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    • 21. 发明授权
    • Tunable light source for label-independent optical reader
    • 用于标签无关光学读卡器的可调光源
    • US08384905B2
    • 2013-02-26
    • US12939606
    • 2010-11-04
    • Qi Wu
    • Qi Wu
    • G01N21/55F21V11/00
    • G01N21/774G01J3/10G01J3/12G01J3/26G01N2021/7776G01N2201/062
    • A tunable light source for interrogating at least one resonant waveguide grating (RWG) biosensor having a resonance linewidth. The tunable light source includes a broadband light source that emits a light beam having a first spectral bandwidth greater than the RWG biosensor resonance linewidth. The broadband light source may be substantially spatially incoherent. A tunable optical filter having a tunable spectral linewidth is arranged to receive and filter the light beam to cause the light beam to have a second spectral bandwidth substantially the same as the RWG biosensor resonance linewidth. Label-independent optical readers that employ the tunable light source are also disclosed.
    • 一种用于询问至少一个具有谐振线宽度的谐振波导光栅(RWG)生物传感器的可调谐光源。 可调谐光源包括宽带光源,其发射具有大于RWG生物传感器谐振线宽的第一光谱带宽的光束。 宽带光源可能基本上在空间上不相干。 具有可调谐谱线宽度的可调谐滤光器被布置成接收和过滤光束以使得光束具有与RWG生物传感器谐振线宽基本相同的第二光谱带宽。 还公开了采用可调谐光源的标签无关光学读取器。
    • 23. 发明申请
    • COMPACT LABEL FREE IMAGING SYSTEM
    • 紧凑的标签免费成像系统
    • US20120274820A1
    • 2012-11-01
    • US13371693
    • 2012-02-13
    • Qi Wu
    • Qi Wu
    • G02B13/16H04N5/335
    • G02B13/22G01N21/253G01N21/553G01N21/658G01N21/7743
    • A compact microplate imaging system, including: a tunable light source; a lens ensemble to collimate the light source onto the microplate and to transmit light that is reflected from the microplate; a beam splitter to divert a portion of the reflected light; an imaging lens to collect diverted light and to produce an optical image of the at least one sensor of the microplate; and an image sensor for receiving the optical image of the at least one sensor of the microplate. A method for interrogating a sensor using the compact microplate imaging system, as further defined herein, is also disclosed.
    • 一种紧凑型微板成像系统,包括:可调光源; 透镜组合,用于将光源准直到微板上并透射从微板反射的光; 分束器,用于转移一部分反射光; 成像透镜,用于收集转向的光并产生所述微板的所述至少一个传感器的光学图像; 以及用于接收微板的至少一个传感器的光学图像的图像传感器。 还公开了如本文进一步定义的使用紧凑型微板成像系统询问传感器的方法。
    • 24. 发明授权
    • Scoring of non-flat materials
    • 非平板材料的评分
    • US08053704B2
    • 2011-11-08
    • US12220948
    • 2008-07-30
    • Anatoli Anatolyevich AbramovLjerka UkrainczykQi WuNaiyue Zhou
    • Anatoli Anatolyevich AbramovLjerka UkrainczykQi WuNaiyue Zhou
    • B23K26/06B23K26/36
    • B23K26/0736C03B33/0215C03B33/0222C03B33/023C03B33/093G02B27/0966Y10T225/12Y10T225/321
    • Disclosed are systems for scoring non-flat materials including non-flat glass sheets (1000). In one embodiment, a laser scoring system is described. The laser scoring system includes a laser (102) and an optical head (106). The optical head (106) is configured to receive output from the laser (102) and focus the output into an elongated laser beam having a beam waist and an extended focal depth of greater than +/−5 mm relative to the center of the beam waist with a power density sufficient for scoring a material having at least a portion within the extended focal depth. In one aspect the system can include a beam expander (104). The beam expander (104) receives the output from the laser (102), expands the output from the laser to an expanded laser beam, and transmits the expanded laser beam to the optical head (106).
    • 公开了用于评估非平板材料(包括非平板玻璃板(1000))的系统。 在一个实施例中,描述了激光评分系统。 激光打标系统包括激光器(102)和光学头(106)。 光学头(106)被配置为接收来自激光器(102)的输出并且将输出聚焦成具有束腰的细长激光束和相对于光束中心大于+/- 5mm的扩展焦深 腰部具有足够的功率密度,用于对在延伸焦点深度内具有至少一部分的材料进行刻痕。 在一个方面,系统可以包括光束扩展器(104)。 光束扩展器(104)接收来自激光器(102)的输出,将激光器的输出扩展到扩展的激光束,并将扩展的激光束传输到光学头(106)。
    • 25. 发明授权
    • Optimized method for LID biosensor resonance detection
    • LID生物传感器共振检测的优化方法
    • US07979241B2
    • 2011-07-12
    • US12266060
    • 2008-11-06
    • Jacques GollierGarrett A. PiechMichael B. WebbQi Wu
    • Jacques GollierGarrett A. PiechMichael B. WebbQi Wu
    • H03F1/26
    • G01J3/28G01J3/02G01J3/0218G01J3/1895G01J3/2803G01N21/7743
    • An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.
    • 本文描述了一种光询问系统,其可以询问标签无关检测(LID)生物传感器并在生物传感器顶部监测生物事件,而不会遇到有问题的寄生反射和/或有问题的像素化效应。 在一个实施例中,光询问系统能够询问生物传感器并使用低通滤波器算法来数字地去除包含在光学共振的光谱中的有问题的寄生反射,这使得更容易确定生物事件是否发生在 生物传感器 在另一个实施例中,光询问系统能够询问生物传感器并使用过采样/平滑算法来减少由问题像素化效应引起的光学共振的估计位置中的振荡,这使得更容易确定生物事件 发生在生物传感器上。