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21. 发明授权

US06170671B2 Blood filter unit 失效
标题翻译：血液过滤器单元
公开(公告)号：US06170671B2
公开(公告)日：2001-01-09
申请号：US09290650
申请日：1999-04-12
申请人： Masao Kitajima , Kenichiro Yazawa , Shigeru Tezuka , Fumio Sugaya , Akemi Higo , Kiyotaka Fujiwara
发明人： Masao Kitajima , Kenichiro Yazawa , Shigeru Tezuka , Fumio Sugaya , Akemi Higo , Kiyotaka Fujiwara
IPC分类号： B01D2900
CPC分类号： B01D39/2017 , B01D61/18 , B01D61/20 , B01D69/12 , G01N33/491
摘要： The blood filter unit of the invention is composed of a blood filtering material made of glass fiber filter and microporous membrane and a holder having a blood inlet and a filtrate outlet. The holder accommodates the blood filtering material so that the microporous membrane is located on the filtrate outlet side, provides a space between the blood filtering material and the filtrate outlet, and provides a means for preventing adhesion of the blood filtering material on the filtrate outlet side. By using the blood filter unit, a necessary volume of plasma or serum for analysis can be separated surely, irrespective of hematocrit value of the blood.
摘要翻译：本发明的血液过滤器单元由玻璃纤维过滤器和微孔膜制成的血液过滤材料和具有血液入口和滤液出口的保持器构成。保持器容纳血液过滤材料，使得微孔膜位于滤液出口侧，提供血液过滤材料和滤液出口之间的空间，并提供防止血液过滤材料在滤液出口侧粘附的手段。通过使用血液过滤器单元，可以确定地分离所需体积的血浆或血清，而不管血液的血细胞比容值如何。

22. 发明授权

US5876605A Preparation of plasma or serum sample from whole blood 失效
标题翻译：从全血制备血浆或血清样品
公开(公告)号：US5876605A
公开(公告)日：1999-03-02
申请号：US784480
申请日：1997-01-17
申请人： Masao Kitajima , Kenichiro Yazawa
发明人： Masao Kitajima , Kenichiro Yazawa
IPC分类号： G01N33/48 , G01N1/28 , G01N33/50 , B01D61/00
CPC分类号： G01N33/491 , G01N33/5002 , Y10T436/25375 , Y10T436/255
摘要： The method of the invention is for preparing a plasma or serum sample from whole blood and includes mixing an aqueous solution of an inorganic salt or an amino acid or salt thereof with the whole blood in an amount of 20% or less of the whole blood volume so that concentration of the inorganic salt or the amino acid or salt thereof becomes 10 to 200 .mu.mol/1 ml whole blood, and then, filtering the whole blood to remove blood cell components. According to the method of the invention, plasma separation from whole blood can be achieved efficiently, and recovered volume of plasma can be increased. By selecting reagent, good plasma which has no deviation in component viewpoint, and which is possible to measure in the same level accuracy as a plasma obtained by centurifuging, can be obtained through a simple filtration operation.
摘要翻译：本发明的方法是从全血中制备血浆或血清样品，包括将无机盐或其氨基酸或其盐的水溶液与全血的全血量的20％或更少的量混合使无机盐或其氨基酸或其盐的浓度成为10〜200μmol/ ml全血，然后过滤全血以除血细胞成分。根据本发明的方法，能够有效地实现全血的血浆分离，能够提高等离子体的回收体积。通过选择试剂，可以通过简单的过滤操作获得组分观点没有偏差的良好的等离子体，并且可以以与通过中间脱色获得的等离子体相同的精度测量。

