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21. 发明申请

US20090092735A1 METHOD FOR PREPARING STABLE HOP POWDER 审中-公开
标题翻译：制备稳定蜂巢粉的方法
公开(公告)号：US20090092735A1
公开(公告)日：2009-04-09
申请号：US11868226
申请日：2007-10-05
申请人： Naoto Yamaguchi , Mitsunori Ono
发明人： Naoto Yamaguchi , Mitsunori Ono
IPC分类号： C12C3/00 , C12C3/02
CPC分类号： C12C3/06
摘要： This invention features a method of making hop powder containing stable alkaline salts of hop bitter acids and an edible carrier. Also within the scope of this invention is a hop product containing alkaline salts of hop bitter acids and an edible carrier.
摘要翻译：本发明的特征在于制备含有稳定的苦酸碱性盐和可食用载体的啤酒花粉的方法。也包括本发明范围内的啤酒花产品，其含有啤酒花苦酸的碱性盐和可食用的载体。

22. 发明申请

US20090005594A1 Synthesis of taxol enhancers 失效
标题翻译：紫杉醇增强剂的合成
公开(公告)号：US20090005594A1
公开(公告)日：2009-01-01
申请号：US12231217
申请日：2008-08-29
申请人： Shoujun Chen , Lijun Sun , Zhi-Qiang Xia , Keizo Kova , Mitsunori Ono
发明人： Shoujun Chen , Lijun Sun , Zhi-Qiang Xia , Keizo Kova , Mitsunori Ono
IPC分类号： C07C327/00
CPC分类号： C07D213/77 , C07C327/56 , C07C2601/14 , C07D209/42 , C07D209/44 , C07D213/83 , C07D261/18 , C07D307/54 , C07D333/38 , Y02P20/55
摘要： Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound is represented by Structural Formula (II): In Structural Formulas (I)-(II), R1 and R2 are independently an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R1 and R2 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. When R2 is an aryl group or a substituted aryl group, then R5 is a hydrazine protecting group; and when R2 is an aliphatic or substituted aliphatic group, then R5 is —H or a hydrazine protecting group. R10 is —H or a substituted or unsubstituted alkyl group. The method comprising the step of reacting the starting compound with a thionylating reagent.
摘要翻译：公开了从酰肼起始化合物制备硫代酰肼产物化合物的方法。酰肼起始化合物由结构式（I）表示：硫代酰肼产物化合物由结构式（II）表示：在结构式（I） - （II）中，R 1和R 2独立地为脂族基团，取代的脂族基团，芳基或取代的芳基，或者R 1和R 2与它们所键合的碳原子和氮原子一起形成任选地与芳环稠合的非芳族杂环。当R 2为芳基或取代芳基时，R 5为肼保护基; 当R 2为脂肪族或取代的脂族基团时，R 5为-H或肼保护基。 R 10为-H或取代或未取代的烷基。该方法包括使起始化合物与亚硫酰化试剂反应的步骤。

