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21. 发明授权

US07833552B2 Xanthohumol-enriched hop extract 有权
标题翻译：富含黄曲霉毒素的啤酒花提取物
公开(公告)号：US07833552B2
公开(公告)日：2010-11-16
申请号：US12190965
申请日：2008-08-13
申请人： Mitsunori Ono , Naoto Yamaguchi
发明人： Mitsunori Ono , Naoto Yamaguchi
IPC分类号： A01N65/00
CPC分类号： A61K36/185
摘要： A method for preparing a xanthohumol-rich hop composition. The method includes providing a solution that contains xanthohumol-containing hop substances and effecting precipitation of non-xanthohumol hop substances by adjusting both the salt concentration and pH value of the solution. The xanthohumol-rich hop composition prepared by this method can be used for treating various diseases, e.g., skin disorders, and bacterial infection.
摘要翻译：一种制备富含黄腐酚的啤酒花组合物的方法。该方法包括提供含有含黄腐酚的啤酒花物质的溶液，并通过调节溶液的盐浓度和pH值来实现非黄褐酮啤酒花物质的沉淀。通过该方法制备的富含黄腐酚酸的啤酒花组合物可用于治疗各种疾病，例如皮肤病和细菌感染。

22. 发明申请

US20090253694A1 Fused hetrocyclic compounds 有权
标题翻译：稠合的杂环化合物
公开(公告)号：US20090253694A1
公开(公告)日：2009-10-08
申请号：US12380007
申请日：2009-02-20
申请人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Zachary Demko , Dinesh Chimmanamada
发明人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Zachary Demko , Dinesh Chimmanamada
IPC分类号： A61K31/5377 , C12N5/00 , A61P37/06 , A61P19/08 , A61P29/00 , A61P25/00
CPC分类号： C07D239/95 , C04B35/632 , C07D215/40 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/04 , C07D413/14 , C07D471/04 , C07D475/06 , C07D491/04
摘要： This invention provides fused heterocyclic compounds, pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12 related disease and disorders.
摘要翻译：本发明提供稠合杂环化合物，化合物的药物组合物，以及使用该化合物治疗特别是IL-12相关疾病和病症的方法。

23. 发明授权

US07470685B2 Pyrimidine compounds 失效
标题翻译：嘧啶化合物
公开(公告)号：US07470685B2
公开(公告)日：2008-12-30
申请号：US11041537
申请日：2005-01-21
申请人： Lijun Sun , Mitsunori Ono , Elena Kostik , Yumiko Wada
发明人： Lijun Sun , Mitsunori Ono , Elena Kostik , Yumiko Wada
IPC分类号： A61K31/506 , A61P3/10 , A61P17/06 , A61P19/02 , A61P25/28 , C07D239/24 , C07D401/04 , C07D405/04 , C07D413/04 , C07D417/04
CPC分类号： C07D239/48 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/541 , C07D401/12 , C07D401/14 , C07D403/12
摘要： This invention features pyrimidine compounds of formula (I): R1 is in which one of Ra and Rb is H or alkyl, and the other is aryl or heteroaryl optionally substituted with Rd and Rem; each of R2 and R4 is H; R3 is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is NRc; Y is covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which Rc is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; Rd is halogen, CN, alkyl, alkyloxy, alkylcarbonyl, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, hydroxyalkyl, alkylamino, or alkylaminocarbonyl; Re is halogen, CN, hydroxyl, alkyl, aryl, heteroaryl, alkoxyl, aryloxyl, or heteroaryloxyl; and m is 0, 1, 2, 3, or 4. The pyrimidine compounds can be used to treat an IL-12 overproduction-related disorder (e.g., rheumatoid arthritis, sepsis, Crohn's disease, multiple sclerosis, psoriasis, or insulin-dependent diabetes mellitus).
摘要翻译：本发明的特征在于式（I）的嘧啶化合物：其中R 1和R b中的一个是H或烷基，另一个是任选被Rd和Rem取代的芳基或杂芳基; R2和R4各自为H; R3是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基; R5是H或烷基; n是0，1，2，3，4，5或6; X是NRc; Y是共价键，CH2，C（O），C-N-Rc，C-N-ORc，C-N-SRc，O，S，S（O），S（O 2）或NRc; Z是N或CH; U和V之一是N，另一个是CRc; 并且W是O，S，S（O），S（O 2），NR c或NC（O）R c; 其中R c是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基; Rd是卤素，CN，烷基，烷氧基，烷基羰基，烷氧基羰基，芳氧基羰基，杂芳氧基羰基，羟基烷基，烷基氨基或烷基氨基羰基; Re是卤素，CN，羟基，烷基，芳基，杂芳基，烷氧基，芳氧基或杂芳氧基; 嘧啶化合物可用于治疗IL-12过度生产相关疾病（例如类风湿性关节炎，败血症，克罗恩病，多发性硬化，牛皮癣或胰岛素依赖型糖尿病）。