23. 发明授权

US4783315A Analysis material sheet 失效
标题翻译：分析材料表
公开(公告)号：US4783315A
公开(公告)日：1988-11-08
申请号：US758562
申请日：1985-07-23
申请人： Fuminori Arai , Kenichiro Yazawa , Hideaki Takeuchi , Masao Kitajima
发明人： Fuminori Arai , Kenichiro Yazawa , Hideaki Takeuchi , Masao Kitajima
IPC分类号： G01N31/22 , G01N33/52 , G01N33/66
CPC分类号： G01N33/525 , Y10T428/31736 , Y10T428/3175
摘要： An analysis material sheet is disclosed which is comprised of layers of material with strong adhesion for one another. The sheet includes a water-impermeable support having provided directly or indirectly thereon a layer of fabric. The fabric contains a hydrophobic organic polymer fiber and is physically activated on at least one surface thereof, with the physically activated surface being adhered directly or indirectly to the support. A reagent layer can be provided directly or indirectly on the liquid sample-spreading layer of fabric. By utilizing a fabric containing a hydrophobic organic polymer fiber, body fluids to be analyzed can be quickly and uniformly spread and by utilizing the physically activated surface of the fabric, strong adhesion between the layers can be obtained.
摘要翻译：公开了一种分析材料片，其由彼此具有强粘合性的材料层组成。片材包括直接或间接地在其上提供织物层的不透水支撑体。织物含有疏水性有机聚合物纤维，并在其至少一个表面上物理活化，物理活化表面直接或间接地粘附到载体上。试剂层可以直接或间接地提供在织物的液体样品铺展层上。通过使用含有疏水性有机聚合物纤维的织物，可以快速且均匀地分散待分析的体液，并且通过利用织物的物理活化表面，可以获得层间的强粘合性。

24. 发明授权

US06220453B1 Blood filter unit 失效
标题翻译：血液过滤器单元
公开(公告)号：US06220453B1
公开(公告)日：2001-04-24
申请号：US09287425
申请日：1999-04-07
申请人： Masao Kitajima , Sigeru Tezuka , Yasuo Washizawa , Kenichiro Yazawa
发明人： Masao Kitajima , Sigeru Tezuka , Yasuo Washizawa , Kenichiro Yazawa
IPC分类号： B01D3500
CPC分类号： G01N1/4077 , A61M1/3633 , B01D19/0031 , B01D61/18 , B01D61/20
摘要： This invention provides a blood filter unit capable of obtaining a necessary volume of a plasma or serum sample from blood to be assayed easily at any place, which comprises a blood filtering material and a holder accommodating the blood filtering material and having a nozzle for sucking blood and a filtrate outlet, and the inside of the holder being kept reduced pressure conditions.
摘要翻译：本发明提供一种血液过滤器单元，其能够在任何地方容易地从血液中获得需要测定血液的血浆或血清样品的必需体积，该血液或血清样品包括血液过滤材料和容纳血液过滤材料的保持器，并具有用于吸入血液的喷嘴和滤液出口，并且保持器的内部保持减压条件。

25. 发明授权

US5979669A Blood filter unit 失效
标题翻译：血液过滤器单元
公开(公告)号：US5979669A
公开(公告)日：1999-11-09
申请号：US784481
申请日：1997-01-17
申请人： Masao Kitajima , Kenichiro Yazawa , Shigeru Tezuka , Fumio Sugaya , Akemi Higo , Kiyotaka Fujiwara
发明人： Masao Kitajima , Kenichiro Yazawa , Shigeru Tezuka , Fumio Sugaya , Akemi Higo , Kiyotaka Fujiwara
IPC分类号： G01N33/48 , B01D39/20 , B01D61/18 , B01D61/20 , B01D69/12 , G01N1/10 , G01N1/28 , G01N33/49 , B01D29/05 , B01D29/56 , B01D29/92
CPC分类号： B01D39/2017 , B01D61/18 , B01D61/20 , B01D69/12 , G01N33/491
摘要： A blood filter unit having a blood filter holder containing a blood filtering material of a glass fiber filter and a microporous membrane is described. The holder has a blood inlet and a filtrate outlet, and accommodates the blood filtering material so that the microporous membrane is located on the filtrate outlet side and has a space between the blood filtering material and the filtrate outlet. The holder provides means for preventing adhesion of the blood filtering material on the filtrate outlet side. The inventive blood filter unit allows separation of a desired volume of plasma or serum for analysis without interference by the hematocrit value of the blood.
摘要翻译：描述了具有含有玻璃纤维过滤器的血液过滤材料和微孔膜的血液过滤器保持器的血液过滤器单元。保持器具有血液入口和滤液出口，并且容纳血液过滤材料，使得微孔膜位于滤液出口侧，并且在血液过滤材料和滤液出口之间具有空间。保持器提供用于防止血液过滤材料在滤液出口侧粘附的装置。本发明的血液过滤器单元允许分离所需体积的血浆或血清用于分析，而不受血液的血细胞比容值的干扰。

