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21. 发明授权

US06326160B1 Microprocessors for use in a device for predicting physiological values 有权
标题翻译：用于预测生理值的设备的微处理器
公开(公告)号：US06326160B1
公开(公告)日：2001-12-04
申请号：US09405976
申请日：1999-09-27
申请人： Timothy C. Dunn , Yalia Jayalakshmi , Ronald T. Kurnik , Matthew J. Lesho , Jonathan James Oliver , Russell O. Potts , Janet A. Tamada , Steven Richard Waterhouse , Charles W. Wei
发明人： Timothy C. Dunn , Yalia Jayalakshmi , Ronald T. Kurnik , Matthew J. Lesho , Jonathan James Oliver , Russell O. Potts , Janet A. Tamada , Steven Richard Waterhouse , Charles W. Wei
IPC分类号： G01N3350
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/441 , Y10S435/808 , Y10S435/817 , Y10S436/805 , Y10S436/806 , Y10S436/815 , Y10T436/115831
摘要： The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.
摘要翻译：本发明一般涉及使用从监测系统和专家混合（MOE）算法获得的一系列测量来测量存在于生物系统中的目标分析物的浓度的方法，系统和装置。在一个实施方案中，本发明描述了用于测量受试者血糖的方法。

22. 发明授权

US6144869A Monitoring of physiological analytes 有权
公开(公告)号：US6144869A
公开(公告)日：2000-11-07
申请号：US309727
申请日：1999-05-11
申请人： Bret Berner , Chia-Ming Chiang , Michael D. Garrison , Janan Jona , Russell O. Potts , Janet A. Tamada , Michael J. Tierney
发明人： Bret Berner , Chia-Ming Chiang , Michael D. Garrison , Janan Jona , Russell O. Potts , Janet A. Tamada , Michael J. Tierney
IPC分类号： G01N27/28 , A61B5/00 , A61B5/145 , A61B5/1477 , A61N1/30 , G01N27/327 , A61B5/05
CPC分类号： A61B5/1486 , A61B5/14532 , C12Q1/006 , A61B5/150022 , A61B5/150091 , A61B5/157 , A61N1/30
摘要： Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.

23. 发明授权

US07725149B2 Devices, methods, and kits for non-invasive glucose measurement 失效
标题翻译：用于非侵入性葡萄糖测量的装置，方法和试剂盒
公开(公告)号：US07725149B2
公开(公告)日：2010-05-25
申请号：US11159587
申请日：2005-06-22
申请人： Thomas A. Peyser , Russell O. Potts , Herbert L. Berman , James W. Moyer , Mikhail A. Kouchnir
发明人： Thomas A. Peyser , Russell O. Potts , Herbert L. Berman , James W. Moyer , Mikhail A. Kouchnir
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/1455 , A61B5/14521 , A61B5/14532 , A61B2562/0295 , G01N33/66 , G06F19/00
摘要： Described are devices, methods, and kits for non-invasively measuring glucose. In general, the devices comprise skin patches for placement on a skin surface and measurement devices for measuring glucose collected in the patches. The patches may include an adhesive material, a collection layer, an interface layer, and a sweat-permeable membrane. The sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion. In this way, non-correlatable skin surface glucose will not be measured. The patches may further include components to induce a local sweat response. The measurement device typically includes a display, a processor, and a measurement mechanism. The methods typically include the steps of wiping the skin surface with a wipe containing at least one solvent for removing glucose, placing a patch on a skin surface, and measuring glucose collected in the patch. Kits comprising the patch and measurement device are also described.
摘要翻译：描述了用于非侵入性测量葡萄糖的装置，方法和试剂盒。通常，这些装置包括用于放置在皮肤表面上的皮肤贴片和用于测量在贴片中收集的葡萄糖的测量装置。贴剂可以包括粘合剂材料，收集层，界面层和汗液渗透膜。透汗膜被配置为作为通过扩散带到皮肤表面的表皮污染物和葡萄糖的屏障。以这种方式，不能测量不相关的皮肤表面葡萄糖。补片还可以包括诱发局部汗水反应的组件。测量装置通常包括显示器，处理器和测量机构。所述方法通常包括以下步骤：用含有至少一种用于除去葡萄糖的溶剂的擦拭物擦拭皮肤表面，将贴片放置在皮肤表面上，以及测量在贴剂中收集的葡萄糖。还描述了包括贴剂和测量装置的试剂盒。

