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21. 发明申请

US20080309940A1 Method of, System For, and Medical Image Acquisition System For Imaging an Interior of a Turbid Medium Taking Into Account the Geometry of the Turbid Medium 审中-公开
公开(公告)号：US20080309940A1
公开(公告)日：2008-12-18
申请号：US12094698
申请日：2006-11-20
申请人： Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
发明人： Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
IPC分类号： G01N21/00
CPC分类号： G01N21/4795 , G01N2021/1787 , G01N2021/4766 , G01N2021/6439
摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume (20); coupling transmission input light (65) from a transmission light source into the receiving volume (12), with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45) and with at least a part of said transmission input light (65) passing through a matching medium (50) in the receiving volume (12), said matching medium (50) being chosen to reduce optical boundary effects at an interface between the turbid medium (45) and its surroundings; detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light (65) from the transmission light source into the receiving volume (12) through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and a medical image acquisition system both using the method. According to the invention, the method, system for imaging an interior of a turbid medium (45), and medical image acquisition system are adapted such that data relating to the exterior of the turbid medium (45) can be obtained. This object is realized in that the method further comprises the following additional steps: coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume (12), with the receiving volume comprising the turbid medium (45), with the receiving volume (12) further comprising a geometry medium (60) for surrounding the turbid medium (45) during coupling of geometry input light (70, 75, 80) into the receiving volume (12), and with the combination of the geometry input light (70, 75, 80), the geometry medium (60), and the interface being chosen for creating a contrast between the turbid medium and its surroundings; —detection of the contrast between the turbid medium (45) and its surroundings; reconstructing an image of an interior of the turbid medium (45) using the detected contrast.

22. 发明申请

US20120170824A1 SYSTEM FOR DETECTING GLOBAL PATIENT MOVEMENT DURING IMAGING PROCEDURES 有权
标题翻译：在成像过程中检测全球患者运动的系统
公开(公告)号：US20120170824A1
公开(公告)日：2012-07-05
申请号：US13320358
申请日：2010-05-10
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Michael Cornelis Van Beek , Peter-Andre Redert , Frederik Jan De Bruijn , Drazenko Babic , Robert Johannes Frederik Homan , Ralph Braspenning , Wei Pien Lee , Karl Catharina Van Bree , Caifeng Shan
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Michael Cornelis Van Beek , Peter-Andre Redert , Frederik Jan De Bruijn , Drazenko Babic , Robert Johannes Frederik Homan , Ralph Braspenning , Wei Pien Lee , Karl Catharina Van Bree , Caifeng Shan
IPC分类号： G06K9/00
CPC分类号： A61B6/025 , A61B6/4423 , A61B6/4441 , A61B6/5247 , A61B90/361 , A61B90/39 , A61B2090/376
摘要： The invention provides a system (102) for accurately detecting a patient's (114) movement during imaging procedures. The system comprises a camera (126) for providing a stream of camera images of a part of a patient's exterior (206). The system (102) furthermore comprises a fiducial element (116), which fiducial element (116) is mountable on said part of the patient's exterior (206), and which fiducial element (116) is detectable in the stream of camera images, and an image processor (128) for detecting a displacement of the fiducial element based on consecutive camera images comprised in at least the stream of camera images and for generating an output signal (129) indicative for said displacement. Herein, the fiducial element (116) has an in-plane stiffness which is substantially larger than an in-plane stiffness of said part of the patient's exterior. In addition, the fiducial element (116) and said part of the patient's exterior are provided with substantially equal outer in-plane dimensions.
摘要翻译：本发明提供一种用于在成像过程期间准确地检测患者（114）运动的系统（102）。该系统包括用于提供患者外部（206）的一部分的相机图像流的照相机（126）。所述系统（102）还包括基准元件（116），所述基准元件（116）可安装在所述患者外部部分（206）的所述部分上，并且所述基准元件（116）在相机图像流中是可检测的，以及图像处理器（128），用于基于包括在至少相机图像流中的连续相机图像来检测基准元素的位移，并且用于生成指示所述位移的输出信号（129）。这里，基准元件（116）具有的面内刚度基本上大于患者外部部分的平面内刚度。此外，基准元件（116）和患者外部的所述部分设置有基本上相等的外部平面外尺寸。