24. 发明授权

US07435843B2 Synthesis of taxol enhancers 失效
标题翻译：紫杉醇增强剂的合成
公开(公告)号：US07435843B2
公开(公告)日：2008-10-14
申请号：US11440429
申请日：2006-05-24
申请人： Shoujun Chen , Lijun Sun , Zhi-Qiang Xia , Keizo Koya , Mitsunori Ono
发明人： Shoujun Chen , Lijun Sun , Zhi-Qiang Xia , Keizo Koya , Mitsunori Ono
IPC分类号： C07C327/56
CPC分类号： C07D213/77 , C07C327/56 , C07C2601/14 , C07D209/42 , C07D209/44 , C07D213/83 , C07D261/18 , C07D307/54 , C07D333/38 , Y02P20/55
摘要： Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound is represented by Structural Formula (II): In Structural Formulas (I)-(II), R1 and R2 are independently an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1 and R2 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. When R2 is an aryl group or a substituted aryl group, then R5 is a hydrazine protecting group; and when R2 is an aliphatic or substituted aliphatic group, then R5 is —H or a hydrazine protecting group. R10 is —H or a substituted or unsubstituted alkyl group. The method comprising the step of reacting the starting compound with a thionylating reagent.
摘要翻译：公开了从酰肼起始化合物制备硫代酰肼产物化合物的方法。酰肼起始化合物由结构式（I）表示：硫代酰肼产物化合物由结构式（II）表示：在结构式（I） - （II）中，R 1和R 2 > 2 独立地是脂族基团，取代的脂族基团，芳基或取代的芳基，或R 1和R 2与与它们键合的碳原子和氮原子形成任选地与芳环稠合的非芳族杂环。当R 2是芳基或取代的芳基时，R 5是肼保护基; 当R 2是脂族或取代的脂族基团时，R 5是-H或肼保护基。 R 10是-H或取代或未取代的烷基。该方法包括使起始化合物与亚硫酰化试剂反应的步骤。

25. 发明授权

US07202232B2 Acrylonitrile derivatives for inflammation and immune-related uses 失效
标题翻译：用于炎症和免疫相关用途的丙烯腈衍生物
公开(公告)号：US07202232B2
公开(公告)日：2007-04-10
申请号：US11090801
申请日：2005-03-24
申请人： Shoujun Chen , Weiwen Ying , Jun Jiang , Mitsunori Ono , Lijun Sun
发明人： Shoujun Chen , Weiwen Ying , Jun Jiang , Mitsunori Ono , Lijun Sun
IPC分类号： A61K31/724 , A61K31/415 , C07D231/10
CPC分类号： C07D231/12 , C07D231/22 , C07D235/10 , C07D235/18 , C07D403/10 , C07D405/10 , C07D409/04 , C07D409/10
摘要： What is claimed is a compound represented by the following structural formula: or a pharmaceutically acceptable salt, solvate or clathrate thereof. The variables for Structural Formula (I) are as described herein.
摘要翻译：所要求保护的是由以下结构式表示的化合物：

26. 发明申请

US20060281811A1 Synthesis of taxol enhancers 失效
标题翻译：紫杉醇增强剂的合成
公开(公告)号：US20060281811A1
公开(公告)日：2006-12-14
申请号：US11440429
申请日：2006-05-24
申请人： Shoujun Chen , Lijun Sun , Zhi-Qiang Xia , Keizo Koya , Mitsunori Ono
发明人： Shoujun Chen , Lijun Sun , Zhi-Qiang Xia , Keizo Koya , Mitsunori Ono
IPC分类号： A61K31/235 , A61K31/195
CPC分类号： C07D213/77 , C07C327/56 , C07C2601/14 , C07D209/42 , C07D209/44 , C07D213/83 , C07D261/18 , C07D307/54 , C07D333/38 , Y02P20/55
摘要： Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound is represented by Structural Formula (II): In Structural Formulas (I)-(II), R1 and R2 are independently an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1 and R2 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. When R2 is an aryl group or a substituted aryl group, then R5 is a hydrazine protecting group; and when R2 is an aliphatic or substituted aliphatic group, then R5 is —H or a hydrazine protecting group. R10 is —H or a substituted or unsubstituted alkyl group. The method comprising the step of reacting the starting compound with a thionylating reagent.
摘要翻译：公开了从酰肼起始化合物制备硫代酰肼产物化合物的方法。酰肼起始化合物由结构式（I）表示：硫代酰肼产物化合物由结构式（II）表示：在结构式（I） - （II）中，R 1和R 2 > 2 独立地是脂族基团，取代的脂族基团，芳基或取代的芳基，或R 1和R 2与与它们键合的碳原子和氮原子形成任选地与芳环稠合的非芳族杂环。当R 2是芳基或取代的芳基时，R 5是肼保护基; 当R 2是脂族或取代的脂族基团时，R 5是-H或肼保护基。 R 10是-H或取代或未取代的烷基。该方法包括使起始化合物与亚硫酰化试剂反应的步骤。

