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21. 发明申请

US20130317134A1 TISSUE ADHESIVE BASED ON TRIFUNCTIONAL ASPARTATES 审中-公开
标题翻译：基于功能性ASPARTATES的组织粘合剂
公开(公告)号：US20130317134A1
公开(公告)日：2013-11-28
申请号：US13984170
申请日：2012-02-06
申请人： Heike Heckroth , Christoph Eggert
发明人： Heike Heckroth , Christoph Eggert
IPC分类号： A61L24/04
CPC分类号： A61L24/046 , C08G18/10 , C08G18/3821 , Y10T137/87571 , C08L75/02
摘要： The present invention relates to a compound of formula (I) wherein R1, R2 each independently of the other are identical or different organic radicals which do not contain Zerewitinoff-active hydrogen, and R4, R5, R6 each independently of the others are saturated, linear or branched organic radicals which do not contain Zerewitinoff-active hydrogen and which are also optionally substituted in the chain by heteroatoms, for use in a polyurea system which is provided in particular for sealing, bonding, gluing or covering cell tissue. The invention further provides a polyurea system comprising the compound according to the invention, and a metering system for the polyurea system according to the invention.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2各自独立地为相同或不同的不含Zerewitinoff活性氢的有机基团，R 4，R 5，R 6各自独立地为饱和的，不含Zerewitinoff-活性氢的线性或支化有机基团，并且其也可任选地被杂原子取代在链中，用于特别用于密封，粘合，胶合或覆盖细胞组织的聚脲体系。本发明还提供一种包含根据本发明的化合物的聚脲体系，以及根据本发明的聚脲体系的计量系统。

22. 发明申请

US20130035235A1 POLYURETHANE DISPERSIONS FOR SEALING THE TEATS OF THE MAMMARY GLANDS IN MILKING ANIMALS 审中-公开
公开(公告)号：US20130035235A1
公开(公告)日：2013-02-07
申请号：US13515036
申请日：2010-12-06
申请人： Sebastian Dörr , Heike Heckroth , Jan Schönberger , Robrecht Froyman , Han-Robert Hehnen , Kristine Fraatz , Hans-Otto Werling
发明人： Sebastian Dörr , Heike Heckroth , Jan Schönberger , Robrecht Froyman , Han-Robert Hehnen , Kristine Fraatz , Hans-Otto Werling
IPC分类号： C09D175/04 , A01N25/10 , A61P31/04 , A61P31/12 , A61P31/10 , A61K47/34 , A01P13/00
CPC分类号： A61L26/0019 , A61K9/0041 , A61L26/0066 , C08L75/04
摘要： The present invention relates to aqueous polyurethane dispersions for sealing teats of animal mammary glands.

23. 发明申请

US20110123479A1 MEDICAL ADHESIVES FOR STOPPING HEAVY BLEEDING AND SEALING LEAKAGES 有权
标题翻译：医用胶粘剂用于停止重型和密封泄漏
公开(公告)号：US20110123479A1
公开(公告)日：2011-05-26
申请号：US13054673
申请日：2009-07-04
申请人： Heike Heckroth , Burkhard Köhler , Sebastian Dörr
发明人： Heike Heckroth , Burkhard Köhler , Sebastian Dörr
IPC分类号： A61K31/785 , A61P7/00 , A61P7/04 , C12N5/071
CPC分类号： A61L24/0094 , A61L24/046 , A61L2400/04 , C08G18/089 , C08G18/10 , C08G18/4837 , C08L75/04 , C09J175/12 , C08G18/48 , C08G18/3821
摘要： The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.
摘要翻译：本发明涉及一种方法，其包括提供具有异氰酸酯官能预聚物和固化组分的制剂，所述固化组分包含将制剂施用于细胞组织的通式（I）的氨基功能性天冬氨酸酯; 并固化制剂，使得血液（止血）或组织液的损失被打开或细胞组织中的泄漏被密封。

24. 发明申请

US20090012206A1 MEDICAL ADHESIVES FOR SURGERY 有权
标题翻译：用于手术的医用胶粘剂
公开(公告)号：US20090012206A1
公开(公告)日：2009-01-08
申请号：US12164278
申请日：2008-06-30
申请人： Heike Heckroth , Burkhard Koehler , Sebastian Doerr
发明人： Heike Heckroth , Burkhard Koehler , Sebastian Doerr
IPC分类号： A61L24/04
CPC分类号： A61L24/046 , C08G18/10 , C08G18/4825 , C08G18/4837 , C08G2190/00 , C08G2210/00 , C08G2230/00 , C09J175/12 , C08L75/04 , C08G18/3821
摘要： The present invention relates to novel, rapidly curing adhesives based on hydrophilic polyisocyanate prepolymers for use in surgery.
摘要翻译：本发明涉及基于用于手术的亲水性多异氰酸酯预聚物的新型快速固化粘合剂。