24. 发明申请

US20090270704A1 PATCHES, SYSTEMS, AND METHODS FOR NON-INVASIVE GLUCOSE MEASUREMENT 审中-公开
标题翻译：用于非入侵葡萄糖测量的配件，系统和方法
公开(公告)号：US20090270704A1
公开(公告)日：2009-10-29
申请号：US12435300
申请日：2009-05-04
申请人： Thomas A. PEYSER , Russell O. Potts , Herbert L. Berman , James W. Moyer , Mikhail A. Kouchnir , Robert N. Blair
发明人： Thomas A. PEYSER , Russell O. Potts , Herbert L. Berman , James W. Moyer , Mikhail A. Kouchnir , Robert N. Blair
IPC分类号： A61B5/1477
CPC分类号： G01N33/66 , A61B5/14521 , A61B5/14532 , A61B5/1486 , A61B5/6833 , A61B10/0064 , A61B2560/0412 , A61B2562/0295
摘要： Described here are patches, systems, and methods for measuring glucose. In general, the patches comprise a microfluidic collection layer and a detector, and the systems comprise a patch and a measurement device. Some methods for measuring glucose comprise cleaning the skin surface, collecting sweat from the skin surface using a microfluidic collection device, and measuring the collected glucose. Other methods comprise cleaning the skin surface, collecting sweat in a patch comprising a microfludic collection layer, and measuring glucose collected in the patch. Still other methods comprise cleaning the skin surface, collecting a first sweat sample from the skin surface in a patch comprising a microfludic collection layer and a detector layer, transferring the first sweat sample from the collection layer to the detector layer, measuring glucose in the first sweat sample, and repeating the collection, transferring, and measuring steps at least once.
摘要翻译：这里描述了用于测量葡萄糖的补丁，系统和方法。通常，贴片包括微流体收集层和检测器，并且系统包括贴片和测量装置。用于测量葡萄糖的一些方法包括清洁皮肤表面，使用微流体收集装置从皮肤表面收集汗液，以及测量收集的葡萄糖。其他方法包括清洁皮肤表面，在包含微量收集层的贴片中收集汗液，以及测量在贴片中收集的葡萄糖。还有其它方法包括清洁皮肤表面，在包括微量收集层和检测器层的贴片中从皮肤表面收集第一汗液样品，将第一汗液样品从收集层转移到检测器层，测量第一汗液样品中的葡萄糖汗液样品，并重复收集，转移和测量步骤至少一次。

25. 发明授权

US06885883B2 Methods for improving performance and reliability of biosensors 有权
标题翻译：提高生物传感器性能和可靠性的方法
公开(公告)号：US06885883B2
公开(公告)日：2005-04-26
申请号：US09859218
申请日：2001-05-14
申请人： Norman A. Parris , Russell O. Potts , Michael J. Tierney , Christopher Uhegbu
发明人： Norman A. Parris , Russell O. Potts , Michael J. Tierney , Christopher Uhegbu
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14532 , A61B5/14514 , A61B5/1486
摘要： The present invention relates to a predictive-kinetic method for use with data processing of a sensor-generated signal, as well as, microprocessors and monitoring systems employing such a predictive-kinetic method. Data from a transient region of a signal is used with suitable models and curve-fitting methods to predict the signal that would be measured for the system at the completion of the reaction. The values resulting from data processing of sensor response using the methods of the present invention are less sensitive to measurement variables.
摘要翻译：本发明涉及一种用于传感器生成信号的数据处理的预测动力学方法，以及采用这种预测动力学方法的微处理器和监视系统。来自信号的瞬态区域的数据与合适的模型和曲线拟合方法一起使用以预测在反应完成时将对系统测量的信号。使用本发明的方法的传感器响应的数据处理产生的值对测量变量较不敏感。

26. 发明授权

US06736777B2 Biosensor, iontophoretic sampling system, and methods of use thereof 有权
标题翻译：用于测量一种或多种分析物的量或浓度的传感器元件
公开(公告)号：US06736777B2
公开(公告)日：2004-05-18
申请号：US10353734
申请日：2003-01-29
申请人： Lynn Kim , Norman A. Parris , Russell O. Potts , Michael J. Tierney
发明人： Lynn Kim , Norman A. Parris , Russell O. Potts , Michael J. Tierney
IPC分类号： A61B500
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/1486 , A61B5/1495 , A61N1/30
摘要： The present invention relates generally to a sensor for use in monitoring the amount or concentration of target chemical analytes present in a biological system. For example, the invention relates to a sensor for measuring the amount or concentration of one or more analytes in a transdermally extracted sample. In one embodiment, the invention includes a sensor element comprising, a sensing electrode that reacts electrochemically with hydrogen peroxide to provide a detectable signal, wherein the sensing electrode comprises a platinum-group metal.
摘要翻译：本发明一般涉及用于监测存在于生物系统中的目标化学分析物的量或浓度的传感器。例如，本发明涉及用于测量经皮提取样品中一种或多种分析物的量或浓度的传感器。在一个实施方案中，本发明包括传感器元件，其包括感测电极，其与电化学反应与过氧化氢反应以提供可检测信号，其中感测电极包含铂族金属。