26. 发明授权

US5569287A Means for collecting and spotting small amount of blood 失效
标题翻译：用于收集和发现少量血液的方法
公开(公告)号：US5569287A
公开(公告)日：1996-10-29
申请号：US353108
申请日：1994-12-09
申请人： Shigeru Tezuka , Hikaru Tsuruta , Teruaki Koizumi , Masao Kitajima
发明人： Shigeru Tezuka , Hikaru Tsuruta , Teruaki Koizumi , Masao Kitajima
IPC分类号： G01N33/48 , A61B5/15 , A61B5/151 , B01L3/02 , A61B17/14
CPC分类号： A61B5/15194 , A61B5/150022 , A61B5/150099 , A61B5/150435 , A61B5/150664 , A61B5/15111 , A61B5/15117
摘要： A means for collecting and spotting a small amount of blood which comprises a cylinder, a piston, and a puncturing tip, wherein: the piston is inserted airtightly into one end of the cylinder; the puncturing tip is airtightly and exchangeably fitted onto another end of the cylinder; the puncturing tip comprises a blood conduit and a needle suspended by a spring within the blood conduit; the blood conduit has a volume which is equal to a volume of blood to be spotted to analytical means; and the needle is arranged to be pushed out from the puncturing tip by descent of the piston and then return back by ascent of the piston.
摘要翻译：一种用于收集和检测少量血液的装置，包括一个气缸，活塞和一个穿刺尖端，其中：活塞被气密地插入气缸的一端; 穿刺尖端气密地并且可交换地安装在气缸的另一端上; 穿刺尖端包括血液导管和由血液导管内的弹簧悬挂的针头; 血液导管的体积等于要分析的血液量; 并且针被布置成通过活塞下降从穿刺尖端推出，然后通过活塞的上升返回。

27. 发明授权

US5122969A Biochemical analysis apparatus, method for correcting the results of biochemical analyses, and correction value recording medium for the same 失效
标题翻译：生物化学分析装置，校正生物化学分析结果的方法和校正值记录介质
公开(公告)号：US5122969A
公开(公告)日：1992-06-16
申请号：US480466
申请日：1990-02-15
申请人： Osamu Seshimoto , Masao Kitajima
发明人： Osamu Seshimoto , Masao Kitajima
IPC分类号： G01N21/78 , G01N1/00 , G01N27/26 , G01N35/00 , G01N35/04
CPC分类号： G01N35/00029 , G01N35/00594 , G01N35/00693 , G01N35/00732 , G01N2035/00039 , G01N2035/00356 , G01N2035/00702 , G01N2035/00752
摘要： A biochemical analysis apparatus comprises a movement device which moves analysis media containing a reagent or an electrochemical sensor, which will interact with a specific biochemical substance contained in liquid samples and give rise to changes in the analysis media, along a movement path connecting an introducing section and an ejecting section. While the analysis media are present in the movement path, a measurement device measures changes which have occurred in analysis media. A reading device reads information about correction values, which are to be used in order to correct a calibration curve so that it becomes suitable for analysis media used in analyses, from a correction value recording medium. A correction device corrects the calibration curve on the basis of the correction values. An operation device uses the corrected calibration curve in order to determine the concentration or the activity of the specific biochemical substance in a liquid sample from the value measured by the measurement device.

