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1. 发明授权

US08657804B2 Visual indication of rupture of drug reservoir 失效
标题翻译：药库破裂的视觉指示
公开(公告)号：US08657804B2
公开(公告)日：2014-02-25
申请号：US12910572
申请日：2010-10-22
申请人： Kenneth N. Horne , Gregory J. R. Spooner , John A. Scholl , John T. Santini, Jr.
发明人： Kenneth N. Horne , Gregory J. R. Spooner , John A. Scholl , John T. Santini, Jr.
IPC分类号： A61M31/00
CPC分类号： A61F9/0017 , A61F2002/30714 , A61F2250/0068 , A61F2250/0089 , A61F2250/0097 , A61K9/0009 , A61K9/0051
摘要： The present disclosure relates to methods for visualizing the opening of a drug reservoir of an implantable medical device. In particular, the present disclosure provides methods for observing the release or exposure of contents from a drug reservoir of a medical device placed within the vitreous of an eye of a subject. The methods include implanting a drug delivery device within an anatomy of a subject. The drug device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker. Furthermore, the drug delivery device comprises a plurality of barrier layers for separating the contents of one of the plurality of reservoirs from the anatomy. The method further includes irradiating at least one of the plurality of barrier layers such that at least one of the plurality of reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device. By visually detecting release of the marker into the anatomy, release of the therapeutic agent into the anatomy is verified.
摘要翻译：本公开涉及用于可视化可植入医疗装置的药物储存器的开口的方法。特别地，本公开提供了观察从放置在受试者的眼睛的玻璃体内的医疗装置的药物储存器释放或暴露内容物的方法。所述方法包括将药物递送装置植入受试者的解剖结构内。药物装置包括多个储存器，每个储存器装载有治疗剂和标记物。此外，药物递送装置包括用于将多个储存器中的一个的内容物与解剖结构分离的多个阻挡层。该方法还包括照射多个阻挡层中的至少一个，使得多个储存器中的至少一个被破坏，从而触发治疗剂和标记物从装置释放。通过目视检测将标记物释放到解剖结构中，验证了治疗剂释放到解剖结构中。

2. 发明申请

US20120035528A1 LOW-PERMEABILITY, LASER-ACTIVATED DRUG DELIVERY DEVICE 有权
标题翻译：低渗透性，激光激活药物递送装置
公开(公告)号：US20120035528A1
公开(公告)日：2012-02-09
申请号：US13023370
申请日：2011-02-08
申请人： Jonathan R. Coppeta , Kenneth N. Horne , John T. Santini, JR. , John A. Scholl , Gregory J.R. Spooner , Cynthia L. Stevenson , Naveed Shams , Andrew Poutiatine
发明人： Jonathan R. Coppeta , Kenneth N. Horne , John T. Santini, JR. , John A. Scholl , Gregory J.R. Spooner , Cynthia L. Stevenson , Naveed Shams , Andrew Poutiatine
IPC分类号： A61M37/00 , B65B1/04
CPC分类号： A61F9/0017 , A61F9/008 , A61K9/0009 , A61K9/0051
摘要： An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.
摘要翻译：一种可植入药物递送装置，其使用多个储存元件来容纳和释放剂量的活性药物成分。该装置包括第一壳单元，其具有第一封闭空腔体积并形成低渗透屏障。第一壳元件被配置为吸收来自激光源的光照射，激光照射引起第一壳元件中的破裂。第一活性药物成分包含在第一封闭空腔体积中，并且当第一壳元件被破坏时被释放。该装置还包括第二壳单元，其具有第二封闭空腔体积并且还形成低渗透屏障。第二活性药物成分包含在第二封闭空腔体积中。该装置还包括包含第一和第二壳单元的包络元件。

3. 发明授权

US07879019B2 Method of opening reservoir of containment device 有权
标题翻译：开启容器装置的方法
公开(公告)号：US07879019B2
公开(公告)日：2011-02-01
申请号：US11925466
申请日：2007-10-26
申请人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr.
发明人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr.
IPC分类号： A61M31/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： A method is provided for selectively opening a containment reservoir. The method includes providing a device which comprises a substrate in which at least one reservoir is located and covered by a reservoir cap; and directing laser light to the reservoir cap to cause the reservoir cap to disintegrate or become permeable. The device may be an implantable medical device. The reservoirs may contain a drug for controlled release or a biosensor.
摘要翻译：提供了一种用于选择性地打开容纳储存器的方法。该方法包括提供一种装置，其包括基板，其中至少一个储存器定位并被储存器盖覆盖; 并将激光引导到储存器盖以使储存器盖分解或变得可渗透。该装置可以是可植入医疗装置。储存器可以含有用于控制释放的药物或生物传感器。