27. 发明申请

US20060188590A1 Compositions for treating diabetes or obesity 审中-公开
标题翻译：用于治疗糖尿病或肥胖的组合物
公开(公告)号：US20060188590A1
公开(公告)日：2006-08-24
申请号：US11326102
申请日：2006-01-04
申请人： Mitsunori Ono
发明人： Mitsunori Ono
IPC分类号： A61K36/906 , A61K36/185 , A61K31/7048 , A61K31/353 , A61K31/522 , A61K36/63
CPC分类号： A61K36/45 , A61K31/353 , A61K31/522 , A61K31/7048 , A61K36/48 , A61K36/87 , A61K45/06 , A61K2300/00
摘要： This invention relates to a composition that includes two compounds selected from a group of nine members, i.e., an α-glucosidase inhibitor, an intestinal glucose transporter inhibitor, a glycation inhibitor, a nitric oxide production inhibitor, an aldose reductase inhibitor, a PPAR agonist, an adipocytokine activator, a glucose uptake enhancer, and a thermogenesis enhancer, in which the two compounds are two different members; and each compound is naturally occurring in a plant and is provided in the form of a plant extract. This invention also relates to a method of treating diabetes or obesity with the above-mentioned composition.
摘要翻译：本发明涉及一种组合物，其包含两种选自九个成员的化合物，即α-葡糖苷酶抑制剂，肠葡萄糖转运蛋白抑制剂，糖化抑制剂，一氧化氮产生抑制剂，醛糖还原酶抑制剂，PPAR激动剂，脂肪细胞因子激活剂，葡萄糖摄取增强剂和生热促进剂，其中两种化合物是两种不同的成员; 并且每种化合物天然存在于植物中并且以植物提取物的形式提供。本发明还涉及用上述组合物治疗糖尿病或肥胖症的方法。

28. 发明授权

US07074952B2 Synthesis of taxol enhancers 失效
公开(公告)号：US07074952B2
公开(公告)日：2006-07-11
申请号：US10807919
申请日：2004-03-24
申请人： Shoujun Chen , Lijun Sun , Zhi-Qiang Xia , Keizo Koya , Mitsunori Ono
发明人： Shoujun Chen , Lijun Sun , Zhi-Qiang Xia , Keizo Koya , Mitsunori Ono
IPC分类号： C07C69/66 , C07C327/00 , A61K31/215 , A61K31/16
CPC分类号： C07D213/77 , C07C327/56 , C07C2601/14 , C07D209/42 , C07D209/44 , C07D213/83 , C07D261/18 , C07D307/54 , C07D333/38 , Y02P20/55
摘要： Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound is represented by Structural Formula (II): In Structural Formulas (I)–(II), R1 and R2 are independently an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1 and R2 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. When R2 is an aryl group or a substituted aryl group, then R5 is a hydrazine protecting group; and when R2 is an aliphatic or substituted aliphatic group, then R5 is —H or a hydrazine protecting group. R10 is —H or a substituted or unsubstituted alkyl group. The method comprising the step of reacting the starting compound with a thionylating reagent.

29. 发明申请

US20050282809A1 Heteroaryl-hydrazone compounds 有权
标题翻译：杂芳基腙化合物
公开(公告)号：US20050282809A1
公开(公告)日：2005-12-22
申请号：US10985716
申请日：2004-11-10
申请人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Elena Kostik , Howard NG
发明人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Elena Kostik , Howard NG
IPC分类号： A61K20060101 , A61K31/497 , A61K31/5377 , C07D213/74 , C07D239/46 , C07D251/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14
CPC分类号： C07D213/74 , C07D239/47 , C07D251/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12
摘要： This invention relates to compounds having a formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, prodrug or polymorph thereof wherein X is —C(Rg)═N-A. The invention also relates to methods of treating IL-12 overproduction-related disorders, methods of treating or preventing disorders related with excessive bone loss, methods for inhibiting osteoclast formation, and methods for treating or preventing a disorder associated with excessive bone resorption.
摘要翻译：本发明涉及具有式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物，水合物，前药或多晶型物，其中X为-C（R） - N-A。本发明还涉及治疗IL-12过度生产相关疾病的方法，治疗或预防与过度骨丢失相关的障碍的方法，用于抑制破骨细胞形成的方法，以及用于治疗或预防与过度骨吸收相关的病症的方法。

30. 发明申请

US20050266121A1 Antioxidative compositions 有权
标题翻译：抗氧化组合物
公开(公告)号：US20050266121A1
公开(公告)日：2005-12-01
申请号：US11124433
申请日：2005-05-06
申请人： Thomas Lines , Mitsunori Ono
发明人： Thomas Lines , Mitsunori Ono
IPC分类号： A23L1/30
CPC分类号： A23L33/105
摘要： This invention relates to a composition that contains quercetin, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin C, caffeine, folate, epigallocatechin gallate, epicatechin, epicatechin gallate, epigallocatechin, and polypheron E.
摘要翻译：本发明涉及含有槲皮素，维生素B1，维生素B2，维生素B3，维生素B6，维生素B12，维生素C，咖啡因，叶酸，表没食子儿茶素没食子酸酯，表儿茶素，表儿茶素没食子酸酯，表没食子儿茶素和多聚乙脑E.

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