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    • 21. 发明申请
    • Mass spectrometer
    • 质谱仪
    • US20060284072A1
    • 2006-12-21
    • US11495534
    • 2006-07-31
    • Yuichiro HashimotoTakashi BabaHideki HasegawaIzumi Waki
    • Yuichiro HashimotoTakashi BabaHideki HasegawaIzumi Waki
    • H01J49/00
    • H01J49/4225H01J49/004H01J49/401
    • A mass spectrometer capable of analyzing a wide mass range with high sensitivity and high mass accuracy. A mass spectrometer has an ionization source generating ions; an ion transfer optics transferring the ions; a first linear trap accumulating the ions and ejecting the ions in the specific mass range; a second linear trap having an end electrode disposed at the exit end ejecting the ions to change a DC potential gradient relative to a DC potential of the end electrode and trapping the ions ejected from the first linear trap to repeatedly eject them in pulse form; a time-of-flight mass spectrometer accelerating the ions ejected from the second linear trap in the orthogonal direction to detect them; and a controller changing the time duration of the ions in which the ions are ejected from the second linear trap or delay time from the completion of ejection to application of an accelerating voltage of the time-of-flight mass spectrometer according to the mass range of the ions ejected from the first linear trap to the second linear trap.
    • 能够以高灵敏度和高质量精度分析宽质量范围的质谱仪。 质谱仪具有产生离子的电离源; 离子转移光学器件转移离子; 积聚离子并在特定质量范围内喷射离子的第一线性阱; 第二线性阱,其具有设置在出射端处的终端电极,其排出离子,以相对于端电极的DC电位改变DC电位梯度,并且捕获从第一线性阱捕获的离子重复地以脉冲形式喷射; 飞行时间质谱仪在正交方向加速从第二线性阱捕获的离子以检测它们; 以及控制器,其将离子从第二线性阱捕获的离子或从完成喷射的延迟时间的持续时间改变为根据飞行时间质谱仪的加速电压的质量范围 离子从第一线性捕集器喷射到第二线性阱。
    • 22. 发明申请
    • Mass spectrometer
    • 质谱仪
    • US20050178955A1
    • 2005-08-18
    • US11006591
    • 2004-12-08
    • Takashi BabaYuichiro Hashimoto
    • Takashi BabaYuichiro Hashimoto
    • G01N27/62H01J49/04H01J49/34H01J49/40H01J49/42H01J49/26
    • H01J49/4225H01J49/0054H01J49/422
    • The present invention provides a mass spectrometry capable of high-efficiency and high-throughput ECD. An electron source and a two-dimensional combined ion trap in which a magnetic field along and generally parallel to a central axis is applied are used, thereby to achieve the foregoing object. First, precursor ions are trapped. By adopting the two-dimensional combined ion trap, it is possible to obtain a high ion trapping efficiency upon being injected and trapping. Subsequently, electrons are made incident thereon in such a manner as to be wound along the central axis to which no radio frequency is applied by using a magnetic field. For this reason, it is possible to allow energy-controlled electrons to reach the precursor ions. It is possible to implement a mass spectrometer capable of avoiding heating due to a radio frequency electric field, and effecting high-throughput/high-efficiency ECD.
    • 本发明提供能够实现高效率和高通量ECD的质谱。 使用其中施加沿着并且大致平行于中心轴的磁场的电子源和二维组合离子阱,从而实现上述目的。 首先,前体离子被捕获。 通过采用二维组合离子阱,可以在注入和捕获时获得高离子捕获效率。 随后,使电子以这样的方式入射,即沿着不通过使用磁场施加射频的中心轴缠绕。 因此,可以使能量控制的电子达到前体离子。 可以实现能够避免由于射频电场引起的加热并且实现高通量/高效率ECD的质谱仪。
    • 23. 发明授权
    • Mass spectrometer and mass spectrometric method
    • 质谱仪和质谱法
    • US06888134B2
    • 2005-05-03
    • US10608263
    • 2003-06-30
    • Yuichiro HashimotoHideki HasegawaTakashi BabaIzumi Waki
    • Yuichiro HashimotoHideki HasegawaTakashi BabaIzumi Waki
    • G01N27/62H01J49/42B01D59/44H01J49/00
    • H01J49/424H01J49/0481
    • There is provided an ion trap mass spectrometer which can detect fragment ions having a low mass and enables high-sensitivity measurement. A mass spectrometer has an ion source generating sample ions; an ion trap having a pair of and endcap electrodes and a ring electrode and accumulating ions generated by the ion source and isolating precursor ions from the accumulated ion and dissociating the isolated precursor ions and ejecting the dissociated ions from the ion trap. A gas introduction hole is arranged in the endcap electrode or the ring electrode for introducing in intermittently-introduced bath gas therethrough into the ion trap. A detector detects the ions ejected from the ion trap. The center axis of the gas introduction hole is arranged so as to pass through a region near the center of gravity of the ion trap.