23. 发明申请

US20060122183A1 Taxol enhancer compounds 有权
标题翻译：紫杉醇增强剂化合物
公开(公告)号：US20060122183A1
公开(公告)日：2006-06-08
申请号：US11244324
申请日：2005-10-05
申请人： Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono
发明人： Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono
IPC分类号： A61K31/53 , A61K31/505 , A61K31/44 , A61K31/337 , A61K31/277 , A61K31/16
CPC分类号： A61K47/48176 , A61K31/16 , A61K31/165 , A61K31/277 , A61K31/337 , A61K31/381 , A61K31/44 , A61K31/505 , A61K31/53 , A61K47/58 , C07C327/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/42 , C07D209/44 , C07D213/83 , C07D261/18 , C07D305/14 , C07D307/68 , C07D333/38 , C07D333/68 , C07D407/12
摘要： Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C=Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or —C(R7R8)—. R1 and R2 are independently an aryl group or a substituted aryl group, R3 and R4 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R5—R6 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R7 and R8 are each independently —H, an aliphatic or substituted aliphatic group, or R7 is —H and R8 is a substituted or unsubstituted aryl group, or, R7 and R8, taken together, are a C2-C6 substituted or unsubstituted alkylene group. Z is ═O or ═S. Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject with cancer by administering to the subject a compound of Structural Formula (I) in combination with taxol or an analog of taxol.
摘要翻译：公开了由结构式（I）表示的化合物：Y是共价键，亚苯基或取代或未取代的直链烃基。此外，Y与它所键合的两个> C = Z基团一起是取代或未取代的芳族基团。优选地，Y是共价键或-C（R 7 R 8） - 。 R 1和R 2分别独立地是芳基或取代的芳基，R 3和R 4是独立的-H，脂族基团，取代的脂族基团，芳基或取代的芳基。 R 5 -R 6独立地是-H，脂族基团，取代的脂族基团，芳基或取代的芳基。 R 7和R 8各自独立地为-H，脂族或取代的脂族基团或R 7为-H， 8是取代或未取代的芳基，或者R 7和R 8一起是C2-C6取代或未取代的亚烷基。 Z是-O或-S。还公开了包含本发明化合物和药学上可接受的载体或稀释剂的药物组合物。还公开了通过向受试者施用结构式（I）的化合物与紫杉醇或紫杉醇的类似物组合治疗患有癌症的受试者的方法。

24. 发明申请

US20050250770A1 Fused heterocyclic compounds 有权
标题翻译：稠合杂环化合物
公开(公告)号：US20050250770A1
公开(公告)日：2005-11-10
申请号：US10985627
申请日：2004-11-10
申请人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Zachary Demko , Dinesh Chimmanamada
发明人： Mitsunori Ono , Lijun Sun , Yumiko Wada , Teresa Przewloka , Hao Li , Zachary Demko , Dinesh Chimmanamada
IPC分类号： A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/541 , C07D239/84 , C07D239/88 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/04 , C07D413/14 , C07D471/04 , C07D475/06 , C07D491/04
CPC分类号： C07D239/95 , C04B35/632 , C07D215/40 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/04 , C07D413/14 , C07D471/04 , C07D475/06 , C07D491/04
摘要： This invention provides fused heterocyclic compounds, pharmaceutical compositions of, the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12 related disease and disorders.
摘要翻译：本发明提供稠合杂环化合物，化合物的药物组合物和使用该化合物治疗特别是IL-12相关疾病和病症的方法。

25. 发明授权

US06800660B2 Taxol enhancer compounds 失效
标题翻译：紫杉醇增强剂化合物
公开(公告)号：US06800660B2
公开(公告)日：2004-10-05
申请号：US10193075
申请日：2002-07-10
申请人： Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono
发明人： Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono
IPC分类号： A61K3116
CPC分类号： A61K47/48176 , A61K31/16 , A61K31/165 , A61K31/277 , A61K31/337 , A61K31/381 , A61K31/44 , A61K31/505 , A61K31/53 , A61K47/58 , C07C327/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/42 , C07D209/44 , C07D213/83 , C07D261/18 , C07D305/14 , C07D307/68 , C07D333/38 , C07D333/68 , C07D407/12
摘要： Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C═Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or —C(R7R8)—. R1 and R2 are independently an aryl group or a substituted aryl group, R3 and R4 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R5-R6 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R7 and R8 are each independently —H, an aliphatic or substituted aliphatic group, or R7 is —H and R8 is a substituted or unsubstituted aryl group, or, R7 and R8, taken together, are a C2-C6 substituted or unsubstituted alkylene group. Z is ═O or ═S. Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject with cancer by administering to the subject a compound of Structural Formula (I) in combination with taxol or an analog of taxol.
摘要翻译：公开了由结构式（I）表示的化合物：Y是共价键，亚苯基或取代或未取代的直链烃基。此外，Y与它所键合的两个> C = Z基团一起是取代或未取代的芳族基团。优选地，Y是共价键或-C（R7R8） - ，R1和R2独立地是芳基或取代的芳基，R3和R4独立地是-H，脂族基团，取代的脂族基团，芳基或取代的芳基.R 5 -R 6独立地是-H，脂族基团，取代的脂族基团，芳基或取代的芳基.R 7和R 8各自独立地为-H，脂族或取代的脂族基团，或者R 7是 -H和R8是取代或未取代的芳基，或者R 7和R 8一起是C 2 -C 6取代或未取代的亚烷基。Z = O或= S。还公开了药物组合物，其包含本发明和药学上可接受的载体或稀释剂。还公开了通过向受试者施用结构式（I）的化合物与紫杉醇或紫杉醇的类似物组合治疗患有癌症的受试者的方法。