27. 发明授权

US06633772B2 Formulation and manipulation of databases of analyte and associated values 有权
标题翻译：分析物和相关值的数据库的制备和操作
公开(公告)号：US06633772B2
公开(公告)日：2003-10-14
申请号：US09927583
申请日：2001-08-10
申请人： Russell Ford , Matthew J. Lesho , Russell O. Potts , Michael J. Tierney , Charles W. Wei
发明人： Russell Ford , Matthew J. Lesho , Russell O. Potts , Michael J. Tierney , Charles W. Wei
IPC分类号： A61B500
CPC分类号： G16H10/40 , G06F19/00 , G06F19/3456 , G16H10/60 , G16H40/63 , Y10S707/99945 , Y10S707/99948
摘要： The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.
摘要翻译：本发明涉及配制分析物数据数据库的方法，数据库本身及其操作方法。一方面，本发明包括分析物数据点，派生数据和数据属性数据库的配方，其包括使用能够频繁地监测分析物浓度或量的分析物监测装置收集的数据点。这样的数据点可以包括获取的数据（例如，对应于由所述分析物监测装置测量的分析物浓度或量的值）。然后将这些数据点与一个或多个相关数据属性相关联。可以操作生成的数据库以确定数据库的组件之间的关系。

28. 发明授权

US06594514B2 Device for monitoring of physiological analytes 有权
公开(公告)号：US06594514B2
公开(公告)日：2003-07-15
申请号：US10026086
申请日：2001-12-20
申请人： Bret Berner , Chia-Ming Chiang , Michael D. Garrison , Janan Jona , Russell O. Potts , Janet A. Tamada , Michael J. Tierney
发明人： Bret Berner , Chia-Ming Chiang , Michael D. Garrison , Janan Jona , Russell O. Potts , Janet A. Tamada , Michael J. Tierney
IPC分类号： A16B505
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/150022 , A61B5/150091 , A61B5/157 , A61N1/30 , C12Q1/006
摘要： Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.

29. 发明授权

US06180416B2 Method and device for predicting physiological values 有权
标题翻译：用于预测生理值的方法和装置
公开(公告)号：US06180416B2
公开(公告)日：2001-01-30
申请号：US09163856
申请日：1998-09-30
申请人： Ronald T. Kurnik , Jonathan James Oliver , Russell O. Potts , Steven Richard Waterhouse , Timothy C. Dunn , Yalia Jayalakshmi , Matthew J. Lesho , Janet A. Tamada , Charles W. Wei
发明人： Ronald T. Kurnik , Jonathan James Oliver , Russell O. Potts , Steven Richard Waterhouse , Timothy C. Dunn , Yalia Jayalakshmi , Matthew J. Lesho , Janet A. Tamada , Charles W. Wei
IPC分类号： G01N33553
CPC分类号： A61B5/14532 , Y10S435/817 , Y10S436/806
摘要： The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.
摘要翻译：本发明一般涉及使用从监测系统和专家混合（MOE）算法获得的一系列测量来测量存在于生物系统中的目标分析物的浓度的方法，系统和装置。在一个实施方案中，本发明描述了用于测量受试者血糖的方法。

30. 发明申请

US20120165626A1 DEVICES, METHODS, AND KITS FOR DETERMINING ANALYTE CONCENTRATIONS 审中-公开
标题翻译：用于确定分析浓度的装置，方法和试剂盒
公开(公告)号：US20120165626A1
公开(公告)日：2012-06-28
申请号：US13383809
申请日：2010-07-01
申请人： Finkelshtein V. Irina , James W. Moyer , Russell O. Potts , Burton H. Sage , Robert J. Shartie , Donald R. Wilson , Bruce D. Wong
发明人： Finkelshtein V. Irina , James W. Moyer , Russell O. Potts , Burton H. Sage , Robert J. Shartie , Donald R. Wilson , Bruce D. Wong
IPC分类号： A61B5/1455 , A61B5/145
CPC分类号： C12Q1/006 , A61B5/14517 , A61B5/14532 , A61B5/1455 , A61B10/0064 , G01N21/78 , G01N21/8483 , G01N33/52 , G01N2021/7786
摘要： Devices, methods, and kits for measuring or otherwise evaluating the concentration of one or more analytes in a body fluid are described. The devices, methods, and/or kits may be non-invasive. In some variations, a method for measuring the concentration of an analyte in sweat of a subject may comprise contacting a colorimetric membrane with a skin surface of the subject so that the membrane collects a volume of sweat from the skin surface, and analyzing the colorimetric membrane to determine the concentration of the analyte in the collected volume of sweat.
摘要翻译：描述了用于测量或以其它方式评价体液中一种或多种分析物的浓度的装置，方法和试剂盒。装置，方法和/或试剂盒可以是非侵入性的。在一些变型中，用于测量受试者汗液中分析物浓度的方法可以包括使比色膜与受试者的皮肤表面接触，使得膜从皮肤表面收集体积的汗液，并分析比色膜以确定所收集体积的汗液中分析物的浓度。

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