE OF RESERVOIR CONTENTS TO SURROUNDINGS 有权
标题翻译：控制环境中储层暴露的装置
公开(公告)号：US20090112188A1
公开(公告)日：2009-04-30
申请号：US12348609
申请日：2009-01-05
申请人： John T. Santini, JR. , Michael J. Cima , Scott Albert Uhland
发明人： John T. Santini, JR. , Michael J. Cima , Scott Albert Uhland
IPC分类号： A61K9/22
CPC分类号： B01L3/50853 , A61K9/0009 , A61K9/0024 , A61K9/0097 , B01L2300/0819 , B01L2400/0677
摘要： Microchip devices are provided that include a substrate; a plurality of reservoirs in the substrate, each reservoir defining an internal volume; and a reservoir cap positioned on or in each of the reservoirs bounding the internal volume from an external environment, the reservoir cap being formed of a material that undergoes a phase change upon heating, wherein the internal volume can communicate with the external environment upon heating said reservoir cap to cause said reservoir cap to undergo a phase change and rupture.
摘要翻译：提供了包括衬底的Microchip器件; 在所述基板中的多个储存器，每个储存器限定内部容积; 以及储存器盖，其定位在从外部环境限定内部容积的每个储存器中或每个储存器中，所述储存器盖由在加热时经历相变的材料形成，其中所述内部容积可以在加热所述内部体积时与外部环境连通储存器盖以使所述储存器盖发生相变和破裂。

24. 发明授权

US07070590B1 Microchip drug delivery devices 失效
标题翻译： Microchip药物输送装置
公开(公告)号：US07070590B1
公开(公告)日：2006-07-04
申请号：US09665303
申请日：2000-09-19
申请人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer
发明人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer
IPC分类号： A61K9/22
CPC分类号： A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M37/00 , A61M2205/0244 , C25F5/00 , C25F7/00 , Y10T137/8242
摘要： Devices are provided for the controlled release of drug or other molecules. The devices include (1) a substrate, which optionally includes two or more substrate portions bonded together, (2) at least two reservoirs in the substrate, (3) a release system disposed in the reservoirs that includes the molecules for release and optionally a matrix material, and (4) active or passive means for controlling release of the molecules from the reservoirs. In one embodiment, a reservoir cap is positioned on, or within a portion of, the reservoir and over the molecules, so that the molecules are controllably released from the device by diffusion through or upon disintegration of the reservoir cap.
摘要翻译：提供了用于药物或其他分子的控制释放的装置。这些装置包括（1）基材，其任选地包括两个或更多个粘结在一起的基底部分，（2）基底中的至少两个储存器，（3）设置在储存器中的释放系统，其包括用于释放的分子，基质材料，（4）用于控制分子从储层释放的主动或被动方式。在一个实施例中，储存器盖位于储存器的一部分上，或位于储存器的一部分上方，并位于分子上方，使得分子通过扩散通过储存器盖的分解或分解而可控制地从装置释放。

25. 发明授权

US06669683B2 Thermally-activated microchip chemical delivery devices 有权
标题翻译：热敏微芯片化学输送装置
公开(公告)号：US06669683B2
公开(公告)日：2003-12-30
申请号：US10341305
申请日：2003-01-13
申请人： John T. Santini, Jr. , Michael J. Cima , Scott Albert Uhland
发明人： John T. Santini, Jr. , Michael J. Cima , Scott Albert Uhland
IPC分类号： A61K911
CPC分类号： B01L3/50853 , A61K9/0009 , A61K9/0024 , A61K9/0097 , B01L2300/0819 , B01L2400/0677
摘要： Microchip delivery devices are provided that control both the rate and time of release of molecules. In one embodiment, an implantable microchip device is provided for the controlled delivery of drug molecules into a patient comprising at least one substrate; a plurality of reservoirs in the substrate; a release system which includes drug molecules for release, the release system being provided in each of the reservoirs; a reservoir cap positioned on or in each of the reservoirs over the release system, the reservoir cap comprising a material that undergoes a phase change in response to a change in temperature; and a heating means capable of selectively causing the phase change independently in each reservoir cap, to release the molecules from the reservoirs. The reservoirs can contain multiple drugs or other molecules in variable dosages. Each of the reservoirs of a single microchip can contain different molecules and/or different amounts and concentrations, which can be released independently.
摘要翻译：提供Microchip输送装置，其控制分子释放的速率和时间。在一个实施例中，提供了可植入微芯片装置，用于将药物分子控制递送到包括至少一个基底的患者中; 在所述基板中的多个储存器; 释放系统，其包括用于释放的药物分子，所述释放系统设置在每个所述储存器中; 储存器盖定位在释放系统上方或每个储存器中，储存器盖包括响应于温度变化而经历相变的材料; 以及能够在每个储存器盖中独立地选择性地引起相变从而从储存器释放分子的加热装置。储层可以含有多种药物或其他可变剂量的分子。单个微芯片的每个储存器可以包含不同的分子和/或不同的量和浓度，其可以独立释放。