25. 发明申请

US20060241127A1 Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors 失效
标题翻译：杂环氧基取代的苯基氨基嘧啶作为rho激酶抑制剂
公开(公告)号：US20060241127A1
公开(公告)日：2006-10-26
申请号：US10531889
申请日：2003-10-16
申请人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Perez , Heimo Ehmke
发明人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Perez , Heimo Ehmke
IPC分类号： A61K31/519 , A61K31/513 , A61K31/506 , C07D487/04 , C07D403/02
CPC分类号： C07D401/14 , C07D403/12 , C07D471/04
摘要： The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive compounds inhibit Rho-Kinase.
摘要翻译：本发明涉及杂芳氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物。本发明化合物抑制Rho-激酶。

26. 发明授权

US09764058B2 Medical adhesives for stopping heavy bleeding and sealing leakages 有权
公开(公告)号：US09764058B2
公开(公告)日：2017-09-19
申请号：US13054673
申请日：2009-07-04
申请人： Heike Heckroth , Burkhard Köhler , Sebastian Dörr
发明人： Heike Heckroth , Burkhard Köhler , Sebastian Dörr
IPC分类号： A61K31/785 , A61P7/00 , A61P7/04 , C12N5/071 , A61L24/00 , A61L24/04 , C08G18/08 , C08G18/10 , C08G18/48 , C09J175/12
CPC分类号： A61L24/0094 , A61L24/046 , A61L2400/04 , C08G18/089 , C08G18/10 , C08G18/4837 , C08L75/04 , C09J175/12 , C08G18/48 , C08G18/3821
摘要： The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.

27. 发明授权

US09421298B2 Tissue adhesive based on nitrogen-modified aspartates 有权
标题翻译：基于氮改性天冬氨酸的组织粘合剂
公开(公告)号：US09421298B2
公开(公告)日：2016-08-23
申请号：US13984186
申请日：2012-02-06
申请人： Heike Heckroth , Christoph Eggert
发明人： Heike Heckroth , Christoph Eggert
IPC分类号： C08L75/02 , C08L75/04 , C09D175/02 , C08G18/10 , A61L24/04 , C08G18/38 , C08G18/42 , C08G18/73 , A61L24/00
CPC分类号： A61L24/046 , A61L24/0015 , C08G18/10 , C08G18/3821 , C08G18/4252 , C08G18/73 , C08L75/04
摘要： The invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers which can be obtained by reacting aliphatic isocyanates A1) with polyols A2) that can have a number-average molecular weight of =400 g/mol and an average OH functionality of 2 to 6 in particular; and as component B) amino-functional aspartic acid esters of the general formula (I) in which X is an organic group containing a secondary amino function, R1, R2 are the same or different organic groups that do not have Zerewitinoff-active hydrogen, and n is a whole number of at least 2, in particular for sealing, bonding, gluing, or covering cell tissue. The invention also relates to a metering system for the polyurea system according to the invention.
摘要翻译：本发明涉及一种包含作为组分A）异氰酸酯官能的预聚物的聚脲体系，该异氰酸酯官能的预聚物可通过使脂族异氰酸酯A1）与数均分子量为400g / mol和平均OH官能度的多元醇A2）特别是2到6; 和作为组分B）通式（I）的氨基官能天冬氨酸酯，其中X是含有仲氨基官能团的有机基团，R 1，R 2是相同或不同的不具有齐维诺芬活性氢的有机基团，并且n是至少为2的整数，特别是用于密封，粘合，胶合或覆盖细胞组织。本发明还涉及根据本发明的聚脲系统的计量系统。