4. 发明授权

US07776024B2 Method of actuating implanted medical device 有权
标题翻译：驱动植入医疗器械的方法
公开(公告)号：US07776024B2
公开(公告)日：2010-08-17
申请号：US11925507
申请日：2007-10-26
申请人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr.
发明人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr.
IPC分类号： A61M31/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： Methods are provided for medical treatment or diagnosis of a patient. The method includes implanting into the patient a device which comprises (i) a substrate in which at least one reservoir is located and covered by a first reservoir cap, (ii) a drug or sensor located in the reservoir, and (iii) control circuitry and a power source for disintegrating or permeabilizing the reservoir cap, and (iv) an external interface to receive incident light energy; and directing focused light to the external interface of the implanted device to actuate disintegration or permeabilization of the reservoir cap to release the drug or expose the sensor. The device may implanted onto or into the sclera or other tissue surface of the eye of the patient. The focused light may be laser light, which may be used to transmit power or data to the device.
摘要翻译：提供了用于治疗或诊断患者的方法。该方法包括向患者植入一种装置，该装置包括：（i）至少一个储存器定位并被第一储存器盖覆盖的基底，（ii）位于储存器中的药物或传感器，以及（iii）控制电路以及用于使储存器盖分解或渗透的电源，以及（iv）外部接口以接收入射光能; 并将聚焦的光引导到植入装置的外部界面以致驱动贮存器盖的分解或透化以释放药物或暴露传感器。该装置可植入患者眼睛的巩膜或其他组织表面上或其中。聚焦光可以是激光，其可以用于将功率或数据传输到设备。

5. 发明授权

US07599737B2 Medical device for neural stimulation and controlled drug delivery 有权
标题翻译：用于神经刺激和受控药物递送的医疗装置
公开(公告)号：US07599737B2
公开(公告)日：2009-10-06
申请号：US10679763
申请日：2003-10-06
申请人： Barry M. Yomtov , Stephen J. Herman , John T. Santini, Jr.
发明人： Barry M. Yomtov , Stephen J. Herman , John T. Santini, Jr.
IPC分类号： A61N1/00
CPC分类号： A61N1/30 , A61K9/0097 , A61N1/08 , A61N1/36071 , G06F19/00
摘要： Medical devices and methods are provided for electrical stimulation of neural tissue and controlled drug delivery to a patient. The device includes an implantable drug delivery module which comprises a plurality of reservoirs, a release system comprising at least one drug contained in each of the reservoirs, and control means for selectively releasing a pharmaceutically effective amount of drug from each reservoir; a neural electrical stimulator which comprises a signal generator connected to at least one stimulation electrode for operable engagement with a neural tissue of the patient; and at least one microcontroller for controlling operational interaction of the drug delivery module and the neural electrical stimulator. The microcontroller may control the signal generator and the control means of the drug delivery module. The device may further include a sensor operable to deliver a signal to the microcontroller, for example to indicate when to deliver electrical stimulation, drug, or both.
摘要翻译：提供医疗装置和方法用于电刺激神经组织和控制药物递送给患者。该装置包括可植入药物递送模块，其包括多个储存器，包含每个储存器中的至少一种药物的释放系统和用于从每个储存器中选择性释放药学有效量的药物的控制装置; 神经电刺激器，其包括连接到至少一个刺激电极的信号发生器，用于与患者的神经组织可操作地接合; 以及用于控制药物递送模块和神经电刺激器的操作相互作用的至少一个微控制器。微控制器可以控制药物递送模块的信号发生器和控制装置。该装置还可以包括可操作以将信号传送到微控制器的传感器，例如以指示何时传递电刺激，药物或两者。