23. 发明授权

US07671973B2 Optical analysis system using multivariate optical elements 失效
标题翻译：光学分析系统采用多元光学元件
公开(公告)号：US07671973B2
公开(公告)日：2010-03-02
申请号：US10596564
申请日：2004-12-16
申请人： Michael Cornelis Van Beek , Frank Jeroen Pieter Schuurmans , Levinus Pieter Bakker
发明人： Michael Cornelis Van Beek , Frank Jeroen Pieter Schuurmans , Levinus Pieter Bakker
IPC分类号： G01N33/48
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/14552 , G01J3/36 , G01N21/65 , G01N33/49
摘要： The present invention provides an optical analysis system for determining an amplitude of a principal component of an optical signal. The principal component is indicative of the concentration of a particular compound or various compounds of a substance that is subject to spectroscopic analysis. The optical signal is subject to wavelength selective weighting and wavelength selective spatial separation specified by a weighting function. The optical signal is preferably separated into two parts that corresponding to a positive and negative spectral band of the weighting function, respectively. The separation provides separate detection of the separated parts of the optical signal without significant loss of intensity, thereby providing an improved signal to noise ratio of the determined principal component. Separation and weighting of the optical signal is realized by two multivariate optical elements.
摘要翻译：本发明提供了一种用于确定光信号的主分量的幅度的光学分析系统。主要成分指示特定化合物或受光谱分析的物质的各种化合物的浓度。光信号经受由加权函数指定的波长选择加权和波长选择性空间分离。光信号优选分为对应于加权函数的正和负光谱带的两部分。分离提供对光信号的分离部分的单独检测，而没有明显的强度损失，从而提供确定的主要分量的改善的信噪比。光信号的分离和加权由两个多元光学元件实现。

24. 发明申请

US20080309941A1 Method of, System for, and Medical Image Acquisition System for Imaging an Interior of a Turbid Medium Taking Into Account the Geometry of the Turbid Medium 审中-公开
公开(公告)号：US20080309941A1
公开(公告)日：2008-12-18
申请号：US12094802
申请日：2006-11-20
申请人： Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
发明人： Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
IPC分类号： G01N21/00
CPC分类号： G01N21/4795 , G01N2021/1787 , G01N2021/4766 , G01N2021/6439
摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume; coupling transmission input light (65) from a transmission light source into the receiving volume, with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45); detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light from the light source into the receiving volume through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and to a medical image acquisition system both using the method. The method, system, and medical image acquisition system are adapted such that an improved way of obtaining data relating to the exterior of the turbid medium (45) is realized. The object of the invention is realized in that the method further comprises the following steps:—coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume, with the receiving volume comprising the turbid medium (45) and with the combination of the geometry input light (70, 75, 80) and the interface (60) being chosen for creating a contrast between the turbid medium (45) and its surroundings; detection of the contrast (60) between the turbid medium (45) and its surroundings through use of a contrast photodetector unit; reconstructing an image of an interior of the turbid medium (45) using a the detected contrast (60). The system for imaging an interior of a turbid medium (45) and the medical image acquisition device are adapted to further comprise a geometry light source and a contrast photodetector unit.

25. 发明授权

US07230674B2 Lithographic apparatus and device manufacturing method 失效
标题翻译：平版印刷设备和器件制造方法
公开(公告)号：US07230674B2
公开(公告)日：2007-06-12
申请号：US11373503
申请日：2006-03-13
申请人： Mark Kroon , Michael Cornelis Van Beek , Peter Dirksen , Ralph Kurt , Cassandra May Owen
发明人： Mark Kroon , Michael Cornelis Van Beek , Peter Dirksen , Ralph Kurt , Cassandra May Owen
IPC分类号： G03B27/52 , G03B27/42 , G03B27/72
CPC分类号： G03F7/70983 , G03F7/70808 , G03F7/70916 , G03F7/70933
摘要： A lithographic apparatus includes a radiation system that provides a beam of radiation, and a support structure that supports a patterning structure. The patterning structure is configured to pattern the beam of radiation according to a desired pattern. The apparatus also includes a substrate support that supports a substrate, and a projection system that projects the patterned beam onto a target portion of the substrate. The projection system includes an optical element that has a beam exit area through each of which the patterned beam passes. The apparatus further includes a fluid cleaning system that cleans a fluid to be introduced into a region in between the optical element and the substrate. The fluid cleaning system includes a fluid inlet, a fluid outlet, and a cleaning zone disposed between the inlet and outlet. The cleaning zone includes a nucleated surface provided with a plurality of nucleation sites.
摘要翻译：光刻设备包括提供辐射束的辐射系统和支撑图案化结构的支撑结构。图形结构被配置为根据期望的图案对辐射束进行图案化。该装置还包括支撑基板的基板支撑件和将图案化的光束投影到基板的目标部分上的投影系统。投影系统包括光学元件，该光学元件具有通过图案化光束通过的每一个的光束出射区域。该装置还包括清洁被引入到光学元件和基板之间的区域中的流体的流体清洁系统。流体清洁系统包括流体入口，流体出口和布置在入口和出口之间的清洁区域。清洁区包括具有多个成核位点的成核表面。