26. 发明授权

US06743919B2 2-aroylimidazole compounds for treating cancer 失效
标题翻译：用于治疗癌症的2-芳酰基咪唑化合物
公开(公告)号：US06743919B2
公开(公告)日：2004-06-01
申请号：US10233371
申请日：2002-08-29
申请人： Keizo Koya , Lijun Sun , Mitsunori Ono , David James , Weiwen Ying , Shoujun Chen
发明人： Keizo Koya , Lijun Sun , Mitsunori Ono , David James , Weiwen Ying , Shoujun Chen
IPC分类号： C07D47102
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/14 , C07D471/04
摘要： Disclosed is a compound represented by Structural Formula (I): R1 is a substituted or unsubstituted 2-imidazolyl group which is optionally fused to a substituted or unsubstituted aryl group. Z1 is ═O, ═S, ═NOR11, or ═NR11. R is represented by a Structural Formula selected from (II)-(VII): The variables in Structural Formulas (II)-(VII) are described below.
摘要翻译：公开了由结构式（I）表示的化合物：R1是任选地与取代或未取代的芳基稠合的取代或未取代的2-咪唑基.Z1 = O，= S，= NOR11或= NR11.R 由选自（II） - （VII）的结构式表示：结构式（II） - （VII）中的变量如下所述。

27. 发明授权

US06693097B2 Pyrimidine compounds 有权
标题翻译：嘧啶化合物
公开(公告)号：US06693097B2
公开(公告)日：2004-02-17
申请号：US10000742
申请日：2001-11-30
申请人： Mitsunori Ono , Shijie Zhang , Teresa Przewloka , K. Koya , Elena Kostik , Yuniko Wada , Lijun Sun , Weiwen Ying
发明人： Mitsunori Ono , Shijie Zhang , Teresa Przewloka , K. Koya , Elena Kostik , Yuniko Wada , Lijun Sun , Weiwen Ying
IPC分类号： C07D41704
CPC分类号： C07D239/48 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/541 , C07D401/12 , C07D401/14 , C07D403/12
摘要： This invention features pyrimidine compounds of formula (I): aryl, or heteroaryl; each of R2 and R4, independently, is Rc, halogen, nitro, cyano, isothionitro, SRc, or ORc; or R2 and R4, taken together, is carbonyl; R3 is Rc, alkenyl, alkynyl, ORc, OC(O)Rc, SO2Rc, S(O)Rc, S(O2)NRcRd, SRc, NRcRd, NRcCORd, NRcC(O)ORd, NRcC(O)NRcRd, NRcSO2Rd, CORc, C(O)ORc, or C(O)NRcRd; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is O, S, S(O), S(O2), or NRc; Y is a covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and each of Rc and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.
摘要翻译：本发明的特征在于式（I）的嘧啶化合物：芳基或杂芳基; R 2和R 4各自独立地是R c，卤素，硝基，氰基，异硫代，SR c或OR c; 或R 2和R 4一起是羰基; R 3是R c，链烯基，炔基，OR c，OC（O）R c，SO 2 R c，S（O）R c，S（O 2）NR c NR c C（O）OR d，NR c C（O）NR c， R d，NR c，SO 2 R d，COR c，C（O）OR c或C（O）NR c R d; R5是H或烷基; n是0，1，2，3，4，5或6; X是O，S，S（O），S（O 2）或NR c; Y是共价键，CH 2，C（O），C = NR c，C = N-OR c，C = N-SR c，O，S，S（O））或NR ; Z是N或CH; U和V之一是N，另一个是CR ; 并且W是O，S，S（O），S（O 2），NR c或NC（O）R c; 其中R 1和R 2各自独立地是H，烷基，芳基，杂芳基; R c和R d各自独立地是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基。

