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21. 发明授权

US07115195B2 Ion selective monoelectrode complex 有权
标题翻译：离子选择性单电极复合物
公开(公告)号：US07115195B2
公开(公告)日：2006-10-03
申请号：US10856650
申请日：2004-05-27
申请人： Masaaki Terashima , Osamu Seshimoto
发明人： Masaaki Terashima , Osamu Seshimoto
IPC分类号： G01N27/333
CPC分类号： G01N27/307 , Y10T29/49002
摘要： An ion selective monoelectrode complex which is favorably employable to manufacture an ion activity measuring apparatus, has on a common non-electroconductive support sheet, plural ion selective monoelectrodes each of which is composed of an electrode composite consisting of, in order, a silver metal layer, a silver halide layer, an electrolytic material layer, and an ion selective membrane, and an electroconductive terminal which is electrically connected to the silver metal layer and which has an exposed surface, under the condition that the ion selective monoelectrodes are aligned, without electric contact with each other, along an imaginary line bridging the electrode composite and the electroconductive terminal.
摘要翻译：有利地用于制造离子活性测量装置的离子选择性单电极配合物在普通的非导电性支持片上具有多个离子选择性单电极，它们由依次由银金属层，卤化银层，电解质层和离子选择性膜，以及在离子选择性单电极排列的情况下，电连接到银金属层并且具有暴露表面的导电端子，没有电沿着桥接电极复合体和导电端子的假想线彼此接触。

22. 发明申请

US20050106757A1 Agglutination assay method in porous medium layer 审中-公开
标题翻译：多孔介质层凝集测定法
公开(公告)号：US20050106757A1
公开(公告)日：2005-05-19
申请号：US11022510
申请日：2004-12-22
申请人： Kentaro Nakamura , Kazuya Kawasaki , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
发明人： Kentaro Nakamura , Kazuya Kawasaki , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
IPC分类号： G01N33/52 , G01N33/543 , G01N33/58 , G01N33/551
CPC分类号： G01N33/54346 , G01N33/525 , G01N33/587
摘要： An agglutination assay method for quantitatively determination of an analyte in an aqueous liquid sample using particles bearing an anti-analyte. The agglutination is conducted in the porous medium layer of the analysis element. A speedy quantitative analysis of the analyte can be conveniently attained with high sensitivity. When the particle-labeled anti-analyte is contained in the porous medium layer, the anti-analyte can be stored with higher stability in the dry state. A dry analysis element for enabling such analysis method is also provided.
摘要翻译：一种用于使用带有抗分析物的颗粒定量测定含水液体样品中的分析物的凝集测定方法。凝集在分析元件的多孔介质层中进行。可以方便地以高灵敏度获得分析物的快速定量分析。当颗粒标记的抗分析物包含在多孔介质层中时，抗分析物可以在干燥状态下以更高的稳定性储存。还提供了用于实现这种分析方法的干燥分析元件。

23. 发明授权

US06858392B2 Blocking of device for detecting biochemically active molecules 有权
标题翻译：用于检测生化活性分子的装置的阻断
公开(公告)号：US06858392B2
公开(公告)日：2005-02-22
申请号：US10021840
申请日：2001-12-13
申请人： Yoshihide Iwaki , Hiroshi Shinoki , Osamu Seshimoto
发明人： Yoshihide Iwaki , Hiroshi Shinoki , Osamu Seshimoto
IPC分类号： G01N33/53 , C07B61/00 , C12N15/09 , C12Q1/68 , G01N33/543 , G01N33/566 , G01N37/00 , C07H21/00 , C12P19/34
CPC分类号： G01N33/54393 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , C07B2200/11 , C40B40/00
摘要： A process for blocking a device for detection of biochemically active molecules is performed by the steps of: bringing in the presence of an aqueous medium a detection device having probe molecules, ionic reactive groups, and non-ionic reactive groups on its surface, into contact with compounds which react with the non-ionic reactive groups to produce covalent bondings and compounds which form electrostatic bondings with the ionic reactive groups, simultaneously or separately; and washing the surface of the detection device with an aqueous solvent or a water-miscible solvent.
摘要翻译：用于阻断用于检测生物化学活性分子的装置的方法通过以下步骤进行：使水性介质存在于其表面上具有探针分子，离子反应性基团和非离子反应性基团的检测装置接触与非离子反应性基团反应产生共价键的化合物和与离子反应基团形成静电键的化合物同时或分开; 并用水溶剂或水混溶性溶剂洗涤检测装置的表面。