6. 发明授权

US07537590B2 Multi-reservoir device for transdermal drug delivery and sensing 有权
标题翻译：用于透皮药物传递和感测的多储器装置
公开(公告)号：US07537590B2
公开(公告)日：2009-05-26
申请号：US11194157
申请日：2005-08-01
申请人： John T. Santini, Jr. , Mark A. Staples , Stephen J. Herman
发明人： John T. Santini, Jr. , Mark A. Staples , Stephen J. Herman
IPC分类号： A61K9/22
CPC分类号： A61K9/703 , A61F2013/00642 , A61K9/0009 , A61K9/0021 , A61K9/0097 , A61K9/7084 , A61K9/7092 , A61M37/0015 , A61M2037/0023 , A61N1/30
摘要： Devices and methods are provided for transdermal administration of a pharmaceutical agent to a patient in need thereof. The device includes a substrate, a plurality of discrete reservoirs in the substrate, one or more pharmaceutical agents stored in the reservoirs, discrete reservoir caps that prevent the pharmaceutical agent from passing out from the reservoirs until desired, control means for actuating release of the one or more pharmaceutical agents from one or more of the reservoirs by disintegrating or permeabilizing the reservoir caps, means for securing the device to the skin of the patient, and means for transporting the pharmaceutical agent to the skin following release from the one or more of the reservoirs. In another embodiment, the device is adapted for diagnostic sensing instead of or in addition to drug delivery.
摘要翻译：提供了用于向有需要的患者透皮施用药剂的装置和方法。该装置包括衬底，衬底中的多个分立贮存器，储存在储存器中的一个或多个药剂，防止药剂从储存器中流出直到期望的离散贮存器盖，用于致动释放一个或更多的药剂从一个或多个储存器中分解或渗透储存器盖，用于将装置固定到患者皮肤的装置，以及用于在药物释放之后将药剂运送到皮肤的装置水库在另一个实施方案中，该装置适用于代替药物递送或除药物递送之外的诊断感测。

7. 发明申请

US20090112188A1 DEVICE FOR CONTROLLING EXPOSURE OF RESERVOIR CONTENTS TO SURROUNDINGS 有权
标题翻译：控制环境中储层暴露的装置
公开(公告)号：US20090112188A1
公开(公告)日：2009-04-30
申请号：US12348609
申请日：2009-01-05
申请人： John T. Santini, JR. , Michael J. Cima , Scott Albert Uhland
发明人： John T. Santini, JR. , Michael J. Cima , Scott Albert Uhland
IPC分类号： A61K9/22
CPC分类号： B01L3/50853 , A61K9/0009 , A61K9/0024 , A61K9/0097 , B01L2300/0819 , B01L2400/0677
摘要： Microchip devices are provided that include a substrate; a plurality of reservoirs in the substrate, each reservoir defining an internal volume; and a reservoir cap positioned on or in each of the reservoirs bounding the internal volume from an external environment, the reservoir cap being formed of a material that undergoes a phase change upon heating, wherein the internal volume can communicate with the external environment upon heating said reservoir cap to cause said reservoir cap to undergo a phase change and rupture.
摘要翻译：提供了包括衬底的Microchip器件; 在所述基板中的多个储存器，每个储存器限定内部容积; 以及储存器盖，其定位在从外部环境限定内部容积的每个储存器中或每个储存器中，所述储存器盖由在加热时经历相变的材料形成，其中所述内部容积可以在加热所述内部体积时与外部环境连通储存器盖以使所述储存器盖发生相变和破裂。

8. 发明申请

US20080033260A1 Cardiac Biosensor Devices and Methods 审中-公开
标题翻译：心脏生物传感器装置和方法
公开(公告)号：US20080033260A1
公开(公告)日：2008-02-07
申请号：US11833011
申请日：2007-08-02
申请人： Norman F. Sheppard , John T. Santini
发明人： Norman F. Sheppard , John T. Santini
IPC分类号： A61B5/02
CPC分类号： A61N1/05 , A61B5/0002 , A61B5/0215 , A61B5/026 , A61B5/145 , A61B5/14532 , A61B5/14539 , A61N1/36557
摘要： Implantable medical devices for cardiac care are provided that include a housing having a power source and control electronics; at least one lead extending from the housing and having one or more discrete reservoirs therein, each reservoir having an opening to an outer surface of the lead; one or more sensors, which monitor or detects an analyte, biomarker, or physical parameter that is associated with cardiac health, located in the reservoirs and in operable communication with said control electronics; and at least one selectively disintegratable reservoir cap sealing each of the reservoir openings, wherein the reservoir cap is operably connected to the power source and control electronics to disintegrate the reservoir cap and expose the sensors in vivo. The sensor may detect an analyte or biomarker selected from potassium ion, sodium ion, lithium ion, magnesium ion, ammonium ion, ionized calcium, lactate, oxygen, carbon dioxide, and creatinine, urea, BUN, and bilirubin.
摘要翻译：提供了用于心脏护理的可植入医疗装置，其包括具有电源和控制电子装置的壳体; 至少一个引线，其从所述壳体延伸并且在其中具有一个或多个分立的储存器，每个储存器具有到所述引线的外表面的开口; 一个或多个传感器，其监测或检测与心脏健康相关联的分析物，生物标志物或物理参数，位于储存器中并与所述控制电子器件可操作地通信; 以及密封每个储存器开口的至少一个可选择性崩解的储存器盖，其中所述储存器盖可操作地连接到所述电源和控制电子装置，以分解所述储存器盖并在体内暴露所述传感器。传感器可以检测选自钾离子，钠离子，锂离子，镁离子，铵离子，离子化钙，乳酸，氧，二氧化碳和肌酸酐，尿素，BUN和胆红素的分析物或生物标志物。