26. 发明授权

US06596224B1 Jetting layers of powder and the formation of fine powder beds thereby 失效
标题翻译：从而喷涂粉末层并形成细粉末床
公开(公告)号：US06596224B1
公开(公告)日：2003-07-22
申请号：US09445670
申请日：2000-03-01
申请人： Emanuel M. Sachs , Michael J. Cima , Michael A. Caradonna , Jason Grau , James G. Serdy , Patrick C. Saxton , Scott A. Uhland , Jooho Moon
发明人： Emanuel M. Sachs , Michael J. Cima , Michael A. Caradonna , Jason Grau , James G. Serdy , Patrick C. Saxton , Scott A. Uhland , Jooho Moon
IPC分类号： B22F702
CPC分类号： B29C41/36 , B22F3/008 , B22F2999/00 , B29C41/003 , B29C41/16 , B29C64/112 , B29C64/165 , B33Y10/00 , B33Y30/00 , B22F3/22
摘要： A powder bed (32) is built up by repeated deposition of a slurry that contains powder. Layers are made by depositing a liquid dispersion of the desired powdered material, which then slip-casts into the forming powder bed to make a new layer (34). The slurry may be deposited in any suitable manner, such as by raster or vector scanning, or by a plurality of simultaneous jets that coalesce before the liquid slip-casts into the bed, or by individual drops, the deposits of which are individually controlled, thereby generating a regular surface for each layer.
摘要翻译：通过重复沉积含有粉末的浆料来形成粉末床（32）。通过沉积所需粉末材料的液体分散体来制备层，然后将其分散到成形粉末床中以形成新的层（34）。浆料可以以任何合适的方式沉积，例如通过光栅或向量扫描，或者通过多个同时喷射在液体滑入床之前聚结，或通过单独的液滴沉积，沉积物被单独控制，从而为每个层产生规则的表面。

27. 发明申请

US20080172043A1 MICROCHIP RESERVOIR DEVICES USING WIRELESS TRANSMISSION OF POWER AND DATA 审中-公开
标题翻译：使用无线传输功率和数据的MICROCHIP储存设备
公开(公告)号：US20080172043A1
公开(公告)日：2008-07-17
申请号：US11747598
申请日：2007-05-11
申请人： Norman F. Sheppard , John T. Santini , Stephen J. Herman , Michael J. Cima , Robert S. Langer , Dennis Ausiello
发明人： Norman F. Sheppard , John T. Santini , Stephen J. Herman , Michael J. Cima , Robert S. Langer , Dennis Ausiello
IPC分类号： A61M5/00
CPC分类号： A61B1/041 , A61B5/0402 , A61B5/0476 , A61B5/14539 , A61K9/0009 , A61K9/0051 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61M2205/0244 , A61M2205/3523 , A61M2210/0612 , A61M2210/1042
摘要： Devices and methods are provided for wirelessly powering and/or communicating with implanted medical devices used for the controlled exposure and release of reservoir contents, such as drugs or sensors. The device may include a substrate having a plurality of reservoirs containing reservoir contents for release or exposure; and a rechargeable or on-demand power source comprising a local component which can wirelessly receive power from a remote transmitter wherein the received power can be used, directly or following transduction, to activate the release or exposure of the reservoir contents.
摘要翻译：提供了用于与用于受控地暴露和释放储存器内容物（例如药物或传感器）的植入式医疗装置的无线供电和/或通信的装置和方法。该装置可以包括具有多个储存器的基板，该储存器包含用于释放或暴露的储存器内容物; 以及可充电或点播电源，其包括本地组件，其可以从远程发射机无线地接收电力，其中可以直接或继续使用所接收的功率来激活所述储存器内容物的释放或暴露。

