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21. 发明授权

US5817479A Human kinase homologs 失效
标题翻译：人类激酶同源物
公开(公告)号：US5817479A
公开(公告)日：1998-10-06
申请号：US700575
申请日：1996-08-07
申请人： Janice Au-Young , Olga Bandman , Phillip R. Hawkins , Craig G. Wilde
发明人： Janice Au-Young , Olga Bandman , Phillip R. Hawkins , Craig G. Wilde
IPC分类号： C12N9/12 , C12N15/54 , C12P21/06 , C12N15/64
CPC分类号： C12N9/1205
摘要： The present invention provides polynucleotides (kin) which identify and encode novel protein kinases (KIN) expressed in various human cells and tissues. The present invention also provides for antisense sequences and oligonucleotides designed from the nucleotide sequences or their complements. The invention further provides genetically engineered expression vectors and host cells for the production of purified KIN peptides, antibodies capable of binding KIN, and inhibitors specifically bind KIN. The invention specifically provides for diagnostic kits and assays which identify a disorder or disease with altered kinase expression and allow monitoring of patients during drug therapy. These assays utilize oligonucleotides or antibodies produced using the kin polynucleotides.
摘要翻译：本发明提供鉴定和编码在各种人细胞和组织中表达的新型蛋白激酶（KIN）的多核苷酸（kin）。本发明还提供了从核苷酸序列或其互补序列设计的反义序列和寡核苷酸。本发明还提供用于产生纯化的KIN肽，能够结合KIN的抗体和特异性结合KIN的抑制剂的遗传工程表达载体和宿主细胞。本发明特别提供了用于鉴定具有改变的激酶表达并允许在药物治疗期间监测患者的病症或疾病的诊断试剂盒和测定法。这些测定法利用使用亲代多核苷酸产生的寡核苷酸或抗体。

22. 发明授权

US5776732A Human induced tumor protein 失效
公开(公告)号：US5776732A
公开(公告)日：1998-07-07
申请号：US689974
申请日：1996-08-16
申请人： Janice Au-Young , Phillip R. Hawkins
发明人： Janice Au-Young , Phillip R. Hawkins
IPC分类号： G01N33/53 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K48/00 , A61P1/00 , A61P15/00 , A61P17/00 , A61P25/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/574 , C12P21/00
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human induced tumor protein (HITP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HITP. The invention also provides for the production and use of substantially purified HITP in pharmaceutical compositions to force differentiation and to stop cell division in cancerous cells. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HITP and the anti-HITP antibodies which specifically bind to HITP.

23. 发明授权

US06190663B1 Human MAP kinase homolog 失效
标题翻译：人MAP激酶同源物
公开(公告)号：US06190663B1
公开(公告)日：2001-02-20
申请号：US09124163
申请日：1998-07-28
申请人： Phillip R. Hawkins , Janice Au-Young , Karl J. Guegler , Craig G. Wilde
发明人： Phillip R. Hawkins , Janice Au-Young , Karl J. Guegler , Craig G. Wilde
IPC分类号： A61K3900
CPC分类号： C12N9/1205 , A61K38/00 , C12N9/12 , Y10S530/827
摘要： The present invention provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach. The present invention also provides for PCR oligomers or hybridization probes for the detection of nucleotide sequences encoding SMAP or SMAP-like molecules, antisense molecules to the nucleotide sequences which encode SMAP, diagnostic tests based on SMAP encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified SMAP, antibodies capable of binding specifically to SMAP, and agonists and inhibitors with specific binding activity for the polypeptide SMAP.
摘要翻译：本发明提供了鉴定和编码在人胃细胞中表达的新的人映射激酶同源物（SMAP）的核酸和氨基酸序列。本发明还提供用于检测编码SMAP或SMAP样分子的核苷酸序列的PCR寡聚体或杂交探针，编码SMAP的核苷酸序列的反义分子，基于SMAP编码核酸分子的诊断测试，基因工程表达载体和用于产生纯化SMAP的宿主细胞，能够特异性结合SMAP的抗体，以及对多肽SMAP具有特异性结合活性的激动剂和抑制剂。

24. 发明授权

US6045792A Human proteins kinases 失效
标题翻译：人类蛋白激酶
公开(公告)号：US6045792A
公开(公告)日：2000-04-04
申请号：US111444
申请日：1998-07-07
申请人： Janice Au-Young , Karl J. Guegler , Phillip R. Hawkins
发明人： Janice Au-Young , Karl J. Guegler , Phillip R. Hawkins
IPC分类号： C12N15/00 , A61K38/00 , A61K38/45 , A61K39/395 , A61K45/00 , A61K48/00 , A61P11/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12Q1/48
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention provides novel human protein kinases (HPK) and polynucleotides which identify and encode HPK. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPK. The invention also provides for pharmaceutical compositions comprising HPK or antagonists of HPK, and antibodies which specifically bind HPK. Additionally, the invention provides antisense molecules to HPK for treatment or prevention of diseases associated with abnormal expression of HPK.
摘要翻译：本发明提供了鉴定和编码HPK的新型人蛋白激酶（HPK）和多核苷酸。本发明提供了包含编码HPK的核酸序列的基因工程表达载体和宿主细胞。本发明还提供包含HPK或HPK拮抗剂的药物组合物，以及特异性结合HPK的抗体。此外，本发明提供了用于治疗或预防与HPK异常表达相关的疾病的HPK的反义分子。