26. 发明授权

US09955927B2 System for detecting global patient movement during imaging procedures 有权
公开(公告)号：US09955927B2
公开(公告)日：2018-05-01
申请号：US13320358
申请日：2010-05-10
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Michael Cornelis Van Beek , Peter-Andre Redert , Frederik Jan De Bruijn , Drazenko Babic , Robert Johannes Frederik Homan , Ralph Braspenning , Wei Pien Lee , Karl Catharina Van Bree , Caifeng Shan
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Michael Cornelis Van Beek , Peter-Andre Redert , Frederik Jan De Bruijn , Drazenko Babic , Robert Johannes Frederik Homan , Ralph Braspenning , Wei Pien Lee , Karl Catharina Van Bree , Caifeng Shan
IPC分类号： G06K9/00 , A61B6/02 , A61B6/00 , A61B90/00
CPC分类号： A61B6/025 , A61B6/4423 , A61B6/4441 , A61B6/5247 , A61B90/361 , A61B90/39 , A61B2090/376
摘要： A system for accurately detecting a patient's movement during imaging procedures includes a camera for providing a stream of camera images of a part of a patient's exterior and a fiducial element mountable on part of the patient's exterior. The fiducial element is detectable in the stream of images. An image processor is configured to detect a displacement of the fiducial element based on consecutive images including in at least the stream of images and to generate an output signal indicative of the displacement. The fiducial element has an in-plane stiffness which is substantially larger than an in-plane stiffness of the part of the patient's exterior. In addition, the fiducial element and the part of the patient's exterior are provided with substantially equal outer in-plane dimensions.

27. 发明申请

US20100002233A1 IMAGING OF TURBID MEDIUM 审中-公开
标题翻译：涡轮介质成像
公开(公告)号：US20100002233A1
公开(公告)日：2010-01-07
申请号：US12447669
申请日：2007-10-24
申请人： Maarten Marinus Johannes Wilhelm Van Herpen , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek
发明人： Maarten Marinus Johannes Wilhelm Van Herpen , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek
IPC分类号： A61B5/00 , G01N21/00
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/4312 , A61B2562/146
摘要： The invention relates to imaging of a turbid medium, for example in connection with optical mammography. A device for imaging a turbid medium (20) is disclosed, the device comprising: a holder (20) arranged for receiving the turbid medium and a matching fluid (21); one or more radiation sources (24) and one or more photodetectors (25). The matching fluid is a vapor with one or more optical properties of the matching fluid substantially matching the corresponding one or more optical properties of the turbid medium. In an embodiment, the matching fluid (21) is a composite vapor comprising at least two components.
摘要翻译：本发明涉及例如结合光学乳腺摄影术的混浊介质的成像。公开了一种用于对浑浊介质（20）进行成像的装置，该装置包括：安置用于接收混浊介质的保持器（20）和匹配流体（21）; 一个或多个辐射源（24）和一个或多个光电检测器（25）。匹配流体是具有匹配流体的一个或多个光学性质的蒸气，其基本上与混浊介质的对应的一个或多个光学特性相匹配。在一个实施例中，匹配流体（21）是包括至少两个组分的复合蒸气。

28. 发明申请

US20080300472A1 Method and Device for Optical Imaging of a Turbid Medium 有权
标题翻译：浊度介质的光学成像方法和装置
公开(公告)号：US20080300472A1
公开(公告)日：2008-12-04
申请号：US12094670
申请日：2006-11-17
申请人： Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
发明人： Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
IPC分类号： A61B5/1455
CPC分类号： A61B5/4312 , A61B5/0091 , A61B5/1455 , A61B5/14551
摘要： Disclosed is a method and a device for optical imaging of a turbid medium. This method comprises a reference measurement of reference intensities of light emanating from the turbid medium at a reference blood oxygen saturation (SaO2) in the turbid medium and a reference imaging step for reconstructing a reference image of the turbid medium from the measured reference intensities. Furthermore the method comprises a contrast measurement of the contrast intensity of the light emanating from the turbid medium at a contrast blood oxygen saturation (SaO2) level in the turbid medium and a contrast imaging step for reconstructing a contrast image of the turbid medium from the measured contrast intensities. A comparison is made between the contrast image to the reference image of the turbid medium.
摘要翻译：公开了一种用于浑浊介质的光学成像的方法和装置。该方法包括在混浊介质中以参考血氧饱和度（SaO2）从混浊介质发出的光的参考光强度的参考测量值，以及用于根据测量的参考光强度重建浊度介质的参考图像的参考成像步骤。此外，该方法包括在浑浊培养基中以对比血氧饱和度（SaO2）水平从浑浊培养基发出的光的对比度强度的对比度测量，以及用于从所测量的重量中重建浑浊培养基的对比度图像的对比度成像步骤对比强度。对比图像与混浊介质的参考图像之间进行比较。