28. 发明授权

US4437970A Device for determining ionic activity 失效
标题翻译：用于测定离子活性的装置
公开(公告)号：US4437970A
公开(公告)日：1984-03-20
申请号：US500600
申请日：1983-06-02
申请人： Masao Kitajima , Osamu Seshimoto , Kikuo Kubotera , Akira Yamaguchi
发明人： Masao Kitajima , Osamu Seshimoto , Kikuo Kubotera , Akira Yamaguchi
IPC分类号： G01N27/28 , G01N27/46 , G01N27/58
CPC分类号： G01N27/307 , G01N27/3335
摘要： A device for determining ionic activity composed of, as essential components, plural pairs of ion-selective solid electrodes each pair having two electrodes (one electrode on each of two sides) and each pair having a different ion-selective layer; two liquid distribution porous members, each member disposed over all the electrodes of each said side of the plural pairs; and a porous capillary bridge disposed on or between the liquid distribution porous members. The bridge can be in liquid contact with all the electrodes through the liquid distribution porous members and achieve electrical conduction between two electrodes in each pair after spotting a test solution and a reference solution. The device preferably further comprises a support frame and a cover having two apertures for liquid spotting. The device can simultaneously determine ionic activities of a plurality of different ions in a test solution, such as whole blood, plasma, serum, urine, etc., by spotting a test solution and a reference solution each in one operation and measuring an electrical potential difference of each pair.
摘要翻译：用于确定离子活性的装置，作为必要组分，每对具有两对电极（两侧各一个电极）和每对具有不同离子选择层的多对离子选择性固体电极，两个液体分配多孔构件，每个构件设置在多对的每个所述侧的所有电极上; 以及布置在液体分配多孔构件之间或之间的多孔毛细管桥。桥接器可以通过液体分配多孔构件与所有电极液体接触，并且在点样测试溶液和参考溶液之后实现每对中两个电极之间的导电。该装置优选地还包括支撑框架和具有用于液体点样的两个孔的盖。该装置可以通过在一个操作中分别检测测试溶液和参考溶液来测量测试溶液中的多种不同离子的离子活性，例如全血，血浆，血清，尿等，并测量电位每对差异。

29. 发明授权

US4135976A Treatment of photographic processing effluents using photosynthetic sulfur bacteria 失效
标题翻译：使用光合硫磺细菌处理摄影加工液
公开(公告)号：US4135976A
公开(公告)日：1979-01-23
申请号：US776556
申请日：1977-03-10
申请人： Masao Kitajima
发明人： Masao Kitajima
IPC分类号： C02F1/32 , C02F3/28 , C02F3/34 , C12P3/00 , C22B3/18 , G03C5/31 , G03C5/395 , C02C5/10 , C22B11/00
CPC分类号： C12P3/00 , C02F1/32 , C02F3/28 , C02F3/345 , C22B3/18 , G03C5/31 , G03C5/3952 , Y02P10/234 , Y10S423/17
摘要： A process of treating a waste photographic processing solution containing reductive sulfur compounds, in particular, a waste fix solution for silver halide photographic materials, by applying thereto photosynthetic sulfur bacteria under anaerobic conditions with the irradiation of light. When the waste solution contains silver, the decontamination of the waste solution and the recovery of silver are performed simultaneously by the process.

30. 发明授权

US5443988A Method for high speed analysis of a dry analytical element 失效
标题翻译：干燥分析元件高速分析方法
公开(公告)号：US5443988A
公开(公告)日：1995-08-22
申请号：US138503
申请日：1993-08-30
申请人： Masao Kitajima
发明人： Masao Kitajima
IPC分类号： G01N35/00 , G01N35/02
CPC分类号： G01N35/00029 , Y10T436/110833 , Y10T436/112499 , Y10T436/114998
摘要： A high speed analyzer for a dry analytical element comprising a movable sample tray onto which the dry analytical element is placed, a sample-pipetting apparatus which spots a plurality of samples onto the dry analytical element placed onto the movable sample tray, an incubator which dries the dry analytical element onto which the samples have been spotted, a reagent-pipetting apparatus which spots a plurality of measuring reagent solutions onto the dry analytical element which has already been dried and a measuring part which measures a plurality of the dry analytical elements wherein reaction proceeds or has already been finished, and evaporation-preventing members which are attached to the dry analytical element onto which the reagents have been spotted to prevent evaporation of moisture from the spotted parts, and a method for measuring a plurality of analytical items of samples using the same. By utilizing the above analyzer, a large number of samples can be analyzed in various analytical items simultaneously rapidly.
摘要翻译：一种用于干燥分析元件的高速分析器，包括可移动的样品托盘，其上放置有干燥的分析元件;样品移液装置，其将多个样品放在放置在可移动的样品托盘上的干燥分析元件上，其上已经点样的干燥分析元件，将多个测量试剂溶液涂在已经被干燥的干燥分析元件上的试剂移液装置和测量多个干燥分析元件的测量部件，其中反应进行或已经完成，并且附着到其上已经点样试剂的干燥分析元件以防止来自点状部分的水分的蒸发的蒸发防止构件，以及用于测量多个样品分析项目的方法，使用一样。通过利用上述分析仪，可以在各种分析项目中快速分析大量样品。

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