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1. 发明授权

US5817479A Human kinase homologs 失效
标题翻译：人类激酶同源物
公开(公告)号：US5817479A
公开(公告)日：1998-10-06
申请号：US700575
申请日：1996-08-07
申请人： Janice Au-Young , Olga Bandman , Phillip R. Hawkins , Craig G. Wilde
发明人： Janice Au-Young , Olga Bandman , Phillip R. Hawkins , Craig G. Wilde
IPC分类号： C12N9/12 , C12N15/54 , C12P21/06 , C12N15/64
CPC分类号： C12N9/1205
摘要： The present invention provides polynucleotides (kin) which identify and encode novel protein kinases (KIN) expressed in various human cells and tissues. The present invention also provides for antisense sequences and oligonucleotides designed from the nucleotide sequences or their complements. The invention further provides genetically engineered expression vectors and host cells for the production of purified KIN peptides, antibodies capable of binding KIN, and inhibitors specifically bind KIN. The invention specifically provides for diagnostic kits and assays which identify a disorder or disease with altered kinase expression and allow monitoring of patients during drug therapy. These assays utilize oligonucleotides or antibodies produced using the kin polynucleotides.
摘要翻译：本发明提供鉴定和编码在各种人细胞和组织中表达的新型蛋白激酶（KIN）的多核苷酸（kin）。本发明还提供了从核苷酸序列或其互补序列设计的反义序列和寡核苷酸。本发明还提供用于产生纯化的KIN肽，能够结合KIN的抗体和特异性结合KIN的抑制剂的遗传工程表达载体和宿主细胞。本发明特别提供了用于鉴定具有改变的激酶表达并允许在药物治疗期间监测患者的病症或疾病的诊断试剂盒和测定法。这些测定法利用使用亲代多核苷酸产生的寡核苷酸或抗体。

2. 发明授权

US06303297B1 Database for storage and analysis of full-length sequences 失效
标题翻译：数据库用于存储和分析全长序列
公开(公告)号：US06303297B1
公开(公告)日：2001-10-16
申请号：US08969987
申请日：1997-11-13
申请人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
发明人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
IPC分类号： C12Q168
CPC分类号： C12N9/6445 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/82 , C07K16/303 , C12Q1/68 , C12Q1/6809 , G01N33/574 , G06F19/18 , G06F19/22 , G06F19/28
摘要： The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
摘要翻译：本发明是用于遗传信息和相关注释信息的计算机化存储和检索系统。系统的数据存储在与公共数据库接口的关系数据库中，以便在本发明的数据库内以及该数据库内的信息和外部公共数据库之间进行分析。序列数据在进入系统之前进行编辑，并存储在策略化的功能集群组织中。与数据相关联的信息存储在链接到序列数据的存储的表达式数据库中。

3. 发明授权

US6113904A Human glycoprotein 失效
标题翻译：人类糖蛋白
公开(公告)号：US6113904A
公开(公告)日：2000-09-05
申请号：US63869
申请日：1998-04-20
申请人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , A61P25/00 , C07K14/705 , C12N1/21 , C12N15/12 , A61K39/00 , C07K1/00
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human glycoprotein (SC2H). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding SC2H. The invention also provides for the use of substantially purified SC2H and its agonists in the commercial production of recombinant proteins for the treatment of diseases associated with the expression of SC2H. Additionally, the invention provides for the use of antisense molecules to SC2H in the treatment of diseases associated with the expression of SC2H. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding SC2H and antibodies which specifically bind to the protein.
摘要翻译：本发明提供鉴定和编码新型人糖蛋白（SC2H）的多核苷酸。本发明提供了包含编码SC2H的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了在商业生产重组蛋白质中用于治疗与SC2H表达相关的疾病的基本纯化的SC2H及其激动剂的用途。另外，本发明提供了用于治疗与SC2H表达相关的疾病的SC2H反义分子的用途。本发明还描述了利用包含与编码SC2H的天然存在的序列和特异性结合蛋白质的抗体杂交的多核苷酸的诊断组合物的诊断测定法。