28. 发明授权

US06660733B2 2,4,6-trisubstituted-pyrimidine compounds 有权
标题翻译： 2,4,6-三取代 - 嘧啶化合物
公开(公告)号：US06660733B2
公开(公告)日：2003-12-09
申请号：US10192347
申请日：2002-07-10
申请人： Lijun Sun , Mitsunori Ono , Teresa Przewloka , Elena Kostic , Yumiko Wada
发明人： Lijun Sun , Mitsunori Ono , Teresa Przewloka , Elena Kostic , Yumiko Wada
IPC分类号： C07D23924
CPC分类号： C07D239/48 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/541 , C07D401/12 , C07D401/14 , C07D403/12
摘要： This invention features pyrimidine compounds of formula (I): R1 is each of R2 and R4 is H; R3 is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is NRc; Y is covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and Rc is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.
摘要翻译：本发明的特征在于式（I）的嘧啶化合物：R1是R2，R4是H; R3是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基; R5是H或烷基; n是0，1，2，3，4，5或6; X是NR c; Y是共价键，CH 2，C（O），C = NR c，C = N-OR c，C = N-SR c，O，S，S（O），或NR ; Z是N或CH; U和V之一是N，另一个是CR ; 并且W是O，S，S（O），S（O 2），NR c或NC（O）R c; 其中R 1和R 2各自独立地是H，烷基，芳基，杂芳基; R c是H，烷基，芳基，杂芳基，环基，杂环基或烷基羰基。

29. 发明授权

US06616959B2 Water-soluble bean-based extracts 失效
标题翻译：水溶性豆类提取物
公开(公告)号：US06616959B2
公开(公告)日：2003-09-09
申请号：US10006326
申请日：2001-11-13
申请人： Mitsunori Ono , Keizo Koya , Noriaki Tatsuta , Naoto Yamaguchi , Lan Bo Chen
发明人： Mitsunori Ono , Keizo Koya , Noriaki Tatsuta , Naoto Yamaguchi , Lan Bo Chen
IPC分类号： A23L120
CPC分类号： A23L33/105 , A23V2002/00 , A23V2250/2116
摘要： This invention relates to a water-soluble bean-based extract including one or more isoflavone glycosides. Also shown is a method of preparing such a water-soluble bean-based extract.
摘要翻译：本发明涉及包含一种或多种异黄酮糖苷的水溶性豆类提取物。还示出了制备这种水溶性豆类提取物的方法。

30. 发明授权

US06462078B1 Epoxyvibsanin B 失效
标题翻译：环氧维生素B
公开(公告)号：US06462078B1
公开(公告)日：2002-10-08
申请号：US10056699
申请日：2002-01-25
申请人： Mitsunori Ono , Yumiko Wada , Naoto Yamaguchi , Jifeng Duan
发明人： Mitsunori Ono , Yumiko Wada , Naoto Yamaguchi , Jifeng Duan
IPC分类号： A61K31336
CPC分类号： C07D303/32
摘要： This invention relates to a new compound, epoxyvibsanin B, which can be used to treat an IL-12 overproduction-related disorder such as an inflammatory disease.
摘要翻译：本发明涉及可用于治疗IL-12过度生产相关疾病如炎性疾病的新化合物环氧维生素B。

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