    • 提供了一种离子阱质谱仪,可以检测低质量的碎片离子,并实现高灵敏度测量。 质谱仪具有产生样品离子的离子源; 具有一对和端盖电极和环形电极的离子阱,并且积聚由离子源产生的离子并且从累积的离子中分离前体离子并解离分离的前体离子并将离解的离子从离子阱中排出。 在端盖电极或环形电极中布置有气体导入孔,用于将间歇导入的浴气引入到离子阱中。 检测器检测从离子阱排出的离子。 气体导入孔的中心轴配置成通过离子阱重心附近的区域。
    • 26. 发明授权
    • Ion mobility separation device
    • 离子迁移分离装置
    • US09302271B2
    • 2016-04-05
    • US14411217
    • 2012-07-04
    • Yuichiro HashimotoHideki HasegawaMasao SugaHiroyuki Satake
    • Yuichiro HashimotoHideki HasegawaMasao SugaHiroyuki Satake
    • H01J49/02B03C7/02G01N27/62G01N27/447B03C3/017B03C3/08B03C3/12B03C3/41B03C3/47B03C3/68
    • B03C7/02B03C3/017B03C3/08B03C3/12B03C3/41B03C3/47B03C3/68G01N27/447G01N27/624
    • In an ion mobility separation device, there are problems that while arraying of separation electrodes and flow paths is restricted, time required for scanning correction voltages becomes longer and the throughput is reduced when the correction voltages are set in detail. These problems are solved for example by the following means. Namely, an ion mobility separation device characterized in that: at least one of a pair of plate electrodes has a first electrode section having a first conductivity, a second electrode section having a second conductivity, and a third electrode section interposed between the first electrode section and the second electrode section, wherein the third electrode section has a third conductivity smaller than the first conductivity and the second conductivity; the first electrode section, the second electrode section and the third electrode section are aligned in a direction perpendicular to a flow path; and a voltage controller applies different direct-current voltages to the first electrode section and the second electrode section.
    • 在离子迁移率分离装置中,存在限制分离电极和流路的排列的问题,当校正电压被详细设定时,扫描校正电压所需的时间变长,吞吐量降低。 这些问题通过以下方式得到解决。 也就是说,一种离子迁移率分离装置,其特征在于:一对平板电极中的至少一个具有具有第一导电性的第一电极部分,具有第二导电性的第二电极部分和介于第一电极部分之间的第三电极部分 和所述第二电极部,其中,所述第三电极部具有小于所述第一导电性和所述第二导电性的第三导电性; 第一电极部分,第二电极部分和第三电极部分在垂直于流路的方向上排列; 并且电压控制器对第一电极部分和第二电极部分施加不同的直流电压。
    • 27. 发明授权
    • Gas concentration controller system
    • 气体浓度控制系统
    • US09116526B2
    • 2015-08-25
    • US13327678
    • 2011-12-15
    • Yuichiro HashimotoJunichi Miyaji
    • Yuichiro HashimotoJunichi Miyaji
    • F17D3/00G05D11/13G01N33/00
    • G05D11/132G01N33/0006Y10T137/0318Y10T137/7759Y10T137/7761Y10T137/87249Y10T137/8729Y10T137/87314Y10T137/87676
    • The present invention is one that prevents standard gas from remaining in a standard gas line to prevent a concentration of standard gas from being reduced due to adsorption, modification, or the like, and has: a diluent gas line provided with a diluent gas flow rate controlling mechanism; a standard gas line provided with a standard gas flow rate controlling mechanism; an output gas line joined by the diluent gas line and standard gas line and outputs the standard gas having a predetermined concentration; an exhaust gas line connected to an upstream side of the standard gas flow rate controlling mechanism in the standard gas line and provided with an on/off valve and a flow rate control part; and a control part that, depending on a flow rate of the standard gas flowing through the standard gas line or the type of the standard gas, switches on/off the on/off valve.