25. 发明授权

US06379913B1 Human serine carboxypeptidase 失效
标题翻译：人丝氨酸羧肽酶
公开(公告)号：US06379913B1
公开(公告)日：2002-04-30
申请号：US09299689
申请日：1999-04-26
申请人： Olga Bandman , Phillip R. Hawkins , Jennifer L. Hillman , Preeti Lal , Surya K. Goli
发明人： Olga Bandman , Phillip R. Hawkins , Jennifer L. Hillman , Preeti Lal , Surya K. Goli
IPC分类号： C12N948
CPC分类号： C12N9/48 , A61K38/00
摘要： The present invention provides a human serine carboxypeptidase (CPEPT) and polynucleotides which identify and encode CPEPT. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of CPEPT.
摘要翻译：本发明提供了人丝氨酸羧肽酶（CPEPT）和识别和编码CPEPT的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与CPEPT表达相关的疾病的方法。

26. 发明授权

US5817482A Disease related nucleotide kinases 失效
标题翻译：疾病相关的核苷酸激酶
公开(公告)号：US5817482A
公开(公告)日：1998-10-06
申请号：US879561
申请日：1997-06-20
申请人： Olga Bandman , Jennifer L. Hillman , Phillip R. Hawkins , Karl J. Guegler , Neil C. Corley
发明人： Olga Bandman , Jennifer L. Hillman , Phillip R. Hawkins , Karl J. Guegler , Neil C. Corley
IPC分类号： A61K38/00 , C12N9/12 , C12N15/00
CPC分类号： C12N9/1205 , A61K38/00
摘要： The invention provides human nucleotide kinases and polynucleotides which identify and encode DRNK. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of DRNK.
摘要翻译：本发明提供鉴定和编码DRNK的人核苷酸激酶和多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与DRNK表达相关的疾病的方法。

27. 发明授权

US5843665A Human pyrophosphatase 失效
公开(公告)号：US5843665A
公开(公告)日：1998-12-01
申请号：US741437
申请日：1996-10-31
申请人： Phillip R. Hawkins , Jennifer L. Hillman
发明人： Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61P29/00 , A61P35/00 , C12N9/14 , C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12N9/14
摘要： The present invention provides a human pyrophosphatase (HPYP) and polynucleotides which identify and encode HPYP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPYP and a method for producing HPYP. The invention also provides for use of HPYP and agonists, antibodies, or antagonists specifically binding HPYP, in the prevention and treatment of cancer and inflammatory diseases. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPYP for the treatment of diseases associated with the expression of HPYP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPYP.

28. 发明授权

US06365714B1 Translational regulator 失效
标题翻译：翻译监管机构
公开(公告)号：US06365714B1
公开(公告)日：2002-04-02
申请号：US09215063
申请日：1998-12-17
申请人： Jennifer L. Hillman , Phillip R. Hawkins
发明人： Jennifer L. Hillman , Phillip R. Hawkins
IPC分类号： C07K1447
CPC分类号： C07K14/4702 , A61K38/00
摘要： The invention provides a human translational regulator (TRANAC) and polynucleotides which identify and encode TRANAC. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of TRANAC.
摘要翻译：本发明提供了人翻译调节子（TRANAC）和识别和编码TRANAC的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与TRANAC表达相关的疾病的方法。

29. 发明授权

US5981232A Human pyrophosphatase 有权
标题翻译：人类焦磷酸酶
公开(公告)号：US5981232A
公开(公告)日：1999-11-09
申请号：US134593
申请日：1998-08-13
申请人： Phillip R. Hawkins , Jennifer L. Hillman
发明人： Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61P29/00 , A61P35/00 , C12N9/14 , C12P21/04 , C07H21/04 , C12N1/20
CPC分类号： C12N9/14
摘要： The present invention provides a human pyrophosphatase (HPYP) and polynucleotides which identify and encode HPYP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPYP and a method for producing HPYP. The invention also provides for use of HPYP and agonists, antibodies, or antagonists specifically binding HPYP, in the prevention and treatment of cancer and inflammatory diseases. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPYP for the treatment of diseases associated with the expression of HPYP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPYP.
摘要翻译：本发明提供了人类焦磷酸酶（HPYP）和识别和编码HPYP的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码HPYP的核酸序列的宿主细胞和用于产生HPYP的方法。本发明还提供了用于预防和治疗癌症和炎性疾病的HPYP和激动剂，抗体或特异性结合HPYP的拮抗剂。此外，本发明提供反义分子用于编码HPYP的多核苷酸用于治疗与HPYP表达相关的疾病。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HPYP的抗体的诊断测定法。

30. 发明授权

US5925521A Human serine carboxypeptidase 失效
公开(公告)号：US5925521A
公开(公告)日：1999-07-20
申请号：US828488
申请日：1997-03-31
申请人： Olga Bandman , Phillip R. Hawkins , Jennifer L. Hillman , Preeti Lal , Surya K. Goli
发明人： Olga Bandman , Phillip R. Hawkins , Jennifer L. Hillman , Preeti Lal , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P3/10 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P39/02 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/48 , C12N9/64 , C12N15/57 , C12Q1/68 , C12N15/63
CPC分类号： C12N9/48 , A61K38/00
摘要： The present invention provides a human serine carboxypeptidase (CPEPT) and polynucleotides which identify and encode CPEPT. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of CPEPT.

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