24. 发明授权

US06664051B1 Fixation of nucleotide derivatives to solid carrier 有权
标题翻译：核苷酸衍生物固定于固体载体
公开(公告)号：US06664051B1
公开(公告)日：2003-12-16
申请号：US09706405
申请日：2000-11-03
申请人： Hiroshi Shinoki , Yukio Sudo , Osamu Seshimoto
发明人： Hiroshi Shinoki , Yukio Sudo , Osamu Seshimoto
IPC分类号： C07H2104
CPC分类号： C40B40/06 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00677 , B82Y30/00 , C40B50/06
摘要： A DNA chip or its analogue composed of nucleotide derivatives attached to a solid carrier is prepared by method of bringing nucleotide derivatives having a reactive group at each one terminal into contact with a solid carrier having thereon reactive groups in an aqueous phase in the presence of a transferase which is capable of producing a covalent bond by rearrangement of the reactive group of the nucleotide derivative and the reactive group of the solid carrier.
摘要翻译：通过以下方法制备DNA芯片或其由连接于固体载体上的核苷酸衍生物组成的类似物的方法：使得在每个末端具有反应性基团的核苷酸衍生物与其中具有反应性基团的固体载体在水相中存在下接触能够通过核苷酸衍生物的反应性基团和固体载体的反应性基团的重排而产生共价键的转移酶。

25. 发明授权

US06468801B2 Method of judging presence of frameless chemical analysis film in chemical analysis film cartridge 失效
标题翻译：化学分析胶片盒中无框化学分析膜的存在方法
公开(公告)号：US06468801B2
公开(公告)日：2002-10-22
申请号：US09867725
申请日：2001-05-29
申请人： Yoshihiro Seto , Shunichi Seto , Osamu Seshimoto
发明人： Yoshihiro Seto , Shunichi Seto , Osamu Seshimoto
IPC分类号： G01N3500
CPC分类号： G01N35/00584 , G01N35/00029 , G01N2035/00059 , G01N2035/00089 , G01N2035/00455 , G01N2035/00683 , Y10T436/112499 , Y10T436/115831
摘要： Whether or not there remains a frameless chemical analysis film in a cartridge in which a plurality of the frameless chemical analysis films are stacked is judged by a film presence detector disposed in a second position different from a position where a film takeout mechanism takes out the frameless chemical analysis films from the cartridge so that the film presence detector does not interfere with the film takeout mechanism.
摘要翻译：在多个无框化学分析膜堆叠的盒中是否存在无框架化学分析膜，通过设置在不同于膜取出机构取出无框架的位置的第二位置的膜存在检测器来判断来自盒的化学分析膜，使得膜存在检测器不影响膜取出机构。

26. 发明授权

US06405876B1 Blood filter cartridge 失效
标题翻译：血液滤芯
公开(公告)号：US06405876B1
公开(公告)日：2002-06-18
申请号：US09464612
申请日：1999-12-15
申请人： Osamu Seshimoto , Kenichiro Yazawa , Takaki Arai
发明人： Osamu Seshimoto , Kenichiro Yazawa , Takaki Arai
IPC分类号： B01D2900
CPC分类号： G01N1/4077 , B01D61/18 , B01D61/20 , B01D69/12 , B01D69/141 , B01D71/68 , G01N33/491 , G01N2001/4016
摘要： The blood filter cartridge which can collect a minor component of blood efficiently in a high concentration comprises a blood filtering material and a holder containing the blood filtering material and having a blood inlet and a filtrate outlet, wherein an antibody or an antigen is immobilized on at least a part from the blood inlet to the filtrate outlet or a filtrate receiver.
摘要翻译：能够以高浓度有效地收集血液的次要成分的血液过滤器滤芯包括血液过滤材料和含有血液过滤材料并具有血液入口和滤液出口的保持器，其中将抗体或抗原固定在从血液入口到滤液出口或滤液接收器的至少一部分。

27. 发明授权

US06383818B1 Method of analyzing blood component 有权
标题翻译：分析血液成分的方法
公开(公告)号：US06383818B1
公开(公告)日：2002-05-07
申请号：US09496082
申请日：2000-02-01
申请人： Takaki Arai , Kenichiro Yazawa , Osamu Seshimoto
发明人： Takaki Arai , Kenichiro Yazawa , Osamu Seshimoto
IPC分类号： G01N100
CPC分类号： G01N33/491 , G01N1/4077 , Y10T436/25375
摘要： The present invention provides a method of analyzing a blood component by filtering blood using a glass fiber filter to obtain a plasma or serum sample and measuring the sample, wherein some plasma or serum samples obtained by using the same type glass fiber filter and by a standard method have previously been measured to determine a and b of the formula Y=ax+b wherein Y is the analytical value obtained by the standard method and x is the analytical value obtained by using the glass fiber filter, and the analytical value of the blood is corrected by using the above formula.
摘要翻译：本发明提供一种通过使用玻璃纤维过滤器过滤血液来分析血液成分的方法，以获得血浆或血清样品并测量样品，其中通过使用相同类型的玻璃纤维过滤器和标准物获得的一些血浆或血清样品先前已经测量了方法以确定糠醛的α和b，Y是通过标准方法获得的分析值，x是通过使用玻璃纤维过滤器获得的分析值，并且通过使用上述方法校正血液的分析值式。