28. 发明申请

US20140065091A1 MEDICAL ADHESIVE FOR STEMMING BLEEDING 有权
标题翻译：医用胶粘剂
公开(公告)号：US20140065091A1
公开(公告)日：2014-03-06
申请号：US14112368
申请日：2012-04-17
申请人： Heike Heckroth , Christoph Eggert
发明人： Heike Heckroth , Christoph Eggert
IPC分类号： A61L24/04
CPC分类号： A61L24/046 , A61L24/0015 , C08G18/10 , C08G18/12 , C08G18/73 , C08G18/3821 , C08L75/02
摘要： The present invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers obtainable by reaction of aliphatic isocyanates A1) with polyols A2), which in particular can have a number-average molecular weight of ≧400 g/mol and a mean OH functionality of from 2 to 6, as component B) an amino-functional compound of the general formula (I) in which X is an organic radical containing a secondary amino function, Y is an organic radical that contains a tertiary amino group and does not contain Zerewitinoff-active hydrogen, R1 is a CH2—COOR3 radical in which R3 is an organic radical that does not contain Zerewitinoff-active hydrogen, a linear or branched C1- to C4-alkyl radical, a cyclopentyl radical, a cyclohexyl radical or H, R2 is an organic radical that does not contain Zerewitinoff-active hydrogen, a is 1 or 2, b is 1 or 2, and a+b=2 or 3, for stemming the escape of blood, and to a metering system for the polyurea system according to the invention.
摘要翻译：本发明涉及包含作为组分A）的异氰酸酯官能的预聚物本发明涉及通过脂族异氰酸酯A1）与多元醇A2）的反应得到的异氰酸酯官能的预聚物，其特别是其数均分子量> 400g / mol，平均OH官能度为2至6，作为组分B）通式（I）的氨基官能化合物，其中X为含有仲氨基官能团的有机基团，Y为含有叔氨基的有机基团，不含Zerewitinoff活性氢，R1是CH2-COOR3基团，其中R3是不含有Zerewitinoff活性氢的有机基团，直链或支链C 1 -C 4烷基，环戊基，环己基或H，R2是不含Zerewitinoff活性氢的有机基团，a是1或2，b为1或2，a + b = 2或3，用于阻止血液的逸出，并且计量系统对于根据本发明的聚脲系统。

29. 发明申请

US20120244107A1 BIODEGRADABLE HYDROGEL 审中-公开
标题翻译：生物可降解水凝胶
公开(公告)号：US20120244107A1
公开(公告)日：2012-09-27
申请号：US13502397
申请日：2010-10-07
申请人： Heike Heckroth , Christoph Eggert , Hartmut Nefzger , Jörg Hofmann , Edward Browne , Klaus Lorenz
发明人： Heike Heckroth , Christoph Eggert , Hartmut Nefzger , Jörg Hofmann , Edward Browne , Klaus Lorenz
IPC分类号： A61K31/785
CPC分类号： A61L31/14 , A61L31/06 , C08G18/10 , C08G18/4866 , C08G2210/00 , C08G18/3281 , C08L75/04
摘要： The present invention relates to a hydrogel on the basis of polyurethane or polyurethane urea, said hydrogel comprising hydrolysable functional groups in the polymer chain, to a method for producing the hydrogel and to the use of the hydrogel as adhesion barriers.
摘要翻译：本发明涉及基于聚氨酯或聚氨酯脲的水凝胶，所述水凝胶包括聚合物链中的可水解官能团，制备水凝胶的方法以及使用水凝胶作为粘合屏障。

30. 发明申请

US20120178847A1 POLYUREA-BASED FABRIC GLUE 有权
标题翻译：基于POLYUREA的织物玻璃
公开(公告)号：US20120178847A1
公开(公告)日：2012-07-12
申请号：US13384295
申请日：2010-07-06
申请人： Heike Heckroth , Hartmut Nefzger , Christoph Eggert
发明人： Heike Heckroth , Hartmut Nefzger , Christoph Eggert
IPC分类号： C09J175/02 , C09D175/02
CPC分类号： A61L24/046 , C08G18/10 , C08G18/18 , C09J175/02 , C09J175/12 , C08G18/3821 , C08L75/04
摘要： The present invention relates to a polyurea system, the use of such a polyurea system for sealing, linking, gluing, or covering of cellular tissue, and a dosing system having two chambers for a polyurea system such as this. The polyurea system comprises as components: A) an isocyanate-functioning prepolymer, which can be derived by reacting aliphatic isocyanates with polyoles, and B) an amino-functioning ester of aspartic acid. According to the invention, water and/or tertiary amine is added to the system, in order to increase the reacting speed of the prepolymer with the amino-functioning ester of aspartic acid while decreasing the setting time at the same time.
摘要翻译：本发明涉及聚脲系统，这种聚脲体系用于密封，连接，胶合或覆盖细胞组织，以及具有用于这种聚脲系统的两个室的计量系统。聚脲体系包含如下组分：A）异氰酸酯官能的预聚物，其可以通过使脂族异氰酸酯与多元醇反应得到，和B）天冬氨酸的氨基官能化酯。根据本发明，向系统中加入水和/或叔胺，以便增加预聚物与天冬氨酸的氨基官能酯的反应速度，同时同时降低凝固时间。

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