9. 发明授权

US07070590B1 Microchip drug delivery devices 失效
标题翻译： Microchip药物输送装置
公开(公告)号：US07070590B1
公开(公告)日：2006-07-04
申请号：US09665303
申请日：2000-09-19
申请人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer
发明人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer
IPC分类号： A61K9/22
CPC分类号： A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M37/00 , A61M2205/0244 , C25F5/00 , C25F7/00 , Y10T137/8242
摘要： Devices are provided for the controlled release of drug or other molecules. The devices include (1) a substrate, which optionally includes two or more substrate portions bonded together, (2) at least two reservoirs in the substrate, (3) a release system disposed in the reservoirs that includes the molecules for release and optionally a matrix material, and (4) active or passive means for controlling release of the molecules from the reservoirs. In one embodiment, a reservoir cap is positioned on, or within a portion of, the reservoir and over the molecules, so that the molecules are controllably released from the device by diffusion through or upon disintegration of the reservoir cap.
摘要翻译：提供了用于药物或其他分子的控制释放的装置。这些装置包括（1）基材，其任选地包括两个或更多个粘结在一起的基底部分，（2）基底中的至少两个储存器，（3）设置在储存器中的释放系统，其包括用于释放的分子，基质材料，（4）用于控制分子从储层释放的主动或被动方式。在一个实施例中，储存器盖位于储存器的一部分上，或位于储存器的一部分上方，并位于分子上方，使得分子通过扩散通过储存器盖的分解或分解而可控制地从装置释放。

10. 发明授权

US06827250B2 Methods for hermetically sealing microchip reservoir devices 有权
标题翻译：密封微芯片储液装置的方法
公开(公告)号：US06827250B2
公开(公告)日：2004-12-07
申请号：US10184259
申请日：2002-06-28
申请人： Scott A. Uhland , Benjamin F. Polito , Stephen J. Herman , John T. Santini, Jr. , John M. Maloney
发明人： Scott A. Uhland , Benjamin F. Polito , Stephen J. Herman , John T. Santini, Jr. , John M. Maloney
IPC分类号： B23K106
CPC分类号： A61K9/0097
摘要： Methods are provided for hermetically sealing the reservoirs of microchip devices and for hermetically sealing the substrate assemblies in a hermetic packaging structure. In one embodiment, the method comprises (1) providing a primary substrate having a front side and a back side, the substrate comprising a plurality of reservoirs positioned between the front side and the back side, each reservoir being loaded with molecules or a secondary device for controlled release or exposure, the reservoirs having at least one opening in need of sealing, the primary substrate including one or more hermetic sealing materials; (2) providing a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; (3) positioning the hermetic sealing substrate over the reservoir openings and contacting said hermetic sealing materials of the primary substrate with said hermetic sealing materials of the hermetic sealing substrate; and (4) applying energy or a mechanical force to the contacted sealing materials effective to form a hermetic seal between the hermetic sealing substrate and the primary substrate to hermetically seal the reservoir openings.
摘要翻译：提供了用于气密地密封微芯片装置的储存器的方法，以及用于密封密封封装结构中的基板组件。在一个实施例中，该方法包括（1）提供具有前侧和后侧的主基底，所述基底包括位于前侧和后侧之间的多个储存器，每个储存器装载有分子或辅助装置为了控制释放或暴露，储存器具有至少一个需要密封的开口，主基底包括一个或多个气密密封材料; （2）提供具有由一种或多种密封材料构成的表面的气密密封基材; （3）将气密密封基板定位在储存器开口上，并使主基板的气密密封材料与气密密封基板的气密密封材料接触; 和（4）将能量或机械力施加到接触的密封材料上，以有效地在气密密封基底和初级基底之间形成气密密封，从而气密地密封储层开口。

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