28. 发明授权

US5496708A Reagent composition for quantitative analysis of inorganic phosphorous and dry analysis element utilizing the same 失效
标题翻译：用于定量分析无机磷和干分析元素的试剂组合物
公开(公告)号：US5496708A
公开(公告)日：1996-03-05
申请号：US259616
申请日：1994-06-14
申请人： Kazuya Kawasaki , Yoshikazu Amano , Osamu Seshimoto , Kiyoshi Yamada
发明人： Kazuya Kawasaki , Yoshikazu Amano , Osamu Seshimoto , Kiyoshi Yamada
IPC分类号： C12Q1/26 , C12Q1/28 , C12Q1/48 , G01N31/22
CPC分类号： C12Q1/48 , Y10S435/805 , Y10S435/97
摘要： A reagent composition for the quantitative analysis of inorganic phosphorus, composted of xanthosine, purine nucleoside phosphorylase, xanthine oxidase and a color-former. The color-former is a precursor for forming a dye in the presence of hydrogen peroxide and peroxidase. The reagent composition of the invention is improved in storage stability and has a wider determination range. Also provided is a dry analysis element composed of reagent layer containing the inventive reagent composition.
摘要翻译：用于定量分析无机磷的试剂组合物，堆肥的黄嘌呤，嘌呤核苷磷酸化酶，黄嘌呤氧化酶和成色剂。成色剂是在过氧化氢和过氧化物酶存在下形成染料的前体。本发明的试剂组合物的贮存稳定性提高，判定范围更广。还提供了由包含本发明试剂组合物的试剂层组成的干分析元件。

29. 发明授权

US4773969A Chlorine ion-selective electrode 失效
标题翻译：氯离子选择性电极
公开(公告)号：US4773969A
公开(公告)日：1988-09-27
申请号：US110565
申请日：1987-10-19
申请人： Kenji Miura , Takehiko Sato , Osamu Seshimoto
发明人： Kenji Miura , Takehiko Sato , Osamu Seshimoto
IPC分类号： G01N27/333 , G01N27/30 , G01N27/50
CPC分类号： G01N27/3335
摘要： In a chlorine ion-selective electrode for analysis of chlorine ion in a liquid sample which comprises a silver metal layer, a silver chloride layer and a chlorine ion-selective membrane, superposed in order, the chlorine ion-selective membrane containing a hydrophobic organic polymer as a binder, the improvement wherein the hydrophobic organic polymer is a vinyl acetal polymer such as vinyl butyral or a copolymer of a vinyl acetal and at least one monomer copolymerizable therewith such as a copolymer of vinyl butyral and vinyl alcohol.
摘要翻译：在用于分析包含银金属层，氯化银层和氯离子选择性膜的液体样品中的氯离子的氯离子选择性电极中，依次叠加含有疏水性有机聚合物的氯离子选择性膜作为粘合剂的改进，其中疏水性有机聚合物是乙烯醇缩醛聚合物如乙烯基缩丁醛或乙烯醇缩醛与至少一种可与其共聚的单体的共聚物，例如乙烯基缩丁醛和乙烯醇的共聚物。

30. 发明授权

US07820402B2 Immunoassay element 失效
标题翻译：免疫测定元件
公开(公告)号：US07820402B2
公开(公告)日：2010-10-26
申请号：US11230127
申请日：2005-09-19
申请人： Yoshiki Sakaino , Hitomi Ito , Toshihiro Mori , Osamu Seshimoto , Toshihisa Ito , Yoshikazu Amano
发明人： Yoshiki Sakaino , Hitomi Ito , Toshihiro Mori , Osamu Seshimoto , Toshihisa Ito , Yoshikazu Amano
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/54386 , G01N2333/924 , Y10S435/966 , Y10S435/969 , Y10S435/97 , Y10S436/807 , Y10S436/81
摘要： The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the labelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase. Highly sensitive assay is realized with high accuracy and high reproducibility and good storage stability.
摘要翻译：用于通过确定由免疫反应引起的酶标记的抗原或抗体的酶活性的变化来定量分析抗原的免疫测定元件。免疫测定元件包括含有在标记酶存在下形成可扩散材料的不扩散基底的底物层和含有用于进一步将可扩散材料分解成较低分子量产物的碎裂酶的试剂层。作为非扩散性底物，使用能够仅与标记酶反应并且不能使片段化酶反应的底物。当使用内源活性葡糖苷酶作为标记酶，并且使用外源活性葡糖苷酶时，试剂层中的断裂酶，底物层的非扩散性基质优选为内型选择性反应性底物，其中是指具有对内源性葡糖苷酶特异性的反应性的底物。高精度，高重现性和良好的储存稳定性实现了高灵敏度测定。

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