4. 发明授权

US6015788A Human nucleic acid binding protein 失效
标题翻译：人核酸结合蛋白
公开(公告)号：US6015788A
公开(公告)日：2000-01-18
申请号：US195855
申请日：1998-11-19
申请人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , C07K14/47
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human nucleic acid binding protein (NABP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NABP. The invention also provides for the use of substantially purified NABP or its antagonists, in pharmaceutical compositions for the treatment of diseases associated with the expression of NABP. Additionally, the invention provides for the use of antisense molecules to NABP in pharmaceutical compositions for treatment of diseases associated with the expression of NABP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding NABP or anti-NABP antibodies which specifically bind to NABP.
摘要翻译：本发明提供鉴定和编码新的人核酸结合蛋白（NABP）的多核苷酸。本发明提供了包含编码NABP的核酸序列的基因工程表达载体和宿主细胞。本发明还提供在药物组合物中用于治疗与NABP表达相关的疾病的基本纯化的NABP或其拮抗剂的用途。另外，本发明提供了用于治疗与NABP表达相关的疾病的药物组合物中NABP的反义分子的用途。本发明还描述了利用包含多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与编码特异性结合NABP的NABP或抗NABP抗体的多核苷酸的基因组序列或转录物杂交。

5. 发明授权

US5856128A Human nucleic acid binding protein 失效
公开(公告)号：US5856128A
公开(公告)日：1999-01-05
申请号：US698407
申请日：1996-08-15
申请人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , C07K14/47 , C12N15/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human nucleic acid binding protein (NABP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NABP. The invention also provides for the use of substantially purified NABP or its antagonists, in pharmaceutical compositions for the treatment of diseases associated with the expression of NABP. Additionally, the invention provides for the use of antisense molecules to NABP in pharmaceutical compositions for treatment of diseases associated with the expression of NABP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding NABP or anti-NABP antibodies which specifically bind to NABP.

6. 发明授权

US5821086A Human glycoprotein 失效
公开(公告)号：US5821086A
公开(公告)日：1998-10-13
申请号：US695355
申请日：1996-08-09
申请人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , A61P25/00 , C07K14/705 , C12N1/21 , C12N15/12 , C12P21/06 , C12N15/00 , C07K1/00 , C07H21/04
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human glycoprotein (SC2H). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding SC2H. The invention also provides for the use of substantially purified SC2H and its agonists in the commercial production of recombinant proteins for the treatment of diseases associated with the expression of SC2H. Additionally, the invention provides for the use of antisense molecules to SC2H in the treatment of diseases associated with the expression of SC2H. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding SC2H and antibodies which specifically bind to the protein.

7. 发明授权

US5936068A Liver expressed chemokine-1 失效
标题翻译：肝表达趋化因子-1
公开(公告)号：US5936068A
公开(公告)日：1999-08-10
申请号：US798143
申请日：1997-02-10
申请人： Craig G. Wilde , Phillip R. Hawkins , Olga Bandman , Jeffrey J. Seilhamer
发明人： Craig G. Wilde , Phillip R. Hawkins , Olga Bandman , Jeffrey J. Seilhamer
IPC分类号： G01N33/566 , C07K14/52 , C07K14/715 , C07K16/24 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/715 , C07K14/523 , C07K16/24 , C12Q1/6876 , C07K2319/00 , C12N2799/026 , Y10S930/14
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (ECs) from liver and pituitary gland tissues. The present invention also provides for antisense molecules to the nucleotide sequences which encode ECs, expression vectors for the production of purified ECs, antibodies capable of binding specifically to ECs, hybridization probes or oligonucleotides for the detection of EC-encoding nucleotide sequences, genetically engineered host cells for the expression of ECs, diagnostic tests for inflammation or disease based on on EC-encoding nucleic acid molecules or antibodies capable of binding specifically to ECs, pharmaceutical compositions to treat inflammation or disease based on EC-encoding nucleic acid molecules or antibodies capable of binding specifically to ECs.
摘要翻译：本发明提供鉴定和编码来自肝脏和垂体腺组织的新型表达趋化因子（EC）的核苷酸和氨基酸序列。本发明还提供编码EC的核苷酸序列的反义分子，用于产生纯化的EC的表达载体，能够特异性结合EC的抗体，用于检测编码EC编码的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主基于编码EC的编码核酸分子或能够特异性结合EC的抗体的ECs表达的细胞，炎症或疾病的诊断性测试，基于编码EC编码的核酸分子的治疗炎症或疾病的药物组合物或能够特异性地结合EC。