29. 发明申请

US20080290256A1 Method and Device for Imaging an Interior of a Turbid Medium 有权
标题翻译：用于成像浊度介质内部的方法和装置
公开(公告)号：US20080290256A1
公开(公告)日：2008-11-27
申请号：US12094634
申请日：2006-11-21
申请人： Levinus Pieter Bakker , Gert T Hooft , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek
发明人： Levinus Pieter Bakker , Gert T Hooft , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek
IPC分类号： H03F3/08
CPC分类号： A61B5/4312 , A61B5/0091
摘要： The invention relates to a method and device (1) for imaging an interior of a turbid medium (55). A turbid medium (55) inside a measurement volume (15) is irradiated from a plurality of source positions (25a) with light from a light source (5), and light emanating from the measurement volume (15) is detected from a plurality of detection positions (25b). An image of the interior of the turbid medium (55) is reconstructed from the detected light. In both the method and the device (1), detector signals can be amplified for each source position-detection position pair by a multi-gain amplification unit comprising an amplifier circuit (60). The amplification factor is selected from a number of possible amplification factors based on detected signal strength in the prior art. According to the invention, however, the method and device are adapted such that the amplification factor is selected for at least one source position-detection position pair on the basis of an estimate of expected electrical signal strength.
摘要翻译：本发明涉及一种用于对浑浊介质（55）的内部进行成像的方法和装置（1）。从多个源位置（25a）利用来自光源（5）的光照射测量体积（15）内部的混浊介质（55），并且从测量体积（15）发出的光从多个检测位置（25b）。从检测到的光重建混浊介质（55）的内部的图像。在方法和装置（1）中，通过包括放大器电路（60）的多增益放大单元，可以为每个源位置检测位置对放大检测器信号。基于现有技术中检测到的信号强度，从多个可能的放大因子中选择放大因子。然而，根据本发明，所述方法和装置被适配成使得根据预期的电信号强度的估计为至少一个源位置检测位置对选择放大系数。

30. 发明申请

US20080285823A1 Device for Imaging an Interior of a Turbid Medium 审中-公开
标题翻译：用于成像混浊介质内部的装置
公开(公告)号：US20080285823A1
公开(公告)日：2008-11-20
申请号：US12094641
申请日：2006-11-13
申请人： Levinus Pieter Bakker , Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark
发明人： Levinus Pieter Bakker , Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark
IPC分类号： G06K9/00
CPC分类号： G01N21/4795 , A61B5/0091 , G01N21/6456 , G01N2021/1787 , G01N2021/6421
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (25). The device (1) may be used to accommodate a turbid medium (25) inside a measurement volume (20) and irradiate the turbid medium (25) with light from a light source (5), after which light emanating from the measurement volume (20) is detected and used to determine an image of the interior of the turbid medium (25). The device (1) is adapted such that additional means are introduced for irradiating the turbid medium (25) with light causing fluorescent emission in a contrast agent present in the turbid medium (25), for detecting the fluorescent emission in at least two spectral regions, and for calculating an image reconstruction for the at least two spectral regions detected. By detecting the fluorescent emission spectroscopically, that is as a function of wavelength, information can be obtained from which the concentration of a predetermined component present inside the turbid medium can be determined.
摘要翻译：本发明涉及一种用于对浑浊介质（25）的内部进行成像的装置（1）。装置（1）可以用于容纳测量体积（20）内部的混浊介质（25），并用来自光源（5）的光照射混浊介质（25），之后从测量体积 20）被检测并用于确定混浊介质（25）内部的图像。装置（1）适于使得附加装置被引入以用在浑浊介质（25）中存在的造影剂中引起荧光发射的光照射混浊介质，用于检测至少两个光谱区域中的荧光发射并且用于计算所检测的所述至少两个光谱区域的图像重建。通过检测荧光发射光谱，即作为波长的函数，可以获得可以确定存在于混浊介质内的预定成分的浓度的信息。

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