    • 本发明是防止标准气体残留在标准气体管线中,以防止标准气体由于吸附,改性等而降低的浓度,并具有:具有稀释气体流量的稀释气体管线 控制机制; 设有标准气体流量控制机构的标准气体管线; 通过稀释气体管线和标准气体管路连接的输出气体管线,输出具有预定浓度的标准气体; 与标准气体流量控制机构的标准气体流量控制机构的上游侧连接并配置有开关阀和流量控制部的排气管路, 以及控制部,其根据流过标准气体管路的标准气体的流量或标准气体的类型来开/关开闭阀。
    • 28. 发明申请
    • Ion Mobility Separation Device
    • 离子迁移分离装置
    • US20150190815A1
    • 2015-07-09
    • US14411217
    • 2012-07-04
    • Yuichiro HashimotoHideki HasegawaMasao SugaHiroyuki Satake
    • Yuichiro HashimotoHideki HasegawaMasao SugaHiroyuki Satake
    • B03C7/02G01N27/447
    • B03C7/02B03C3/017B03C3/08B03C3/12B03C3/41B03C3/47B03C3/68G01N27/447G01N27/624
    • In an ion mobility separation device, there are problems that while arraying of separation electrodes and flow paths is restricted, time required for scanning correction voltages becomes longer and the throughput is reduced when the correction voltages are set in detail. These problems are solved for example by the following means. Namely, an ion mobility separation device characterized in that: at least one of a pair of plate electrodes has a first electrode section having a first conductivity, a second electrode section having a second conductivity, and a third electrode section interposed between the first electrode section and the second electrode section, wherein the third electrode section has a third conductivity smaller than the first conductivity and the second conductivity; the first electrode section, the second electrode section and the third electrode section are aligned in a direction perpendicular to a flow path; and a voltage controller applies different direct-current voltages to the first electrode section and the second electrode section.
    • 在离子迁移率分离装置中,存在限制分离电极和流路的排列的问题,当校正电压被详细设定时,扫描校正电压所需的时间变长,吞吐量降低。 这些问题通过以下方式得到解决。 也就是说,一种离子迁移率分离装置,其特征在于:一对平板电极中的至少一个具有具有第一导电性的第一电极部分,具有第二导电性的第二电极部分和介于第一电极部分之间的第三电极部分 和所述第二电极部,其中,所述第三电极部具有小于所述第一导电性和所述第二导电性的第三导电性; 第一电极部分,第二电极部分和第三电极部分在垂直于流路的方向上排列; 并且电压控制器对第一电极部分和第二电极部分施加不同的直流电压。
    • 30. 发明授权
    • Mass spectrometer and mass spectrometry method
    • 质谱仪和质谱法
    • US07800058B2
    • 2010-09-21
    • US11979811
    • 2007-11-08
    • Masuyuki SugiyamaYuichiro HashimotoHideki HasegawaIzumi Waki
    • Masuyuki SugiyamaYuichiro HashimotoHideki HasegawaIzumi Waki
    • H01J49/00
    • H01J49/4225H01J49/4215
    • A mass spectrometer that is switchable to operate as a linear trap or as a mass filter, and attaining both high ejection efficiency when operated as a linear trap and high mass resolving power when operated as a mass filter. A mass spectrometer includes an ion source for ionizing a sample, a linear trap quadrupole rod lens supplied with ionized ions, a trap electrode for forming a potential to trap the supplied ions between one end of the quadrupole lens and the other end, a control unit to regulate the trap lens voltage, and a mass analyzer or detector to detect ions ejected from the linear trap, and characterized in switching between an operation where the supplied ions are trapped in a section quadrupole rod lens and ejected by the controller unit regulating the trap electrode voltage; and an operation where ions are selective passed through according to their mass. The ejection efficiency when operated as an ion trap, and the mass resolving power when operated as a quadrupole mass filter are vastly improved compared to conventional methods.
    • 可以切换为线性捕集器或质量过滤器的质谱仪,当作为质量过滤器操作时,作为线性捕集器操作时获得高喷射效率和高质量分辨能力的质谱仪。 质谱仪包括用于电离样品的离子源,提供有离子化离子的线性捕获四极杆透镜,用于形成用于捕获四极透镜的一端与另一端之间的供应离子的电位的捕获电极,控制单元 调节陷波透镜电压,以及质量分析器或检测器,用于检测从线性阱捕获的离子,并且其特征在于,在所提供的离子被捕获在四极杆棒状透镜中并由调节阱的控制器单元喷射的操作之间进行切换 电极电压; 以及根据其质量选择性地通过离子的操作。 当作为离子阱操作时的喷射效率以及当作为四极质量过滤器操作时的质量分辨能力与常规方法相比大大提高。