8. 发明授权

US5602008A DNA encoding a liver expressed chemokine 失效
标题翻译：编码肝脏的DNA表达趋化因子
公开(公告)号：US5602008A
公开(公告)日：1997-02-11
申请号：US347492
申请日：1994-11-29
申请人： Craig G. Wilde , Phillip R. Hawkins , Olga Bandman , Jeffrey J. Seilhamer
发明人： Craig G. Wilde , Phillip R. Hawkins , Olga Bandman , Jeffrey J. Seilhamer
IPC分类号： G01N33/566 , C07K14/52 , C07K14/715 , C07K16/24 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/715 , C07K14/523 , C07K16/24 , C12Q1/6876 , C07K2319/00 , C12N2799/026 , Y10S930/14
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (ECs) from liver and pituitary gland tissues. The present invention also provides for antisense molecules to the nucleotide sequences which encode ECs, expression vectors for the production of purified ECs, antibodies capable of binding specifically to ECs, hybridization probes or oligonucleotides for the detection of EC-encoding nucleotide sequences, genetically engineered host cells for the expression of ECs, diagnostic tests for inflammation or disease based on on EC-encoding nucleic acid molecules or antibodies capable of binding specifically to ECs, pharmaceutical compositions to treat inflammation or disease based on EC-encoding nucleic acid molecules or antibodies capable of binding specifically to ECs.
摘要翻译：本发明提供鉴定和编码来自肝脏和垂体腺组织的新型表达趋化因子（EC）的核苷酸和氨基酸序列。本发明还提供编码EC的核苷酸序列的反义分子，用于产生纯化的EC的表达载体，能够特异性结合EC的抗体，用于检测编码EC编码的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主基于编码EC的编码核酸分子或能够特异性结合EC的抗体的ECs表达的细胞，炎症或疾病的诊断性测试，基于编码EC编码的核酸分子的治疗炎症或疾病的药物组合物或能够特异性地结合EC。

9. 发明申请

US20110053217A1 Polynucleotides encoding signal peptide-containing molecules 有权
标题翻译：编码含有信号肽的分子的多核苷酸
公开(公告)号：US20110053217A1
公开(公告)日：2011-03-03
申请号：US12457389
申请日：2009-06-09
申请人： Preeti Lal , Y. Tom Tang , Gina A. Gorgone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice Au-Young , Henry Yue , Chandra Patterson , Roopa Reddy , Jennifer L. Hillman , Olga Bandman
发明人： Preeti Lal , Y. Tom Tang , Gina A. Gorgone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice Au-Young , Henry Yue , Chandra Patterson , Roopa Reddy , Jennifer L. Hillman , Olga Bandman
IPC分类号： C12P21/00 , C07H21/04 , C12N1/21 , C07H21/02 , C07K14/435
CPC分类号： G01N33/57419 , A61K38/00 , A61K38/1709 , A61K39/3955 , A61K45/06 , C07K14/47 , C07K16/18 , C07K16/40 , C07K2317/76 , G01N2333/916
摘要： The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
摘要翻译：本发明提供了人信号肽肽蛋白（HSPP）和识别和编码HSPP的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HSPP表达相关的障碍的方法。

10. 发明申请

US20050155089A1 Signal peptide-containing molecules 审中-公开
标题翻译：含信号肽的分子
公开(公告)号：US20050155089A1
公开(公告)日：2005-07-14
申请号：US10820474
申请日：2004-04-07
申请人： Preeti Lal , Y. Tang , Gina Gorgone , Neil Corley , Karl Guegler , Mariah Baughn , Ingrid Akerblom , Janice Au-Young , Henry Yue , Chandra Patterson , Roopa Reddy , Jennifer Hillman , Olga Bandman
发明人： Preeti Lal , Y. Tang , Gina Gorgone , Neil Corley , Karl Guegler , Mariah Baughn , Ingrid Akerblom , Janice Au-Young , Henry Yue , Chandra Patterson , Roopa Reddy , Jennifer Hillman , Olga Bandman
IPC分类号： G01N33/68 , A61K38/00 , A61K39/395 , A61K45/00 , A61P9/00 , A61P15/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , A01K67/00 , C07H21/04 , C12N9/64
CPC分类号： G01N33/57419 , A61K38/00 , A61K38/1709 , A61K39/3955 , A61K45/06 , C07K14/47 , C07K16/18 , C07K16/40 , C07K2317/76 , G01N2333/916
摘要： The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
摘要翻译：本发明提供了人信号肽肽蛋白（HSPP）和识别和编码HSPP的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HSPP表达相关的障碍的方法。

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