28. 发明授权

US09918656B2 Implantable magnetic relaxation sensors and methods of measuring a sensor's cumulative exposure to a biomarker 有权
公开(公告)号：US09918656B2
公开(公告)日：2018-03-20
申请号：US13806348
申请日：2011-06-27
申请人： Michael J. Cima , Paul Huang , Yibo Ling , Terrence Pong , Christophoros C. Vassiliou
发明人： Michael J. Cima , Paul Huang , Yibo Ling , Terrence Pong , Christophoros C. Vassiliou
IPC分类号： A61B5/055 , A61B5/00 , A61B5/145 , G01R33/56 , G01R33/30 , G01R33/50
CPC分类号： A61B5/055 , A61B5/0031 , A61B5/14546 , A61B2562/0285 , G01R33/302 , G01R33/50 , G01R33/5601
摘要： An implantable magnetic relaxation sensor is provided that comprises superparamagnetic nanoparticies functionalized with one or more agents that bond with a biomarker of interest. The sensor is configured for minimally-invasive implantation into a human or animal, and is configured to indicate the implanted sensor's cumulative exposure to the biomarker of interest by analysis using magnetic resonance relaxometry.

29. 发明授权

US09017312B2 Implantable device for controlled drug delivery 有权
标题翻译：用于受控药物输送的可植入装置
公开(公告)号：US09017312B2
公开(公告)日：2015-04-28
申请号：US12851494
申请日：2010-08-05
申请人： Heejin Lee , Michael J. Cima , Karen Daniel , Cheryl Larrivee-Elkins
发明人： Heejin Lee , Michael J. Cima , Karen Daniel , Cheryl Larrivee-Elkins
IPC分类号： A61K9/22 , A61M31/00 , A61K9/00 , A61K31/167
CPC分类号： A61K9/0092 , A61K9/0004 , A61K9/0034 , A61K31/167 , A61M31/002
摘要： Implantable devices and methods for delivery of lidocaine or other drugs to a patient are provided. In one embodiment, the device includes a first drug portion which has a first drug housing which contains a first drug formulation in a solid form which includes a pharmaceutically acceptable salt of lidocaine; and a second drug portion which includes a second drug housing which contains a second drug formulation which includes lidocaine base. In another embodiment, the device includes a drug reservoir component which has an elastic tube having at least one lumen bounded by a porous sidewall having an open-cell structure, a closed-cell structure, or a combination thereof; and a drug formulation contained within the at least one lumen, wherein the device is deformable between a low-profile deployment shape and a relatively expanded retention shape.
摘要翻译：提供了用于将利多卡因或其他药物递送给患者的可植入装置和方法。在一个实施方案中，该装置包括第一药物部分，其具有第一药物外壳，其包含固体形式的第一药物制剂，其包含利多卡因的药学上可接受的盐; 和第二药物部分，其包括含有包含利多卡因碱的第二药物制剂的第二药物外壳。在另一个实施方案中，该装置包括药物储存器部件，该药物储存器部件具有弹性管，该弹性管具有由具有开孔结构，闭孔结构或其组合的多孔侧壁限定的至少一个内腔; 以及包含在所述至少一个内腔内的药物制剂，其中所述装置可在低轮廓展开形状和相对扩张的保留形状之间变形。

30. 发明授权

US08801694B2 Intravesical drug delivery device 有权
标题翻译：膀胱内药物输送装置
公开(公告)号：US08801694B2
公开(公告)日：2014-08-12
申请号：US11463956
申请日：2006-08-11
申请人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
发明人： Heejin Lee , Karen Daniel , Hong Linh Ho Duc , Michael J. Cima , Mario Castillo , Steven Froelich , Jordan Dimitrakov , Grace Y. Kim
IPC分类号： A61F2/00 , A61M31/00 , A61L29/16 , A61K9/00 , A61L29/06
CPC分类号： A61M31/002 , A61K9/0034 , A61L29/06 , A61L29/16 , A61L2300/402 , A61L2300/406 , A61L2300/45 , A61L2300/63 , A61M2202/06 , A61M2205/0216 , A61M2210/1085 , C08L83/04
摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.
摘要翻译：用于膀胱内给药和局部药物输送的植入装置。该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。该装置构造成用于微创地插入诸如膀胱的体腔中。中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在体腔。身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

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